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UMC Repository: Recent submissions

  • Molecular and clinical heterogeneity within MYC-family amplified medulloblastoma is associated with survival outcomes: A multicenter cohort study 
    Schwalbe, Edward C.; Lindsey, Janet C.; Danilenko, Marina; Hill, Rebecca M.; Crosier, Stephen; Ryan, Sarra L.; Williamson, Daniel; Castle, Jemma; Hicks, Debbie; Kool, Marcel; Milde, Till; Korshunov, Andrey; Pfister, Stefan M.; Bailey, Simon; Clifford, Steven C. (Oxford University Press, 2025-01-01)
    Background.MYC/MYCN are the most frequent oncogene amplifications in medulloblastoma (MB) and its primary biomarkers of high-risk (HR) disease. However, while many patients’ MYC(N)-amplified tumors are treatment-refractory, ...
  • Electrocardiogram-gated cardiac computed tomography-based patient- and segment-specific cardiac motion estimation method in stereotactic arrhythmia radioablation for ventricular tachycardia 
    Xie, Jingyang; Bicu, Alicia S.; Grehn, Melanie; Kuru, Mustafa; Zaman, Adrian; Lu, Xinyu; Janorschke, Christian; van der Pol, Luuk H.G.; Fast, Martin F.; Fleckenstein, Jens; Both, Marcus; Hohmann, Stephan; Borzov, Egor; Winkler, Peter; Tilz, Roland R.; Rades, Dirk; Giordano, Frank A.; Buergy, Daniel; Rudic, Boris; Duncker, David; Merten, Roland; Charas, Tomer; Suleiman, Mahmoud; Brunner, Thomas; Scherr, Daniel; Lian, Evgeny; Schweikard, Achim; Blanck, Oliver; Boda-Heggemann, Judit; Kaestner, Lena (Elsevier, 2025-01)
    Background and purpose: Motion management strategies such as gating under breath-hold can reduce breathing-induced motion during stereotactic arrhythmia radioablation (STAR) for refractory ventricular tachycardia. However, ...
  • The development of the Postdoctoral Nurses Competence Scale: A Delphi consensus and content validity study 
    Sterkenburg, Annika; van Dongen, Lisa J.C.; Hafsteinsdóttir, Thóra B. (W.B. Saunders, 2025-03-01)
    Background: PhD prepared nurses advance nursing science through research and integration of findings into practice. They demonstrate expertise in research, education, patient care, and policy. Various professional competencies ...
  • The need for a cancer exposome atlas: a scoping review 
    Young, Anna S.; Mullins, Catherine E.; Sehgal, Neha; Vermeulen, Roel C.H.; Kolijn, P. Martijn; Vlaanderen, Jelle; Rahman, Mohammad L.; Birmann, Brenda M.; Barupal, Dinesh; Lan, Qing; Rothman, Nathaniel; Walker, Douglas I. (Oxford University Press, 2025-02-01)
    Background: Despite advances in understanding genetic susceptibility to cancer, much of cancer heritability remains unidentified. At the same time, the makeup of industrial chemicals in our environment only grows more ...
  • Advanced Radiotherapy Technologies in Spine Tumors: What the Surgeon Needs to Know 
    Chen, Hanbo; Ghia, Amol J.; Maralani, Pejman J.; Bettegowda, Chetan; Boriani, Stefano; Dea, Nicolas; Fisher, Charles G.; Gasbarrini, Alessandro; Gokaslan, Ziya L.; Laufer, Ilya; Lazary, Aron; Reynolds, Jeremy; Verlaan, Jorrit Jan; Rhines, Laurence D.; Sahgal, Arjun (SAGE Publications Inc., 2025-01)
    Study Design: Narrative review of existing literature. Objectives: Significant technological advancements in radiotherapy planning and delivery have enabled new radiotherapy techniques for the management of spine tumors. ...
  • Prevention and Management of Posterior Wound Complications Following Oncologic Spine Surgery: Narrative Review of Available Evidence and Proposed Clinical Decision-Making Algorithm 
    Leary, Owen P.; Setty, Aayush; Gong, Jung Ho; Ali, Rohaid; Fridley, Jared S.; Fisher, Charles G.; Sahgal, Arjun; Rhines, Laurence D.; Reynolds, Jeremy J.; Lazáry, Áron; Laufer, Ilya; Gasbarrini, Alessandro; Dea, Nicolas; Verlaan, Jorrit Jan; Bettegowda, Chetan; Boriani, Stefano; Mesfin, Addisu; Luzzati, Alessandro; Shin, John H.; Cecchinato, Riccardo; Hornicek, Francis J.; Goodwin, Matthew L.; Gokaslan, Ziya L. (SAGE Publications Inc., 2025-01)
    Study Design: Narrative Review. Objective: Contextualized by a narrative review of recent literature, we propose a wound complication prevention and management algorithm for spinal oncology patients. We highlight available ...
