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UMC Repository: Recent submissions

  • Surgical fixation of distal ulna neck and head fractures 
    van Rossenberg, Lx; van de Wall, Bjm; Diwersi, N.; Scheuble, L.; Beeres, Fjp; van Heijl, M.; Ferree, S. (Urban und Vogel, 2023-12)
    Objectives: Distal ulna plate fixation for ulnar neck and head fractures (excluding ulnar styloid fractures) aims to anatomically reduce the distal ulna fracture (DUF) by open reduction and internal fixation, while obtaining ...
  • Prevalence of Antimicrobial Resistance in Gram-Negative Bacteria Bloodstream Infections in Peru and Associated Outcomes: VIRAPERU Study 
    Krapp, Fiorella; Garcıa, Coralith; Hinostroza, Noemi; Astocondor, Lizeth; Rondon, Claudia R.; Ingelbeen, Brecht; Alpaca-Salvador, Hugo A.; Amaro, Catherine; Ventura, Carla Aguado; Barco-Yaipen, Evelyn; Fernandez, Cesar Bocangel; Briones, Alexander; Burgos, Antonio; Campana, Rene; Castillo, Kelly; Castañeda-Sabogal, Alex; Coaquira, Angelica; Concha-Velasco, Fatima; Cuadros, Edwin Cuaresma; Chincha, Omayra; Diaz, Juan Carlos; Sipion, Roberto Dıaz; Fernandez, Victor; Hueda-Zavaleta, Miguel; Lopez, Enrique; Valera-Krumdieck, Marıa; Vasquez, Ruben; Vidaurre Torres, Ana Marıa; Villegas-Chiroque, Miguel; Lopez, Favio Sarmiento; Sullon Zavaleta, Pedro Alberto; Chavez, Elizett Sierra; Peralta, Eduardo Paricahua; Cordova, Teresa Peralta; Pino-Dueñas, Jimena Edith; Jacobs, Jan (American Society of Tropical Medicine and Hygiene, 2023-11)
    Surveillance of antimicrobial resistance among gram-negative bacteria (GNB) is of critical importance, but data for Peru are not available. To fill this gap, a non-interventional hospital-based surveillance study was ...
  • Evaluation of a biomarker for amyotrophic lateral sclerosis derived from a hypomethylated DNA signature of human motor neurons 
    Harvey, Calum; Nowak, Alicja; Zhang, Sai; Moll, Tobias; Weimer, Annika K.; Barcons, Aina Mogas; Souza, Cleide Dos Santos; Ferraiuolo, Laura; Kenna, Kevin; Zaitlen, Noah; Caggiano, Christa; Shaw, Pamela J.; Snyder, Michael P.; Mill, Jonathan; Hannon, Eilis; Cooper-Knock, Johnathan (BioMed Central, 2025-01-14)
    Amyotrophic lateral sclerosis (ALS) lacks a specific biomarker, but is defined by relatively selective toxicity to motor neurons (MN). As others have highlighted, this offers an opportunity to develop a sensitive and ...
  • A diagnostic host-specific transcriptome response for Mycoplasma pneumoniae pneumonia to guide pediatric patient treatment 
    Viz-Lasheras, Sandra; Gómez-Carballa, Alberto; Bello, Xabier; Rivero-Calle, Irene; Dacosta, Ana Isabel; Kaforou, Myrsini; Habgood-Coote, Dominic; Cunnington, Aubrey J.; Emonts, Marieke; Herberg, Jethro A.; Wright, Victoria J.; Carrol, Enitan D.; Paulus, Stephane C.; Zenz, Werner; Kohlfürst, Daniela S.; Schweintzger, Nina; Van der Flier, Michiel; de Groot, Ronald; Schlapbach, Luregn J.; Agyeman, Philipp; Pollard, Andrew J.; Fink, Colin; Kuijpers, Taco T.; Anderson, Suzanne; Von Both, Ulrich; Pokorn, Marko; Zavadska, Dace; Tsolia, María; Moll, Henriëtte A.; Vermont, Clementien; Levin, Michael; Martinón-Torres, Federico; Salas, Antonio; EUCLIDS, PERFORM, and DIAMONDS consortia (Nature Publishing Group, 2025-01-15)
    Mycoplasma pneumoniae causes atypical pneumonia in children and young adults. Its lack of a cell wall makes it resistant to beta-lactams, which are the first-line treatment for typical pneumonia. Current diagnostic tests ...
