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UMC Repository: Recent submissions

  • Growth-related sports injuries among young male professional football players in the Netherlands: a prospective cohort study concerning injury incidence, severity and burden 
    Juch, Else E.A.E.; van de Koppel, Vincent C.; Blokland, Donna; Wouters, Renko A.; Backx, Frank J.G.; Goedhart, Edwin A.; van der Horst, Nick (Taylor and Francis Ltd., 2025)
    Objectives: To investigate the incidence, type and location of growth-related sports injuries (GRSI) in youth professional football in the Netherlands. Secondary, to gain more knowledge on the injury severity and burden ...
  • FIGO opinion paper: Drivers and solutions to the cesarean delivery epidemic with emphasis on the increasing rates in Africa and Southeastern Europe 
    Visser, Gerard H.A.; Ubom, Akaninyene Eseme; Neji, Khaled; Nassar, Anwar; Jacobsson, Bo; Nicholson, Wanda (John Wiley & Sons Inc., 2023-10)
    Cesarean delivery rates are rapidly increasing in Southeastern Europe (to more than 60%), North Africa (with a rate as high as 72% in Egypt), and in urban areas in Southern Africa (a rate of over 50% in Lagos, Nigeria). ...
  • Serous Maculopathy Due to Aspecific Choroidopathy (SMACH) 
    Van Dijk, Elon H.C.; Ossewaarde-Van Norel, Jeannette; Vingerling, Johannes R.; Cohen, Salomon Y.; Boon, Camiel J.F. (Elsevier, 2023-09-21)
  • First Iranian guidelines for the diagnosis, management, and treatment of hyperlipidemia in adults 
    Bagheri Kholenjani, Fahimeh; Shahidi, Shahla; Vaseghi, Golnaz; Ashoorion, Vahid; Sarrafzadegan, Nizal; Siavash, Mansour; Heidarpour, Maryam; Shahidi, Shahrzad; Sadeghi, Masoumeh; Mohammadifard, Noushin; Jorjani, Masoumeh; Mobarhan, Majid Ghayour; Shafie, Davood; Farshidi, Hossein; Khorvash, Fariborz; Ghabaei, Mojdeh; Teimouri-Jervekani, Zahra; Mortazavi, Mojgan; Hajhashemi, Valiollah; Roshanravan, Neda; Yazdanpanah, Leila; Davari, Majid; Fatemi, Behzad; Khorasani, Elaheh; Hoseinkhani, Ramesh; Zarean, Elaheh; Ahmadi, Alireza; Babadi, Maryam Eghbali; Assareh, Ahmadreza; Shadmani, Mehdi; Kojuri, Javad; Shirani, Farimah; Sanjari, Mojgan; Haghighatdoost, Fahimeh; Hassannejad, Razieh; Hashemi, Elham; Moaddab, Mohammad Hassan; Gheisari, Alaleh; Dehghan, Bahar; Naseri, Mitra; Ghaemi, Nosrat; Noohi, Fereidoun; Haghdoost, Ali Akbar; Salehi-Abargouei, Amin; Beigrezaie, Sara; Doosti-Irani, Amin; Ramezani-Jolfaie, Nahid; Eraj, Bijan; Hashemipour, Mahin; Nematipour, Ebrahim; Guideline Developing Group; Systematics Review Group; External Review Group (Wolters Kluwer Medknow Publications, 2024-03)
    This guideline is the first Iranian guideline developed for the diagnosis, management, and treatment of hyperlipidemia in adults. The members of the guideline developing group (GDG) selected 9 relevant clinical questions ...
  • Hydroxychloroquine monotherapy in sarcoidosis: Indications, efficacy, and side effects 
    Vermeer, Britney; Veltkamp, Marcel; Raasing, Lisette Regina Maria; Wind, Anne Elisabeth; Vorselaars, Adriane Dore Marie (Mattioli 1885 S.p.A., 2024)
    Background and aim: In sarcoidosis that is not threatening vital internal organs such as the heart, central nervous system or lungs, immunomodulatory treatment, such as hydroxychloroquine can be considered. Despite its ...
