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Debbie Zittema, Niek F. Casteleijn, Stephan J. L. Bakker, Lianne S. M. Boesten, A. A. Margreeth Duit, Casper F. M. Franssen, Carlo A. J. M. Gaillard, Ron T. Gansevoort
Urine Concentrating Capacity, Vasopressin and Copeptin in ADPKD and IgA Nephropathy Patients with Renal Impairment
www.plosone.org
www.plosone.org
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4.4334 0 Td
(analyses)Tj
3.5716 0 Td
(were)Tj
2.1656 0 Td
(performed)Tj
4.5695 0 Td
(to)Tj
1.0431 0 Td
(test)Tj
1.6441 0 Td
(associations)Tj
5.125 0 Td
(between)Tj
3.6056 0 Td
(plasma)Tj
-34.52 -1.3039 Td
(and)Tj
1.7631 0 Td
(urine)Tj
2.4094 0 Td
(osmolality,)Tj
4.7112 0 Td
(AVP,)Tj
2.4264 0 Td
(copeptin,)Tj
4.0479 0 Td
(AQP2-creatinine)Tj
7.2056 0 Td
(ratio,)Tj
2.3867 0 Td
(hTKV,)Tj
3.0104 0 Td
(albumin-creatinine)Tj
-27.9607 -1.2982 Td
(ratio)Tj
2.1486 0 Td
(\(ACR\))Tj
2.9253 0 Td
(and)Tj
1.7632 0 Td
(urine-to-plasma)Tj
6.8428 0 Td
(urea)Tj
2.0182 0 Td
(ratio)Tj
2.1543 0 Td
(\(U/P)Tj
2.2281 0 Td
(Urea\).)Tj
2.8176 0 Td
(AVP,)Tj
2.4264 0 Td
(copeptin,)Tj
4.0479 0 Td
(AQP2-creatinine)Tj
-29.3724 -1.2983 Td
(ratio,)Tj
2.3867 0 Td
(hTKV,)Tj
3.0104 0 Td
(ACR)Tj
2.2223 0 Td
(and)Tj
1.7632 0 Td
(U/P)Tj
1.8765 0 Td
(Urea)Tj
2.228 0 Td
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(log)Tj
1.474 0 Td
(\(ln\))Tj
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(transformed)Tj
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1.0489 0 Td
(fulfill)Tj
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(the)Tj
1.5024 0 Td
(requirement)Tj
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(of)Tj
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(distribution)Tj
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(the)Tj
1.508 0 Td
(residuals)Tj
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1.4173 0 Td
(regression)Tj
4.4277 0 Td
(analysis.)Tj
3.651 0 Td
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(investigate)Tj
4.5808 0 Td
(differences)Tj
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(between)Tj
-33.3579 -1.2983 Td
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(two)Tj
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(groups)Tj
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1.5024 0 Td
(categorical)Tj
4.6318 0 Td
(variable)Tj
3.4469 0 Td
(`study)Tj
2.6815 0 Td
(group')Tj
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(\(ADPKD)Tj
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(vs.)Tj
1.2926 0 Td
(IgAN\))Tj
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(was)Tj
1.7348 0 Td
(added)Tj
2.7155 0 Td
(to)Tj
-36.4759 -1.2983 Td
(the)Tj
1.5023 0 Td
(regression)Tj
4.4277 0 Td
(analysis.)Tj
3.651 0 Td
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5.7486 0 Td
(to)Tj
1.0432 0 Td
(investigate)Tj
4.5864 0 Td
(whether)Tj
3.5489 0 Td
(associations)Tj
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(between)Tj
3.6057 0 Td
(copeptin)Tj
-33.2388 -1.3039 Td
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2.4434 0 Td
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(the)Tj
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3.2712 0 Td
(interaction)Tj
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1.7347 0 Td
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(by)Tj
-36.2492 -1.2982 Td
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3.0557 0 Td
(product)Tj
3.4696 0 Td
(terms)Tj
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(including)Tj
4.1386 0 Td
(`study)Tj
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2.8857 0 Td
(and)Tj
1.7688 0 Td
(the)Tj
1.5024 0 Td
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5.3914 0 Td
(variable)Tj
3.4469 0 Td
(to)Tj
1.0488 0 Td
(this)Tj
1.7178 0 Td
(model.)Tj
-33.6583 -1.2983 Td
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4.5637 0 Td
(\(crude\))Tj
3.2485 0 Td
(linear)Tj
2.5795 0 Td
(regression)Tj
4.4277 0 Td
(models)Tj
3.1748 0 Td
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1.4796 0 Td
(presented)Tj
4.2123 0 Td
(with)Tj
2.0409 0 Td
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1.5024 0 Td
(correlation)Tj
4.7395 0 Td
(coefficient)Tj
-31.9689 -1.3039 Td
(whereas)Tj
3.5206 0 Td
(for)Tj
1.4173 0 Td
(multiple)Tj
3.6566 0 Td
(variable)Tj
3.4469 0 Td
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3.1692 0 Td
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1.5023 0 Td
(standardized)Tj
5.4879 0 Td
(regression)Tj
4.4276 0 Td
(coefficient)Tj
4.5014 0 Td
(beta)Tj
1.9219 0 Td
(\(St.)Tj
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1.6044 0 Td
()Tj
/F7 1 Tf
(\))Tj
1.0715 0 Td
(is)Tj
-35.7276 -1.2983 Td
(given.)Tj
-0.004 Tc
1.1962 -1.2982 Td
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1.4003 0 Td
(statistical)Tj
3.9061 0 Td
(analyses)Tj
3.4866 0 Td
(were)Tj
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4.4674 0 Td
(using)Tj
2.3924 0 Td
(SPSS)Tj
2.2053 0 Td
(22)Tj
1.1679 0 Td
(\(SPSS)Tj
2.5512 0 Td
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3.9287 0 Td
(Inc.,)Tj
1.9786 0 Td
(Chicago,)Tj
3.7361 0 Td
(IL,)Tj
1.3209 0 Td
(U.S.)Tj
-35.858 -1.2983 Td
(A.\).)Tj
1.6951 0 Td
(A)Tj
0.9014 0 Td
(p-value)Tj
3.1748 0 Td
(of)Tj
/F11 1 Tf
0 Tc
1.0147 0 Td
(<)Tj
/F7 1 Tf
-0.004 Tc
(0.05)Tj
2.6419 0 Td
(was)Tj
1.7008 0 Td
(considered)Tj
4.6034 0 Td
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1.0262 0 Td