  • How to perform and evaluate a myocardial perfusion imaging by computed tomography 
    Mushtaq, Saima; Baggiano, Andrea; Cannata, Francesco; Del Torto, Alberico; Fazzari, Fabio; Fusini, Laura; Junod, Daniele; Maragna, Riccardo; Tassetti, Luigi; Volpe, Alessandra; Carrabba, Nazario; Conte, Edoardo; Guglielmo, Marco; La Mura, Lucia; Pergola, Valeria; Pedrinelli, Roberto; Perrone Filardi, Pasquale; Guaricci, Andrea Igoren; Pontone, Gianluca (2025-01)
    Stress computed tomography perfusion (CTP) delivers a comprehensive evaluation of both the anatomical and functional aspects in a single examination. It stands out as the only non-invasive technique capable of quantifying ...
  • Early mobilisation in critically ill COVID-19 patients: a subanalysis of the ESICM-initiated UNITE-COVID observational study 
    Kloss, Philipp; Lindholz, Maximilian; Milnik, Annette; Azoulay, Elie; Cecconi, Maurizio; Citerio, Giuseppe; De Corte, Thomas; Duska, Frantisek; Galarza, Laura; Greco, Massimiliano; Girbes, Armand R.J.; Kesecioglu, Jozef; Mellinghoff, Johannes; Ostermann, Marlies; Pellegrini, Mariangela; Teboul, Jean Louis; De Waele, Jan; Wong, Adrian; Schaller, Stefan J. (Springer-Verlag GmbH and Co. KG, 2023-12)
    Background: Early mobilisation (EM) is an intervention that may improve the outcome of critically ill patients. There is limited data on EM in COVID-19 patients and its use during the first pandemic wave. Methods: This is ...
  • Is the association between blood pressure and cognition in the oldest-old modified by physical, vascular or brain pathology markers? The EMIF-AD 90 + Study 
    Legdeur, Nienke; Moonen, Justine E.; Badissi, Maryam; Sudre, Carole H.; Pelkmans, Wiesje; Gordon, Mark Forrest; Barkhof, Frederik; Peters, Mike; Visser, Pieter Jelle; Muller, Majon (BioMed Central, 2023-12)
    Background: Prior studies suggest a changing association between blood pressure (BP) and cognition with aging, however work in the oldest-old has yielded ambiguous results. Potentially, these mixed results can be explained ...
  • A ‘semi-custom’ unibody single-branch endograft to preserve the left subclavian artery during thoracic endovascular aortic repair in zone 2: the answer to any question? 
    Xodo, Andrea; de Kort, Jasper F.; Trimarchi, Santi; Piffaretti, Gabriele (2023-10-01)
  • Genome-wide association study meta-analysis of blood pressure traits and hypertension in sub-Saharan African populations: an AWI-Gen study 
    Singh, Surina; Choudhury, Ananyo; Hazelhurst, Scott; Crowther, Nigel J.; Boua, Palwendé R.; Sorgho, Hermann; Agongo, Godfred; Nonterah, Engelbert A.; Micklesfield, Lisa K.; Norris, Shane A.; Kisiangani, Isaac; Mohamed, Shukri; Gómez-Olivé, Francesc X.; Tollman, Stephen M.; Choma, Solomon; Brandenburg, J. T.; Ramsay, Michèle (Nature Publishing Group, 2023-12)
    Most hypertension-related genome-wide association studies (GWASs) focus on non-African populations, despite hypertension (a major risk factor for cardiovascular disease) being highly prevalent in Africa. The AWI-Gen study ...
  • A Machine Learning Model to Aid Detection of Familial Hypercholesterolemia 
    Gratton, Jasmine; Futema, Marta; Humphries, Steve E.; Hingorani, Aroon D.; Finan, Chris; Schmidt, Amand F. (Elsevier, 2023-06)
    Background: People with monogenic familial hypercholesterolemia (FH) are at an increased risk of premature coronary heart disease and death. With a prevalence of 1:250, FH is relatively common; but currently there is no ...
