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UMC Repository: Recent submissions

  • Mending the Language Barrier: The Need for Ethics Communication in Neuroethics 
    Bassil, Katherine (Taylor and Francis Inc., 2023)
  • COLUMBUS-AD: phase III study of adjuvant encorafenib + binimetinib in resected stage IIB/IIC BRAF V600-mutated melanoma 
    Van Akkooi, Alexander C.J.; Hauschild, Axel; Long, Georgina V.; Mandala, Mario; Kicinski, Michal; Govaerts, Anne Sophie; Klauck, Isabelle; Ouali, Monia; Lorigan, Paul C.; Eggermont, Alexander M.M. (Taylor and Francis Ltd., 2023-09-01)
    Stage IIB/IIC melanoma has a high risk of recurrence after surgical resection. While, for decades, surgery was the only option for high-risk stage II disease in most countries, adjuvant therapies now exist. Anti-programmed ...
  • Sex differences in risk factors for incident peripheral artery disease hospitalisation or death: Cohort study of UK Biobank participants 
    Xu, Ying; Harris, Katie; Pouncey, Anna Louise; Carcel, Cheryl; Low, Gary; Peters, Sanne A.E.; Woodward, Mark (Public Library of Science, 2023-10)
    Background Women with peripheral artery disease (PAD) often have atypical symptoms, late hospital presentations, and worse prognosis. Risk factor identification and management are important. We assessed sex differences in ...
  • Vaccine value profile for cytomegalovirus 
    Boppana, Suresh B.; van Boven, Michiel; Britt, William J.; Gantt, Soren; Griffiths, Paul D.; Grosse, Scott D.; Hyde, Terri B.; Lanzieri, Tatiana M.; Mussi-Pinhata, Marisa M.; Pallas, Sarah E.; Pinninti, Swetha G.; Rawlinson, William D.; Ross, Shannon A.; Vossen, Ann C.T.M.; Fowler, Karen B. (Elsevier, 2023-11-03)
    Cytomegalovirus (CMV) is the most common infectious cause of congenital malformation and a leading cause of developmental disabilities such as sensorineural hearing loss (SNHL), motor and cognitive deficits. The significant ...
  • Apolipoprotein-CIII O-Glycosylation, a Link between GALNT2 and Plasma Lipids 
    Naber, Annemieke; Demus, Daniel; Slieker, Roderick; Nicolardi, Simone; Beulens, Joline W.J.; Elders, Petra J.M.; Lieverse, Aloysius G.; Sijbrands, Eric J.G.; ’t Hart, Leen M.; Wuhrer, Manfred; van Hoek, Mandy (Multidisciplinary Digital Publishing Institute (MDPI), 2023-10)
    Apolipoprotein-CIII (apo-CIII) is involved in triglyceride-rich lipoprotein metabolism and linked to beta-cell damage, insulin resistance, and cardiovascular disease. Apo-CIII exists in four main proteoforms: non-glycosylated ...