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3.4072 0 Td
(statistical)Tj
3.9061 0 Td
(significance)Tj
4.9379 0 Td
(and)Tj
1.7292 0 Td
(all)Tj
1.1508 0 Td
(statistical)Tj
3.9061 0 Td
(tests)Tj
-35.7956 -1.3039 Td
(were)Tj
2.1203 0 Td
(2-tailed.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 434.211 cm
BT
/F2 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Results)Tj
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0 -1.5023 Td
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(water)Tj
2.6409 0 Td
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5.041 0 Td
(at)Tj
1.0488 0 Td
(baseline)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 399.1748 cm
BT
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1 TL
0.009 Tc
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3.6056 0 Td
(characteristics)Tj
6.1001 0 Td
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2.0523 0 Td
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(to)Tj
1.0488 0 Td
(age,)Tj
1.8199 0 Td
(sex)Tj
1.508 0 Td
(and)Tj
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(eGFR)Tj
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(ADPKD)Tj
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3.4695 0 Td
(and)Tj
1.7688 0 Td
(the)Tj
1.5081 0 Td
(IgAN)Tj
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1.8312 0 Td
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1.7348 0 Td
(successful)Tj
4.2973 0 Td
(\()Tj
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(Table)Tj
2.8573 0 Td
(1)Tj
0 g
(\).)Tj
1.3039 0 Td
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-33.6016 -1.2983 Td
(pressure)Tj
3.6793 0 Td
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1.7405 0 Td
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3.1861 0 Td
(higher)Tj
2.8856 0 Td
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1.7688 0 Td
(24-hour)Tj
3.5433 0 Td
(urine)Tj
2.4265 0 Td
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3.2768 0 Td
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1.7348 0 Td
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(ADPKD)Tj
-33.1538 -1.2982 Td
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3.4695 0 Td
(than)Tj
2.0807 0 Td
(in)Tj
1.0658 0 Td
(IgAN)Tj
2.4944 0 Td
(controls.)Tj
3.8268 0 Td
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2.3811 0 Td
(solute,)Tj
2.897 0 Td
(urea)Tj
2.0296 0 Td
(and)Tj
1.7688 0 Td
(creatinine)Tj
4.3596 0 Td
(excretion)Tj
4.0649 0 Td
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1.5817 0 Td
(not)Tj
1.6101 0 Td
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(the)Tj
1.5081 0 Td
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(indicating)Tj
4.3994 0 Td
(that)Tj
1.8255 0 Td
(both)Tj
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3.0501 0 Td
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(similar)Tj
3.0784 0 Td
(nutritional)Tj
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(intake)Tj
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(and)Tj
1.7688 0 Td
(muscle)Tj
-33.8397 -1.2982 Td
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2.4831 0 Td
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3.6113 0 Td
(plasma)Tj
3.1068 0 Td
(osmolality,)Tj
4.7281 0 Td
(copeptin)Tj
3.8268 0 Td
(and)Tj
1.7744 0 Td
(AVP)Tj
2.194 0 Td
(were)Tj
2.177 0 Td
(similar)Tj
3.0728 0 Td
(in)Tj
1.0658 0 Td
(both)Tj
2.109 0 Td
(study)Tj
2.4547 0 Td
(groups,)Tj
-32.6038 -1.2983 Td
(although)Tj
3.855 0 Td
(plasma)Tj
3.1125 0 Td
(osmolality)Tj
4.49 0 Td
(tended)Tj
3.0501 0 Td
(to)Tj
1.0488 0 Td
(be)Tj
1.1792 0 Td
(lower)Tj
2.5171 0 Td
(in)Tj
1.0602 0 Td
(ADPKD)Tj
3.6737 0 Td
(patients)Tj
3.4696 0 Td
(than)Tj
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(in)Tj
1.0658 0 Td
(IgAN)Tj
2.4945 0 Td
(controls)Tj
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(\()Tj
0.83 0.64 0.02 0 k
(Table)Tj
2.8573 0 Td
(2)Tj
0 g
(\).)Tj
1.3039 0 Td
(A)Tj
0.9127 0 Td
(spot)Tj
1.9559 0 Td
(urine)Tj
2.4265 0 Td
(sample)Tj
3.0954 0 Td
(collected)Tj
3.8607 0 Td
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(start)Tj
2.0466 0 Td
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1.0431 0 Td
(the)Tj
1.508 0 Td
(water)Tj
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(deprivation)Tj
4.9776 0 Td
(test,)Tj
1.8935 0 Td
(showed)Tj
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(less)Tj
1.661 0 Td
(concentrated)Tj
5.6069 0 Td
(urine)Tj
2.4208 0 Td
(with)Tj
2.0523 0 Td
(lower)Tj
2.5171 0 Td
(urine)Tj
2.4208 0 Td
(osmolality,)Tj
4.7282 0 Td
(sodium)Tj
3.3108 0 Td
(and)Tj
1.7688 0 Td
(urea)Tj
2.0296 0 Td
(in)Tj
1.0602 0 Td
(ADPKD)Tj
3.6736 0 Td
(patients)Tj
-33.2501 -1.2982 Td
(than)Tj
2.0806 0 Td
(IgAN)Tj
2.4944 0 Td
(controls)Tj
3.5887 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(Table)Tj
2.863 0 Td
(3)Tj
0 g
(\).)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 242.9858 cm
BT
/F0 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(After)Tj
2.3149 0 Td
(water)Tj
2.641 0 Td
(deprivation)Tj
5.041 0 Td
(at)Tj
1.0488 0 Td
(maximal)Tj
3.8977 0 Td
(urine)Tj
2.4094 0 Td
(concentration)Tj
ET
Q
q
1 j
1 J
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10 0 0 10 200.0125 225.9779 cm
BT
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1 TL
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1.4229 0 Td
(patients)Tj
3.4413 0 Td
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4.6544 0 Td
(a)Tj
