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UMC Repository: Recent submissions

  • Health literacy and pain neuroscience education in an interdisciplinary pain management programme: A qualitative study of patient perspectives 
    Oosterhaven, Janke; Pell, Christopher D.; Schröder, Carin D.; Popma, Hans; Spierenburg, Loes; Devillé, Walter L.J.M.; Wittink, Harriet (Lippincott Williams & Wilkins, 2023-12-18)
    Introduction:Pain neuroscience education is part of interdisciplinary pain management programs (IPMPs). To date, the role of health literacy on patients' understanding of pain neuroscience education has not sufficiently ...
  • Is assessment of skeletal muscle mass useful to predict time-to-awake in awake craniotomies? 
    Lai, Yen Mie; Van Heusden, Hugo C.; De Graaf, Pim; Van Den Brom, Charissa E.; De Witt Hamer, Philip C.; Schober, Patrick (Lippincott Williams & Wilkins, 2023-11-24)
    Awake craniotomy is the gold standard for the resection of brain lesions near eloquent areas. For the commonly used asleep-awake-asleep technique, the patient must be awake and fully cooperative as soon as possible after ...
  • Salivary concentrations of secretory leukocyte protease inhibitor and matrix metallopeptidase-9 following a single bout of exercise are associated with intensity and hydration status 
    Knipping, Karen; Kartaram, Shirley W.; Teunis, Marc; Zuithoff, Nicolaas P.A.; Buurman, Nicole; M’Rabet, Laura; van Norren, Klaske; Witkamp, Renger; Pieters, Raymond; Garssen, Johan (Public Library of Science, 2023-11)
    Aim To investigate the effects of exercise on salivary concentrations of inflammatory markers by analyzing a panel of 25 inflammatory markers in subjects who had participated in bicycle ergometer tests varying in workload ...
  • Analysis of trends and allergenicity risk assessments in novel food approvals within the European Union between 2018 and 2023 
    Yue, Sim Ray; Verhoeckx, Kitty C M; Houben, Geert F; Bøgh, Katrine Lindholm (Elsevier Limited, 2025-03)
    Novel food (NF) approvals in the European Union between 2018 and 2023 (n = 117) were retrieved and analysed. They consist of new NF (52.1%), modification (38.5%), and traditional food (9.4%). The average time taken for new ...
  • Newborn Screening by DNA-First: Systematic Evaluation of the Eligibility of Inherited Metabolic Disorders Based on Treatability 
    Veldman, Abigail; Sikkema-Raddatz, Birgit; Derks, Terry G J; van Karnebeek, Clara D M; Kiewiet, M B Gea; Mulder, Margaretha F; Nelen, Marcel R; Rubio-Gozalbo, M Estela; Sinke, Richard J; de Sain-van der Velden, Monique G; Visser, Gepke; de Vries, Maaike C; Westra, Dineke; Williams, Monique; Wevers, Ron A; Heiner-Fokkema, M Rebecca; van Spronsen, Francjan J (Multidisciplinary Digital Publishing Institute (MDPI), 2024-12-28)
    The biomarker-based Dutch Newborn Screening (NBS) panel (as of 2024) comprises 19 inherited metabolic disorders (IMDs). With the use of next-generation sequencing (NGS) as a first-tier screen, NBS could expand to include ...
  • Single-cell sequencing of human Langerhans cells identifies altered gene expression profiles in patients with atopic dermatitis 
    Tamminga, Sara M; Van Der Wal, M Marlot; Saager, Elise S; Van Der Gang, Lian F; Boesjes, Celeste M; Hendriks, Astrid; Pannekoek, Yvonne; De Bruin, Marjolein S; Van Wijk, Femke; Van Sorge, Nina M (NLM (Medline), 2025-02)
    Atopic dermatitis (AD) is characterized by dysregulated T cell immunity and skin microbiome dysbiosis with predominance of Staphylococcus aureus, which is associated with exacerbating AD skin inflammation. Specific ...
  • Rationale and design of the HOVON 170 DLBCL-ANTICIPATE trial: preventing anthracycline-induced cardiac dysfunction with dexrazoxane 
    Linschoten, Marijke; Geels, Jesse; van Werkhoven, Erik; Visser-Wisselaar, Heleen; Chamuleau, Martine E D; Teske, Arco J; Robbers, Lourens; Oerlemans, Simone; Crommelin, Heleen; Breems-de Ridder, Marleen; Schut, Astrid; Asselbergs, Folkert W; van Rhenen, Anna; HOVON 170 DLBCL – ANTICIPATE consortium (BioMed Central Ltd., 2025-01-28)
    BACKGROUND: Dexrazoxane has been studied for its ability to prevent anthracycline-induced cardiac dysfunction (AICD) in several trials but its use in clinical practice remains limited. This is related to the low to moderate ...
