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UMC Repository: Recent submissions

  • Relationships of pericoronary and epicardial fat measurements in male and female patients with and without coronary artery disease 
    Ma, Runlei; van Assen, Marly; Sidorenkov, Grigory; Ties, Daan; Jan Pelgrim, Gert; Stillman, Arthur; de Cecco, Carlo; van der Harst, Pim; Vliegenthart, Rozemarijn (Elsevier Ireland Ltd, 2023-12)
    Introduction: Although pericoronary adipose tissue (PCAT) is a component of the epicardial adipose tissue (EAT) depot, they may have different associations to coronary artery disease (CAD). We explored relationships between ...
  • Implications of Cellular Mechanical Memory in Bioengineering 
    Dudaryeva, Oksana Y.; Bernhard, Stéphane; Tibbitt, Mark W.; Labouesse, Céline (American Chemical Society, 2023-11-13)
    The ability to maintain and differentiate cells in vitro is critical to many advances in the field of bioengineering. However, on traditional, stiff (E ≈ GPa) culture substrates, cells are subjected to sustained mechanical ...
  • Structural and non-coding variants increase the diagnostic yield of clinical whole genome sequencing for rare diseases 
    Pagnamenta, Alistair T.; Camps, Carme; Giacopuzzi, Edoardo; Taylor, John M.; Hashim, Mona; Calpena, Eduardo; Kaisaki, Pamela J.; Hashimoto, Akiko; Yu, Jing; Sanders, Edward; Schwessinger, Ron; Hughes, Jim R.; Lunter, Gerton; Dreau, Helene; Ferla, Matteo; Lange, Lukas; Kesim, Yesim; Ragoussis, Vassilis; Vavoulis, Dimitrios V.; Allroggen, Holger; Ansorge, Olaf; Babbs, Christian; Banka, Siddharth; Baños-Piñero, Benito; Beeson, David; Ben-Ami, Tal; Bennett, David L.; Bento, Celeste; Blair, Edward; Brasch-Andersen, Charlotte; Bull, Katherine R.; Cario, Holger; Cilliers, Deirdre; Conti, Valerio; Davies, E. Graham; Dhalla, Fatima; Dacal, Beatriz Diez; Dong, Yin; Dunford, James E.; Guerrini, Renzo; Harris, Adrian L.; Hartley, Jane; Hollander, Georg; Javaid, Kassim; Kane, Maureen; Kelly, Deirdre; Kelly, Dominic; Knight, Samantha J.L.; Kreins, Alexandra Y.; Kvikstad, Erika M.; Langman, Craig B.; Lester, Tracy; Lines, Kate E.; Lord, Simon R.; Lu, Xin; Mansour, Sahar; Manzur, Adnan; Maroofian, Reza; Marsden, Brian; Mason, Joanne; McGowan, Simon J.; Mei, Davide; Mlcochova, Hana; Murakami, Yoshiko; Németh, Andrea H.; Okoli, Steven; Ormondroyd, Elizabeth; Ousager, Lilian Bomme; Palace, Jacqueline; Patel, Smita Y.; Pentony, Melissa M.; Pugh, Chris; Rad, Aboulfazl; Ramesh, Archana; Riva, Simone G.; Roberts, Irene; Roy, Noémi; Salminen, Outi; Schilling, Kyleen D.; Scott, Caroline; Sen, Arjune; Smith, Conrad; Stevenson, Mark; Thakker, Rajesh V.; Twigg, Stephen R.F.; Uhlig, Holm H.; van Wijk, Richard; Vona, Barbara; Wall, Steven; Wang, Jing; Watkins, Hugh; Zak, Jaroslav; Schuh, Anna H.; Kini, Usha; Wilkie, Andrew O.M.; Popitsch, Niko; Taylor, Jenny C. (BioMed Central, 2023-12)
    Background: Whole genome sequencing is increasingly being used for the diagnosis of patients with rare diseases. However, the diagnostic yields of many studies, particularly those conducted in a healthcare setting, are ...
  • Targeted Genomic Sequencing of TSC1 and TSC2 Reveals Causal Variants in Individuals for Whom Previous Genetic Testing for Tuberous Sclerosis Complex Was Normal 
    West, Hannah D.; Nellist, Mark; Brouwer, Rutger W.W.; Van Den Hout-Van Vroonhoven, Mirjam C.G.N.; De Almeida, Luiz Gustavo Dufner; Hendriks, Femke; Elfferich, Peter; Raja, Meera; Giles, Peter; Alfano, Rosa M.; Peron, Angela; Sznajer, Yves; De Waele, Liesbeth; Jansen, Anna; Koopmans, Marije; Kievit, Anneke; Farach, Laura S.; Northrup, Hope; Sampson, Julian R.; Thomas, Laura E.; Van Ijcken, Wilfred F.J. (John Wiley & Sons Inc., 2023)
    Tuberous sclerosis complex (TSC) is caused by inactivating variants in TSC1 and TSC2. Somatic mosaicism, as well as the size and complexity of the TSC1 and TSC2 loci, makes variant identification challenging. Indeed, in ...