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(standard)Tj
3.7928 0 Td
(prolonged)Tj
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(water)Tj
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1.0318 0 Td
(the)Tj
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(the)Tj
1.4966 0 Td
(safety)Tj
2.5342 0 Td
(stopping)Tj
3.7757 0 Td
(criteria)Tj
3.1465 0 Td
(during)Tj
2.982 0 Td
(the)Tj
1.4967 0 Td
(test.)Tj
1.8708 0 Td
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3.1295 0 Td
(osmolality)Tj
4.4503 0 Td
(increased)Tj
4.0819 0 Td
(significantly)Tj
5.2044 0 Td
(in)Tj
-35.9544 -1.2983 Td
(ADPKD)Tj
3.651 0 Td
(patients)Tj
3.4412 0 Td
(but)Tj
1.5817 0 Td
(not)Tj
1.5987 0 Td
(in)Tj
1.0545 0 Td
(IgAN)Tj
2.4832 0 Td
(controls.)Tj
3.787 0 Td
(Upon)Tj
2.5682 0 Td
(water)Tj
2.4718 0 Td
(deprivation,)Tj
5.1703 0 Td
(copeptin)Tj
3.7985 0 Td
(and)Tj
1.7574 0 Td
(AVP)Tj
-33.3635 -1.3039 Td
(increased)Tj
4.0818 0 Td
(significantly)Tj
5.2044 0 Td
(in)Tj
1.0545 0 Td
(ADPKD)Tj
3.651 0 Td
(patients)Tj
3.4412 0 Td
(and)Tj
1.7575 0 Td
(IgAN)Tj
2.4831 0 Td
(controls)Tj
3.5546 0 Td
(in)Tj
1.0545 0 Td
(a)Tj
0.6633 0 Td
(similar)Tj
3.0444 0 Td
(way)Tj
1.8198 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(Table)Tj
2.8403 0 Td
(2)Tj
0 g
(\).)Tj
-34.6504 -1.2983 Td
(Urine)Tj
2.6078 0 Td
(osmolality)Tj
4.456 0 Td
(increased)Tj
4.0762 0 Td
(both)Tj
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(in)Tj
1.0544 0 Td
(ADPKD)Tj
3.6567 0 Td
(patients)Tj
3.4356 0 Td
(and)Tj
1.7575 0 Td
(IgAN)Tj
2.4831 0 Td
(controls)Tj
3.5546 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(Table)Tj
2.8346 0 Td
(3)Tj
0 g
(\).)Tj
1.287 0 Td
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-33.3012 -1.2982 Td
(the)Tj
1.4966 0 Td
(maximal)Tj
3.7701 0 Td
(achieved)Tj
3.77 0 Td
(urine)Tj
2.4038 0 Td
(osmolality)Tj
4.4504 0 Td
(was)Tj
1.7291 0 Td
(significantly)Tj
5.2044 0 Td
(lower)Tj
2.4944 0 Td
(in)Tj
1.0545 0 Td
(ADPKD)Tj
3.6567 0 Td
(patients)Tj
3.4412 0 Td
(in)Tj
1.0488 0 Td
(com-)Tj
-34.52 -1.2983 Td
(parison)Tj
3.2881 0 Td
(to)Tj
1.0432 0 Td
(IgAN)Tj
2.4831 0 Td
(controls,)Tj
3.7871 0 Td
(especially)Tj
4.1045 0 Td
(due)Tj
1.7291 0 Td
(to)Tj
1.0432 0 Td
(a)Tj
0.6633 0 Td
(decreased)Tj
4.2179 0 Td
(urine)Tj
2.3981 0 Td
(urea)Tj
2.0126 0 Td
(concentration.)Tj
6.1738 0 Td
(AQP2)Tj
2.7212 0 Td
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-35.6652 -1.3039 Td
(maximal)Tj
3.77 0 Td
(urine)Tj
2.3981 0 Td
(concentration)Tj
5.9357 0 Td
(was)Tj
1.7291 0 Td
(similar)Tj
3.0501 0 Td
(in)Tj
1.0545 0 Td
(both)Tj
2.0919 0 Td
(groups)Tj
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(and)Tj
1.7575 0 Td
(decreased)Tj
4.2122 0 Td
(in)Tj
1.0545 0 Td
(a)Tj
0.6633 0 Td
(similar)Tj
3.0501 0 Td
(way)Tj
1.8198 0 Td
(dur-)Tj
-35.6142 -1.2983 Td
(ing)Tj
1.525 0 Td
(water)Tj
2.4774 0 Td
(deprivation.)Tj
5.1704 0 Td
(After)Tj
2.3301 0 Td
(DDAVP)Tj
3.6736 0 Td
(administration,)Tj
6.531 0 Td
(urine)Tj
2.4038 0 Td
(osmolality)Tj
4.4504 0 Td
(increased)Tj
4.0818 0 Td
(in)Tj
1.0545 0 Td
(ADPKD)Tj
-33.698 -1.2982 Td
(patients)Tj
3.4412 0 Td
(with)Tj
2.0296 0 Td
(an)Tj
1.2189 0 Td
(average)Tj
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(of)Tj
1.0318 0 Td
(+4.7%)Tj
2.7779 0 Td
(\(p)Tj
1.0942 0 Td
(=)Tj
0.8107 0 Td
(0.001\).)Tj
2.9764 0 Td
(However,)Tj
4.1499 0 Td
(numerically)Tj
5.0796 0 Td
(this)Tj
1.7121 0 Td
(increase)Tj
3.5433 0 Td
(was)Tj
1.7235 0 Td
(small)Tj
-34.8829 -1.304 Td
(and)Tj
1.7574 0 Td
(similar)Tj
3.0501 0 Td
(to)Tj
1.0431 0 Td
(the)Tj
1.4967 0 Td
(increase)Tj
3.5433 0 Td
(in)Tj
1.0545 0 Td
(the)Tj
1.4967 0 Td
(IgAN)Tj
2.4774 0 Td
(control)Tj
3.1861 0 Td
(group)Tj
2.6533 0 Td
(\(+4.5%,)Tj
3.3618 0 Td
(p)Tj
0.7484 0 Td
(=)Tj
0.805 0 Td
(0.01,)Tj
2.143 0 Td
(ADPKD)Tj
3.6566 0 Td
(vs.)Tj
1.287 0 Td
(IgAN:)Tj
-33.7604 -1.2982 Td
(p)Tj
0.7426 0 Td
(=)Tj
0.8107 0 Td
(0.4\).)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
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BT
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1 TL
-0.005 Tc
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1.5591 0 Td
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(urine)Tj
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(6)Tj
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11.9999 0 0 11.9999 200.0125 217.0204 cm
BT
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(0.003,)Tj
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(adjustment)Tj
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(and)Tj
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(hTKV)Tj
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(at)Tj
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(baseline)Tj
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1.559 0 Td
()Tj
/F7 1 Tf
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(=)Tj
0.7994 0 Td
(0.82,)Tj
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(0.001\))Tj
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(\(St.)Tj
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1.5591 0 Td
()Tj
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(=)Tj
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(0.58,)Tj
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(p)Tj
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(=)Tj
0.805 0 Td
(0.06\).)Tj
2.4378 0 Td
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(the)Tj
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(control)Tj