  • Adverse health outcomes and health-related quality of life (HRQoL) among long-term adolescent and young adult (AYA) brain tumour survivors: results from the population-based SURVAYA study 
    Angoumis, Konstantinos; Padilla, Catarina S.; Kouwenhoven, Mathilde C.M.; Bijlsma, Rhodé M.; Kaal, Suzanne E.J.; Tromp, Jacqueline M.; Bos, Monique E.M.M.; van der Hulle, Tom; Broen, Martinus P.G.; Nuver, Janine; van der Graaf, Winette T.A.; Pauge, Sophie; Husson, Olga (2025-01-14)
    PURPOSE: Adolescent and young adult (AYA) malignant brain tumour (BT) survivors are at risk of adverse health outcomes, which may impact their health-related quality of life (HRQoL). This study aimed to investigate the (1) ...
  • Impact of Pharmacovigilance Interventions Targeting Fluoroquinolones on Antibiotic Use in the Netherlands and the United Kingdom 
    Lasys, Tomas; Santa-Ana-Tellez, Yared; Siiskonen, Satu J.; Groenwold, Rolf H.H.; Gardarsdottir, Helga (John Wiley & Sons Inc., 2025-02)
    Purpose: Fluoroquinolones are antibiotics associated with adverse events that prompted the European Medicines Agency to implement risk minimization measures (RMMs) in 2018/19 and 2020. Our aim is to assess the RMMs' impact ...
  • Defining Spine Cancer Pain Syndromes: A Systematic Review and Proposed Terminology 
    Pahuta, Markian; Laufer, Ilya; Lo, Sheng fu Larry; Boriani, Stefano; Fisher, Charles; Dea, Nicolas; Weber, Michael H.; Chou, Dean; Sahgal, Arjun; Rhines, Laurence; Reynolds, Jeremy; Lazary, Aron; Gasbarrinni, Alessandro; Verlaan, Jorrit Jan; Gokaslan, Ziya; Bettegowda, Chetan; Sarraj, Mohamed; Barzilai, Ori; On behalf of the AO Spine Knowledge Forum Tumor (SAGE Publications Inc., 2025-01)
    Study Design: Systematic Review. Objectives: Formalized terminology for pain experienced by spine cancer patients is lacking. The common descriptors of spine cancer pain as mechanical or non-mechanical is not exhaustive. ...
  • Detection of clinically relevant variants in the TP53 gene below 10% allelic frequency: A multicenter study by ERIC, the European Research Initiative on CLL 
    Pavlova, Sarka; Malcikova, Jitka; Radova, Lenka; Bonfiglio, Silvia; Cowland, Jack B.; Brieghel, Christian; Andersen, Mette K.; Karypidou, Maria; Biderman, Bella; Doubek, Michael; Lazarian, Gregory; Rapado, Inmaculada; Vynck, Matthijs; Porret, Naomi A.; Andres, Martin; Rosenberg, Dina; Sahar, Dvora; Martínez-Laperche, Carolina; Buño, Ismael; Hindley, Andrew; Donaldson, David; Sánchez, Julio B.; García-Marco, José A.; Serrano-Alcalá, Alicia; Ferrer-Lores, Blanca; Fernández-Rodriguez, Concepción; Bellosillo, Beatriz; Stilgenbauer, Stephan; Tausch, Eugen; Nikdin, Hero; Quinn, Fiona; Atkinson, Emer; van de Corput, Lisette; Yildiz, Cafer; Bilbao-Sieyro, Cristina; Florido, Yanira; Thiede, Christian; Schuster, Caroline; Stoj, Anastazja; Czekalska, Sylwia; Chatzidimitriou, Anastasia; Laidou, Stamatia; Bidet, Audrey; Dussiau, Charles; Nollet, Friedel; Piras, Giovanna; Monne, Maria; Smirnova, Svetlana; Nikitin, Eugene; Sloma, Ivan; Claudel, Alexis; Largeaud, Laetitia; Ysebaert, Loïc; Valk, Peter J.M.; Christian, Amy; Walewska, Renata; Oscier, David; Sebastião, Marta; da Silva, Maria Gomes; Galieni, Piero; Angelini, Mario; Rossi, Davide; Spina, Valeria; Matos, Sónia; Martins, Vânia; Stokłosa, Tomasz; Pepek, Monika; Baliakas, Panagiotis; Andreu, Rafa; Luna, Irene; Kahre, Tiina; Murumets, Ülle; Pikousova, Tereza; Kurucova, Terezia; Laird, Sophie; Ward, Daniel; Alcoceba, Miguel; Balanzategui, Ana; Scarfo, Lydia; Gandini, Francesca; Zapparoli, Ettore; Blanco, Adoración; Abrisqueta, Pau; Rodríguez-Vicente, Ana E.; Benito, Rocío; Bravetti, Clotilde; Davi, Frédéric; Gameiro, Paula; Martinez-Lopez, Joaquin; Tazón-Vega, Bárbara; Baran-Marszak, Fanny; Davis, Zadie; Catherwood, Mark; Sudarikov, Andrey; Rosenquist, Richard; Niemann, Carsten U.; Stamatopoulos, Kostas; Ghia, Paolo; Pospisilova, Sarka (Wolters Kluwer Health, 2025-01)
    In chronic lymphocytic leukemia, the reliability of next-generation sequencing (NGS) to detect TP53 variants ≤10% allelic frequency (low-VAF) is debated. We tested the ability to detect 23 such variants in 41 different ...
