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Jean-François Millau, Patrick Wijchers, Luc Gaudreau
High-Resolution 4C Reveals Rapid p53-Dependent Chromatin Reorganization of the CDKN1A Locus in Response to Stress
www.plosone.org
www.plosone.org
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[(6)1()13()-6()-5()-2()8()]TJ
3.4979 0 Td
[(6)-5()2()13()11()4()1( )-7()11()4()]TJ
5.6806 0 Td
[(6)-16()11()2()8()11()-4()3()18(\r)-5()2()11()]TJ
5.9357 0 Td
[(6)-10()18(\n)11(\r)10()1()13()]TJ
3.4413 0 Td
[()-1()11(-)]TJ
-34.9056 -1.2983 Td
[(\n)6()2()-6()]TJ
1.9275 0 Td
[(\r)6()]TJ
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[()2()-6()1(\n)]TJ
2.092 0 Td
[( )-7()-6()10()2()1()4()1()8()]TJ
4.6771 0 Td
[(.*6- )-7()-6(1)]TJ
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[()8()]TJ
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[()13()-9()8()-5()-4()]TJ
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[(\r)-4()3()18(\r)]TJ
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[()-1()6()4()2( )2()1()81(9)93( )]TJ
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[()-11()13()11()]TJ
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[(\n)]TJ
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[(\r)-6()8()8()7()1(\r)]TJ
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[()7()1()4()]TJ
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[()-9()-9()1()2()2( )]TJ
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[()1()]TJ
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[()13()2( )5(\n)-9()11()8( )-7()]TJ
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[(\r)6()]TJ
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[( )5(\r)-5()13()2( )5( )]TJ
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[()-1()11()1()4()2()2()2( )]TJ
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[()-3()12(\r)-4()]TJ
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[(\r)-4()4()]TJ
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[()11()]TJ
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[()6()2()13()11()3()18(\r)-5()1()]TJ
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[()2()-9()11(\n)1( )]TJ
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[(\r)-4()3()18(\r)]TJ
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[( )5()3()18(\n)-9()]TJ
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[(\r)-4()4()]TJ
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[( )5(\n)-5()18(\r)-5()-2()-4()]TJ
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[()8()13()6()2()12(\r)6()-6()-6(\r)10()1()13()]TJ
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[()11()]TJ
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[(\r)-4()4()2( )-7()]TJ
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[()2()-9()6()]TJ
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[(8)17()1()3()-4()-5()7()74()]TJ
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[()8()]TJ
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[( )5()4()15()]TJ
2.296 0 Td
[(\r)-4()3()18(\r)]TJ
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[(\r)-4()4()2( )-7()]TJ