  • Cesarean section in Suriname using robson classification: a two-year nationwide cross-sectional study on rates, risk factors and perinatal outcomes of cesarean section 
    Prüst, Zita D; Dupont, Josephine A I; Liesdek, Safir; Bloemenkamp, Kitty W M; van den Akker, Thomas; Verschueren, Kim J C; Kodan, Lachmi R (BioMed Central, 2025-01-20)
    BACKGROUND: Optimizing CS performance is a global health priority, given the maternal and perinatal morbidity and mortality associated with both underuse and overuse. This study aims to (1) determine the facility-based CS ...
  • Hepatobiliary scintigraphy and liver function changes in patients with hepatocellular carcinoma treated with 166Ho-radioembolization: HBS in HCC treated with holmium-166. 
    Reinders, Margot T M; Smits, Maarten J L; van Erpecum, Karel; de Bruijne, Joep; Bruijnen, Rutger C G; Sprengers, Dave; de Man, Rob; Vegt, Erik; IJzermans, Jan N M; Lam, Marnix G E H; Braat, Arthur J A T (Springer Berlin, 2025-01-09)
    Background: To study the feasibility of hepatobiliary scintigraphy (HBS) to improve selection and planning of patients with hepatocellular carcinoma (HCC) treated with holmium-166 (166Ho)-microspheres radioembolization. ...
  • The built environment and cardiovascular disease: an umbrella review and meta-meta-analysis 
    Liu, Mingwei; Meijer, Paul; Lam, Thao Minh; Timmermans, Erik J.; Grobbee, Diederick E.; Beulens, Joline W.J.; Vaartjes, Ilonca; Lakerveld, Jeroen (Oxford University Press, 2023-11-01)
    Aims: To provide a comprehensive overview of the current evidence on objectively measured neighbourhood built environment exposures in relation to cardiovascular disease (CVD) events in adults. Methods and results: We ...
  • Gene-educational attainment interactions in a multi-population genome-wide meta-analysis identify novel lipid loci 
    de las Fuentes, Lisa; Schwander, Karen L.; Brown, Michael R.; Bentley, Amy R.; Winkler, Thomas W.; Sung, Yun Ju; Munroe, Patricia B.; Miller, Clint L.; Aschard, Hugo; Aslibekyan, Stella; Bartz, Traci M.; Bielak, Lawrence F.; Chai, Jin Fang; Cheng, Ching Yu; Dorajoo, Rajkumar; Feitosa, Mary F.; Guo, Xiuqing; Hartwig, Fernando P.; Horimoto, Andrea; Kolčić, Ivana; Lim, Elise; Liu, Yongmei; Manning, Alisa K.; Marten, Jonathan; Musani, Solomon K.; Noordam, Raymond; Padmanabhan, Sandosh; Rankinen, Tuomo; Richard, Melissa A.; Ridker, Paul M.; Smith, Albert V.; Vojinovic, Dina; Zonderman, Alan B.; Alver, Maris; Boissel, Mathilde; Christensen, Kaare; Freedman, Barry I.; Gao, Chuan; Giulianini, Franco; Harris, Sarah E.; He, Meian; Hsu, Fang Chi; Kühnel, Brigitte; Laguzzi, Federica; Li, Xiaoyin; Lyytikäinen, Leo Pekka; Nolte, Ilja M.; Poveda, Alaitz; Rauramaa, Rainer; Riaz, Muhammad; Robino, Antonietta; Sofer, Tamar; Takeuchi, Fumihiko; Tayo, Bamidele O.; van der Most, Peter J.; Verweij, Niek; Ware, Erin B.; Weiss, Stefan; Wen, Wanqing; Yanek, Lisa R.; Zhan, Yiqiang; Amin, Najaf; Arking, Dan E.; Ballantyne, Christie; Boerwinkle, Eric; Brody, Jennifer A.; Broeckel, Ulrich; Campbell, Archie; Canouil, Mickaël; Chai, Xiaoran; Chen, Yii Der Ida; Chen, Xu; Chitrala, Kumaraswamy Naidu; Concas, Maria Pina; de Faire, Ulf; de Mutsert, Renée; de Silva, H. Janaka; de Vries, Paul S.; Do, Ahn; Faul, Jessica D.; Fisher, Virginia; Floyd, James S.; Forrester, Terrence; Friedlander, Yechiel; Girotto, Giorgia; Gu, C. Charles; Hallmans, Göran; Heikkinen, Sami; Heng, Chew