  • BrainFit: improving executive and subjective cognitive functioning in late-life mood disorders - a double-blind randomized active-controlled study evaluating the effect of online cognitive training 
    Oudega, Mardien L.; Wagenmakers, Margot J.; Palsma, Tanya; Hoogendoorn, Adriaan W.; Vriend, Chris; van den Heuvel, Odile A.; Schouws, Sigfried; Dols, Annemiek (Frontiers Research Foundation, 2024)
    Introduction: Unipolar and bipolar mood disorders in older adults are accompanied by cognitive impairment, including executive dysfunction, with a severe impact on daily life. Up and till now, strategies to improve cognitive ...
  • Fatal meningitis during pregnancy in the Netherlands: a nationwide confidential enquiry 
    Schaap, T P; Schutte, J M; Zwart, J J; Schuitemaker, N W E; van Roosmalen, J; Dutch Maternal Mortality Committee (Wiley-Blackwell, 2012-12)
    OBJECTIVE: To determine the incidence of maternal deaths attributable to meningitis in the Netherlands, and to assess clinical features and risk factors. DESIGN: Confidential enquiry into the causes of maternal deaths. ...
  • Classification of Fibro-osseous Tumors in the Craniofacial Bones using DNA Methylation and Copy Number Alterations 
    Kleijn, Tony G; Ameline, Baptiste; Schreuder, Willem H; Szuhai, Károly; Kooistra, Wierd; van Kempen, Léon; Japalagh, Ghazaleh S H; Briaire-de Bruijn, Inge H; van der Meeren, Stijn W; Kleijwegt, Maarten C; Witjes, Max; Pichardo, Sarina E C; van Furth, Wouter R; Lausová, Tereza; Breimer, Gerben E; Braunius, W Weibel; de Lange, Jan; van Langevelde, Kirsten; Kroon, Herman M; van den Hout, Mari F C M; Koppes, Sjors A; Haefliger, Simon; Ooft, Marc L; van Engen-van Grunsven, Ilse C H; Flucke, Uta E; Hiemcke-Jiwa, Laura; Savci-Heijink, Dilara C; Diercks, Gilles F H; Doff, Jan J; Suurmeijer, Albert J H; Bovée, Judith V M G; von Deimling, Andreas; Baumhoer, Daniel; Cleven, Arjen H G (Elsevier, 2025-06)
    Fibro-osseous tumors of the craniofacial bones are a heterogeneous group of lesions comprising cemento-osseous dysplasia (COD), cemento-ossifying fibroma (COF), juvenile trabecular ossifying fibroma (JTOF), psammomatoid ...
  • Intravesical Instillation of Chemotherapy Before Radical Surgery for Upper Urinary Tract Urothelial Carcinoma: The REBACARE Trial 
    van Doeveren, Thomas; Remmers, Sebastiaan; Boevé, Egbert R; Cornel, Erik B; van der Heijden, Antoine G; Hendricksen, Kees; Cauberg, Evelyne C C; Jacobs, Rens; Kroon, Bin K; Leliveld, Annemarie M; Meijer, Richard P; van Melick, Harm; Merks, Bob; Oddens, Jorg R; Pradere, Benjamin; Roelofs, Luc A J; Somford, Diederik M; de Vries, Peter; Wijsman, Bart; Windt, Willemijn A K M; Yska, Marit; Zwaan, Peter J; Aben, Katja K H; van Leeuwen, Pim J; Boormans, Joost L (Elsevier, 2025-04)
    Background and objective: Intravesical instillation of chemotherapy (IIC) after radical surgery for upper urinary tract urothelial carcinoma (UTUC) reduces the risk of intravesical recurrence (IVR). However, compliance is ...