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[( )5(\r)-5()13()2( )5( -)2()1(\n)-9()1()4()2()1()19(\r)]TJ
6.9561 0 Td
[()6()2()13()11()3()18(\r)-5()1()]TJ
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[()2()-9()11(\n)1( )]TJ
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[()8()13()]TJ
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[()1()19(\n)-9()11()-10(\r)-6()8()19(\r)]TJ
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[()-9()-6()-3()18()3( )-7()]TJ
3.2995 0 Td
[(\r)-4()4()-9()]TJ
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[()-1()11()19(\r)-5()-4()5()11()12(\r)6()]TJ
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[(\r)6()]TJ
1.0205 0 Td
[()7()1()4()]TJ
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[()13()-1()1()-5()-2()18(\r)-5()2()11()]TJ
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[()11()]TJ
/F8 1 Tf
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[()13()]TJ
/F7 1 Tf
[()]TJ
4.235 0 Td
[()99()1()7()1(\r)-4()4()1()64()]TJ
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[(\r)-4()4()2( )-7()]TJ
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[()-11()1()4()1()1()8()2( )]TJ
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[()2()1()4()11()8( )5(\r)-5()18(\r)6()]TJ
5.2043 0 Td
[(\r)-4()3()18(\r)]TJ
1.7915 0 Td
[()6()2()13()11()3()18(\r)-5()1()]TJ
4.3937 0 Td
[()2()-9()11(\n)1( )]TJ
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[()8()13()]TJ
1.44 0 Td
[()13()1()4()-9()2()5()2()-6()]TJ
4.4447 0 Td
[()12()1()-4()1()8()]TJ
2.8913 0 Td
[(\r)-4()4()]TJ
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[()-1()5()-5()12()-5()-2()8()]TJ
3.1294 0 Td
[( )5(\r)-5()13()2( )5( )]TJ
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[()13()2( )5(\n)-9()11()8( )-7()]TJ
3.7134 0 Td
[()8()4()]TJ
1.7234 0 Td
[()-1()11(-)]TJ
-34.9509 -1.3039 Td
[(\r)-5()-4()5()11()12(\r)6()]TJ
2.8856 0 Td
[(\r)6()]TJ
1.0261 0 Td
[(\r)-4()4()]TJ
1.4684 0 Td
[(\n)]TJ
1.7008 0 Td
[(\r)-5()8()8( )-7()-4()12(\n)11(\r)-5()2()11()3()-4()]TJ
6.0944 0 Td
[(\n)11()13()1()-5()8()]TJ
ET
Q
q
1 j
1 J
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11.9999 0 0 11.9999 200.0125 368.0503 cm
BT
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1 TL
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(and)Tj
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ET
Q
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BT
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[( )-6()18()1()4()11()-10()5()11()2()1()]TJ
5.8166 0 Td
[()8()4()]TJ
1.7235 0 Td
[(\()31()6()7()8()1(\r)-4()23()-7()2()1()2()1()2()1()4()]TJ
7.2056 0 Td
[(.\()5(:1)]TJ
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[()8()1()13()]TJ
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[()5()11(\r)-6()8()1()4()-6()]TJ
3.702 0 Td
[()-11()13()11()]TJ
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ET
Q
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BT
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BT
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[(7)11(6$$5)]TJ