Kiat; Homuth, Georg; Hunt, Steven; Ikram, M. Arfan; Jacobs, David R.; Kavousi, Maryam; Khor, Chiea Chuen; Kilpeläinen, Tuomas O.; Koh, Woon Puay; Komulainen, Pirjo; Langefeld, Carl D.; Liang, Jingjing; Liu, Kiang; Liu, Jianjun; Lohman, Kurt; Mägi, Reedik; Manichaikul, Ani W.; McKenzie, Colin A.; Meitinger, Thomas; Milaneschi, Yuri; Nauck, Matthias; Nelson, Christopher P.; O’Connell, Jeffrey R.; Palmer, Nicholette D.; Pereira, Alexandre C.; Perls, Thomas; Peters, Annette; Polašek, Ozren; Raitakari, Olli T.; Rice, Kenneth; Rice, Treva K.; Rich, Stephen S.; Sabanayagam, Charumathi; Schreiner, Pamela J.; Shu, Xiao Ou; Sidney, Stephen; Sims, Mario; Smith, Jennifer A.; Starr, John M.; Strauch, Konstantin; Tai, E. Shyong; Taylor, Kent D.; Tsai, Michael Y.; Uitterlinden, André G.; van Heemst, Diana; Waldenberger, Melanie; Wang, Ya Xing; Wei, Wen Bin; Wilson, Gregory; Xuan, Deng; Yao, Jie; Yu, Caizheng; Yuan, Jian Min; Zhao, Wei; Becker, Diane M.; Bonnefond, Amélie; Bowden, Donald W.; Cooper, Richard S.; Deary, Ian J.; Divers, Jasmin; Esko, Tõnu; Franks, Paul W.; Froguel, Philippe; Gieger, Christian; Jonas, Jost B.; Kato, Norihiro; Lakka, Timo A.; Leander, Karin; Lehtimäki, Terho; Magnusson, Patrik K.E.; North, Kari E.; Ntalla, Ioanna; Penninx, Brenda; Samani, Nilesh J.; Snieder, Harold; Spedicati, Beatrice; van der Harst, Pim; Völzke, Henry; Wagenknecht, Lynne E.; Weir, David R.; Wojczynski, Mary K.; Wu, Tangchun; Zheng, Wei; Zhu, Xiaofeng; Bouchard, Claude; Chasman, Daniel I.; Evans, Michele K.; Fox, Ervin R.; Gudnason, Vilmundur; Hayward, Caroline; Horta, Bernardo L.; Kardia, Sharon L.R.; Krieger, Jose Eduardo; Mook-Kanamori, Dennis O.; Peyser, Patricia A.; Province, Michael M.; Psaty, Bruce M.; Rudan, Igor; Sim, Xueling; Smith, Blair H.; van Dam, Rob M.; van Duijn, Cornelia M.; Wong, Tien Yin; Arnett, Donna K.; Rao, Dabeeru C.; Gauderman, James; Liu, Ching Ti; Morrison, Alanna C.; Rotter, Jerome I.; Fornage, Myriam (Frontiers Media S. A., 2023)
    Introduction: Educational attainment, widely used in epidemiologic studies as a surrogate for socioeconomic status, is a predictor of cardiovascular health outcomes. Methods: A two-stage genome-wide meta-analysis of ...
  • A robust mRNA signature obtained via recursive ensemble feature selection predicts the responsiveness of omalizumab in moderate-to-severe asthma 
    Kidwai, Sarah; Barbiero, Pietro; Meijerman, Irma; Tonda, Alberto; Perez-Pardo, Paula; Lio ́, Pietro; van der Maitland-Zee, Anke H.; Oberski, Daniel L.; Kraneveld, Aletta D.; Lopez-Rincon, Alejandro (BioMed Central, 2023-11)
    Background: Not being well controlled by therapy with inhaled corticosteroids and long-acting β2 agonist bronchodilators is a major concern for severe-asthma patients. The current treatment option for these patients is the ...
  • Insights into the Notch signaling pathway in degenerative musculoskeletal disorders: Mechanisms and perspectives 
    Liu, Gaoming; Wei, Jun; Xiao, Wenfeng; Xie, Wenqing; Ru, Qin; Chen, Lin; Wu, Yuxiang; Mobasheri, Ali; Li, Yusheng (Elsevier Masson, 2023-12-31)
    Degenerative musculoskeletal disorders are a group of age-related diseases of the locomotive system that severely affects the patient's ability to work and cause adverse sequalae such as fractures and even death. The ...
