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UMC Repository: Recent submissions

  • Pharmacokinetic exposure and treatment outcomes of lenvatinib in patients with renal cell carcinoma and differentiated thyroid carcinoma 
    Meertens, Marinda; Giraud, Eline L.; Hassan, Esbar; Zielhuis, Sybrand W.J.; Snels, Tiemen T.; Desar, Ingrid M.E.; Walraven, Janneke E.W.; Wilgenhof, Sofie; van Thienen, Johannes V.; de Boer, Jan Paul; Steeghs, Neeltje; van Erp, Nielka P.; Huitema, Alwin D.R. (Springer-Verlag, 2025-01-17)
    PURPOSE: After initial approval of lenvatinib for radioiodine-refractory differentiated thyroid cancer (DTC), it has also shown promising outcomes in among others metastatic renal cell carcinoma (mRCC). Given that trial ...
  • Future developments in training 
    Last, Katharina; Power, Nicholas R; Dellière, Sarah; Velikov, Petar; Šterbenc, Anja; Antunovic, Ivana Antal; Lopes, Maria João; Schweitzer, Valentijn; Barac, Aleksandra; Trainee Association of the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) (Elsevier, 2021-11)
    BACKGROUND: The coronavirus disease 2019 (COVID-19) pandemic has demonstrated the value of highly skilled and extensively trained specialists in clinical microbiology (CM) and infectious diseases (ID). Training curricula ...
  • Aims and challenges of building national trainee networks in clinical microbiology and infectious disease disciplines 
    Dellière, Sarah; Peiffer-Smadja, Nathan; João-Lopes, Maria; Cevik, Muge; Pichon, Maxime; Bleibtreu, Alexandre; Schweitzer, Valentijn; Last, Katharina; Ferreira, Théo G; Lemaignen, Adrien; Barac, Aleksandra (Taylor and Francis Ltd., 2021-07)
    Trainees represent the medical practice of tomorrow. Interactions and collaborations at the early stage in career will strengthen the future of our specialties, clinical microbiology and infectious diseases. Trainee networks ...
  • Role and perception of clinical microbiology and infectious diseases trainees during the COVID-19 crisis 
    Bouiller, Kevin; Peiffer-Smadja, Nathan; Cevik, Muge; Last, Katharina; Antunović, Ivana A; Šterbenc, Anja; Lopes, Maria J; Barac, Aleksandra; Schweitzer, Valentijn; Dellière, Sarah (Taylor and Francis Ltd., 2022-04)
    Aim: To evaluate the role and perceptions of trainees during the COVID-19 pandemic. Method: An online survey was designed to provide an insight into the significance of the COVID-19 pandemic on working conditions of ...
  • Non-COVID-19 respiratory viral infection 
    Nunes-Silva, Cláudio; Vilares, Ana Teresa; Schweitzer, Valentijn; Castanhinha, Susana; Martins, António; Lopes, Maria João; Ascoli-Bartoli, Tommaso; Canelas, Gabriela; Keir, Holly R; Cunha, Flávia; Silva-Pinto, André; Rebelo, Sandra; Cunha, Rui Guimarães; Tavares, Margarida (European Respiratory Society, 2022-03)
    Implemented control measures brought about by the coronavirus disease 2019 (COVID-19) pandemic have changed the prevalence of other respiratory viruses, often relegating them to a secondary plan. However, it must not be ...
  • Identifying Patient Subgroups in the Heterogeneous Chronic Pain Population Using Cluster Analysis 
    Rijsdijk, Mienke; Smits, Hidde M; Azizoglu, Hazal R; Brugman, Sylvia; van de Burgt, Yoeri; van Charldorp, Tessa C; van Gelder, Dewi J; de Grauw, Janny C; van Lange, Eline A; Meye, Frank J; Strick, Madelijn; Walravens, Hedi W A; Winkens, Laura H H; Huygen, Frank J P M; Drylewicz, Julia; Willemen, Hanneke L D M (Churchill Livingstone, 2025-03)
    Chronic pain is an ill-defined disease with complex biopsychosocial aspects, posing treatment challenges. We hypothesized that treatment failure results, at least partly, from limited understanding of diverse patient ...