3.6623 0 Td
[(\n;<;)]TJ
3.1408 0 Td
[()8()4()]TJ
1.7064 0 Td
[(7)11(6$$5)]TJ
3.6623 0 Td
[(\n-<-)]TJ
2.6986 0 Td
[()-1()5()-5()3( )]TJ
1.8992 0 Td
[(.)]TJ
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[()-5()1()-7(\r)]TJ
1.5137 0 Td
[()-11()13()11()]TJ
2.1657 0 Td
[( )1()64()]TJ
1.5193 0 Td
[(=)-19()1()-10(\r)]TJ
1.8709 0 Td
[(>)97()1()7()5()3( )5(\r)6()1()1()]TJ
4.5978 0 Td
[(7)25()15()1()8()13()]TJ
3.4525 0 Td
[(7)39()1()-6()4()2( )]TJ
-32.8816 -1.2982 Td
[(?)26()-6()1()2()-3()-4()]TJ
3.3732 0 Td
[()17()8( )5(\r)-5()12(\r)10()12(\r)6()6()]TJ
3.736 0 Td
[(=)-7()-4()12(\r)-5()1()4()11()13()6()]TJ
4.32 0 Td
[(? 1)]TJ
2.1656 0 Td
[()8()1()13()]TJ
2.075 0 Td
[()-6()-5()12(\r)10()1()13()-6()]TJ
3.4979 0 Td
[()1()]TJ
1.0148 0 Td
[()]TJ
0.652 0 Td
[(@)]TJ
1.44 0 Td
[(6)-7(4)]TJ
ET
Q
q
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7.4999 0 0 6.6659 436.6488 274.0535 cm
BT
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1 TL
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[(%)]TJ
ET
Q
q
1 j
1 J
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10 0 0 10 440.1637 275.6976 cm
BT
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1 TL
-0.005 Tc
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[(-)-1()11()19(\r)-6()8()1()2()1()8()]TJ
4.7848 0 Td
[()18(\r)-5()4()1( )5(\n)6()4()1()13()]TJ
4.8415 0 Td
[()1()]TJ
-33.6412 -1.2982 Td
[( )14(?:?)]TJ
3.2655 0 Td
[(.)-2(A)37()3( )-7()1()19(\r1)]TJ
3.7247 0 Td
[( )5()12(\n)11(\n)6()2()1()4()1()19(\r)6()-6()]TJ
5.7713 0 Td
[()-3()12(\r)-4()]TJ
1.9672 0 Td
[($B@)]TJ
1.9162 0 Td
[()8()1(\r)-6()-4()]TJ
1.8935 0 Td
[()-9()15()-3()1()4()]TJ
2.8744 0 Td
[( )-7()1()-10()1()]TJ
2.6758 0 Td
[(.0)6()1()-5()3(1)]TJ
3.5262 0 Td
[(B%3<C)]TJ
3.7587 0 Td
[(\n)-9()1()2()2()-5()-5()1()1()]TJ
3.8948 0 Td
[(')]TJ
-35.2683 -1.3039 Td
[()8()4()]TJ
1.7064 0 Td
[($BB)]TJ
1.6441 0 Td
[()8(<C)]TJ
3.1351 0 Td
[( )5(\r)-5()13()1(\n)11(\r)6()11()23()8()1()]TJ
5.4255 0 Td
[(.)17()23()-3()12(\r)-5()13()1()7()1(1)]TJ
5.2441 0 Td
[(3)42()-5()2()2( )5( )]TJ
2.8573 0 Td
[( )5(\n)-9()-6()1()-11()2()-6()]TJ
3.6453 0 Td
[()11(\r)-4()4()1()-29()-3()3( )-7()6()]TJ
4.2292 0 Td
[()-1()5()-5()3( )]TJ
1.8935 0 Td
[( )5(\r)-5()13()2( )5( )]TJ
2.3697 0 Td
[(\r)-5()13()-5()18(\r)-5()4()1()19(\r)]TJ
-32.1502 -1.2983 Td
[()-1()11()8( )2()3( )5(\r)6()-6()]TJ
3.8664 0 Td
[()11()]TJ
1.0035 0 Td
[(%B)]TJ
1.6441 0 Td
[(?)]TJ
1.6384 0 Td
[()-2()18()1()4()11()-10()5()11()2()1()]TJ
5.5502 0 Td
[(.0)6()1()-5()3(1)]TJ
3.3108 0 Td
[()8()11()]TJ
1.3606 0 Td
[(,)]TJ
0.6974 0 Td
[()]TJ
0.9581 0 Td
[(")-4()-5()]TJ
1.3946 0 Td
[()13()2( )5()-5()12(\r )]TJ
2.7722 0 Td
[(\n)11()13()2( )-7()1()19(\r)6()-6()]TJ
4.0421 0 Td
[()-3()12(\r)-4()]TJ
1.9729 0 Td
[(0)11(:?)]TJ
2.126 0 Td
[()8()1()13()]TJ
-32.3373 -1.2983 Td
[()5()11(\r)-6()8()1()4()-6()]TJ
3.6623 0 Td
[()-11()13()11()]TJ
2.1713 0 Td
[()1()4()2()1(\n)-9()1()4()2()1()19(\r)]TJ
5.1704 0 Td
[()11()2()6()2()1()-5()2()-3()-4()]TJ
4.0025 0 Td
[(\r)-5()-4()12(\n)6()1()2()-3()18(\r)6()2( )]TJ
4.2803 0 Td
[(0)14(\r)-6()18(\r)-5()3( )5(\r)-5()2()-1( )]TJ
3.651 0 Td
[()8()1()13()]TJ