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(group)Tj
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(not)Tj
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(with)Tj
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(ACR)Tj
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(baseline,)Tj
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(neither)Tj
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(crude)Tj
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(\(p)Tj
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(=)Tj
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(0.2\))Tj
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(nor)Tj
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(after)Tj
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(eGFR)Tj
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(=)Tj
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(0.7\).)Tj
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(maximal)Tj
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(urine)Tj
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(concentration)Tj
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(copeptin)Tj
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(tended)Tj
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(to)Tj
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(be)Tj
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(\(R)Tj
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(=)Tj
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(0.50,)Tj
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(p)Tj
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(=)Tj
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(0.06\),)Tj
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(lost)Tj
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(significance)Tj
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(copeptin)Tj
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(furthermore)Tj
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(associated)Tj
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(hTKV)Tj
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(=)Tj
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(0.58,)Tj
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(p)Tj
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(=)Tj
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(0.03\).)Tj
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175.3294 703.3893 l
175.3294 690.3893 l
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f*
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498.3965 590.3898 m
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497.8964 578.3899 l
497.8964 590.3898 l
f*
498.3965 577.8899 m
390.7074 577.8899 l
390.7074 578.3899 l
497.8964 578.3899 l
f*
575.9997 577.8899 m
498.3965 577.8899 l
498.3965 578.3899 l
575.9997 578.3899 l
f*
175.3294 577.8899 m
175.3294 565.3899 l
174.8293 565.89 l
174.8293 577.8899 l
f*
175.3294 565.3899 m
36 565.3899 l
36 565.89 l
174.8293 565.89 l
f*
283.0184 577.8899 m
283.0184 565.3899 l
282.5184 565.89 l
282.5184 577.8899 l
f*
283.0184 565.3899 m
175.3294 565.3899 l
175.3294 565.89 l
282.5184 565.89 l
f*
390.7074 577.8899 m
390.7074 565.3899 l
390.2074 565.89 l
390.2074 577.8899 l
f*
390.7074 565.3899 m
283.0184 565.3899 l
283.0184 565.89 l
390.2074 565.89 l
f*
498.3965 577.8899 m
498.3965 565.3899 l
497.8964 565.89 l
497.8964 577.8899 l
f*
498.3965 565.3899 m
390.7074 565.3899 l
390.7074 565.89 l
497.8964 565.89 l
f*
575.9997 565.3899 m
498.3965 565.3899 l
498.3965 565.89 l
575.9997 565.89 l
f*
175.3294 565.3899 m
175.3294 552.89 l
174.8293 553.39 l
174.8293 565.3899 l
f*
175.3294 552.89 m
36 552.89 l
36 553.39 l
174.8293 553.39 l
f*
283.0184 565.3899 m
283.0184 552.89 l
282.5184 553.39 l
282.5184 565.3899 l
f*
283.0184 552.89 m
175.3294 552.89 l
175.3294 553.39 l
282.5184 553.39 l
f*
390.7074 565.3899 m
390.7074 552.89 l
390.2074 553.39 l
390.2074 565.3899 l
f*
390.7074 552.89 m
283.0184 552.89 l
283.0184 553.39 l
390.2074 553.39 l
f*
498.3965 565.3899 m
498.3965 552.89 l
497.8964 553.39 l
497.8964 565.3899 l
f*
498.3965 552.89 m
390.7074 552.89 l
390.7074 553.39 l
497.8964 553.39 l
f*
575.9997 552.89 m
498.3965 552.89 l
498.3965 553.39 l
575.9997 553.39 l
f*
175.3294 552.89 m
175.3294 540.39 l
174.8293 540.8901 l
174.8293 552.89 l
f*
175.3294 540.39 m
36 540.39 l
36 540.8901 l
174.8293 540.8901 l
f*
283.0184 552.89 m
283.0184 540.39 l
282.5184 540.8901 l
282.5184 552.89 l
f*
283.0184 540.39 m
175.3294 540.39 l
175.3294 540.8901 l
282.5184 540.8901 l
f*
390.7074 552.89 m
390.7074 540.39 l
390.2074 540.8901 l
390.2074 552.89 l
f*
390.7074 540.39 m
283.0184 540.39 l
283.0184 540.8901 l
390.2074 540.8901 l
f*
498.3965 552.89 m
498.3965 540.39 l
497.8964 540.8901 l
497.8964 552.89 l
f*
498.3965 540.39 m
390.7074 540.39 l
390.7074 540.8901 l
497.8964 540.8901 l
f*
575.9997 540.39 m
498.3965 540.39 l
498.3965 540.8901 l
575.9997 540.8901 l
f*
175.3294 540.39 m
175.3294 527.8901 l
174.8293 528.3901 l
174.8293 540.39 l
f*
175.3294 527.8901 m
36 527.8901 l
36 528.3901 l
174.8293 528.3901 l
f*
283.0184 540.39 m
283.0184 527.8901 l
282.5184 528.3901 l
282.5184 540.39 l
f*
283.0184 527.8901 m
175.3294 527.8901 l
175.3294 528.3901 l
282.5184 528.3901 l
f*
390.7074 540.39 m
390.7074 527.8901 l
390.2074 528.3901 l