  • Mapping Trajectories of Gait Recovery in Clinical Stroke Rehabilitation 
    Felius, Richard A.W.; Punt, Michiel; Wouda, Natasja C.; Geerars, Marieke; Bruijn, Sjoerd M.; Wittink, Harriet; van Dieën, Jaap H. (SAGE Publications Inc., 2025-04)
    Background: How gait changes during the early stages of stoke rehabilitation, and which patient characteristics are associated with these changes is still largely unknown. Objective: he first objective was to describe the ...
  • A multicenter Phase II randomized, placebo-controlled single-blind trial with the SV2A ligand seletracetam in photosensitive epilepsy patients 
    Kasteleijn-Nolst Trenité, Dorothee; Stockis, Armel; Hirsch, Edouard; Genton, Pierre; Abou-Khalil, Bassel W.; French, Jacqueline A.; Masnou, Pascal; Löscher, Wolfgang (Academic Press Inc., 2025-03)
    The objective of this study was to evaluate the effect of seletracetam (SEL), a potent modulator of synaptic vesicle glycoprotein 2A (SV2A), in patients with photoparoxysmal EEG response (PPR) to intermittent photic ...
  • Symptoms at population Eliciting Doses ≤ED05 for 11 priority allergenic foods are mild to moderate 
    Blom, W. Marty; Westerhout, Joost; Le, Thuy My; Taylor, Steve L.; Baumert, Joseph L.; Houben, Geert F. (Elsevier Limited, 2025-03)
    Insight into symptoms at low doses of protein from priority allergenic foods may support decision making and acceptance of harmonized reference doses for Precautionary Allergen Labeling (PAL). Symptoms were extracted from ...
  • Assessing the role of spatial aggregation schemes with varying campaign durations of mobile measurements on land use regression models for estimating nitrogen dioxide 
    Tian, Tian; Helbich, Marco; Yuan, Zhendong; Vermeulen, Roel; Hoek, Gerard; Kerckhoffs, Jules (Elsevier, 2025-03-01)
    Mobile air pollution measurements are typically aggregated by varying road segment lengths, grid cell sizes, and time intervals. How these spatiotemporal aggregation schemas affect the modeling performance of land use ...
  • Hypoxia inducible factor-dependent upregulation of Agrp in glomus type I cells of the carotid body 
    Leon-Mercado, Luis; Menendez-Montes, Ivan; Tao, Jonathan; Chen, Bandy; Olson, David P.; Mackaaij, C.; Cleypool, C. G.J.; Gautron, Laurent (Elsevier, 2025-02)
    Agouti-related peptide (AgRP) is a well-established potent orexigenic peptide primarily expressed in hypothalamic neurons. Nevertheless, the expression and functional significance of extrahypothalamic AgRP remain poorly ...
  • Exploring Social Health in Patients with Atopic Dermatitis: An Observational, Cross-sectional, Questionnaire Based Study on Social Participation and Emotional Support 
    Kamphuis, Esmé; Loman, Laura; De Bruin-Weller, Marjolein; Schuttelaar, Marie Louise (Medical Journals Sweden AB, 2025-01-08)
  • NAC regulates metabolism and cell fate in intestinal stem cells 
    Ramalho, Sofia; Alkan, Ferhat; Prekovic, Stefan; Jastrzebski, Katarzyna; Barberà, Eric Pintó; Hoekman, Liesbeth; Altelaar, Maarten; de Heus, Cecilia; Liv, Nalan; Rodríguez-Colman, Maria J.; Yilmaz, Mehmet; van der Kammen, Rob; Fedry, Juliette; de Gooijer, Mark C.; Suijkerbuijk, Saskia Jacoba Elisabeth; Faller, William J.; Silva, Joana (American Association for the Advancement of Science, 2025-01-10)
    Intestinal stem cells (ISCs) face the challenge of integrating metabolic demands with unique regenerative functions. Studies have shown an intricate interplay between metabolism and stem cell capacity; however, it is still ...
