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UMC Repository: Recent submissions

  • How Does Routine Prostate-specific Membrane Antigen Positron Emission Tomography/Computed Tomography Modify the Current Management of Prostate Cancer? A Multidisciplinary View 
    Oprea-Lager, Daniela E.; van Elst, Tessa; Aluwini, Shafak; Dewulf, Els; der Poel, Henk van; Stoevelaar, Herman; Bangma, Chris H.; Beeker, Aart; Boudewijns, Steve; Budiharto, Tom; de Jong, Igle Jan; de Vries, Kim C.; Donswijk, Maarten L.; Fütterer, Jurgen J.; Hamberg, Paul; Heijmen, Linda; Hoekstra, Robert J.; Kerkhofs, Thomas M.A.; Lavalaye, Jules; Bruin, Daphne Luijendijk de; Noordzij, Walter; Oving, Irma M.; Robbrecht, Debbie G.J.; Schaake, Eva E.; van de Luijtgaarden, Addy C.M.; van den Bergh, Roderick C.N.; van den Berkmortel, Franchette; van der Hulle, Tom; van der Mijn, Johannes C.K.; van Dodewaard-de Jong, Joyce M.; van Kruchten, Michel; van Leeuwen, Pim J.; van Limbergen, Evert; van Moorselaar, R. Jeroen A.; van Oort, Inge M.; van Roermund, Joep G.H.; van Soest, Robert J.; Veninga, Theo; Vis, André N.; Voortman, Jens; Willemse, Peter Paul M.; Yakar, Derya; Mehra, Niven (Elsevier, 2025-05)
    Background and objective: Prostate-specific membrane antigen positron emission tomography/computed tomography (PSMA-PET/CT) and new treatment modalities have expanded the possibilities for diagnosing and managing metastatic ...
  • Transforming cardiology with AI: the eko CORE 500 digital stethoscope 
    van der Harst, Pim; Nathoe, Hendrik (Bohn Stafleu van Loghum, 2025-04)
  • Organs at risk proximity in central lung stereotactic ablative radiotherapy: A comparison of four-dimensional computed tomography and magnetic resonance-guided breath-hold delivery techniques 
    Giraud, Nicolas; Tekatli, Hilâl; Schneiders, Famke L.; van Sornsen de Koste, John R.; Marzo, Marco; Palacios, Miguel A.; Senan, Suresh (Elsevier, 2025-04)
    Higher toxicity rates are associated with stereotactic ablative radiotherapy (SABR) to central lung tumors. Breath-hold (BH) magnetic resonance-guided SABR (MR-SABR) can reduce doses to organs at risk (OAR). We quantified ...
  • Automatic reorientation algorithm for myocardial perfusion SPECT using segmentation 
    Vijande, Ezequiel; Campisi, Roxana; Juarez-Orozco, Luis Eduardo; Agüero, Roberto; Geronazzo, Ricardo; Namías, Mauro (Wiley-Blackwell, 2025-04)
    Background: Cardiac reorientation is a necessary step in processing myocardial perfusion images. This task usually requires manual intervention and thus introduces intra- and inter-operator variability in the processing ...
  • Unique methotrexate polyglutamates distributions in peripheral blood mononuclear cells of rheumatoid arthritis patients: Development and validation of a UPLC-MS/MS method 
    Sundaresan, Janani; Lin, Marry; Jansen, Gerrit; Hebing, Renske C F; Bulatović-Ćalasan, Maja; de Jonge, Robert; Struys, Eduard A; de Rotte, Maurits C F J (Elsevier, 2025-09-01)
    Methotrexate is pivotal in treating immune-mediated inflammatory diseases. Intracellularly, methotrexate is metabolized to methotrexate-polyglutamates (MTX-PG1-7), comprising up to six additional glutamate moieties, crucial ...