2.0805 0 Td
[()-3()-4()2()-6()-5()-2()18(\r)6()-6()]TJ
4.1386 0 Td
[()3( )2()1()8()]TJ
2.347 0 Td
[(0)14(\r)10()2()2()1()19(\r)28(9)93( )]TJ
/F8 1 Tf
3.8325 0 Td
[( )]TJ
/F7 1 Tf
[(-\r)6()2( )5(\r)-1()]TJ
ET
Q
q
1 j
1 J
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11.9999 0 0 11.9999 200.0125 196.3275 cm
BT
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1 TL
0 0 Td
(ChIP)Tj
2.4378 0 Td
(assays)Tj
ET
Q
q
1 j
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10 0 0 10 200.0125 179.3763 cm
BT
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[(6)-5(\()]TJ
2.3017 0 Td
[()1( )5( )-6()18()1( )]TJ
2.6532 0 Td
[()8()1()13()]TJ
2.0976 0 Td
[(\n)-9()1()-4()8()11()-4()4()-6()]TJ
4.4277 0 Td
[()1( )]TJ
1.0261 0 Td
[()2()2( )-7()-4()5()-9()-6()]TJ
4.0025 0 Td
[(\n)11()13()-9()-3()2()11()3( )5()7()]TJ
4.337 0 Td
[()3( )2()1()8()]TJ
2.3698 0 Td
[(\r)-4()4()]TJ
1.474 0 Td
[()8()19(\r)-5()5()-9()-9()1()2()2( )]TJ
4.3256 0 Td
[()1()3( )5(\r)6()-6()]TJ
2.3357 0 Td
[()1()]TJ
0.83 0.64 0.02 0 k
1.0262 0 Td
[(0$)]TJ
1.1678 0 Td
[()92()9()6()2()]TJ
0 g
-33.5449 -1.3039 Td
[(#)]TJ
0.83 0.64 0.02 0 k
[($2)]TJ
0 g
[(&)]TJ
2.0862 0 Td
[()1()4()]TJ
1.7802 0 Td
[()13()-6()-1()15()8()1()13()-6()]TJ
4.0989 0 Td
[( )9(!)37(")]TJ
2.381 0 Td
[()1()1( )]TJ
1.7008 0 Td
[()8()3()-4()7(\))-2()-6()]TJ
3.702 0 Td
[()15()]TJ
1.1792 0 Td
[(\(6/)]TJ
2.5682 0 Td
[()3( )2()1()8()]TJ
2.3641 0 Td
[(\r)-4()4()]TJ
1.474 0 Td
[(\n)11()-4()1()4()1()]TJ
2.9594 0 Td
[( )-7()1(\r )]TJ
1.6724 0 Td
[()1()3( )5(\r)6()-6()]TJ
2.3357 0 Td
[()1()]TJ
0.83 0.64 0.02 0 k
1.0205 0 Td
[(0%)]TJ
1.1679 0 Td
[()92()9()6()2()]TJ
0 g
[()]TJ
ET
Q
q
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1 J
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11.9999 0 0 11.9999 200.0125 139.011 cm
BT
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1 TL
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(ChIP-seq)Tj
4.3701 0 Td
(assays)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 122.0031 cm
BT
/F7 1 Tf
1 TL
0 0 Td
[(/)-18()2(%$)]TJ
2.7495 0 Td
[(6)-5(\()49(- )-7()-6()]TJ
3.9572 0 Td
[()1()1( )]TJ
1.7008 0 Td
[(\n)-9()1()-4()8()11()-4()4()-6()]TJ
4.4276 0 Td
[( )2()1()2()-5()-2()8()5()7()]TJ
3.6851 0 Td
[(\r)6()]TJ
1.0204 0 Td
[()13()-1()1()-5()-2()8()]TJ
3.0387 0 Td
[(6)-5(\()]TJ
2.3018 0 Td
[()2(\n)-9()1()-4()1()4()1()19(\r )]TJ
5.1136 0 Td
[()2()9()-1()1(\n)11(\r)]TJ
2.761 0 Td
[()8()11()]TJ
1.3776 0 Td
[(\r)-4()4()]TJ
1.474 0 Td
[()8()6()-5()2()15()-3()1()8()]TJ
-33.6073 -1.2982 Td
[( )5(\r)6()1(\n)1( )]TJ
2.4094 0 Td
[(8)20()11()]TJ
1.6044 0 Td
[()-5()2()6()]TJ
2.0239 0 Td
[(\r)-5()13()-5()18(\r)-5()4()1()19(\r)]TJ
4.1216 0 Td
[()-1()11()4()1()12(\r)-5()2()11()8( )]TJ
4.4333 0 Td
[( )2()]TJ
1.3153 0 Td
[()1()2()19()1()4(-\n)11()13()-6()12(\n)11()12(\r)-6()18(\r)-5()2()11()8( )]TJ
9.496 0 Td
[()8()1()13()]TJ
2.0976 0 Td
[(\n)-9()1()-4()8()11()-4()4()-6()6()]TJ
4.6488 0 Td
[()17()2()19()1()4(-)]TJ
-32.1503 -1.3039 Td
[(\n)11()13()-6()12(\n)11()12(\r)-6()18(\r)-5()2()11()8( )]TJ
5.6862 0 Td
[()8()1()13()]TJ
2.0863 0 Td
[(\n)-9()1()-4()8()11()-4()4()-6()]TJ
4.4277 0 Td