  • The implementation of intrathecal morphine for caesarean delivery into clinical practice, and assessment of its impact on patient-reported quality of recovery using the ObsQoR-10-Dutch scale: A single-centre cohort study 
    van den Bosch, Oscar F C; Rijsdijk, Mienke; Rosier, Suzanne E; van Baal, Lottie; Schaap, Timme P; Sultan, Pervez; Bühre, Wolfgang (Lippincott Williams & Wilkins, 2025-04-01)
    BACKGROUNDOptimising a mother's quality of recovery following caesarean delivery is of paramount importance as it facilitates maternal care of the newborn and affects physical, psychological and emotional well being. ...
  • Risk of Lymph Node Metastasis in T2 Colon Cancer: A Nationwide Population-Based Cohort Study 
    Hanevelt, Julia; Brohet, Richard M; Moons, Leon M G; Laclé, Miangela M; Vleggaar, Frank P; van Westreenen, Henderik L; de Vos Tot Nederveen Cappel, Wouter H (Springer New York, 2025)
    BACKGROUND: Similar to T1 colon cancer (CC), risk stratification may guide T2 CC treatment and reduce unnecessary major surgery. In this study, prediction models were developed that could identify T2 CC patients with a ...
  • Genomics yields biological and phenotypic insights into bipolar disorder 
    O'Connell, Kevin S; Koromina, Maria; van der Veen, Tracey; Boltz, Toni; David, Friederike S; Yang, Jessica Mei Kay; Lin, Keng-Han; Wang, Xin; Coleman, Jonathan R I; Mitchell, Brittany L; McGrouther, Caroline C; Rangan, Aaditya V; Lind, Penelope A; Koch, Elise; Harder, Arvid; Parker, Nadine; Bendl, Jaroslav; Adorjan, Kristina; Agerbo, Esben; Albani, Diego; Alemany, Silvia; Alliey-Rodriguez, Ney; Als, Thomas D; Andlauer, Till F M; Antoniou, Anastasia; Ask, Helga; Bass, Nicholas; Bauer, Michael; Beins, Eva C; Bigdeli, Tim B; Pedersen, Carsten Bøcker; Boks, Marco P; Børte, Sigrid; Bosch, Rosa; Brum, Murielle; Brumpton, Ben M; Brunkhorst-Kanaan, Nathalie; Budde, Monika; Bybjerg-Grauholm, Jonas; Byerley, William; Cabana-Domínguez, Judit; Cairns, Murray J; Carpiniello, Bernardo; Casas, Miquel; Cervantes, Pablo; Chatzinakos, Chris; Vreeker, Annabel; Kahn, René S; Luykx, Jurjen J; Ophoff, Roel A; 23andMe Research Team (Nature Research, 2025)
    Bipolar disorder is a leading contributor to the global burden of disease 1. Despite high heritability (60-80%), the majority of the underlying genetic determinants remain unknown 2. We analysed data from participants of ...
  • Overview of Molecular Prognostication for Common Solid Tumor Histologies – What the Surgeon Should Know 
    Goodwin, C. Rory; De la Garza Ramos, Rafael; Bettegowda, Chetan; Barzilai, Ori; Shreyaskumar, Patel; Fehlings, Michael G.; Laufer, Ilya; Sahgal, Arjun; Rhines, Laurence D.; Reynolds, Jeremy J.; Lazary, Aron; Gasbarrini, Alessandro; Dea, Nicolas; Verlaan, Jorrit Jan; Sullivan, Patricia Zadnik; Gokaslan, Ziya L.; Fisher, Charles G.; Boriani, Stefano; Shin, John H.; Hornicek, Francis J.; Weber, Michael H.; Goodwin, Matthew L.; Charest-Morin, Raphaële; AO Spine Knowledge Forum Tumor (SAGE Publications Inc., 2025-01)
    Study design: Narrative Literature review. Objective: To provide a general overview of important molecular markers and targeted therapies for the most common neoplasms (lung, breast, prostate and melanoma) that metastasize ...