390.2074 540.39 l
f*
390.7074 527.8901 m
283.0184 527.8901 l
283.0184 528.3901 l
390.2074 528.3901 l
f*
498.3965 540.39 m
498.3965 527.8901 l
497.8964 528.3901 l
497.8964 540.39 l
f*
498.3965 527.8901 m
390.7074 527.8901 l
390.7074 528.3901 l
497.8964 528.3901 l
f*
575.9997 527.8901 m
498.3965 527.8901 l
498.3965 528.3901 l
575.9997 528.3901 l
f*
175.3294 527.8901 m
175.3294 515.3902 l
174.8293 515.8902 l
174.8293 527.8901 l
f*
175.3294 515.3902 m
36 515.3902 l
36 515.8902 l
174.8293 515.8902 l
f*
283.0184 527.8901 m
283.0184 515.3902 l
282.5184 515.8902 l
282.5184 527.8901 l
f*
283.0184 515.3902 m
175.3294 515.3902 l
175.3294 515.8902 l
282.5184 515.8902 l
f*
390.7074 527.8901 m
390.7074 515.3902 l
390.2074 515.8902 l
390.2074 527.8901 l
f*
390.7074 515.3902 m
283.0184 515.3902 l
283.0184 515.8902 l
390.2074 515.8902 l
f*
498.3965 527.8901 m
498.3965 515.3902 l
497.8964 515.8902 l
497.8964 527.8901 l
f*
498.3965 515.3902 m
390.7074 515.3902 l
390.7074 515.8902 l
497.8964 515.8902 l
f*
575.9997 515.3902 m
498.3965 515.3902 l
498.3965 515.8902 l
575.9997 515.8902 l
f*
575.9997 502.8902 m
36 502.8902 l
36 503.3903 l
575.9997 503.3903 l
f*
175.3294 502.8902 m
175.3294 490.3903 l
174.8293 490.8903 l
174.8293 502.8902 l
f*
175.3294 490.3903 m
36 490.3903 l
36 490.8903 l
174.8293 490.8903 l
f*
283.0184 502.8902 m
283.0184 490.3903 l
282.5184 490.8903 l
282.5184 502.8902 l
f*
283.0184 490.3903 m
175.3294 490.3903 l
175.3294 490.8903 l
282.5184 490.8903 l
f*
390.7074 502.8902 m
390.7074 490.3903 l
390.2074 490.8903 l
390.2074 502.8902 l
f*
390.7074 490.3903 m
283.0184 490.3903 l
283.0184 490.8903 l
390.2074 490.8903 l
f*
498.3965 502.8902 m
498.3965 490.3903 l
497.8964 490.8903 l
497.8964 502.8902 l
f*
498.3965 490.3903 m
390.7074 490.3903 l
390.7074 490.8903 l
497.8964 490.8903 l
f*
575.9997 490.3903 m
498.3965 490.3903 l
498.3965 490.8903 l
575.9997 490.8903 l
f*
175.3294 490.3903 m
175.3294 477.8904 l
174.8293 478.3904 l
174.8293 490.3903 l
f*
175.3294 477.8904 m
36 477.8904 l
36 478.3904 l
174.8293 478.3904 l
f*
283.0184 490.3903 m
283.0184 477.8904 l
282.5184 478.3904 l
282.5184 490.3903 l
f*
283.0184 477.8904 m
175.3294 477.8904 l
175.3294 478.3904 l
282.5184 478.3904 l
f*
390.7074 490.3903 m
390.7074 477.8904 l
390.2074 478.3904 l
390.2074 490.3903 l
f*
390.7074 477.8904 m
283.0184 477.8904 l
283.0184 478.3904 l
390.2074 478.3904 l
f*
498.3965 490.3903 m
498.3965 477.8904 l
497.8964 478.3904 l
497.8964 490.3903 l
f*
498.3965 477.8904 m
390.7074 477.8904 l
390.7074 478.3904 l
497.8964 478.3904 l
f*
575.9997 477.8904 m
498.3965 477.8904 l
498.3965 478.3904 l
575.9997 478.3904 l
f*
175.3294 477.8904 m
175.3294 465.3904 l
174.8293 465.8905 l
174.8293 477.8904 l
f*
175.3294 465.3904 m
36 465.3904 l
36 465.8905 l
174.8293 465.8905 l
f*
283.0184 477.8904 m
283.0184 465.3904 l
282.5184 465.8905 l
282.5184 477.8904 l
f*
283.0184 465.3904 m
175.3294 465.3904 l
175.3294 465.8905 l
282.5184 465.8905 l
f*
390.7074 477.8904 m
390.7074 465.3904 l
390.2074 465.8905 l
390.2074 477.8904 l
f*
390.7074 465.3904 m
283.0184 465.3904 l
283.0184 465.8905 l
390.2074 465.8905 l
f*
498.3965 477.8904 m
498.3965 465.3904 l
497.8964 465.8905 l
497.8964 477.8904 l
f*
498.3965 465.3904 m
390.7074 465.3904 l
390.7074 465.8905 l
497.8964 465.8905 l
f*
575.9997 465.3904 m
498.3965 465.3904 l
498.3965 465.8905 l
575.9997 465.8905 l
f*
175.3294 465.3904 m
175.3294 452.8905 l
174.8293 453.3905 l
174.8293 465.3904 l
f*
175.3294 452.8905 m
36 452.8905 l
36 453.3905 l
174.8293 453.3905 l
f*
283.0184 465.3904 m
283.0184 452.8905 l
282.5184 453.3905 l
282.5184 465.3904 l
f*
283.0184 452.8905 m
175.3294 452.8905 l
175.3294 453.3905 l
282.5184 453.3905 l
f*
390.7074 465.3904 m
390.7074 452.8905 l
390.2074 453.3905 l
390.2074 465.3904 l
f*
390.7074 452.8905 m
283.0184 452.8905 l
283.0184 453.3905 l
390.2074 453.3905 l
f*
498.3965 465.3904 m
498.3965 452.8905 l
497.8964 453.3905 l
497.8964 465.3904 l
f*
498.3965 452.8905 m
390.7074 452.8905 l
390.7074 453.3905 l
497.8964 453.3905 l
f*
575.9997 452.8905 m
498.3965 452.8905 l
498.3965 453.3905 l
575.9997 453.3905 l
f*
175.3294 452.8905 m
175.3294 440.3906 l
174.8293 440.8906 l
174.8293 452.8905 l
f*
175.3294 440.3906 m
36 440.3906 l
36 440.8906 l
174.8293 440.8906 l
f*
283.0184 452.8905 m
283.0184 440.3906 l
282.5184 440.8906 l
282.5184 452.8905 l
f*
283.0184 440.3906 m
175.3294 440.3906 l
175.3294 440.8906 l
282.5184 440.8906 l
f*
390.7074 452.8905 m
390.7074 440.3906 l
390.2074 440.8906 l
390.2074 452.8905 l
f*
390.7074 440.3906 m
283.0184 440.3906 l
283.0184 440.8906 l
390.2074 440.8906 l
f*
498.3965 452.8905 m
498.3965 440.3906 l
497.8964 440.8906 l
497.8964 452.8905 l
f*
498.3965 440.3906 m
390.7074 440.3906 l
390.7074 440.8906 l
497.8964 440.8906 l
f*
575.9997 440.3906 m
498.3965 440.3906 l
498.3965 440.8906 l
575.9997 440.8906 l
f*
175.3294 440.3906 m
175.3294 427.8906 l
174.8293 428.3906 l
174.8293 440.3906 l
f*
175.3294 427.8906 m
36 427.8906 l
36 428.3906 l
174.8293 428.3906 l
f*
283.0184 440.3906 m
283.0184 427.8906 l
282.5184 428.3906 l
282.5184 440.3906 l
f*
283.0184 427.8906 m
175.3294 427.8906 l
175.3294 428.3906 l
282.5184 428.3906 l
f*
390.7074 440.3906 m
390.7074 427.8906 l
390.2074 428.3906 l
390.2074 440.3906 l
f*
390.7074 427.8906 m
283.0184 427.8906 l
283.0184 428.3906 l
390.2074 428.3906 l
f*
498.3965 440.3906 m
498.3965 427.8906 l
497.8964 428.3906 l
497.8964 440.3906 l