  • Corrigendum to "Implementation of paediatric precision oncology into clinical practice: The individualized therapies for children with cancer program 'iTHER'" [Eur J Cancer 175 (2022) 311-325] 
    Langenberg, Karin P S; Meister, Michael T; Bakhuizen, Jette J; Boer, Judith M; van Eijkelenburg, Natasha K A; Hulleman, Esther; Ilan, Uri; Looze, Eleonora J; Dierselhuis, Miranda P; Lugt, Jasper van der; Breunis, Willemijn; Schild, Linda G; Ober, Kimberley; van Hooff, Sander R; Scheijde-Vermeulen, Marijn A; Hiemcke-Jiwa, Laura S; Flucke, Uta E; Kranendonk, Mariette E G; Wesseling, Pieter; Sonneveld, Edwin; Punt, Simone; Boltjes, Arjan; van Dijk, Freerk; Verwiel, Eugene T P; Volckmann, Richard; Hehir-Kwa, Jayne Y; Kester, Lennart A; Koudijs, Marco M J; Waanders, Esme; Holstege, Frank C P; Vormoor, H Josef; Hoving, Eelco W; Noesel, Max M van; Pieters, Rob; Kool, Marcel; Stumpf, Miriam; Blattner-Johnson, Mirjam; Balasubramanian, Gnana P; Van Tilburg, Cornelis M; Jones, Barbara C; Jones, David T W; Witt, Olaf; Pfister, Stefan M; Jongmans, Marjolijn C J; Kuiper, Roland P; de Krijger, Ronald R; Wijnen, Marc H W; den Boer, Monique L; Zwaan, C Michel; Kemmeren, Patrick; Koster, Jan; Tops, Bastiaan B J; Goemans, Bianca F; Molenaar, Jan J (Elsevier Limited, 2025-05-15)
  • Diffusion MRI tractography with along-tract profiling reveals subtle neurodevelopmental differences between moderate and late preterm infants 
    Verschuur, Anouk S; Tax, Chantal MW; Nijholt, Ingrid M; van Wezel-Meijler, Gerda; Hendson, Leonora; Zein, Hussein; Scotland, Jeanne; King, Regan; Mohammad, Khorshid; Boomsma, Martijn F; Leemans, Alexander; Leijser, Lara M (Elsevier Ireland Ltd, 2025-06)
    PURPOSE: Moderately preterm (MP) infants (32-33 weeks' gestation) are at increased risk for developmental problems compared to late preterm (LP) infants (34-36 weeks' gestation). Fiber bundle tractography remains an ...
  • Impact of recent clinical trials on meta-analysis of stereotactic body radiation therapy for spine metastases and urgent call for consistent study endpoints 
    Wong, Henry C Y; Lee, Shing Fung; Ryu, Samuel; Chan, Adrian Wai; Caini, Saverio; Johnstone, Peter; van der Linden, Yvette; van der Velden, Joanne M; Martin, Emily; Alcorn, Sara; Johnstone, Candice; Choi, J Isabelle; Marta, Gustavo Nader; Oldenburger, Eva; Raman, Srinivas; Rembielak, Agata; Vassiliou, Vassilios; Bonomo, Pierluigi; Nguyen, Quynh-Nhu; Tse, Shirley; Hoskin, Peter J; Simone, Charles B (AME Publishing Company, 2025-03)
    Pain from spinal metastases can result in significant impact to patients' quality of life. Conventional external beam radiation therapy (cEBRT) has long been shown to be effective in the pain control of patients with spinal ...
  • Single-cell RNA sequencing reveals sex differences in the subcellular composition and associated gene-regulatory network activity of human carotid plaques 
    Sukhavasi, Katyayani; Mocci, Giuseppe; Ma, Lijiang; Hodonsky, Chani J; Diez Benevante, Ernest; Muhl, Lars; Liu, Jianping; Gustafsson, Sonja; Buyandelger, Byambajav; Koplev, Simon; Lendahl, Urban; Vanlandewijck, Michael; Singha, Prosanta; Örd, Tiit; Beter, Mustafa; Selvarajan, Ilakya; Laakkonen, Johanna P; Väli, Marika; den Ruijter, Hester M; Civelek, Mete; Hao, Ke; Ruusalepp, Arno; Betsholtz, Christer; Järve, Heli; Kovacic, Jason C; Miller, Clint L; Romanoski, Casey; Kaikkonen, Minna U; Björkegren, Johan L M (Nature Publishing Group, 2025-04)
    Carotid stenosis causes ischemic stroke in both sexes, but the clinical presentation and plaque characteristics differ. Here we run deep single-cell sequencing of 7,690 human carotid plaque cells from male and female ...
  • Measuring the Performance of Survival Models to Personalize Treatment Choices 
    Efthimiou, Orestis; Hoogland, Jeroen; Debray, Thomas P A; Aponte Ribero, Valerie; Knol, Wilma; Koek, Huiberdina L; Schwenkglenks, Matthias; Henrard, Séverine; Egger, Matthias; Rodondi, Nicolas; White, Ian R (John Wiley & Sons Inc., 2025-03-30)
    Various statistical and machine learning algorithms can be used to predict treatment effects at the patient level using data from randomized clinical trials (RCTs). Such predictions can facilitate individualized treatment ...