  • PROTAC-Mediated GSPT1 Degradation Impairs the Expression of Fusion Genes in Acute Myeloid Leukemia 
    Perzolli, Alicia; Steinebach, Christian; Krönke, Jan; Gütschow, Michael; Zwaan, C. Michel; Barneh, Farnaz; Heidenreich, Olaf (Multidisciplinary Digital Publishing Institute (MDPI), 2025-01)
    Background: Proteolysis targeting chimeras (PROTACs) are heterobifunctional small molecules that utilize the ubiquitin–proteasome system to selectively degrade target proteins. This innovative technology has shown remarkable ...
  • Oral Glucose-Lowering Agents vs Insulin for Gestational Diabetes: A Randomized Clinical Trial 
    Rademaker, Doortje; De Wit, Leon; Duijnhoven, Ruben G.; Voormolen, Daphne N.; Mol, Ben Willem; Franx, Arie; Devries, J. Hans; Painter, Rebecca C.; Van Rijn, Bas B.; Siegelaar, Sarah E.; Akerboom, Bettina M.C.; Kiewiet-Kemper, Rosalie M.; Verwij-Didden, Marion A.L.; Assouiki, Fahima; Kuppens, Simone M.; Oosterwerff, Mirjam M.; Stekkinger, Eva; Diekman, Mattheus J.M.; Vogelvang, Tatjana E.; Belle-Van Meerkerk, Gerdien; Galjaard, Sander; Verdonk, Koen; Lub, Annemiek; Klooker, Tamira K.; Krabbendam, Ineke; Van Wijk, Jeroen P.H.; Huisjes, Anjoke J.M.; Van Bemmel, Thomas; Nijman, Remco G.W.; Van Den Beld, Annewieke W.; Hermes, Wietske; Johannsson-Vidarsdottir, Solrun; Vlug, Anneke G.; Dullemond, Remke C.; Jansen, Henrique J.; Sueters, Marieke; De Koning, Eelco J.P.; Van Laar, Judith O.E.H.; Wouters-Van Poppel, Pleun; Evers, Inge M.; Sanson-Van Praag, Marina E.; Van Den Akker, Eline S.; Brouwer, Catherine B.; Hermsen, Brenda B.; Scholten, Ralph; Meijer, Rick I.; Van Leeuwen, Marsha; Wijbenga, Johanna A.M.; Wijnberger, Lia D.E.; De Valk, Harold W.; Nijkamp, Ellen; SUGAR-DIP Study Group (2025-02-11)
    Importance: Metformin and glyburide monotherapy are used as alternatives to insulin in managing gestational diabetes. Whether a sequential strategy of these oral agents results in noninferior perinatal outcomes compared ...
  • High-intensive physical rehabilitation approach in children and adolescents with acquired brain injury during subacute phase (REHABILITY): a feasibility study protocol 
    Gmelig Meyling, Christiaan; Verschuren, Olaf; Rentinck, Ingrid; Van Der Steen, Irene; Engelbert, Raoul; Gorter, Jan Willem (BMJ Publishing Group, 2025-01-20)
    Introduction While principles of neuroplasticity and motor learning emphasise the potential of high dosage of physical rehabilitation in children and adolescents with acquired brain injury (ABI) during the subacute phase, ...
  • Radiotherapy and surgery: can this combination be further optimized for patients with metastatic spine disease? 
    Amelink, Jantijn J.G.J.; Bindels, Bas J.J.; Kasperts, Nicolien; MacDonald, Shannon M.; Tobert, Daniel G.; Verlaan, Jorrit Jan (2025-01)
    This narrative review provides a comprehensive overview of the current status, recent advancements, and future directions in the management of metastatic spine disease using both radiotherapy and surgery. Emphasis has been ...