f*
498.3965 427.8906 m
390.7074 427.8906 l
390.7074 428.3906 l
497.8964 428.3906 l
f*
575.9997 427.8906 m
498.3965 427.8906 l
498.3965 428.3906 l
575.9997 428.3906 l
f*
575.9997 358.1408 m
36 358.1408 l
36 358.6408 l
575.9997 358.6408 l
f*
0 g
7.9999 0 0 7.9999 36 708.7181 cm
BT
/F2 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Table)Tj
2.7992 0 Td
(2.)Tj
1.2614 0 Td
(Measuremen)Tj
6.0237 0 Td
(ts)Tj
1.0913 0 Td
(in)Tj
1.1055 0 Td
(plasma)Tj
3.6143 0 Td
(at)Tj
1.0984 0 Td
(baseline)Tj
4.1669 0 Td
(\(5)Tj
1.0914 0 Td
(p.m.\))Tj
2.5795 0 Td
(and)Tj
1.9843 0 Td
(at)Tj
1.0914 0 Td
(maxima)Tj
3.6638 0 Td
(l)Tj
0.496 0 Td
(urine)Tj
2.6363 0 Td
(concentrat)Tj
5.0386 0 Td
(ion)Tj
1.715 0 Td
(during)Tj
3.3024 0 Td
(a)Tj
0.7653 0 Td
(standard)Tj
4.3867 0 Td
(prolonged)Tj
5.0669 0 Td
(water)Tj
2.7851 0 Td
(deprivation)Tj
5.5489 0 Td
(test.)Tj
0 Tc
-63.3123 -1.8567 Td
(Plasma)Tj
20.934 0 Td
(Overall)Tj
3.6071 0 Td
(n)Tj
0.8433 0 Td
(=)Tj
0.8079 0 Td
(30)Tj
8.1284 0 Td
(ADPKD)Tj
3.7559 0 Td
(n)Tj
0.8433 0 Td
(=)Tj
0.815 0 Td
(15)Tj
8.6457 0 Td
(IgAN)Tj
2.5583 0 Td
(n)Tj
0.8433 0 Td
(=)Tj
0.8079 0 Td
(15)Tj
8.2914 0 Td
(P-value)Tj
/F16 1 Tf
-60.8815 -1.6228 Td
(At)Tj
1.2756 0 Td
(baseline)Tj
/F0 1 Tf
-0.2764 -1.5591 Td
(Osmola)Tj
3.4228 0 Td
(lity)Tj
1.4457 0 Td
(\(mOsmol/k)Tj
4.8189 0 Td
(g\))Tj
12.0616 0 Td
(291)Tj
/F6 1 Tf
[( )]TJ
/F0 1 Tf
(8)Tj
13.4575 0 Td
(289)Tj
/F6 1 Tf
[( )]TJ
/F0 1 Tf
(5)Tj
13.1883 0 Td
(294)Tj
/F6 1 Tf
[( )]TJ
/F0 1 Tf
(10)Tj
12.2883 0 Td
(0.14)Tj
-60.6831 -1.5661 Td
(Sodium)Tj
3.5929 0 Td
(\(mmol/L\))Tj
17.7379 0 Td
(140)Tj
/F6 1 Tf
[( )]TJ
/F0 1 Tf
(2.5)Tj
13.4576 0 Td
(141)Tj
/F6 1 Tf
[( )]TJ
/F0 1 Tf
(2.9)Tj
13.4647 0 Td
(140)Tj
/F6 1 Tf
[( )]TJ
/F0 1 Tf
(2.0)Tj
12.43 0 Td
(0.67)Tj
-60.6831 -1.5591 Td
(Potassiu)Tj
3.8055 0 Td
(m)Tj
1.063 0 Td
(\(mmol/L\))Tj
16.597 0 Td
(4.3)Tj
/F6 1 Tf
[( )]TJ
/F0 1 Tf
(0.4)Tj
13.4647 0 Td
(4.3)Tj
/F6 1 Tf
[( )]TJ
/F0 1 Tf
(0.4)Tj
13.4576 0 Td
(4.3)Tj
/F6 1 Tf
[( )]TJ
/F0 1 Tf
(0.5)Tj
12.2953 0 Td
(0.97)Tj
-60.6831 -1.5661 Td
(Urea)Tj
2.374 0 Td
(\(mmol/L\))Tj
18.8151 0 Td
(11.2)Tj
/F6 1 Tf
[( )]TJ
/F0 1 Tf
(5.3)Tj
13.4647 0 Td
(10.3)Tj
/F6 1 Tf
[( )]TJ
/F0 1 Tf
(3.7)Tj
13.4576 0 Td
(12.1)Tj
/F6 1 Tf
[( )]TJ
/F0 1 Tf
(6.6)Tj
12.5717 0 Td
(0.35)Tj
-60.6831 -1.5591 Td
(AVP)Tj
2.2181 0 Td
(\(pmol/L\))Tj
17.8301 0 Td
(4.4)Tj
1.6086 0 Td
(\(1.412.0\))Tj
11.8489 0 Td
(2.2)Tj
1.6158 0 Td
(\(1.314)Tj
3.3591 0 Td
(.0\))Tj
8.4898 0 Td
(6.3)Tj
1.6087 0 Td
(\(1.412.0\))Tj
12.104 0 Td
(0.49)Tj
-60.6831 -1.5662 Td
(Copep)Tj
2.9126 0 Td
(tin)Tj
1.2827 0 Td
(\(pmol/L\))Tj
15.5765 0 Td
(11.9)Tj
2.1614 0 Td
(\(7.128.3\))Tj
11.3033 0 Td
(14.0)Tj
2.1614 0 Td
(\(6.130)Tj
3.3591 0 Td
(.1\))Tj
7.937 0 Td
(11.9)Tj
2.1615 0 Td
(\(7.327.7\))Tj
11.8276 0 Td
(0.98)Tj
/F16 1 Tf
-61.6823 -1.559 Td
(At)Tj
1.2756 0 Td
(maximal)Tj
4.2094 0 Td
(urine)Tj
2.6717 0 Td
(concentr)Tj
4.2024 0 Td
(ation)Tj
/F0 1 Tf
-11.3599 -1.5662 Td
(Osmola)Tj
3.4228 0 Td
(lity)Tj
1.4457 0 Td
(\(mOsmol/k)Tj
4.8189 0 Td
(g\))Tj
12.0616 0 Td
(294)Tj
/F6 1 Tf
[( )]TJ
/F0 1 Tf
(8)Tj
13.4575 0 Td
(293)Tj
/F6 1 Tf
[( )]TJ
/F0 1 Tf
(6)Tj
13.1883 0 Td
(295)Tj
/F6 1 Tf
[( )]TJ
/F0 1 Tf
(10)Tj
12.2883 0 Td
(0.51)Tj
-60.6831 -1.5591 Td
(Sodium)Tj
3.5929 0 Td
(\(mmol/L\))Tj
17.7379 0 Td
(142)Tj
/F6 1 Tf
[( )]TJ
/F0 1 Tf
(1.9)Tj
13.4576 0 Td
(142)Tj
/F6 1 Tf
[( )]TJ
/F0 1 Tf
(2.4)Tj
13.4647 0 Td
(141)Tj
/F6 1 Tf
[( )]TJ
/F0 1 Tf
(1.0)Tj
12.43 0 Td
(0.10)Tj
-60.6831 -1.5661 Td
(Potassiu)Tj
3.8055 0 Td
(m)Tj
1.063 0 Td
(\(mmol/L\))Tj
16.597 0 Td
(4.4)Tj
/F6 1 Tf
[( )]TJ
/F0 1 Tf
(0.5)Tj
13.4647 0 Td
(4.3)Tj
/F6 1 Tf
[( )]TJ
/F0 1 Tf
(0.5)Tj
13.4576 0 Td
(4.5)Tj
/F6 1 Tf
[( )]TJ
/F0 1 Tf
(0.6)Tj
12.2953 0 Td
(0.30)Tj
-60.6831 -1.5591 Td
(Urea)Tj
2.374 0 Td
(\(mmol/L\))Tj
18.8151 0 Td
(11.0)Tj
/F6 1 Tf
[( )]TJ
/F0 1 Tf
(5.3)Tj
13.4647 0 Td
(10.3)Tj
/F6 1 Tf
[( )]TJ
/F0 1 Tf
(3.5)Tj
13.4576 0 Td
(11.7)Tj
/F6 1 Tf
[( )]TJ
/F0 1 Tf
(6.6)Tj
12.5717 0 Td
(0.47)Tj
-60.6831 -1.5661 Td
(AVP)Tj
2.2181 0 Td
(\(pmol/L\))Tj
17.8301 0 Td
(9.6)Tj
1.6086 0 Td
(\(2.412.3\))Tj
11.8489 0 Td
(9.2)Tj
1.6158 0 Td
(\(1.412)Tj
3.3591 0 Td
(.0\))Tj
8.2134 0 Td
(10.0)Tj
2.1615 0 Td
(\(2.513.0\))Tj
11.8276 0 Td
(0.57)Tj
-60.6831 -1.5591 Td
(Copep)Tj
2.9126 0 Td
(tin)Tj
1.2827 0 Td
(\(pmol/L\))Tj
15.3001 0 Td
(23.7)Tj
2.1614 0 Td
(\(10.644.6\))Tj
11.3033 0 Td
(26.6)Tj
2.1614 0 Td
(\(12.74)Tj
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503.3645 403.3908 l
f*
575.9989 402.8907 m
503.8645 402.8907 l
503.8645 403.3908 l
575.9989 403.3908 l
f*
199.7779 402.8907 m
199.7779 390.3908 l
199.2779 390.8908 l
199.2779 402.8907 l
f*
199.7779 390.3908 m
36 390.3908 l
36 390.8908 l
199.2779 390.8908 l
f*
299.6725 402.8907 m
299.6725 390.3908 l
299.1725 390.8908 l
299.1725 402.8907 l
f*
299.6725 390.3908 m
199.7779 390.3908 l
199.7779 390.8908 l
299.1725 390.8908 l
f*
399.5671 402.8907 m
399.5671 390.3908 l
399.0671 390.8908 l
399.0671 402.8907 l
f*
399.5671 390.3908 m
299.6725 390.3908 l
299.6725 390.8908 l
399.0671 390.8908 l
f*
503.8645 402.8907 m
503.8645 390.3908 l
503.3645 390.8908 l
503.3645 402.8907 l
f*
503.8645 390.3908 m
399.5671 390.3908 l
399.5671 390.8908 l
503.3645 390.8908 l
f*
575.9989 390.3908 m
503.8645 390.3908 l
503.8645 390.8908 l
575.9989 390.8908 l
f*
199.7779 390.3908 m
199.7779 377.8909 l
199.2779 378.3909 l
199.2779 390.3908 l
f*
199.7779 377.8909 m
36 377.8909 l
36 378.3909 l
199.2779 378.3909 l
f*
299.6725 390.3908 m