  • Respiratory navigator-guided multi-slice free-breathing cardiac T1 mapping on a magnetic resonance-guided linear accelerator 
    Pontré, Beau P; Mandija, Stefano; Aubert, Manon M N; Schakel, Tim; Akdag, Osman; Keijnemans, Katrinus; Borman, Pim T S; van Lier, Astrid L H M W; van den Berg, Cornelis A T; Fast, Martin F (Elsevier, 2025-04)
    BACKGROUND AND PURPOSE: Image-guided cardiac radioablation on a magnetic resonance-guided linear accelerator (MR-linac) is emerging as a non-invasive treatment alternative for patients with cardiac arrhythmia. Precise ...
  • Open science interventions to improve reproducibility and replicability of research: a scoping review 
    Dudda, Leonie; Kormann, Eva; Kozula, Magdalena; DeVito, Nicholas J; Klebel, Thomas; Dewi, Ayu P M; Spijker, René; Stegeman, Inge; Van den Eynden, Veerle; Ross-Hellauer, Tony; Leeflang, Mariska M G (The Royal Society, 2025-04)
    Various open science practices have been proposed to improve the reproducibility and replicability of scientific research, but not for all practices, there may be evidence they are indeed effective. Therefore, we conducted ...
  • Real-world bleeding rates on emicizumab: the value of using nationwide digital treatment diary data in clinical research 
    Brands, Martijn R; Taal, Elisabeth M; Voshaar, Martijn Oude; Driessens, Mariëtte H E; van Veen, Caroline M E; Kruip, Marieke J H A; den Exter, Paul L; Laros-van Gorkom, Britta A P; Stein-Wit, Marjet A; Fischer, Kathelijn; Meijer, Stephan; Meijer, Karina; Beijlevelt, Marlène; Fijnvandraat, Karin; Gouw, Samantha C (Elsevier, 2025-02)
    BACKGROUND: People with hemophilia in the Netherlands log bleeds and infusions through a digital treatment diary. With the current innovations in hemophilia treatments, the use of patient-reported bleeding data will become ...
  • Accelerating the transition from a linear to a circular healthcare sector: ESCH-R: study design and methodology 
    Huijben, Jilske; van Raaij, Erik; Wagelmans, Albert; Piscicelli, Laura; Shen, Wei-Shan; van Vliet, Bas; Gommers, Diederik; Tibboel, Dick; Bakker, Ellen; Dekkers, Florijn; van Leeuwen, Redmer; Diehl, Jan Carel; Hunfeld, Nicole (Frontiers Media S. A., 2025-03-26)
    Due to the significant environmental impact of healthcare, there is an urgent need to accelerate its circular transition. We provide an overview of the ESCH-R project study design and methodology for accelerating the ...
  • Change of skeletal muscle mass and associated factors during radiotherapy and chemoradiotherapy in patients with head and neck squamous cell carcinoma 
    Schaeffers, Anouk W.M.A.; Scholten, Hannah A.; Kok, Annemieke; Reinders, Floris C.J.; Stellato, Rebecca K.; Smid, Ernst J.; van Beers, Maartje A.; van Gils, Carla H.; Speksnijder, Caroline M.; Philippens, Marielle P.; Devriese, Lot A.; de Bree, Remco (2025-06)
    Background and purpose: The aim is to investigate whether lumbar skeletal muscle index (LSMI) decreases during treatment of head and neck squamous cell carcinoma (HNSCC) patients, and which pre-treatment variables are ...
  • The V89L Polymorphism in the 5-α-Reductase Type 2 Gene and Risk of Breast Cancer 
    Van Gils, Carla H.; Onland-Moret, N. Charlotte; Roest, Mark; Van Noord, Paulus A.H.; Peeters, Petra H.M. (2003-11)
    Women with high androgen levels appear to be at increased risk for breast cancer. The 5-α-reductase type 2 enzyme (SRD5A2) is an important mediator of local androgen actions. The SRD5A2 gene contains a polymorphism leading ...