[()3( )2()1()8()]TJ
2.3584 0 Td
[( )-18()-3()3()9()-9()-5()2()3( )]TJ
4.6261 0 Td
[()-1()11()12(\n)6()2()-6()]TJ
3.3562 0 Td
[(\r)6()]TJ
1.0205 0 Td
[(\n)11()13()11(\r)6()1()1()]TJ
3.1181 0 Td
[(")]TJ
0.9014 0 Td
[(.C)-5()1()8()]TJ
2.0579 0 Td
[()99()-6()6()2()4()6()2()1()-5()2()2( 1)]TJ
5.8337 0 Td
[()-3()12(\r)-4(-)]TJ
-35.4725 -1.2983 Td
[()11()12(\r)]TJ
1.542 0 Td
[(\n)11()13(-)6()2()-5()8()-4()1()8()-3()]TJ
5.244 0 Td
[()1()4()]TJ
1.7859 0 Td
[()1()5()11()8()-4()2()2( )]TJ
3.4412 0 Td
[()8()11()]TJ
1.3776 0 Td
[()2()-6()1(\n- )-7()-6()10()2()1()4()1()8()]TJ
6.9052 0 Td
[()8()1()13()]TJ
2.0976 0 Td
[(\n)11()13()1(\n)-5()8()13()-6()]TJ
3.7814 0 Td
[()-11()13()11()]TJ
2.194 0 Td
[($B)]TJ
1.1792 0 Td
[()8()]TJ
1.2189 0 Td
[(6)-5(\()31()-6()]TJ
3.2428 0 Td
[( )9(!)37(")]TJ
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
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W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 397.8141 745.7952 cm
BT
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4.0252 0 Td
(n)Tj
0.7724 0 Td
(Loop)Tj
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(Remodel)Tj
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(ing)Tj
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(Stress)Tj
ET
Q
q
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36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
7.9999 0 0 7.9999 36 36 cm
BT
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(ONE)Tj
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(DOI:10.1)Tj
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[(0)14()12(\n)-9()1()-4()3()18(\r)-6()8()19(\r)]TJ
5.0229 0 Td
[()1()1( )]TJ
1.6838 0 Td
[()13()-6()-1()15()8()1()13()-6()]TJ
4.0535 0 Td
[()8()4()]TJ
1.7065 0 Td
[()]TJ
0.6519 0 Td
[()]TJ
0.6974 0 Td
[(F)]TJ
0.9694 0 Td
[()-4()1()2()10()2()11(\r)6()]TJ
3.3789 0 Td
[()1()1( )]TJ
1.6894 0 Td
[()-1()6(-)]TJ
-35.0416 -1.2982 Td
[()2()-6()-6(\r)6()-6()]TJ
2.5114 0 Td
[()1( )]TJ
1.0148 0 Td
[($@)]TJ
1.44 0 Td
[()1()19(\n)11()12(\r)-1()]TJ
2.5569 0 Td
[(!)25()2(\r)-1()]TJ
2.3414 0 Td
[(BB)]TJ
1.644 0 Td
[(F)]TJ
0.9752 0 Td
[()11()]TJ
0.9977 0 Td
[(\n)6()4()1()4()6(<)6()-5()2()11()13()11()8()11()-4()]TJ
7.7613 0 Td
[()8()4()]TJ
1.7064 0 Td
[(%BB)]TJ
1.6441 0 Td
[(F)]TJ
0.9694 0 Td
[()11()]TJ
1.0035 0 Td
[()7()1( )2()3( )]TJ
1.8935 0 Td
[( )-7()6()12()12(\r)-5()2()11()]TJ
3.4242 0 Td
[()8()1()13()]TJ
2.075 0 Td
[()2()2()2()-6()]TJ
2.6135 0 Td
[(\r)6()]TJ
-36.5723 -1.2983 Td
[(BB)]TJ
1.644 0 Td
[(F)]TJ
0.9695 0 Td
[()11()]TJ
1.0034 0 Td
[()7()1( )-6()18(\r)6()6()]TJ
2.6362 0 Td
[(\r)-4()4()]TJ
1.457 0 Td
[( )-7()6()12()12(\r)-5()2()11()]TJ
3.4186 0 Td
[()1()1( )]TJ
1.6894 0 Td
[(\r)-4()4()1()]TJ
1.9899 0 Td
[()8()11()-10(\r)6()2()9()-6()]TJ
3.634 0 Td
[()8()4()]TJ
1.7065 0 Td
[()-1()1()19(\r)-5()1()-7()1()2()18(\r)6()-6()]TJ
5.0513 0 Td
[()18(\r)]TJ
0.9468 0 Td
[($%BBB)]TJ
2.8062 0 Td
[()-10(\n)11()]TJ
1.9049 0 Td
[()8()11()]TJ
1.3663 0 Td
[()]TJ
0.6916 0 Td
[()2()1()]TJ
2.0353 0 Td
[()1()4()]TJ
-34.9509 -1.3039 Td
[()2()10()2()-6()11()3( )]TJ
3.4582 0 Td
[(\n)6()3()1( )-7()]TJ
2.4661 0 Td