299.6725 377.8909 l
299.1725 378.3909 l
299.1725 390.3908 l
f*
299.6725 377.8909 m
199.7779 377.8909 l
199.7779 378.3909 l
299.1725 378.3909 l
f*
399.5671 390.3908 m
399.5671 377.8909 l
399.0671 378.3909 l
399.0671 390.3908 l
f*
399.5671 377.8909 m
299.6725 377.8909 l
299.6725 378.3909 l
399.0671 378.3909 l
f*
503.8645 390.3908 m
503.8645 377.8909 l
503.3645 378.3909 l
503.3645 390.3908 l
f*
503.8645 377.8909 m
399.5671 377.8909 l
399.5671 378.3909 l
503.3645 378.3909 l
f*
575.9989 377.8909 m
503.8645 377.8909 l
503.8645 378.3909 l
575.9989 378.3909 l
f*
199.7779 377.8909 m
199.7779 365.3909 l
199.2779 365.891 l
199.2779 377.8909 l
f*
199.7779 365.3909 m
36 365.3909 l
36 365.891 l
199.2779 365.891 l
f*
299.6725 377.8909 m
299.6725 365.3909 l
299.1725 365.891 l
299.1725 377.8909 l
f*
299.6725 365.3909 m
199.7779 365.3909 l
199.7779 365.891 l
299.1725 365.891 l
f*
399.5671 377.8909 m
399.5671 365.3909 l
399.0671 365.891 l
399.0671 377.8909 l
f*
399.5671 365.3909 m
299.6725 365.3909 l
299.6725 365.891 l
399.0671 365.891 l
f*
503.8645 377.8909 m
503.8645 365.3909 l
503.3645 365.891 l
503.3645 377.8909 l
f*
503.8645 365.3909 m
399.5671 365.3909 l
399.5671 365.891 l
503.3645 365.891 l
f*
575.9989 365.3909 m
503.8645 365.3909 l
503.8645 365.891 l
575.9989 365.891 l
f*
199.7779 365.3909 m
199.7779 352.891 l
199.2779 353.391 l
199.2779 365.3909 l
f*
199.7779 352.891 m
36 352.891 l
36 353.391 l
199.2779 353.391 l
f*
299.6725 365.3909 m
299.6725 352.891 l
299.1725 353.391 l
299.1725 365.3909 l
f*
299.6725 352.891 m
199.7779 352.891 l
199.7779 353.391 l
299.1725 353.391 l
f*
399.5671 365.3909 m
399.5671 352.891 l
399.0671 353.391 l
399.0671 365.3909 l
f*
399.5671 352.891 m
299.6725 352.891 l
299.6725 353.391 l
399.0671 353.391 l
f*
503.8645 365.3909 m
503.8645 352.891 l
503.3645 353.391 l
503.3645 365.3909 l
f*
503.8645 352.891 m
399.5671 352.891 l
399.5671 353.391 l
503.3645 353.391 l
f*
575.9989 352.891 m
503.8645 352.891 l
503.8645 353.391 l
575.9989 353.391 l
f*
199.7779 352.891 m
199.7779 340.3911 l
199.2779 340.8911 l
199.2779 352.891 l
f*
199.7779 340.3911 m
36 340.3911 l
36 340.8911 l
199.2779 340.8911 l
f*
299.6725 352.891 m
299.6725 340.3911 l
299.1725 340.8911 l
299.1725 352.891 l
f*
299.6725 340.3911 m
199.7779 340.3911 l
199.7779 340.8911 l
299.1725 340.8911 l
f*
399.5671 352.891 m
399.5671 340.3911 l
399.0671 340.8911 l
399.0671 352.891 l
f*
399.5671 340.3911 m
299.6725 340.3911 l
299.6725 340.8911 l
399.0671 340.8911 l
f*
503.8645 352.891 m
503.8645 340.3911 l
503.3645 340.8911 l
503.3645 352.891 l
f*
503.8645 340.3911 m
399.5671 340.3911 l
399.5671 340.8911 l
503.3645 340.8911 l
f*
575.9989 340.3911 m
503.8645 340.3911 l
503.8645 340.8911 l
575.9989 340.8911 l
f*
199.7779 340.3911 m
199.7779 327.8911 l
199.2779 328.3911 l
199.2779 340.3911 l
f*
199.7779 327.8911 m
36 327.8911 l
36 328.3911 l
199.2779 328.3911 l
f*
299.6725 340.3911 m
299.6725 327.8911 l
299.1725 328.3911 l
299.1725 340.3911 l
f*
299.6725 327.8911 m
199.7779 327.8911 l
199.7779 328.3911 l
299.1725 328.3911 l
f*
399.5671 340.3911 m
399.5671 327.8911 l
399.0671 328.3911 l
399.0671 340.3911 l
f*
399.5671 327.8911 m
299.6725 327.8911 l
299.6725 328.3911 l
399.0671 328.3911 l
f*
503.8645 340.3911 m
503.8645 327.8911 l
503.3645 328.3911 l
503.3645 340.3911 l
f*
503.8645 327.8911 m
399.5671 327.8911 l
399.5671 328.3911 l
503.3645 328.3911 l
f*
575.9989 327.8911 m
503.8645 327.8911 l
503.8645 328.3911 l
575.9989 328.3911 l
f*
199.7779 327.8911 m
199.7779 315.3912 l
199.2779 315.8912 l
199.2779 327.8911 l
f*
199.7779 315.3912 m
36 315.3912 l
36 315.8912 l
199.2779 315.8912 l
f*
299.6725 327.8911 m
299.6725 315.3912 l
299.1725 315.8912 l
299.1725 327.8911 l
f*
299.6725 315.3912 m
199.7779 315.3912 l
199.7779 315.8912 l
299.1725 315.8912 l
f*
399.5671 327.8911 m
399.5671 315.3912 l
399.0671 315.8912 l
399.0671 327.8911 l
f*
399.5671 315.3912 m
299.6725 315.3912 l
299.6725 315.8912 l
399.0671 315.8912 l
f*
503.8645 327.8911 m
503.8645 315.3912 l
503.3645 315.8912 l
503.3645 327.8911 l
f*
503.8645 315.3912 m
399.5671 315.3912 l
399.5671 315.8912 l
503.3645 315.8912 l
f*
575.9989 315.3912 m
503.8645 315.3912 l
503.8645 315.8912 l
575.9989 315.8912 l
f*
575.9989 245.6413 m
36 245.6413 l
36 246.1414 l
575.9989 246.1414 l
f*
0 g
7.9999 0 0 7.9999 36 708.7181 cm
BT
/F2 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Table)Tj
2.7992 0 Td
(3.)Tj
1.2614 0 Td
(Measuremen)Tj
6.0237 0 Td
(ts)Tj
1.0913 0 Td
(in)Tj
1.1055 0 Td
(spot)Tj
2.3103 0 Td
(urine)Tj
2.6362 0 Td
(at)Tj
1.0914 0 Td
(baseline)Tj
4.167 0 Td
(\(5)Tj
1.0913 0 Td
(p.m.\))Tj
2.5866 0 Td
(and)Tj
1.9772 0 Td
(at)Tj
1.0914 0 Td
(maximal)Tj
4.1669 0 Td
(urine)Tj
2.6292 0 Td
(concentrat)Tj
5.0386 0 Td
(ion)Tj
1.715 0 Td
(during)Tj
3.3024 0 Td
(a)Tj
0.7653 0 Td
(standard)Tj
4.3867 0 Td
(prolonged)Tj
5.0669 0 Td
(water)Tj
2.7922 0 Td
(depriv)Tj
2.9551 0 Td
(ation)Tj
2.5867 0 Td
(test.)Tj
0 Tc
-64.6375 -1.8567 Td
(Spot)Tj
2.4519 0 Td
(urine)Tj
21.0545 0 Td
(Overal)Tj
3.0898 0 Td
(l)Tj
0.5103 0 Td
(n)Tj
0.8433 0 Td
(=)Tj
0.8149 0 Td
(30)Tj
7.1505 0 Td
(ADPKD)Tj
3.7559 0 Td
(n)Tj
0.8433 0 Td
(=)Tj
0.815 0 Td
(15)Tj
7.9513 0 Td
(IgAN)Tj
2.5512 0 Td
(n)Tj
0.8433 0 Td
(=)Tj
0.8149 0 Td
(15)Tj
7.7316 0 Td
(P-value)Tj
/F16 1 Tf
-61.2217 -1.6228 Td
(At)Tj
1.2756 0 Td
(baseline)Tj
/F0 1 Tf
-1.2756 -1.5591 Td
(Osmolality)Tj
4.8685 0 Td
(\(mOsmol/k)Tj
4.8189 0 Td
(g\))Tj
15.0734 0 Td
(438)Tj
/F6 1 Tf