  • Mega-analysis of association between obesity and cortical morphology in bipolar disorders: ENIGMA study in 2832 participants 
    Mcwhinney, Sean R.; Abé, Christoph; Alda, Martin; Benedetti, Francesco; Boen, Erlend; Del Mar Bonnin, Caterina; Borgers, Tiana; Brosch, Katharina; Canales-Rodríguez, Erick J.; Cannon, Dara M.; Dannlowski, Udo; Diaz-Zuluaga, Ana M.; Dietze, Lorielle M.F.; Elvsåshagen, Torbjorn; Eyler, Lisa T.; Fullerton, Janice M.; Goikolea, Jose M.; Goltermann, Janik; Grotegerd, Dominik; Haarman, Bartholomeus C.M.; Hahn, Tim; Howells, Fleur M.; Ingvar, Martin; Jahanshad, Neda; Kircher, Tilo T.J.; Krug, Axel; Kuplicki, Rayus T.; Landén, Mikael; Lemke, Hannah; Liberg, Benny; Lopez-Jaramillo, Carlos; Malt, Ulrik F.; Martyn, Fiona M.; Mazza, Elena; Mcdonald, Colm; Mcphilemy, Genevieve; Meier, Sandra; Meinert, Susanne; Meller, Tina; Melloni, Elisa M.T.; Mitchell, Philip B.; Nabulsi, Leila; Nenadic, Igor; Opel, Nils; Ophoff, Roel A.; Overs, Bronwyn J.; Pfarr, Julia Katharina; Pineda-Zapata, Julian A.; Pomarol-Clotet, Edith; Raduà, Joaquim; Repple, Jonathan; Richter, Maike; Ringwald, Kai G.; Roberts, Gloria; Ross, Alex; Salvador, Raymond; Savitz, Jonathan; Schmitt, Simon; Schofield, Peter R.; Sim, Kang; Stein, Dan J.; Stein, Frederike; Temmingh, Henk S.; Thiel, Katharina; Thomopoulos, Sophia I.; Van Haren, Neeltje E.M.; Vargas, Cristian; Vieta, Eduard; Vreeker, Annabel; Waltemate, Lena; Yatham, Lakshmi N.; Ching, Christopher R.K.; Andreassen, Ole A.; Thompson, Paul M.; Hajek, Tomas (Cambridge University Press, 2023-10-27)
    Background: Obesity is highly prevalent and disabling, especially in individuals with severe mental illness including bipolar disorders (BD). The brain is a target organ for both obesity and BD. Yet, we do not understand ...
  • AZD9567 versus prednisolone in patients with active rheumatoid arthritis: A phase IIa, randomized, double-blind, efficacy, and safety study 
    van Laar, Jacob M.; Lei, Alejhandra; Safy-Khan, Mary; Almquist, Joachim; Belfield, Graham; Edman, Karl; Öberg, Lisa; Angermann, Bastian R.; Dillmann, Inken; Berntsson, Pia; Etal, Damla; Dainty, Ian; Astbury, Carol; Belvisi, Maria G.; Nemes, Szilárd; Platt, Adam; Prothon, Susanne; Samuelsson, Sara; Svanberg, Petter; Keen, Christina (John Wiley & Sons Inc., 2023-12)
    Oral corticosteroid use is limited by side effects, some caused by off-target actions on the mineralocorticoid receptor that disrupt electrolyte balance. AZD9567 is a selective, nonsteroidal glucocorticoid receptor modulator. ...
  • Correction: Understanding the impact of tuberous sclerosis complex: development and validation of the TSC-PROM (BMC Medicine, (2023), 21, 1, (298), 10.1186/s12916-023-03012-4) 
    Müller, Annelieke R.; Luijten, Michiel A.J.; Haverman, Lotte; de Ranitz-Greven, Wendela L.; Janssens, Peter; Rietman, André B.; Hoopen, Leontine W.ten; de Graaff, Laura C.G.; de Wit, Marie Claire; Jansen, Anna C.; Gipson, Tanjala; Capal, Jamie K.; de Vries, Petrus J.; van Eeghen, Agnies M. (BioMed Central Ltd., 2023-12)
    The original article [1] contained typographical errors in Additional Files 2 and 3 which have since been amended.
  • Relative expression of hormone receptors by endothelial and smooth muscle cells in proliferative and non-proliferative areas of congenital arteriovenous malformations 
    Utami, A. M.; Halfwerk, J. B.G.; de Boer, O. J.; Mackaaij, C.; Pabittei, D. R.; van der Horst, C. M.A.M.; Meijer-Jorna, L. B.; van der Wal, A. C. (BioMed Central Ltd., 2023-12)
    Background: Episodic growth due to microvascular proliferations (MVP) has been reported in congenital arteriovenous malformations (AVM), which are normally quiescent lesions composed of mature malformed vessels. Since AVM ...