[()1()1( )]TJ
1.6895 0 Td
[()-1()6()-5()2()-6()-6(\r)6()-6()]TJ
3.668 0 Td
[()8()4()]TJ
1.7064 0 Td
[(\r)-5()8()8( )2()8()1()-4()13()-6()]TJ
4.5524 0 Td
[(\r)6()]TJ
1.0148 0 Td
[()]TJ
0.652 0 Td
[(')-7()5(-C)-9()-9()6()]TJ
3.8494 0 Td
[(\r)10()5()-9()]TJ
1.9389 0 Td
[()-1()11()19(\r)-6()8()1()2()1()8()]TJ
4.439 0 Td
[(BB)]TJ
1.6441 0 Td
[(F)]TJ
0.9695 0 Td
[()11()]TJ
1.0034 0 Td
[(\n)6()4()1()4()6(<)]TJ
-33.0517 -1.2983 Td
[()6()-5()2()11()13()11()8()11()-4()]TJ
4.9209 0 Td
[()1()4()]TJ
1.7688 0 Td
[( )-7()6()12()12(\r)-5()2()11()]TJ
3.4185 0 Td
[()1()1( )]TJ
1.6895 0 Td
[(\r)-4()4()1()]TJ
1.9899 0 Td
[()2()9()-6()]TJ
2.6759 0 Td
[()15()]TJ
1.1735 0 Td
[()1()23()8()1()7( )2()2()11()]TJ
3.8834 0 Td
[()8()4()]TJ
1.7065 0 Td
[()-1()1()19(\r)-5()-4()1()-7()1()2()18(\r)6()-6()]TJ
5.4141 0 Td
[()18(\r)]TJ
0.9468 0 Td
[($*BBB)]TJ
2.8063 0 Td
[()-10(\n)11()]TJ
1.9048 0 Td
[()8()11()]TJ
1.3663 0 Td
[($)]TJ
-35.6652 -1.2983 Td
[()2()1()]TJ
2.0352 0 Td
[()1()4()]TJ
1.7688 0 Td
[()2()10()2()-6()11()3( )]TJ
3.4583 0 Td
[(\n)6()3()1( )-7()]TJ
2.4661 0 Td
[()1()1( )]TJ
1.6894 0 Td
[()-1()6()-5()2()-6()-6(\r)6()-6()6()]TJ
3.8778 0 Td
[(\r)-5()8()8( )2()8()1()-4()13()-6()]TJ
4.5581 0 Td
[(\r)6()]TJ
1.0091 0 Td
[()]TJ
0.6576 0 Td
[(\r)10()5()-9()]TJ
1.9389 0 Td
[()-1()11()19(\r)-6()8()1()2()1()8()]TJ
4.4334 0 Td
[($BB)]TJ
1.6441 0 Td
[(F)]TJ
1.1792 0 Td
[()11()]TJ
1.0034 0 Td
[(\n)11()13()11(\r)6()1()1()3()1( )-7()]TJ
4.2973 0 Td
[(D)]TJ
-36.0167 -1.3039 Td
[()8()4()]TJ
1.7064 0 Td
[(\r)-4()4()1()]TJ
1.9899 0 Td
[()1()4()-6()5()-5()18(\r)6()-6()]TJ
4.0989 0 Td
[()15()8()1()23(-)2()1()-6()19(\r)]TJ
4.3596 0 Td
[()18(\r)]TJ
0.9525 0 Td
[(5H6)]TJ
2.364 0 Td
[(\()22()8()-4()-5()2()5()]TJ
3.1522 0 Td
[(\r)6()]TJ
1.0091 0 Td
[(\r)-4()2()3( )]TJ
1.8765 0 Td
[(BB)]TJ
1.6441 0 Td
[(F)]TJ
0.9694 0 Td
[()11()]TJ
1.0035 0 Td
[(:)]TJ
1.389 0 Td
[()1( )]TJ
1.0091 0 Td
[()8()5()-5()]TJ
1.7971 0 Td
[()1( )]TJ
1.0148 0 Td
[($BB)]TJ
1.6441 0 Td
[(F)]TJ
1.1792 0 Td
[()11()]TJ
1.0035 0 Td
[(\n)11()13()11(\r)6()1()1(-)]TJ
-34.1629 -1.2982 Td
[()1( )-7()]TJ
1.4229 0 Td
[(D)]TJ
0.8844 0 Td
[()8()1()13()]TJ
2.075 0 Td
[()2()2()2()-6()]TJ
2.6135 0 Td
[(\r)6()]TJ
1.0148 0 Td
[(\r)-4()4()]TJ
1.457 0 Td
[()1()19(\n)11()12(\r)]TJ
2.3414 0 Td
[()-4()1()2()10()2()11(\r)6()6()]TJ
3.5943 0 Td
[()-7()2()2()6()]TJ
2.6135 0 Td
[()1()1( )]TJ
1.6838 0 Td
[(\r)-4()4()1()]TJ
1.9956 0 Td
[()1()4()-6()5()-5()18(\r)6()-6()]TJ
4.0932 0 Td
[()15()8()1()23(-)2()1()-6()19(\r)]TJ
4.3653 0 Td
[()18(\r)]TJ
0.9468 0 Td
[(5H6)]TJ
2.3641 0 Td
[()1()4()]TJ
1.7688 0 Td
[()4()2(\r)]TJ
-35.2344 -1.2983 Td
[()-2()18()74()]TJ
1.8368 0 Td
[(B)]TJ
1.1679 0 Td
[(F)]TJ
1.1792 0 Td
[()11()]TJ
1.0034 0 Td
[(/!)25()1( )-7()]TJ
2.7723 0 Td
[(")]TJ
0.9014 0 Td
[()8()1()13()]TJ
2.0749 0 Td
[()2()2()2()-6()]TJ
2.6136 0 Td
[(\r)6()]TJ
1.0148 0 Td
[(\r)-4()4()]TJ
1.457 0 Td
[( )-6()8()19(\n)6()2()2( )]TJ
3.5659 0 Td
[()-7()2()2()6()]TJ
2.6136 0 Td
[()8()1()13()]TJ
2.0806 0 Td
[(\r)-4()4()1()]TJ
1.9899 0 Td
[()1()4()-6()5()-5()18(\r)6()-6()]TJ
4.0989 0 Td
[()8()11()]TJ
1.3606 0 Td
[($)]TJ
0.6973 0 Td
[()]TJ
0.7427 0 Td