  • Cigarette smoking and risk of histological subtypes of epithelial ovarian cancer in the EPIC cohort study 
    Gram, Inger T.; Lukanova, Annekatrin; Brill, Ilene; Braaten, Tonje; Lund, Eiliv; Lundin, Eva; Overvad, Kim; Tjã̧nneland, Anne; Clavel-Chapelon, Francoise; Chabbert-Buffet, Nathalie; Bamia, Christina; Trichopoulou, Antonia; Zylis, Dimosthenis; Masala, Giovanna; Berrino, Franco; Galasso, Rocco; Tumino, Rosario; Sacerdote, Carlotta; Gavrilyuk, Oxana; Kristiansen, Steinar; Rodríguez, Laudina; Bonet, Catalina; Huerta, José María; Barricarte, Aurelio; Sánchez, Maria José; Dorronsoro, Miren; Jirström, Karin; Almquist, Martin; Idahl, Annika; Bueno-De-Mesquita, H. Bas; Braem, Marie; Onland-Moret, Charlotte; Tsilidis, Konstantinos K.; Allen, Naomi E.; Fedirko, Veronika; Riboli, E.; Kaaks, Rudolf (John Wiley & Sons Inc., 2012-05-01)
    New data regarding a positive association between smoking and risk of epithelial ovarian cancer (EOC), especially the mucinous tumor type, has started to emerge. The purpose of this study was to examine the association ...
  • Tumor necrosis factor (TNF)-α, soluble TNF receptors and endometrial cancer risk: The EPIC study 
    Dossus, Laure; Becker, Susen; Rinaldi, Sabina; Lukanova, Annekatrin; Tjønneland, Anne; Olsen, Anja; Overvad, Kim; Chabbert-Buffet, Nathalie; Boutron-Ruault, Marie Christine; Clavel-Chapelon, Françoise; Teucher, Birgit; Chang-Claude, Jenny; Pischon, Tobias; Boeing, Heiner; Trichopoulou, Antonia; Benetou, Vasiliki; Valanou, Elisavet; Palli, Domenico; Sieri, Sabina; Tumino, Rosario; Sacerdote, Carlotta; Galasso, Rocco; Redondo, Maria Luísa; Bonet, Catalina Bonet; Molina-Montes, Esther; Altzibar, Jone M.; Chirlaque, Maria Dolores; Ardanaz, Eva; Bas Bueno-De-Mesquita, H.; Van Duijnhoven, Fränzel J.B.; Peeters, Petra H.M.; Charlotte Onland-Moret, N.; Lundin, Eva; Idahl, Annika; Khaw, Kay Tee; Wareham, Nicholas; Allen, Naomi; Romieu, Isabelle; Fedirko, Veronika; Hainaut, Pierre; Romaguera, Dora; Norat, Teresa; Riboli, Elio; Kaaks, Rudolf (John Wiley & Sons Inc., 2011-10-15)
    Chronic inflammation has been hypothesized to play a role in endometrial cancer development. Tumor necrosis factor-α (TNF-α), one of the major pro-inflammatory cytokines, has also been implicated in endometrial physiology. ...
  • Use of previous screening mammograms to identify features indicating cases that would have a possible gain in prognosis following earlier detection 
    Broeders, M. J.M.; Onland-Moret, N. C.; Rijken, H. J.T.M.; Hendriks, J. H.C.L.; Verbeek, A. L.M.; Holland, R. (Elsevier Limited, 2003-08)
    False-negative screening mammograms generally refer to breast cancers that were overlooked or misinterpreted at screening. An important question is whether earlier detection could have made a difference in the prognosis ...
  • Reproducibility of the Determination of 13C-Labeling of Glutamate and Glutamine in the Human Brain Using selPOCE-MRS at 7 T Upon [U-13C]-Labeled Glucose Infusion 
    Ahmadian, Narjes; Jacobs, Sarah M; Gosselink, Mark; van der Kemp, Wybe J M; Hoogduin, Hans; Coppoli, Anastasia; Mason, Graeme F; de Graaf, Robin A; Norouzizadeh, Helia; Mahon, Chantal; Eijsden, Pieter van; Tiessen, Renger; Cerneus, Dirk; Miller, Corin O; Lepeleire, Inge De; Basile, Anthony S; Klomp, Dennis W J; Prompers, Jeanine J; Wiegers, Evita C (John Wiley & Sons Inc., 2025-05)
    Glutamate (Glu) is the major excitatory neurotransmitter in the central nervous system. The measurement of Glu/glutamine (Gln) neurotransmitters in the brain provides valuable insights into the dynamic aspects of neuroenergetics ...