  • An artificial intelligence tool for automated analysis of large-scale unstructured clinical cine cardiac magnetic resonance databases 
    Mariscal-Harana, Jorge; Asher, Clint; Vergani, Vittoria; Rizvi, Maleeha; Keehn, Louise; Kim, Raymond J.; Judd, Robert M.; Petersen, Steffen E.; Razavi, Reza; King, Andrew P.; Ruijsink, Bram; Puyol-Antón, Esther (Oxford University Press, 2023-10)
    Aims: Artificial intelligence (AI) techniques have been proposed for automating analysis of short-axis (SAX) cine cardiac magnetic resonance (CMR), but no CMR analysis tool exists to automatically analyse large (unstructured) ...
  • Managing periprosthetic fractures: Perspectives on periprosthetic pelvic fractures 
    De Ridder, Victor A.; Pape, Hans Christoph; Chana-Rodríguez, Francisco; Boudissa, Mehdi; Claudia, Glowalla; Fabian, Stuby; Steven, Herath; Tina, Histing; Konstantinos, Tilkeridis; Zoe, Dailiana (Wolters Kluwer Health, 2023-03-01)
    Periacetabular periprosthetic fractures are rare but potentially disastrous for the longevity of the adjacent implants, leading to multiple revision surgeries. It is of paramount importance to identify and treat intraoperative ...
  • The burden and dynamics of hospital-acquired SARS-CoV-2 in England 
    Cooper, Ben S.; Evans, Stephanie; Jafari, Yalda; Pham, Thi Mui; Mo, Yin; Lim, Cherry; Pritchard, Mark G.; Pople, Diane; Hall, Victoria; Stimson, James; Eyre, David W.; Read, Jonathan M.; Donnelly, Christl A.; Horby, Peter; Watson, Conall; Funk, Sebastian; Robotham, Julie V.; Knight, Gwenan M. (Nature Research, 2023-10-18)
    Hospital-based transmission had a dominant role in Middle East respiratory syndrome coronavirus (MERS-CoV) and severe acute respiratory syndrome coronavirus (SARS-CoV) epidemics1,2, but large-scale studies of its role in ...
  • Effectiveness of homologous/heterologous booster COVID-19 vaccination schedules against severe illness in general population and clinical subgroups in three European countries 
    Riefolo, Fabio; Castillo-Cano, Belén; Martín-Pérez, Mar; Messina, Davide; Elbers, Roel; Brink-Kwakkel, Dorieke; Villalobos, Felipe; Ingrasciotta, Ylenia; Garcia-Poza, Patricia; Swart-Polinder, Karin; Souverein, Patrick; Saiz, Luis Carlos; Bissacco, Carlo Alberto; Leache, Leire; Tari, Michele; Crisafulli, Salvatore; Grimaldi, Lamiae; Vaz, Tiago; Gini, Rosa; Klungel, Olaf; Martín-Merino, Elisa (Elsevier, 2023-11-13)
    Using 4 data-sources (Spain, Italy, United Kingdom) data and a 1:1 matched cohort study, we aimed to estimate vaccine effectiveness (VE) in preventing SARS-CoV-2 infections with hospitalisations (±30 days) and death (±56 ...
  • Review of Studies Evaluating Effectiveness of Risk Minimization Measures Assessed by the European Medicines Agency Between 2016 and 2021 
    Grupstra, Renske J.; Goedecke, Thomas; Scheffers, Jet; Strassmann, Valerie; Gardarsdottir, Helga (Wiley-Blackwell, 2023-12)
    The European Medicines Agency (EMA) supervises medicines' safe and effective use throughout the product's life cycle by, for example, monitoring the implementation of risk minimization measures (RMMs). Limited information ...