  • Criticality is Associated with Future Psychotherapy Response in Patients with Post-Traumatic Stress Disorder: A Pilot Study 
    van Lutterveld, Remko; Sterk, Myrthe; Spitoni, Cristian; Kennis, Mitzy; van Rooij, Sanne J.H.; Geuze, Elbert (SAGE Publications Inc., 2025-01)
    Background: Trauma-focused psychotherapy is treatment of choice for post-traumatic stress disorder (PTSD). However, about half of patients do not respond. Recently, there is increased interest in brain criticality, which ...
  • A 5-transcript signature for discriminating viral and bacterial etiology in pediatric pneumonia 
    Viz-Lasheras, Sandra; Gómez-Carballa, Alberto; Pardo-Seco, Jacobo; Bello, Xabier; Rivero-Calle, Irene; Dacosta, Ana Isabel; Kaforou, Myrsini; Habgood-Coote, Dominic; Cunnington, Aubrey J.; Emonts, Marieke; Herberg, Jethro A.; Wright, Victoria J.; Carrol, Enitan D.; Paulus, Stephane C.; Zenz, Werner; Kohlfürst, Daniela S.; Van der Flier, Michiel; de Groot, Ronald; Schlapbach, Luregn J.; Agyeman, Philipp; Pollard, Andrew J.; Fink, Colin; Kuijpers, Taco T.; Anderson, Suzanne; Calvo, Cristina; Martínez-Padilla, María del Carmen; Pérez-Aragón, Ana; Gómez-Sánchez, Esteban; Valencia-Ramos, Juan; Giménez-Sánchez, Francisco; Alonso-Quintela, Paula; Moreno-Galarraga, Laura; von Both, Ulrich; Pokorn, Marko; Zavadska, Dace; Tsolia, María; Vermont, Clementien L.; Moll, Henriëtte A.; Levin, Michael; Martinón-Torres, Federico; Salas, Antonio; DIAMONDS; GENDRES and; PERFORM consortia (Elsevier, 2025-02-21)
    Pneumonia stands as the primary cause of death among children under five, yet current diagnosis methods often result in inadequate or unnecessary treatments. Our research seeks to address this gap by identifying host ...
  • Risk Factors for the Development of Neurological Deficits in Metastatic Spinal Disease: An International, Multicenter Delphi Study 
    Huele, Eline H.; Gal, Roxanne; Eppinga, Wietse S.C.; Verkooijen, Helena M.; O’Toole, John E.; Laufer, Ilya; Sciubba, Daniel M.; Netzer, Cordula; Foppen, Wouter; Sahgal, Arjun; Fehlings, Michael G.; Lo, Sheng fu L.; Fisher, Charles G.; Rhines, Laurence D.; Reynolds, Jeremy J.; Lazary, Aron; Gasbarrini, Alessandro; Dea, Nicolas; Weber, Michael H.; Verlaan, Jorrit Jan (SAGE Publications Inc., 2025-01)
    Study Design: Delphi study Objective: The objective of this study was to identify risk factors associated with the development and/or progression of neurological deficits in patients with metastatic spinal disease. Methods: ...
  • Real-world outcomes of the CROSS regimen in patients with resectable esophageal or gastro-esophageal junction adenocarcinoma: a nationwide cohort study in the Netherlands 
    van Laarhoven, Hanneke; Verhoeven, Rob; van Berge Henegouwen, Mark; Mohammad, Nadia Haj; van Hillegersberg, Richard; Slingerland, Marije; Muijs, Christina T.; Wijnhoven, Bas; Mostert, Bianca; Beerepoot, Laurens; Nieuwenhuijzen, Grard; Derks, Sarah; van Rossum, Peter S.N. (Elsevier, 2025-02)
    Background: Recent studies in patients with resectable adenocarcinoma of the esophagus or gastroesophageal junction (GEJ)—Neo-AEGIS and ESOPEC—have explored the comparison of neoadjuvant chemoradiotherapy (nCRT) with ...