  • Antibody and B-cell Immune Responses Against Bordetella Pertussis Following Infection and Immunization 
    Abu-Raya, Bahaa; Esser, Mirjam J.; Nakabembe, Eve; Reiné, Jesús; Amaral, Kyle; Diks, Annieck M.; Imede, Esther; Way, Sing Sing; Harandi, Ali M.; Gorringe, Andrew; Le Doare, Kirsty; Halperin, Scott A.; Berkowska, Magdalena A.; Sadarangani, Manish (Academic Press Inc., 2023-12-15)
    Neither immunization nor recovery from natural infection provides life-long protection against Bordetella pertussis. Replacement of a whole-cell pertussis (wP) vaccine with an acellular pertussis (aP) vaccine, mutations ...
  • Evaluation of pliable bioresorbable, elastomeric aortic valve prostheses in sheep during 12 months post implantation 
    Vis, Annemijn; de Kort, Bente J.; Szymczyk, Wojciech; van Rijswijk, Jan Willem; Dekker, Sylvia; Driessen, Rob; Wijkstra, Niels; Gründeman, Paul F.; Niessen, Hans W.M.; Janssen, Henk M.; Söntjens, Serge H.M.; Dankers, Patricia Y.W.; Smits, Anthal I.P.M.; Bouten, Carlijn V.C.; Kluin, Jolanda (Springer Nature, 2023-12)
    Pliable microfibrous, bioresorbable elastomeric heart valve prostheses are investigated in search of sustainable heart valve replacement. These cell-free implants recruit cells and trigger tissue formation on the valves ...
  • Early Warning Scores to Support Continuous Wireless Vital Sign Monitoring for Complication Prediction in Patients on Surgical Wards: Retrospective Observational Study 
    van Rossum, Mathilde C.; Bekhuis, Robin E.M.; Wang, Ying; Hegeman, Johannes H.; Folbert, Ellis C.; Vollenbroek-Hutten, Miriam M.R.; Kalkman, Cornelis J.; Kouwenhoven, Ewout A.; Hermens, Hermie J. (JMIR Publications Inc., 2023)
    Background: Wireless vital sign sensors are increasingly being used to monitor patients on surgical wards. Although early warning scores (EWSs) are the current standard for the identification of patient deterioration in a ...
  • Nonverbal Executive Functioning in Relation to Vocabulary and Morphosyntax in Preschool Children With and Without Developmental Language Disorder 
    Everaert, Emma; Boerma, Tessel; Selten, Iris; Gerrits, Ellen; Houben, Michiel; Vorstman, Jacob; Wijnen, Frank (American Speech-Language-Hearing Association (ASHA), 2023-10)
    Purpose: Developmental language disorder (DLD) is characterized by persistent and unexplained difficulties in language development. Accumulating evidence shows that children with DLD also present with deficits in other ...
  • Reclassifying variations of unknown significance in diseases affecting Saudi Arabia’s population reveal new associations 
    Al Eissa, Mariam M.; Alotibi, Raniah S.; Alhaddad, Bader; Aloraini, Taghrid; Samman, Manar S.; AlAsiri, Abdulrahman; Abouelhoda, Mohamed; AlQahtani, Amerh S. (Frontiers Media S. A., 2023)
    Introduction: Physicians face diagnostic dilemmas upon reports indicating disease variants of unknown significance (VUS). The most puzzling cases are patients with rare diseases, where finding another matched genotype and ...
  • Global variation in diabetes diagnosis and prevalence based on fasting glucose and hemoglobin A1c 
    Timmermans, Erik J.; van Rossem, Lenie; NCD Risk Factor Collaboration (NCD-RisC) (Nature Research, 2023-11)
    Fasting plasma glucose (FPG) and hemoglobin A1c (HbA1c) are both used to diagnose diabetes, but these measurements can identify different people as having diabetes. We used data from 117 population-based studies and ...
  • Contradictions and Opportunities: Reconciling Professional Identity Formation and Competency-Based Medical Education 
    Sternszus, Robert; Slattery, Natasha Khursigara; Cruess, Richard L.; Cate, Olle Ten; Hamstra, Stanley J.; Steinert, Yvonne (Ubiquity Press, 2023)
    The widespread adoption of Competency-Based Medical Education (CBME) has resulted in a more explicit focus on learners’ abilities to effectively demonstrate achievement of the competencies required for safe and unsupervised ...