  • Hippocampal Glutamate, Resting Perfusion and the Effects of Cannabidiol in Psychosis Risk 
    Davies, Cathy; Bossong, Matthijs G.; Martins, Daniel; Wilson, Robin; Appiah-Kusi, Elizabeth; Blest-Hopley, Grace; Allen, Paul; Zelaya, Fernando; Lythgoe, David J.; Brammer, Michael; Perez, Jesus; McGuire, Philip; Bhattacharyya, Sagnik (Oxford University Press, 2023-01)
    Background: Preclinical and human data suggest that psychosis onset involves hippocampal glutamatergic dysfunction, driving hyperactivity and hyperperfusion in a hippocampal-midbrain-striatal circuit. Whether glutamatergic ...
  • Associations between the neighbourhood food environment and cardiovascular disease: a systematic review 
    Meijer, Paul; Numans, Hidser; Lakerveld, Jeroen (Oxford University Press, 2023-11-01)
    Aims: To systematically review the current evidence on the association between the neighbourhood food environment and cardiovascular disease (CVD) in adults. Methods and results: We searched the literature databases CINAHL, ...
  • WIP1 is a novel specific target for growth hormone action 
    Apaydin, Tugce; Zonis, Svetlana; Zhou, Cuiqi; Valencia, Christian Wong; Barrett, Robert; Strous, Ger J.; Mol, Jan A.; Chesnokova, Vera; Melmed, Shlomo (Elsevier, 2023-11-17)
    DNA damage repair (DDR) is mediated by phosphorylating effectors ATM kinase, CHK2, p53, and γH2AX. We showed earlier that GH suppresses DDR by suppressing pATM, resulting in DNA damage accumulation. Here, we show GH acting ...
  • Global, regional, and national burden of spinal cord injury, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019 
    Harlianto, Netanja I.; GBD Spinal Cord Injuries Collaborators (Elsevier Limited, 2023-11)
    Background: Spinal cord injury (SCI) is a major cause of health loss due to premature mortality and long-term disability. We aimed to report on the global, regional, and national incidence, prevalence, and years of life ...
  • 2023 Focused Update of the 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure Developed by the task force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC) With the special contribution of the Heart Failure Association (HFA) of the ESC 
    McDonagh, Theresa A.; Metra, Marco; Adamo, Marianna; Gardner, Roy S.; Baumbach, Andreas; Böhm, Michael; Burri, Haran; Butler, Javed; Celutkiene, Jelena; Chioncel, Ovidiu; Cleland, John G.F.; Crespo-Leiro, Maria Generosa; Farmakis, Dimitrios; Gilard, Martine; Heymans, Stephane; Hoes, Arno W.; Jaarsma, Tiny; Jankowska, Ewa A.; Lainscak, Mitja; Lam, Carolyn S.P.; Lyon, Alexander R.; McMurray, John J.V.; Mebazaa, Alexandre; Mindham, Richard; Muneretto, Claudio; Francesco, Massimo; Price, Susanna; Rosano, Giuseppe M.C.; Ruschitzka, Frank; Skibelund, Anne Kathrine; Task Force Members; ESC Scientific Document Group (Oxford University Press, 2023-10-01)
  • The Diagnostic Process of Spinal Post-traumatic Deformity: An Expert Survey of 7 Cases, Consensus on Clinical Relevance Does Exist 
    De Gendt, Erin E.A.; Benneker, Lorin M.; Joaquim, Andrei F.; El-Sharkawi, Mohammad; Dhakal, Gaurav R.; Kandziora, Frank; Tee, Jin; Bransford, Richard J.; Vialle, Emiliano N.; Vaccaro, Alex R.; Popescu, Eugen C.; Kanna, Rishi M.; Polly, David W.; Schnake, Klaus J.; Berjano, Pedro; Ryabykh, Sergey; Neva, Marko; Lamartina, Claudio; Rothenfluh, Dominique A.; Lewis, Stephan J.; Muijs, Sander P.J.; Cumhur Oner, F. (Lippincott Williams & Wilkins, 2023-10-01)
    Study Design: Survey of cases. Objective: To evaluate the opinion of experts in the diagnostic process of clinically relevant Spinal Post-traumatic Deformity (SPTD). Summary of Background Data: SPTD is a potential complication ...