  • Update on the INTEnsive ambulance-delivered blood pressure Reduction in hyper-ACute stroke Trial (INTERACT4): progress and baseline features in 2053 participants 
    Chen, Chen; Lin, Yapeng; Liu, Feifeng; Chen, Xiaoying; Billot, Laurent; Li, Qiang; Guo, Yiija; Liu, Hueiming; Si, Lei; Ouyang, Menglu; Zhang, Chunfang; Arima, Hisatomi; Bath, Philip M.; Ford, Gary A.; Robinson, Thompson; Sandset, Else Charlotte; Saver, Jeffrey L.; Sprigg, Nikola; van der Worp, H. Bart; Liu, Gang; Song, Lili; Yang, Jie; Li, Gang; Anderson, Craig S. (BioMed Central, 2023-12)
    Background and aims: Uncertainty persists over the effects of blood pressure (BP) lowering in acute stroke. The INTEnsive ambulance-delivered blood pressure Reduction in hyper-Acute stroke Trial (INTERACT4) aims to determine ...
  • Inclusive Health Tracking: Unlock the True Potential of Digital Health Solutions 
    Schuuring, Mark J.; Man, Jelle P.; Chamuleau, Steven A.J. (Elsevier, 2023-09)
  • Unraveling schwannomas 
    Flucke, Uta E.; Hiemcke-Jiwa, Laura S.; Wesseling, Pieter (Oxford University Press, 2023-12-01)
  • The prognostic and predictive effect of body mass index in hormone receptor-positive breast cancer 
    Lammers, Senna W.M.; Geurts, Sandra M.E.; Van Hellemond, Irene E.G.; Swinkels, Astrid C.P.; Smorenburg, Carolien H.; Van Der Sangen, Maurice J.C.; Kroep, Judith R.; De Graaf, Hiltje; Honkoop, Aafke H.; Erdkamp, Frans L.G.; De Roos, Wilfred K.; Linn, Sabine C.; Imholz, Alexander L.T.; Smidt, Marjolein L.; Vriens, Ingeborg J.H.; Tjan-Heijnen, Vivianne C.G. (Oxford University Press, 2023-12)
    Background: Obesity has been associated with an adverse prognosis and reduced efficacy of endocrine therapy in patients with hormone receptor-positive (HR+) breast cancer (BC). This study determines the prognostic and ...
  • Lymph Node Staging and Treatment in Pediatric Patients With Soft Tissue Sarcomas: A Consensus Opinion from the Children's Oncology Group, European paediatric Soft tissue sarcoma Study Group, and the Cooperative Weichteilsarkom Studiengruppe 
    Terwisscha van Scheltinga, Sheila; Schoot, Reineke A.; Routh, Jonathan C.; Seitz, Guido; Kao, Simon C.; de Keizer, Bart; Shulkin, Barry; Ewijk, Roelof van; McCarville, Beth; Casey, Dana; Allen-Rhoades, Wendy; Mercolini, Federico; Merks, Hans; Orbach, Daniel; Kapadia, Tejas; Walterhouse, David O.; Davila Fajardo, Raquel; Hiemcke-Jiwa, Laura; Franzius, Christiane; De Corti, Federica; Tang, Vivian; Metts, Jonathan; Oberoi, Saphna; Vokuhl, Christian; Dasgupta, Roshni; Birz, Suzi; Rodeberg, David (Wiley-Liss Inc., 2025-04)
    Accurate staging of nodal involvement in pediatric sarcoma patients is important to determine correct systemic and local therapy, with the goal to reduce subsequent recurrences. However, differences in lymph node staging ...
