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UMC Repository: Recent submissions

  • Antibody Response Following COVID-19 Vaccination in Malaysian Cancer Patients and Healthy Individuals 
    Song, Chin Vern; Ahmad Bustamam, Ros Suzanna; Gin Gin, Gan; Saad, Marniza; Abdul Satar, Nur Fadhlina; Ramasamy, Alagu Manthiram; Sam, I-Ching; Kong, Yek-Ching; Alagir Rajah, Harenthri Devy; Chan, Yoke Fun; Fu, Jolene Yin Ling; Tan, Cheng Siang; Danaee, Mahmoud; Yip, Cheng Har; Van Gils, Carla H; Bhoo-Pathy, Nirmala (2024-11)
    INTRODUCTION: There is a lack of real-world evidence on direct comparisons between COVID-19 vaccines in multiethnic low- and middle-income settings. Cancer patients have an impaired vaccine response due to the disease ...
  • Rethinking phase 2 trials in amyotrophic lateral sclerosis 
    Benatar, Michael; McDermott, Christopher; Turner, Martin R; van Eijk, Ruben P A (Oxford University Press, 2025-04-03)
    There is a long history in amyotrophic lateral sclerosis (ALS) of promoting therapies based on Phase 2 data, which then fail in Phase 3 trials. Experience suggests that studies of 6 months in duration are too short, ...
  • First-trimester fetal fraction measurement in noninvasive prenatal testing: a response 
    Becking, Ellis C; Scheffer, Peter G; Bekker, Mireille N (Mosby Inc., 2025-04)
  • The effect of sample site and collection procedure on identification of SARS-CoV-2 infection 
    Davenport, Clare; Arevalo-Rodriguez, Ingrid; Mateos-Haro, Miriam; Berhane, Sarah; Dinnes, Jacqueline; Spijker, René; Buitrago-Garcia, Diana; Ciapponi, Agustín; Takwoingi, Yemisi; Deeks, Jonathan J; Emperador, Devy; Leeflang, Mariska M G; Van den Bruel, Ann; Cochrane COVID-19 Diagnostic Test Accuracy Group (John Wiley & Sons Inc., 2024-12-16)
    BACKGROUND: Sample collection is a key driver of accuracy in the diagnosis of SARS-CoV-2 infection. Viral load may vary at different anatomical sampling sites and accuracy may be compromised by difficulties obtaining ...
  • Predictors of coronary atherosclerosis in middle-aged and older athletes: the MARC-2 study 
    Berge, Kristian; Janssen, Sylvan L J E; Velthuis, Birgitta K; Myhre, Peder Langeland; Mosterd, Arend; Omland, Torbjørn; Eijsvogels, Thijs M H; Aengevaeren, Vincent L (Oxford University Press, 2025-03-03)
    Aims: Exercise improves cardiovascular health, but high-volume high-intensity exercise is associated with increased coronary artery calcification (CAC). We aimed to identify predictors of CAC in athletes. Methods and ...
  • Lifestyle factors and incident multimorbidity related to chronic disease: a population-based cohort study 
    Du, Yihui; de Bock, Geertruida H; Vonk, Judith M; Pham, An Thanh; van der Ende, M Yldau; Snieder, Harold; Smidt, Nynke; Krabbe, Paul F M; Alizadeh, Behrooz Z; Lunter, Gerton; Corpeleijn, Eva (Springer Science and Business Media B.V., 2024-11-28)
    BACKGROUND: Multimorbidity is linked to poor quality of life, and increased healthcare costs, and multimorbidity risk is potentially mitigated by a healthy lifestyle. This study evaluated the individual and joint contributions ...
  • Microvascular resistance reserve in relation to total and vessel-specific atherosclerotic burden 
    Hoshino, Masahiro; Jukema, Ruurt A; Hoek, Roel; Dahdal, Jorge; Raijmakers, Pieter; Driessen, Roel; Bom, Michiel J; van Diemen, Pepijn; Twisk, Jos; Danad, Ibrahim; Kakuta, Tsunekazu; Knuuti, Juhani; Knaapen, Paul (Oxford University Press, 2025-03-03)
    Aims: The relationship between coronary artery atherosclerosis and microvascular resistance remains unclear. This study aims to clarify the relationship between total atherosclerotic and vessel-specific atherosclerotic ...