  • Regulatory workshop on standardisation of clinical procedures, endpoints and data robustness of human challenge studies: A stakeholder meeting report 
    Meln, Irina; Cnossen, Victor; Corti, Nicoletta; Andeweg, Arno; Baay, Marc; Chiu, Christopher; Coia, John; Cornely, Oliver; Cox, Rebecca J.; Dasyam, Dileep; De Keersmaecker, Sigrid C.J.; Deming, Meagan; Waldock, Joanna; Engelhardt, Othmar G.; Guo, Manman; Haj-Ali Saflo, Okba; Hensen, Annefleur; Jeeninga, Rienk; Kolstoe, Simon; Krut, Oleg; Kuijper, Ed J.; Leal, Lorna; Mazur, Natalie; Mohn, Kristin G.I.; Morel, Sandra; Osterhaus, Ab; Moreira, Augustin Portela; Smits, Wiep Klaas; Sridhar, Saranya; Toomey, Danny; van Gerven, Joop; Vehreschild, Maria J.G.T.; Yarzabal, Juan Pablo; Zimmer-Harwood, Paul; Neels, Pieter; Olesen, Ole F.; Roestenberg, Meta; Kamerling, Ingrid M.C. (Academic Press Inc., 2025-05)
    Inno4Vac, a public-private partnership funded by the IMI2/EU/EFPIA Joint Undertaking (IMI2 JU), brings together academic institutions, SMEs, and pharmaceutical companies to accelerate and de-risk vaccine development. The ...
  • Experiences of patients with metastatic colorectal cancer participating in a supervised exercise intervention during chemotherapy 
    Brouwer, Calvin G.; Tusscher, Marieke R.Ten; de Roos, Bente M.; Gootjes, Elske C.; Buffart, Tineke E.; Versteeg, Kathelijn S.; Mast, Isa H.; Streppel, Mirte M.; Werter, Inge M.; May, Anne M.; Verheul, Henk M.W.; Buffart, Laurien M.; AMICO Consortium (Springer-Verlag, 2025-02)
    PURPOSE: Patients with metastatic colorectal cancer (mCRC) undergoing systemic treatment often experience toxicities. Although exercise may improve physical fitness and quality of life and counteract treatment toxicity, ...
  • Estimated Prevalence, Tumor Spectrum, and Neurofibromatosis Type 1-Like Phenotype of CDKN2A -Related Melanoma-Astrocytoma Syndrome 
    Sargen, Michael R.; Kim, Jung; Potjer, Thomas P.; Velthuizen, Mary E.; Martir-Negron, Arelis E.; Odia, Yazmin; Helgadottir, Hildur; Hatton, Jessica N.; Haley, Jeremy S.; Thone, Gretchen; Widemann, Brigitte C.; Gross, Andrea M.; Yohe, Marielle E.; Kaplan, Rosandra N.; Shern, Jack F.; Sundby, R. Taylor; Astiazaran-Symonds, Esteban; Yang, Xiaohong R.; Carey, David J.; Tucker, Margaret A.; Stewart, Douglas R.; Goldstein, Alisa M. (American Medical Association, 2023-10-18)
    Importance: Knowledge about the prevalence and tumor types of CDKN2A-related melanoma-astrocytoma syndrome (MAS) is limited and could improve disease recognition. Objective: To estimate the prevalence and describe the tumor ...
  • Improving traffic-related air pollution estimates by modelling minor road traffic volumes 
    Alvarado-Molina, Miguel; Curto, Ariadna; Wheeler, Amanda J.; Tham, Rachel; Cerin, Ester; Nieuwenhuijsen, Mark; Vermeulen, Roel; Donaire-Gonzalez, David (Elsevier, 2023-12-01)
    Accurately estimating annual average daily traffic (AADT) on minor roads is essential for assessing traffic-related air pollution (TRAP) exposure, particularly in areas where most people live. Our study assessed the direct ...