[()18(\r)]TJ
0.9524 0 Td
[(EH6)]TJ
-34.1232 -1.2983 Td
[( )9(!)37(")]TJ
2.364 0 Td
[()1()1( )]TJ
1.6838 0 Td
[(\r)-4()4()1()]TJ
1.9956 0 Td
[(\n)11()1()-4()1()-11()2()-6()]TJ
3.3392 0 Td
[()3( )2()1()8()]TJ
2.3414 0 Td
[(I)9()38(")26()10()1()2()6()]TJ
4.1385 0 Td
[(\(6/)]TJ
2.041 0 Td
[(\()2()1()-4()1()-11()2()-3()18(\r)-5()2()11()]TJ
4.8869 0 Td
[(D)7()12(\r)]TJ
1.4343 0 Td
[()8()4()]TJ
1.7064 0 Td
[()5()12()12(\r)6()-6()]TJ
2.6192 0 Td
[()3( )2()1()8()]TJ
2.3414 0 Td
[(EBB)]TJ
1.6441 0 Td
[(F)]TJ
0.9695 0 Td
[()11()]TJ
1.0034 0 Td
[()5()12()12(\r)-5()2()11()]TJ
-34.5087 -1.3039 Td
[()11()1()-11()8()1()64()]TJ
2.7892 0 Td
[(\(6/)]TJ
2.5455 0 Td
[()8()1()13()]TJ
2.0806 0 Td
[( )5()5()1( )-7()-6()10()2()1()19(\r)-4()7()]TJ
5.3291 0 Td
[(\n)-9()1()-4()8()11()-4()4()-6()]TJ
4.388 0 Td
[()3( )2()1()8()]TJ
2.3414 0 Td
[(\r)-4()4()]TJ
1.457 0 Td
[(\n)11()-4()1()4()1()7( )]TJ
3.2939 0 Td
[()13()1(\n)-9()11()-10(\r)6()-6()]TJ
3.5886 0 Td
[()1()]TJ
1.0148 0 Td
[(\r)-4()4()]TJ
0.83 0.64 0.02 0 k
1.4513 0 Td
[(0*)]TJ
1.1622 0 Td
[()92()9()6()2()]TJ
0 g
[()]TJ
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 235.2755 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(High-resolution)Tj
6.9024 0 Td
(4C)Tj
1.4882 0 Td
(assay)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 218.2677 cm
BT
/F7 1 Tf
1 TL
0 0 Td
[(*6)]TJ
1.3549 0 Td
[()2(\n)-9()1()-4()1()4()1()19(\r )]TJ
5.108 0 Td
[()8()1()13()]TJ
2.0976 0 Td
[(\n)-9()1()-4()8()11()-4()4()-6()]TJ
4.4334 0 Td
[()8()4()]TJ
1.7234 0 Td
[()8()3()-4()7(\))-2()-6()]TJ
3.7021 0 Td
[()1( )]TJ
1.0204 0 Td
[(\n)11()13()-9()-3()2()11()3( )5()7()]TJ
4.337 0 Td
[()2()2( )-7()-4()5()-9()-6()]TJ
4.0082 0 Td
[(#)]TJ
0.83 0.64 0.02 0 k
[(%B)]TJ
0 g
[()]TJ
0.83 0.64 0.02 0 k
1.7404 0 Td
[(%$)]TJ
0 g
[(&)]TJ
1.7405 0 Td
[(/)-3()2( )5(\r)-5()-4()2()-6(\r)-5()2()11()]TJ
-31.2659 -1.2982 Td
[()1(\))-3()4()2( )]TJ
3.651 0 Td
[()3( )-7()-6()]TJ
2.0409 0 Td
[()1( )]TJ
1.0261 0 Td
[()-11()1()7( )5(\r)]TJ
1.8028 0 Td
[()-6()12(\r)10(\r)6()1()7( )]TJ
2.9084 0 Td
[()8()1()13()]TJ
2.0976 0 Td
[( )-4(\n)11()]TJ
2.6816 0 Td
[(.!)25()-9()]TJ
2.398 0 Td
[(:)-1()8()-6()-2()8()4()]TJ
3.5377 0 Td
[(=)8()2()6()-2()9()1( 1)]TJ
3.4639 0 Td
[()11()]TJ
1.0828 0 Td
[(6 )5(\n5$)]TJ
2.7212 0 Td
[(.8)20()1()-4()4()1()19(\r)-6()1( 1)]TJ
5.3121 0 Td
[(\r)-4()4()]TJ
-34.7241 -1.2983 Td
[()13()2( )5(\r)-5()-4()2()-6(\r)-5()2()11()]TJ
4.3143 0 Td
[()1(\))-3()4()]TJ
3.2881 0 Td
[()3( )-7()-6()]TJ
2.0466 0 Td
[()1( )]TJ
1.0205 0 Td
[( )-7()-6()-1()11()4()]TJ
2.982 0 Td
[()-6()12(\r)10(\r)6()1()]TJ
2.5455 0 Td
[()1()1( )]TJ
1.7008 0 Td
[(=)8()-1()]TJ
1.8652 0 Td
[(.!)25()-9()]TJ
2.4037 0 Td
[(:)-1()8()-6()-2()8()4()]TJ
3.532 0 Td
[(=)8()2()6()-2()9()1( 1)]TJ
3.685 0 Td
[()1()4()]TJ
1.7801 0 Td
[()1()3( )5(\r)]TJ
1.4004 0 Td
[()11()]TJ
1.0091 0 Td
[(*6)]TJ
1.3606 0 Td
[(\n)11()-4()1(-)]TJ
-34.9339 -1.3039 Td
[()1()7( )]TJ
1.3662 0 Td
[()3( )]TJ
0.8448 0 Td
[()13()1(\n)-9()11()-10(\r)6()-6()]TJ
3.6283 0 Td
[()1()]TJ
0.83 0.64 0.02 0 k
1.0261 0 Td
[(0)]TJ
1.1679 0 Td
[()92()9()6()2()]TJ
0 g
[()]TJ