  • Allogeneic stem cell transplantation in difficult-to-treat rheumatoid arthritis 
    Van Compernolle, Kevin; Selleslag, Dominik; Hazlewood, Glen S; Storek, Jan; van Laar, Jacob M; Piette, Yves (Clinical and Experimental Rheumatology S.A.S., 2025-03-12)
  • Association of circulating fatty acids with cardiovascular disease risk: Analysis of individual-level data in three large prospective cohorts and updated meta-analysis 
    Shi, Fanchao; Chowdhury, Rajiv; Sofianopoulou, Eleni; Koulman, Albert; Sun, Luanluan; Steur, Marinka; Aleksandrova, Krasimira; Dahm, Christina C; Schulze, Matthias B; van der Schouw, Yvonne T; Agnoli, Claudia; Amiano, Pilar; Boer, Jolanda M A; Bork, Christian S; Cabrera-Castro, Natalia; Eichelmann, Fabian; Elbaz, Alexis; Farràs, Marta; Heath, Alicia K; Kaaks, Rudolf; Katzke, Verena; Keski-Rahkonen, Pekka; Masala, Giovanna; Moreno-Iribas, Conchi; Panico, Salvatore; Papier, Keren; Petrova, Dafina; Quirós, J Ramón; Ricceri, Fulvio; Severi, Gianluca; Tjønneland, Anne; Tong, Tammy Y N; Tumino, Rosario; Wareham, Nick; Weiderpass, Elisabete; Di Angelantonio, Emanuele; Forouhi, Nita; Danesh, John; Butterworth, Adam S; Kaptoge, Stephen (Oxford University Press, 2025-02)
    Aims Associations of saturated and unsaturated fatty acids (FAs) with cardiovascular disease (CVD) remain controversial. We therefore aimed to investigate the prospective associations of objectively measured FAs with CVD, ...
  • Impact of a Digital Scribe System on Clinical Documentation Time and Quality: Usability Study 
    van Buchem, Marieke Meija; Kant, Ilse M J; King, Liza; Kazmaier, Jacqueline; Steyerberg, Ewout W; Bauer, Martijn P (JMIR Publications Inc., 2024-09-23)
    BACKGROUND: Physicians spend approximately half of their time on administrative tasks, which is one of the leading causes of physician burnout and decreased work satisfaction. The implementation of natural language ...
  • Finding very high lipoprotein(a): the need for routine assessment 
    Nurmohamed, Nick S; Kaiser, Yannick; Schuitema, Pauline C E; Ibrahim, Shirin; Nierman, Melchior; Fischer, Johan C; Chamuleau, Steven A J; Knaapen, Paul; Stroes, Erik S G (Oxford University Press, 2022-05-05)
    AIMS: To validate the reported increased atherosclerotic cardiovascular disease (ASCVD) risk associated with very high lipoprotein(a) [Lp(a)] and to investigate the impact of routine Lp(a) assessment on risk reclassification. ...
  • Diffused responsibilities in technology-driven health research: The case of artificial intelligence systems in decentralized clinical trials 
    The Hypermarker Consortium; the Trials@Home Consortium (Elsevier Limited, 2025-02-03)
    Innovations such as artificial intelligence (AI) and decentralized clinical trials (DCTs) offer opportunities to enhance trial quality and efficiency. However, these innovations raise ethical questions about key responsibilities ...
  • Organ development in growth-restricted fetuses in the reduced uterine perfusion pressure rat model: A vascular approach of brain, heart, and kidney 
    Alhama-Riba, J; van Kammen, C M; Nijholt, K T; Viveen, D; Amarouchi, K; Shasha, D; Krebber, M M; Hoebeek, F E; Lely, A T; Nijboer, C H A; Terstappen, F (John Wiley & Sons Inc., 2025-02)
    Fetal growth restriction (FGR) increases the risk of developing cardiovascular, renal, and neurovascular diseases. An overlapping vascular pathophysiology as a response to chronic hypoxia and circulatory redistribution in ...
  • Lactate controls cancer stemness and plasticity through epigenetic regulation 
    Nguyen, Nguyen T B; Gevers, Sira; Kok, Rutger N U; Burgering, Lotte M; Neikes, Hannah; Akkerman, Ninouk; Betjes, Max A; Ludikhuize, Marlies C; Gulersonmez, Can; Stigter, Edwin C A; Vercoulen, Yvonne; Drost, Jarno; Clevers, Hans; Vermeulen, Michiel; van Zon, Jeroen S; Tans, Sander J; Burgering, Boudewijn M T; Rodríguez Colman, Maria J (Cell Press, 2025-04-01)
    Tumors arise from uncontrolled cell proliferation driven by mutations in genes that regulate stem cell renewal and differentiation. Intestinal tumors, however, retain some hierarchical organization, maintaining both cancer ...
  • Haematology dimension reduction, a large scale application to regular care haematology data 
    Joosse, Huibert-Jan; Chumsaeng-Reijers, Chontira; Huisman, Albert; Hoefer, Imo E; van Solinge, Wouter W; Haitjema, Saskia; van Es, Bram (BioMed Central, 2025-02-12)
    BACKGROUND: The routine diagnostic process increasingly entails the processing of high-volume and high-dimensional data that cannot be directly visualised. This processing may provide scaling issues that limit the ...