  • CORR Insights®: Development and Validation of a Convolutional Neural Network Model to Predict a Pathologic Fracture in the Proximal Femur Using Abdomen and Pelvis CT Images of Patients With Advanced Cancer 
    Groot, Olivier Quinten (Springer New York, 2023-11-01)
  • Refining the role of reproductive factors on heart health 
    Peters, Sanne A.E. (BMJ Publishing Group, 2023-10-25)
  • Scoring System for Predicting No Hearing Recovery in Unilateral Idiopathic Sudden Sensorineural Hearing Loss 
    Safitri, Eka Dian; Harimurti, Kuntjoro; Ranakusuma, Respati W.; Alviandi, Widayat; Bashirudin, Jenny; Savitri, Ary I. (Indonesian Society of Internal Medicine, 2023)
    Background: The varying degrees of hearing recovery in idiopathic sudden sensory neural hearing loss (ISSHL) patients indicate the need of model to predict no hearing recovery. We aimed to aid in the counseling of ISSHL ...
  • Exploring the Role of Plasma Lipids and Statin Interventions on Multiple Sclerosis Risk and Severity A Mendelian Randomization Study 
    Almramhi, Mona M.; Finan, Chris; Storm, Catherine S.; Schmidt, Amand F.; Kia, Demis A.; Coneys, Rachel; Chopade, Sandesh; Hingorani, Aroon D.; Wood, Nick W. (Lippincott Williams & Wilkins, 2023-10-24)
    Background and Objectives There has been considerable interest in statins because of their pleiotropic effects beyond their lipid-lowering properties. Many of these pleiotropic effects are predominantly ascribed to Rho ...
  • Unraveling the relationships between alpha- and beta-adrenergic modulation and the risk of heart failure 
    Baudier, Claire; Fougerousse, Françoise; Asselbergs, Folkert W.; Guedj, Mickael; Komajda, Michel; Kotecha, Dipak; Thomas Lumbers, R.; Schmidt, Amand F.; Tyl, Benoît (Frontiers Media S. A., 2023)
    Background: The effects of α and ß adrenergic receptor modulation on the risk of developing heart failure (HF) remains uncertain due to a lack of randomized controlled trials. This study aimed to estimate the effects of α ...
  • Sense of Security Mediates the Relationship Between Self-care Behavior and Health Status of Patients With Heart Failure 
    Ingadottir, Brynja; Jaarsma, Tiny; Norland, Kristján; Ketilsdóttir, Auður (Elsevier, 2023-11-01)
    Background: Promoting patients' sense of security is among the goals of nursing care within heart failure management. Objective: The aim of this study was to examine the role of sense of security in the relationship between ...
  • Update of the international HerniaSurge guidelines for groin hernia management 
    Stabilini, Cesare; van Veenendaal, Nadine; Aasvang, Eske; Agresta, Ferdinando; Aufenacker, Theo; Berrevoet, Frederik; Burgmans, Ine; Chen, David; de Beaux, Andrew; East, Barbora; Garcia-Alamino, Jose; Henriksen, Nadia; Köckerling, Ferdinand; Kukleta, Jan; Loos, Maarten; Lopez-Cano, Manuel; Lorenz, Ralph; Miserez, Marc; Montgomery, Agneta; Morales-Conde, Salvador; Oppong, Chris; Pawlak, Maciej; Podda, Mauro; Reinpold, Wolfgang; Sanders, David; Sartori, Alberto; Tran, Hanh Minh; Verdaguer, Mireia; Wiessner, Reiko; Yeboah, Michael; Zwaans, Willem; Simons, Maarten (John Wiley & Sons Inc., 2023-10-01)
    Background: Groin hernia repair is one of the most common operations performed globally, with more than 20 million procedures per year. The last guidelines on groin hernia management were published in 2018 by the HerniaSurge ...
  • Effects of Escherichia coli LPS Structure on Antibacterial and Anti-Endotoxin Activities of Host Defense Peptides 
    Javed, Ali; Balhuizen, Melanie D.; Pannekoek, Arianne; Bikker, Floris J.; Heesterbeek, Dani A.C.; Haagsman, Henk P.; Broere, Femke; Weingarth, Markus; Veldhuizen, Edwin J.A. (Multidisciplinary Digital Publishing Institute, 2023-10)
    The binding of Host Defense Peptides (HDPs) to the endotoxin of Gram-negative bacteria has important unsolved aspects. For most HDPs, it is unclear if binding is part of the antibacterial mechanism or whether LPS actually ...