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 151.9937 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(Luciferase)Tj
4.8094 0 Td
(reporter)Tj
3.704 0 Td
(assay)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 134.9858 cm
BT
/F7 1 Tf
1 TL
0 0 Td
[(A)97()]TJ
1.6043 0 Td
[()3( )-7()-6()]TJ
2.0467 0 Td
[(\n'C)]TJ
2.4604 0 Td
[()-5()1( )2()2()-1()]TJ
2.4208 0 Td
[(\n'C)]TJ
2.4604 0 Td
[(\n)11()13()11()4()11(\r)6()1()64()]TJ
4.2236 0 Td
[()8()4()]TJ
1.7235 0 Td
[(\n/C)11(-0>*B)]TJ
4.371 0 Td
[(.\()7()13()11()4()-1()2(1)]TJ
4.4617 0 Td
[(\r)6()]TJ
1.0205 0 Td
[()1( )5( )-7()2( )5( )]TJ
2.5341 0 Td
[(\n)11()13()11()4()11(\r)6()1()64()]TJ
4.2236 0 Td
[()1()-5()3()8()4()-1()1()]TJ
-33.5506 -1.2982 Td
[()8()4()]TJ
1.7177 0 Td
[()13()1(\n)11()13()2( )5( )-7()11()]TJ
3.9005 0 Td
[()2()-6(\r)-5()7()-3()12(\r)-2()]TJ
3.1237 0 Td
[()11()]TJ
1.0092 0 Td
[(\n)11()12(\r)-6()18(\r)-5()7()8()]TJ
3.4412 0 Td
[()13()-1()1()-5()-2()18(\r)6()11()-29()]TJ
4.2973 0 Td
[()5()2()1()4()1()19(\r )]TJ
3.9628 0 Td
[(6)-16()5()-5()3( )]TJ
2.16 0 Td
[()8()1()13()]TJ
2.0976 0 Td
[()-6()-5()12(\r)10()1()13()-6()]TJ
3.5376 0 Td
[()1()]TJ
1.0205 0 Td
[( )2(-)8()5()-5()]TJ
3.2655 0 Td
[(\n)6()-2()18(\r)6()2( )]TJ
-33.5336 -1.2983 Td
[(\r)-5()8()8( )2()8()-6()-6(\r)6()-6()]TJ
4.5977 0 Td
[()3( )2()1()8()]TJ
2.3698 0 Td
[(\()5(:)]TJ
1.6781 0 Td
[()-3()12(\r)-4()]TJ
1.9899 0 Td
[($BB)]TJ
1.6611 0 Td
[()8()]TJ
1.2189 0 Td
[()11()]TJ
1.0148 0 Td
[(\n'C)]TJ
2.4604 0 Td
[()8()-6()-6(\r)6()11()64()]TJ
2.9027 0 Td
[(%)]TJ
1.3946 0 Td
[()8()]TJ
1.2246 0 Td
[()11()]TJ
1.0091 0 Td
[(\n/C)11(-0>*B)]TJ
4.5921 0 Td
[()8()4()]TJ
1.7178 0 Td
[($BBB)]TJ
2.1373 0 Td
[()8()]TJ
1.2245 0 Td
[()11()]TJ
1.0092 0 Td
[(\n':G)]TJ
-34.2026 -1.3039 Td
[()1( )]TJ
1.0204 0 Td
[()-3()8()-4()-4()2()1()]TJ
2.846 0 Td
[( )9(!)37(")]TJ
2.6022 0 Td
[()8()4()]TJ
1.7178 0 Td
[()-1()6()-5()2()-6()-6(\r)6()-6()]TJ
3.7133 0 Td
[(%*)]TJ
1.7121 0 Td
[()-2()18(\r)6()1()64()]TJ
2.211 0 Td
[(A)14()4()1()]TJ
2.6816 0 Td
[()]TJ
0.6576 0 Td
[()-2()18()1()4()11()-10()5()11()2()1()]TJ
5.6126 0 Td
[(\r)-5()13()-5()18(\r)-5()4()1()19(\r)]TJ
4.1159 0 Td
[()1()1( )]TJ
1.7008 0 Td
[(\n)-9()1()-4()8()11()-4()4()-6()6()]TJ
-30.5913 -1.2983 Td
[(7)11(6$$5)]TJ
3.6906 0 Td
[()-1()5()-5()3( )]TJ
1.9219 0 Td
[()8()1()13()]TJ
2.092 0 Td
[(\r)-5()8()8( )2()8()-6()-6(\r)6()-6()]TJ
4.6034 0 Td
[()8()4()]TJ
1.7178 0 Td
[(\r)-5()13()-5()18(\r)6()-6()]TJ
2.982 0 Td
[($5)]TJ
1.1849 0 Td
[()]TJ
0.7483 0 Td
[()-2()18(\r)6()1()]TJ
1.9956 0 Td
[()-3()12(\r)-4()]TJ
1.9899 0 Td
[(%B)]TJ
1.6611 0 Td
[(?)]TJ
1.6441 0 Td
[()-2()18()1()4()11()-10()5()11()2()1()]TJ
5.6126 0 Td
[()8()11()]TJ
1.3776 0 Td
[(,)]TJ
1.4513 0 Td
[(8)17()1()13()1()-17()7()]TJ
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 397.8141 745.7952 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(Chromati)Tj
4.0252 0 Td
(n)Tj
0.7724 0 Td
(Loop)Tj
2.4237 0 Td
(Remodel)Tj
3.9614 0 Td
(ing)Tj
1.5449 0 Td
(in)Tj
0.9851 0 Td
(Respons)Tj
3.9118 0 Td
(e)Tj
0.7724 0 Td
(to)Tj
1.0489 0 Td
(Stress)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
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