  • Sex and outcomes of patients with microsatellite instability-high and BRAF V600E mutated metastatic colorectal cancer receiving immune checkpoint inhibitors. 
    Nasca, Vincenzo; Zhao, Joseph; Ros, Javier; Lonardi, Sara; Zwart, Koen; Cohen, Romain; Fakih, Marwan; Jayachandran, Priya; Roodhart, Jeanine M L; Derksen, Jeroen; Intini, Rossana; Bergamo, Francesca; Mazzoli, Giacomo; Ghelardi, Filippo; Ligero, Marta; Jonnagaddala, Jitendra; Hawkins, Nicholas; Ward, Robyn L; Wankhede, Durgesh; Brenner, Hermann; Hoffmeister, Michael; Vitellaro, Marco; Salvatore, Lisa; Gallois, Claire; Laurent-Puig, Pierre; Cremolini, Chiara; Overman, Michael J; Taieb, Julien; Tougeron, David; Andre, Thierry; Kather, Jakob Nikolas; Sundar, Raghav; Carmona, Javier; Elez, Elena; Koopman, Miriam; Pietrantonio, Filippo (BioMed Central Ltd., 2025-02-10)
    BACKGROUND: Immune checkpoint inhibitors (ICIs) are the gold standard therapy in patients with deficient mismatch repair (dMMR)/microsatellite instability-high (MSI-H) metastatic colorectal cancer (mCRC). A significant ...
  • Nivolumab With or Without Ipilimumab in Patients With Recurrent or Metastatic Merkel Cell Carcinoma: A Nonrandomized, Open-Label, International, Multicenter Phase I/II Study 
    Bhatia, Shailender; Topalian, Suzanne L; Sharfman, William; Meyer, Tim; Steven, Neil; Lao, Christopher D; Fariñas-Madrid, Lorena; Devriese, Lot A; Moore, Kathleen; Ferris, Robert L; Honma, Yoshitaka; Elias, Ileana; Srirangam, Anjaiah; Garnett-Benson, Charlie; Lee, Michelle; Nghiem, Paul (Lippincott Williams & Wilkins, 2025-03-20)
    PURPOSE: Approximately 50% of patients with advanced Merkel cell carcinoma (MCC) have primary or acquired resistance to PD-(L)1 blockade, which may be overcome using combination immune checkpoint inhibition (ICI) with ...
  • Elevated levels of circulating microbial-associated uremic toxins are associated with metastatic duodenopancreatic neuroendocrine tumors in patients with Multiple Endocrine Neoplasia Type 1 
    Ballarò, Riccardo; Wasylishen, Amanda R; Pieterman, Carolina R C; Olsen, Courtney; Irajizad, Ehsan; Wu, Ranran; Katayama, Hiroyuki; Liu, Huiling; Cai, Yining; León-Letelier, Ricardo A; Dennison, Jennifer B; Waguespack, Steven; Do, Kim-Anh; Agarwal, Sunita K; Walter, Mary; Welch, James; Weinstein, Lee; Blau, Jenny E; Jha, Smita; Nilubol, Naris; Vriens, Menno R; van Leeuwaarde, Rachel S; van Treijen, Mark J C; Valk, Gerlof D; Perrier, Nancy D; Hanash, Samir M; Fahrmann, Johannes F (Elsevier Ireland Ltd, 2025-04-01)
    Metastatic duodenopancreatic neuroendocrine tumors (dpNETs) are the primary cause of mortality among patients with Multiple Endocrine Neoplasia Type 1 (MEN1). Emerging evidence implicates the microbiome and microbial-derived ...
  • Is transthyretin amyloid cardiomyopathy heading towards losing its rare disease classification? 
    Achten, Anouk; Muller, Steven A; Zwetsloot, Peter-Paul; Michels, Michelle; van der Meer, Peter; Nienhuis, Hans L A; van der Meer, Manon G; van Empel, Vanessa P M; Oerlemans, Marish I F J; Knackstedt, Christian (Taylor and Francis Ltd., 2025)
  • FAST-EM array tomography: a workflow for multibeam volume electron microscopy 
    Kievits, Arent J; Duinkerken, B H Peter; Lane, Ryan; de Heus, Cecilia; van Beijeren Bergen En Henegouwen, Daan; Höppener, Tibbe; Wolters, Anouk H G; Liv, Nalan; Giepmans, Ben N G; Hoogenboom, Jacob P (2024-04)
    Elucidating the 3D nanoscale structure of tissues and cells is essential for understanding the complexity of biological processes. Electron microscopy (EM) offers the resolution needed for reliable interpretation, but the ...