  • Innovating spinal muscular atrophy models in the therapeutic era 
    Signoria, Ilaria; van der Pol, W. Ludo; Groen, Ewout J.N. (Company of Biologists Ltd, 2023-09)
    Spinal muscular atrophy (SMA) is a severe, monogenetic, neuromuscular disease. A thorough understanding of its genetic cause and the availability of robust models has led to the development and approval of three gene-targeting ...
  • Relationship of maternal ophthalmic artery Doppler with uterine artery Doppler, hemodynamic indices and gestational age: prospective MATERA study 
    Ali, S.; Mukasa, D. C.; Lukakamwa, D.; Nakayenga, A.; Namagero, P.; Biira, J.; Byamugisha, J.; Papageorghiou, A. T. (John Wiley & Sons Inc., 2025-02)
    Objectives: To examine the relationship of ophthalmic artery (OA) Doppler indices with uterine artery (UtA) Doppler indices, selected maternal hemodynamic parameters and gestational age, and to evaluate the intraobserver ...
  • Guía para el desarrollo y la validación de las actividades profesionales a confiar 
    Durante, Eduardo; Diéguez, Marcelo García; Ladenheim, Roberta; Palis, Ana Gabriela; López, María José; Arceo, María Dolores; Cate, Olle Ten (Universidad Nacional Autonoma de Mexico, 2023-10)
    Competency-based Education (CBE) or outcome-based education has spread worldwide in recent decades. Competencies must be inferred from the observable performances of students or residents; this observation provides the ...
  • Chronic fatigue in childhood cancer survivors is associated with lifestyle and psychosocial factors; a DCCSS LATER study 
    Penson, A.; Walraven, I.; Bronkhorst, E.; Grootenhuis, M. A.; Maurice-Stam, H.; de Beijer, I.; van der Heiden-van der Loo, M.; Tissing, W. J.E.; van der Pal, H. J.H.; de Vries, A. C.H.; Bresters, D.; Ronckers, C. M.; van den Heuvel-Eibrink, M. M.; Neggers, S.; Versluys, B. A.B.; Louwerens, M.; Pluijm, S. M.F.; Blijlevens, N.; van Dulmen-den Broeder, E.; Kremer, L. C.M.; Knoop, H.; Loonen, J.; Dutch LATER Study group (Elsevier, 2023-12)
    Background: The purpose of this study was to determine factors associated with chronic fatigue (CF) in childhood cancer survivors (CCS). Patients and methods: Participants were included from the Dutch Childhood Cancer ...
  • Root-cause analysis of mortality after pancreatic resection in a nationwide cohort 
    Henry, Anne Claire; Smits, F. Jasmijn; Daamen, Lois A.; Busch, Olivier R.; Bosscha, Koop; van Dam, Ronald M.; van Dam, Coen J.L.; van Eijck, Casper H.; Festen, Sebastiaan; van der Harst, Erwin; de Hingh, Ignace H.J.T.; Kazemier, Geert; Liem, Mike S.; de Meijer, Vincent E.; Noordzij, Peter; Patijn, Gijs A.; Schreinemakers, Jennifer M.J.; Stommel, Martijn W.J.; Bonsing, Bert A.; Koerkamp, Bas G.; Besselink, Marc G.; Verdonk, Robert C.; van Santvoort, Hjalmar C.; Molenaar, I. Quintus; for the Dutch Pancreatic Cancer Group (John Wiley & Sons Inc., 2025-04)
    Background: This study evaluates leading causes of in-hospital mortality after pancreatic resection nationwide to determine areas for improvement. Methods: This observational cohort study included all in-hospital mortality ...
  • The disproportionate vulnerability of older people in humanitarian emergencies 
    van Boetzelaer, Elburg; Franco, Oscar H.; Moussally, Krystel; Khammash, Umiayek; Escobio, Favila (Elsevier, 2023-11-04)
  • Diagnostic Accuracy of Median Nerve Cross-Sectional Area in Suspected Amyotrophic Lateral Sclerosis 
    Stikvoort García, Diederik J.L.; van den Berg, Leonard H.; Sleutjes, Boudewijn T.H.M.; Goedee, H. Stephan (John Wiley & Sons Inc., 2025-04)
    Introduction/Aims: Reduced nerve sizes obtained by nerve ultrasound (NUS) have been proposed as a potential diagnostic marker for amyotrophic lateral sclerosis (ALS). However, prospective studies evaluating patients with ...
  • The interaction between the community food environment and cooking skills in association with diet-related outcomes in Dutch adults 
    Siddiqui, Noreen Z.; Pinho, Maria G.M.; Rutters, Femke; Beulens, Joline W.J.; Mackenbach, Joreintje D. (Cambridge University Press, 2023-12-18)
    Objective: We examined whether associations between the food environment, frequency of home cooking, diet quality and BMI were modified by the level of cooking skills. Design: Cross-sectional study using linear and modified ...