[( )]TJ
/F0 1 Tf
(160)Tj
12.4867 0 Td
(378)Tj
/F6 1 Tf
[( )]TJ
/F0 1 Tf
(157)Tj
12.7631 0 Td
(498)Tj
/F6 1 Tf
[( )]TJ
/F0 1 Tf
(144)Tj
11.7426 0 Td
(0.04)Tj
-61.7532 -1.5661 Td
(Sodium)Tj
3.5929 0 Td
(\(mmol/L\))Tj
21.7206 0 Td
(66)Tj
/F6 1 Tf
[( )]TJ
/F0 1 Tf
(32)Tj
12.4867 0 Td
(55)Tj
/F6 1 Tf
[( )]TJ
/F0 1 Tf
(29)Tj
12.7631 0 Td
(77)Tj
/F6 1 Tf
[( )]TJ
/F0 1 Tf
(32)Tj
11.1899 0 Td
(0.06)Tj
-61.7532 -1.5591 Td
(Potassium)Tj
4.8685 0 Td
(\(mmol/L\))Tj
20.445 0 Td
(46)Tj
/F6 1 Tf
[( )]TJ
/F0 1 Tf
(21)Tj
12.4867 0 Td
(44)Tj
/F6 1 Tf
[( )]TJ
/F0 1 Tf
(20)Tj
12.7631 0 Td
(49)Tj
/F6 1 Tf
[( )]TJ
/F0 1 Tf
(23)Tj
11.1899 0 Td
(0.46)Tj
-61.7532 -1.5661 Td
(Urea)Tj
2.3811 0 Td
(\(mmol/L\))Tj
22.6561 0 Td
(207)Tj
/F6 1 Tf
[( )]TJ
/F0 1 Tf
(81)Tj
12.4867 0 Td
(177)Tj
/F6 1 Tf
[( )]TJ
/F0 1 Tf
(80)Tj
12.7631 0 Td
(237)Tj
/F6 1 Tf
[( )]TJ
/F0 1 Tf
(71)Tj
11.4662 0 Td
(0.04)Tj
-61.7532 -1.5591 Td
(Creatinine)Tj
4.748 0 Td
(\(mmol/L\))Tj
20.2821 0 Td
(7.9)Tj
/F6 1 Tf
[( )]TJ
/F0 1 Tf
(3.8)Tj
12.4938 0 Td
(7.2)Tj
/F6 1 Tf
[( )]TJ
/F0 1 Tf
(4.3)Tj
12.756 0 Td
(8.7)Tj
/F6 1 Tf
[( )]TJ
/F0 1 Tf
(3.3)Tj
11.4733 0 Td
(0.28)Tj
-61.7532 -1.5662 Td
(Albumin)Tj
3.8126 0 Td
(\(mg/L\))Tj
20.2253 0 Td
(98)Tj
1.3252 0 Td
(\(38218\))Tj
11.1615 0 Td
(64)Tj
1.3323 0 Td
(\(21127)Tj
3.6284 0 Td
(\))Tj
7.5261 0 Td
(137)Tj
1.8779 0 Td
(\(64476\))Tj
10.8639 0 Td
(0.045)Tj
-61.7532 -1.559 Td
(Albumin/c)Tj
4.3583 0 Td
(reatinine)Tj
4.0323 0 Td
(ratio)Tj
2.1614 0 Td
(\(mg/mmol)Tj
4.4221 0 Td
(\))Tj
9.6095 0 Td
(14)Tj
1.3323 0 Td
(\(729\))Tj
11.4308 0 Td
(9)Tj
0.7795 0 Td
(\(326\))Tj
11.7072 0 Td
(19)Tj
1.3323 0 Td
(\(951\))Tj
10.5875 0 Td
(0.10)Tj
-61.7532 -1.5662 Td
(AQP2)Tj
2.8913 0 Td
(\(ng/mL)Tj
3.0898 0 Td
(\))Tj
17.2277 0 Td
(986)Tj
1.885 0 Td
(\(283339)Tj
4.1812 0 Td
(6\))Tj
6.4205 0 Td
(584)Tj
1.8851 0 Td
(\(171329)Tj
4.1811 0 Td
(7\))Tj
6.4205 0 Td
(1562)Tj
2.4307 0 Td
(\(2933693\))Tj
11.1403 0 Td
(0.54)Tj
-61.7532 -1.5591 Td
(AQP2/crea)Tj
4.8685 0 Td
(tinine)Tj
2.6008 0 Td
(ratio)Tj
2.1614 0 Td
(\()Tj
/F6 1 Tf
[()]TJ
/F0 1 Tf
(g/mmol)Tj
4.1599 0 Td
(\))Tj
9.971 0 Td
(177)Tj
1.8779 0 Td
(\(45361\))Tj
10.6088 0 Td
(106)Tj
1.8779 0 Td
(\(28532\))Tj
10.8852 0 Td
(189)Tj
1.8779 0 Td
(\(50325\))Tj
10.8639 0 Td
(0.87)Tj
/F16 1 Tf
-61.7532 -1.5661 Td
(At)Tj
1.2756 0 Td
(maximal)Tj
4.2094 0 Td
(urine)Tj
2.6717 0 Td
(concentr)Tj
4.2024 0 Td
(ation)Tj
/F0 1 Tf
-12.3591 -1.5591 Td
(Osmolality)Tj
4.8685 0 Td
(\(mOsm/kg\))Tj
19.8923 0 Td
(587)Tj
/F6 1 Tf
[( )]TJ
/F0 1 Tf
(151)Tj
12.4867 0 Td
(533)Tj
/F6 1 Tf
[( )]TJ
/F0 1 Tf
(138)Tj
12.7631 0 Td
(642)Tj
/F6 1 Tf
[( )]TJ
/F0 1 Tf
(148)Tj
11.7426 0 Td
(0.046)Tj
-61.7532 -1.5661 Td
(Sodium)Tj
3.5929 0 Td
(\(mmol/L\))Tj
21.7206 0 Td
(77)Tj
/F6 1 Tf
[( )]TJ
/F0 1 Tf
(31)Tj
12.4867 0 Td
(75)Tj
/F6 1 Tf
[( )]TJ
/F0 1 Tf
(24)Tj
12.7631 0 Td
(80)Tj
/F6 1 Tf
[( )]TJ
/F0 1 Tf
(38)Tj
11.1899 0 Td
(0.65)Tj
-61.7532 -1.5591 Td
(Potassium)Tj
4.8685 0 Td
(\(mmol/L\))Tj
20.445 0 Td
(81)Tj
/F6 1 Tf
[( )]TJ
/F0 1 Tf
(35)Tj
12.4867 0 Td
(78)Tj
/F6 1 Tf
[( )]TJ
/F0 1 Tf
(28)Tj
12.7631 0 Td
(84)Tj
/F6 1 Tf
[( )]TJ
/F0 1 Tf
(41)Tj
11.1899 0 Td
(0.61)Tj
-61.7532 -1.5662 Td
(Urea)Tj
2.3811 0 Td
(\(mmol/L\))Tj
22.6561 0 Td
(261)Tj
/F6 1 Tf
[( )]TJ
/F0 1 Tf
(81)Tj
12.4867 0 Td
(223)Tj
/F6 1 Tf
[( )]TJ
/F0 1 Tf
(74)Tj
12.7631 0 Td
(299)Tj
/F6 1 Tf
[( )]TJ
/F0 1 Tf
(72)Tj
11.4662 0 Td
(0.008)Tj
-61.7532 -1.559 Td
(Creatinine)Tj
4.748 0 Td
(\(mmol/L\))Tj
20.0128 0 Td
(12.8)Tj
/F6 1 Tf
[( )]TJ
/F0 1 Tf
(4.7)Tj
12.4867 0 Td
(11.5)Tj
/F6 1 Tf
[( )]TJ
/F0 1 Tf
(4.2)Tj
12.7631 0 Td
(14.1)Tj
/F6 1 Tf
[( )]TJ
/F0 1 Tf
(5.1)Tj
11.7426 0 Td
(0.14)Tj
-61.7532 -1.5662 Td
(Albumin)Tj
3.8126 0 Td
(\(mg/L\))Tj
20.2253 0 Td
(92)Tj
1.3252 0 Td
(\(57245\))Tj
11.1615 0 Td
(64)Tj
1.3323 0 Td
(\(26130)Tj
3.6284 0 Td
(\))Tj
7.5261 0 Td
(160)Tj
1.8779 0 Td
(\(86554\))Tj
10.8639 0 Td
(0.01)Tj
-61.7532 -1.559 Td
(Albumin/c)Tj
4.3583 0 Td
(reatinine)Tj
4.0323 0 Td
(ratio)Tj
2.1614 0 Td
(\(mg/mmol)Tj
4.4221 0 Td
(\))Tj
9.6095 0 Td
(10)Tj
1.3323 0 Td
(\(449\))Tj
11.8135 0 Td
(7)Tj
0.7866 0 Td
(\(-13\))Tj
11.5938 0 Td
(11)Tj
1.3323 0 Td
(\(96\))Tj
10.3111 0 Td
(0.045)Tj
-61.7532 -1.5662 Td
(AQP2)Tj
2.8913 0 Td
(\(ng/mL)Tj
3.0898 0 Td
(\))Tj
17.2277 0 Td
(676)Tj
1.885 0 Td
(\(343144)Tj
4.1812 0 Td
(4\))Tj
6.4205 0 Td
(410)Tj
1.8851 0 Td
(\(274284)Tj
4.1811 0 Td
(4\))Tj
6.6969 0 Td
(833)Tj
1.8851 0 Td
(\(42512)Tj
3.6283 0 Td
(74\))Tj
7.7812 0 Td
(0.33)Tj
-61.7532 -1.5591 Td
(AQP/creat)Tj
4.5992 0 Td
(inine)Tj
2.3173 0 Td
(ratio)Tj
2.1615 0 Td
(\()Tj
/F6 1 Tf
[()]TJ
/F0 1 Tf
(g/mmol\))Tj
14.9599 0 Td
(52)Tj
1.3252 0 Td
(\(31130\))Tj
11.1615 0 Td
(33)Tj
1.3323 0 Td
(\(21290)Tj
3.6284 0 Td
(\))Tj
7.8024 0 Td
(56)Tj
1.3252 0 Td
(\(39109\))Tj
11.1403 0 Td
(0.60)Tj
/F16 1 Tf
-61.7532 -1.5661 Td
(Change)Tj
3.8834 0 Td
(between)Tj
4.2166 0 Td
(baseline)Tj
4.2166 0 Td
(and)Tj
2.0055 0 Td
(maximal)Tj
4.2095 0 Td
(urine)Tj
2.6717 0 Td
(concentr)Tj
4.2024 0 Td
(ation)Tj
/F0 1 Tf
-25.4057 -1.5591 Td
(Osmolality)Tj
4.8685 0 Td
(\(%\))Tj
20.1687 0 Td
(52)Tj
/F6 1 Tf
[( )]TJ
/F0 1 Tf
(81)Tj
/F5 1 Tf
[()]TJ
/F0 1 Tf
12.2103 0 Td
(68)Tj
/F6 1 Tf
[( )]TJ
/F0 1 Tf
(107)Tj
/F5 1 Tf
[()]TJ
/F0 1 Tf
13.0395 0 Td
(36)Tj
/F6 1 Tf
[( )]TJ
/F0 1 Tf
(41)Tj
/F5 1 Tf
[()]TJ
/F0 1 Tf
11.4662 0 Td
(0.29)Tj
-61.7532 -1.5661 Td
(Sodium)Tj
3.5929 0 Td
(\(%\))Tj
21.4443 0 Td
(37)Tj
/F6 1 Tf
[( )]TJ
/F0 1 Tf
(83)Tj
/F5 1 Tf
[()]TJ
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