  • Billion-Scale Expansion of Functional hiPSC-Derived Cardiomyocytes in Bioreactors Through Oxygen Control and Continuous Wnt Activation 
    Vicente, Pedro; Inocêncio, Lara R.; Ullate-Agote, Asier; Louro, Ana F.; Jacinto, João; Gamelas, Beatriz; Iglesias-García, Olalla; Martin-Uriz, Patxi San; Aguirre-Ruiz, Paula; Ríos-Muñoz, Gonzalo R.; Fernández-Santos, María Eugenia; van Mil, Alain; Sluijter, Joost P.G.; Prósper, Felipe; Vega, Manuel M.Mazo; Alves, Paula M.; Serra, Margarida (Wiley-VCH Verlag, 2025-03)
    Generation of upscaled quantities of human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM), for therapeutic or testing applications, is both expensive and time-consuming. Herein, a scalable bioprocess for ...
  • Role of Posterior Carbon Fiber Implants in Spine Tumor Surgery 
    Alvarez-Breckenridge, Christopher A.; North, Robert; Tatsui, Claudio; Kumar, Naresh; Lo, Sheng Fu; Mohammed, Karim; Reynolds, Jeremy; Lazary, Aron; Laufer, Ilya; Verlaan, Jorrit Jan; Gokaslan, Ziya; Luzzati, Alessandro; Cecchinato, Riccardo; Shin, John; Hornicek, Francis; Disch, Alexander; Goodwin, Matthew; Goodwin, Rory; Sahgal, Arjun; Gasbarrini, Alessandro; Boriani, Stefano (SAGE Publications Inc., 2025-01)
    Study Design: Narrative Review. Objective: The management of spinal tumors requires a multi-disciplinary approach including surgery, radiation, and systemic therapy. Surgical approaches typically require posterior segmental ...
  • Latest Developments in Targeted Biological Therapies in the Management of Chordoma and Chondrosarcoma 
    Biczo, Adam; Sahgal, Arjun; Verlaan, Jorrit Jan; Shreyaskumar, Patel; Szoverfi, Zsolt; Schultheiss, Markus; Rhines, Laurence; Reynolds, Jeremy; Laufer, Ilya; Gasbarrini, Alessandro; Dea, Nicolas; Gokaslan, Ziya; Fisher, Charles; Bettegowda, Chetan; Boriani, Stefano; Hornicek, Francis; Goodwin, Rory; Lazary, Aron (SAGE Publications Inc., 2025-01)
    Study Design: Systematic review. Objectives: The objective of this review paper was to summarize targeted molecular therapy options for spinal chordoma and chondrosarcoma, and to provide an update on the relevant clinical ...
  • What is the Optimal Management of Metastatic Spine Patients With Intermediate Spinal Instability Neoplastic Scores: To Operate or Not to Operate? 
    Kwan, William Chu; Zuckerman, Scott L.; Fisher, Charles G.; Laufer, Ilya; Chou, Dean; O'Toole, John E.; Schultheiss, Markus; Weber, Michael H.; Sciubba, Daniel M.; Pahuta, Markian; Shin, John H.; Fehlings, Michael G.; Versteeg, Anne; Goodwin, Matthew L.; Boriani, Stefano; Bettegowda, Chetan; Lazary, Aron; Gasbarrini, Alessandro; Reynolds, Jeremy J.; Verlaan, Jorrit Jan; Sahgal, Arjun; Gokaslan, Ziya L.; Rhines, Laurence D.; Dea, Nicolas (SAGE Publications Inc., 2025-01)
    Study Design: Systematic review. Objective: In patients with extradural metastatic spine disease, we sought to systematically review the outcomes and complications of patients with intermediate Spinal Instability Neoplastic ...
  • Liquid Biopsy for Spinal Tumors: On the Frontiers of Clinical Application 
    Tan, Sze Kiat; Bettegowda, Chetan; Yip, Stephen; Sahgal, Arjun; Rhines, Laurence; Reynolds, Jeremy; Lazary, Aron; Laufer, Ilya; Gasbarrini, Alessandro; Dea, Nicolas; Verlaan, J. J.; Gokaslan, Ziya L.; Fisher, Charles G.; Boriani, Stefano; Cecchinato, Riccardo; Goodwin, Matthew L.; Goodwin, C. Rory; Charest-Morin, Raphaële (SAGE Publications Inc., 2025-01)
    Study Design: Narrative review. Objectives: This article aims to provide a narrative review of the current state of research for liquid biopsy in spinal tumors and to discuss the potential application of liquid biopsy in ...