  • The influence of the dynamic context of the pandemic on the predictive performance of mortality predictions over time in older patients hospitalized for COVID-19 
    van Raaij, Bas F.M.; Zahra, Anum; Steyerberg, Ewout W.; de Hond, Anne A.H.; Smits, Rosalinde A.L.; van der Klei, Veerle M.G.T.H.; Polinder-Bos, Harmke A.; Minnema, Julia; Appelman, Brent; Smorenberg, Annemieke; Trompet, Stella; Peeters, Geeske; van Smeden, Maarten; Moons, Karel G.M.; Gussekloo, Jacobijn; Mooijaart, Simon P.; Noordam, Raymond (Elsevier, 2025-03)
    Objectives: During the COVID-19 pandemic, dynamic factors, such as governmental policies, improved treatment, prevention options, and viral mutations changed the incidence of outcomes and possibly changed the relation ...
  • Favorable Living Donor Kidney Transplantation Outcomes within a National Kidney Exchange Program: A Propensity Score Matching Analysis 
    van de Laar, Stijn C; de Weerd, Annelies E; Bemelman, Frederike J; Idu, Mirza M; de Vries, Aiko P J; Alwayn, Ian P J; Berger, Stefan P; Pol, Robert A; van Zuilen, Arjan D; Toorop, Raechel J; Hilbrands, Luuk B; Poyck, Paul P; Christiaans, Maarten H L; van Laanen, Jorinde H H; van de Wetering, Jacqueline; Kimenai, Hendrikus J A N; Reinders, Marlies E J; Porte, Robert J; Dor, Frank J M F; Minnee, Robert C (Lippincott Williams & Wilkins, 2025-03-01)
    BACKGROUND: KEPs (kidney exchange programs) facilitate living donor kidney transplantations (LDKT) for patients with incompatible donors, who are typically higher risk than non-KEP patients because of higher sensitization ...
  • Supercooling: a promising technique for prolonged preservation in solid organ transplantation, and early perspectives in vascularized composite allografts 
    Berkane, Yanis; Hayau, Justine; Filz von Reiterdank, Irina; Kharga, Anil; Charlès, Laura; Mink van der Molen, Abele B.; Coert, J. Henk; Bertheuil, Nicolas; Randolph, Mark A.; Cetrulo, Curtis L.; Longchamp, Alban; Lellouch, Alexandre G.; Uygun, Korkut (2023)
    Ex vivo preservation of transplanted organs is undergoing spectacular advances. Machine perfusion is now used in common practice for abdominal and thoracic organ transportation and preservation, and early results are in ...
  • Sleep, internalizing symptoms, and health-related quality of life in children with neurodevelopmental disorders: a cross-sectional analysis of cohort data from three research programs in Canada 
    The OBI Cross-integrated Discovery Program Sleep Team (Frontiers Media SA, 2023)
    Objective: The objectives of this study were to determine rates of sleep disturbances in children with neurodevelopmental disorders (NDDs) within and across disorders and compared to typically developing (TD) children and ...
  • Young women’s social support networks during pregnancy in Soweto, South Africa 
    Mabetha, Khuthala; Soepnel, Larske M.; Klingberg, Sonja; Mabena, Gugulethu; Motlhatlhedi, Molebogeng; Norris, Shane A.; Draper, Catherine E. (AOSIS (Pty) Ltd, 2023)
    Background: Although studies from high-income countries have examined social support during pregnancy, it remains unclear what type of support is received by expectant mothers from low- and middle-income country settings. ...
  • Development of a Core Set of Self-Management Support Needs of Esophageal Cancer Patients: Results from a Delphi Study among Healthcare Professionals 
    Adriaans, Daniëlle J.M.; Heesakkers, Fanny B.M.; Teijink, Joep A.W.; Dierick-Van Daele, Angelique T.M.; Haveman, Jan Willem; Sosef, Meindert N.; van den Berg, Jan Willem; van Det, Marc J.; Hartgrink, Henk H.; Jansen, Walther J.B.M.; Rosman, Camiel; Lagarde, Sjoerd M.; van Esser, Stijn; van der Harst, Erwin; van Laarhoven, Hanneke W.M.; Nieuwenhuijzen, Grard A.P. (Wiley-Blackwell, 2023)
    Objective. We aimed to gain consensus on HCPs’ perspectives on self-management support information needs of patients with esophageal cancer during the preoperative phase. Methods. Based on the literature, observations of ...