  • Development and external validation of the SMA2SH2ERS risk prediction model for aneurysmal subarachnoid haemorrhage in the general population: a population-based prospective cohort study 
    Klieverik, Vita M.; Kanning, Jos P.; Rissanen, Ina L.; Rannikmae, Kristiina; Martinsen, Amy E.; Winsvold, Bendik S.; Geerlings, Mirjam I.; Ruigrok, Ynte M. (BMJ Publishing Group, 2025-01-15)
    Objectives Aneurysmal subarachnoid haemorrhage (ASAH) is a severe stroke type, preventable by screening for intracranial aneurysms followed by treatment in high-risk individuals. We aimed to develop and validate a risk ...
  • Preferences of pregnant women and obstetric healthcare professionals on using noninvasive prenatal testing to predict adverse pregnancy outcomes: a discrete choice experiment 
    Becking, Ellis; Akkerman, Elisabeth; Scheffer, Peter; Smith, Ian; Stemkens, Daphne; Bax, Caroline J.; Bekker, Mireille N.; Crombag, Neeltje; Schuit, Ewoud; Henneman, Lidewij (BMJ Publishing Group, 2025-01-15)
    Objectives Noninvasive prenatal testing (NIPT) to screen for fetal aneuploidies by analysing cell-free DNA in maternal plasma is available to pregnant women worldwide. In the future, the scope of NIPT could potentially be ...
  • Longitudinal health-related quality of life in patients with pancreatic cancer stratified by treatment: a nationwide cohort study 
    Gehrels, Anne M.; Vissers, Pauline A.J.; Sprangers, Mirjam A.G.; Fijnheer, Nienke M.; Pijnappel, Esther N.; van der Geest, Lydia G.; Cirkel, Geert A.; de Vos-Geelen, Judith; Homs, Marjolein Y.V.; Creemers, Geert Jan; Stommel, Martijn W.J.; Daamen, Lois A.; Besselink, Marc G.; Wilmink, Johanna W.; van Laarhoven, Hanneke W.M.; Dutch Pancreatic Cancer Group (Elsevier, 2025-02)
    Background: Pancreatic adenocarcinoma (PAC) has a poor prognosis and substantially impairs health-related quality of life (HRQoL). Large studies on longitudinal HRQoL in patients with PAC, taking patient treatment into ...
  • Optimizing Medical Pretreatment for Balloon Pulmonary Angioplasty: Overshoot or Stride Toward Optimal Multimodal Treatment 
    Staal, D P; van Leusden, F J; van Thor, M C J; Peper, J; Rensing, B J M W; van Kuijk, J P; Mulder, B J M; van den Heuvel, D; Boomars, K A; Boerman, S; Mager, J J; Post, M C (John Wiley & Sons Inc., 2025-01)
    In patients with chronic thromboembolic pulmonary hypertension (CTEPH) who undergo balloon pulmonary angioplasty (BPA), pretreatment with PH-targeted medical therapy may be beneficial to improve clinical parameters and ...
  • Drivers of extended spectrum β-lactamase (ESBL)-producing Enterobacterales colonization among residents of long-term health care facilities: a European multicentric prospective cohort study 
    Göpel, Siri; Guther, Julia; Gladstone, Beryl Primrose; Conzelmann, Nadine; Bunk, Stefanie; Terzer, Tobias; Verschuuren, Tess D; Martak, Daniel; Salamanca, Elena; Autenrieth, Ingo B; Peter, Silke; Kluytmans, Jan A J W; Hocquet, Didier; Rodriguez-Baño, Jesus; Tacconelli, Evelina; MODERN WP1 study group (W.B. Saunders Ltd, 2025-03)
    Background: Extended-spectrum β-lactamase (ESBL)-producing Enterobacterales (ESBL-PE) are highly prevalent in long-term care (LTCF) settings. In order to estimate the acquisition rate of ESBL-producing Escherichia coli and ...
  • Global, regional, and national burden of other musculoskeletal disorders, 1990–2020, and projections to 2050: a systematic analysis of the Global Burden of Disease Study 2021 
    Harlianto, Netanja I.; GBD 2021 Other Musculoskeletal Disorders Collaborators (Elsevier Limited, 2023-11)
    Background: Musculoskeletal disorders include more than 150 different conditions affecting joints, muscles, bones, ligaments, tendons, and the spine. To capture all health loss from death and disability due to musculoskeletal ...