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UMC Repository: Recent submissions

  • Integrated malaria vector control strategies and their effectiveness in sub-Saharan Africa: a systematic review protocol for interventional studies 
    Kombate, Gountante; Djalogue, Lihanimpo; Ngangue, Patrice; Soubeiga, Kamba Andre-Marie; Grobbee, Diederick E; van der Sande, Marianne (BMJ Publishing Group, 2025-02-07)
    INTRODUCTION: Sub-Saharan Africa has the highest malaria burden in the world. Several vector control strategies are being implemented to reduce mosquito density and protect the most vulnerable populations, such as children ...
  • Trans-ancestry genome-wide study of depression identifies 697 associations implicating cell types and pharmacotherapies 
    Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium (Elsevier, 2025-02-06)
    In a genome-wide association study (GWAS) meta-analysis of 688,808 individuals with major depression (MD) and 4,364,225 controls from 29 countries across diverse and admixed ancestries, we identify 697 associations at 635 ...
  • Impact of climate change, biodiversity loss, and pollution on the incidence and manifestation of depressive and anxiety disorders 
    Karl, Sebastian; Brandt, Lasse; Luykx, Jurjen J.; Dom, Geert (Lippincott Williams & Wilkins, 2025-01-01)
    Purpose of review Climate change, biodiversity loss, and pollution present a major threat to health. Although emphasis has been put on physical health impacts, evidence on the mental health consequences is now also ...
  • BMI trajectories in the first 3 months after childhood craniopharyngioma resection: a plea for early management of BMI changes 
    Hulsmann, Sanne C; Hoving, Eelco; Bakker, Boudewijn; Janssens, G O; van Schaik, Jiska; de Vos-Kerkhof, E; Tissing, Wje; van Santen, H M (BioScientifica Ltd., 2025-04-01)
    OBJECTIVE: Hypothalamic obesity (HO) is a severe condition following childhood craniopharyngioma (cCP) treatment. Despite multidisciplinary and centralized care, severe body mass index (BMI) changes are still often encountered ...
  • Undergraduate education as catalyst for public-private partnership in biotechnology 
    Ten Broeke, Toine; Koorman, Thijs; Crnko, Sandra; Voets, Erik; de Goeje, Pauline; Schakelaar, Michael Y; Rebel, Heggert G; Pijnappel, Emma W; Sanders, Jorine G F; Meeldijk, Jan; Terveer-Couperus, Rian; Geven, Esther L; Dilaver, Gönül; van Tilborg, Erik; Beekman, Lucas M P; Guelen, Lars; Bovenschen, Niels (Nature Research, 2025-02)
    An innovative challenge-based and research-driven educational model immerses groups of undergraduate students in the discovery stages of biotech industry research.
  • Clinical Relevance of ATRX/DAXX Gene Mutations and ALT in Functioning Pancreatic Neuroendocrine Tumors 
    van T Veld, Brenna R; Hackeng, Wenzel M; Luchini, Claudio; Brosens, Lodewijk A A; Dreijerink, Koen M A (Humana Press, 2025-02-15)
    Functioning pancreatic neuroendocrine tumors (PanNETs) represent a subset of PanNETs that cause symptoms due to hormonal activity. Insulinoma is the most common functioning PanNET type. Mutations in the alpha thalassemia/mental ...
  • ER-detect: a pipeline for robust detection of early evoked responses in BIDS-iEEG electrical stimulation data 
    van den Boom, Max A; Gregg, Nicholas M; Valencia, Gabriela Ojeda; Lundstrom, Brian N; Miller, Kai J; van Blooijs, Dorien; Huiskamp, Geertjan J M; Leijten, Frans S S; Worrell, Gregory A; Hermes, Dora (Elsevier, 2025-06)
    BACKGROUND: Human brain connectivity can be measured in different ways. Intracranial EEG (iEEG) measurements during single pulse electrical stimulation provide a unique way to assess the spread of electrical information ...
  • Charlson comorbidity index has no incremental value for mortality risk prediction in nursing home residents with COVID-19 disease 
    Zahra, Anum; van Smeden, Maarten; Elders, Petra J.M.; Festen, Jan; Gussekloo, Jacobijn; Joling, Karlijn J.; van Loon, Anouk; Luijken, Kim; Melis, René J.F.; Mooijaart, Simon P.; Moons, Karel G.M.; Peeters, Geeske; Polinder-Bos, Harmke A.; Wouters, Fenne; de Hond, Anne (BioMed Central, 2025-01-30)
    Background: During the COVID-19 pandemic, nursing home (NH) residents faced the highest risk of severe COVID-19 disease and mortality. Due to their frailty status, comorbidity burden can serve as a useful predictive indicator ...
  • Cerebellar Development and the Burden of Prematurity 
    Muehlbacher, Tobias; Dudink, Jeroen; Steggerda, Sylke J. (Springer New York, 2025-04)
    The role of the cerebellum in the neurodevelopmental outcomes of preterm infants has often been neglected. However, accumulating evidence indicates that normal cerebellar development is disrupted by prematurity-associated ...
  • Secondary prevention after acute and chronic coronary syndromes: are we still not there? 
    Voskuil, Michiel (Bohn Stafleu van Loghum, 2025)
  • Cognitive presentation at psychosis onset through premorbid deterioration and exposure to environmental risk factors 
    Ferraro, Laura; Di Forti, Marta; La Barbera, Daniele; La Cascia, Caterina; Morgan, Craig; Tripoli, Giada; Jongsma, Hannah; Seminerio, Fabio; Sartorio, Crocettarachele; Sideli, Lucia; Tarricone, Ilaria; Carloni, Anna Lisa; Szoke, Andrei; Pignon, Baptiste; Bernardo, Miguel; De Haan, Lieuwe; Arango, Celso; Velthorst, Eva; Gayer-Anderson, Charlotte; Kirkbride, James; Rutten, Bart P.F.; Lasalvia, Antonio; Tosato, Sarah; Del Ben, Cristina Marta; Menezes, Paulo Rossi; Bobes, Julio; Arrojo, Manuel; Tortelli, Andrea; Jones, Peter; Selten, Jean Paul; Van Os, Jim; Murray, Robin; Quattrone, Diego; Vassos, Evangelos; The WP2 EU-GEI Group (Cambridge University Press, 2025-02-05)
    Background Previous studies identified clusters of first-episode psychosis (FEP) patients based on cognition and premorbid adjustment. This study examined a range of socio-environmental risk factors associated with clusters ...
  • Treatment of Boerhaave syndrome: experience from a tertiary center 
    Kooij, Cezanne D.; Boptsi, Eleni; Weusten, Bas L.A.M.; de Vries, D. R.; Ruurda, Jelle P.; van Hillegersberg, Richard (Springer New York, 2025-04)
    Background: Boerhaave syndrome is a rare, life-threatening condition, characterized by spontaneous esophageal rupture. This study aims to share our 13-year experience in managing Boerhaave syndrome. Methods: A retrospective, ...
  • IDH-mutant astrocytomas with primitive neuronal component have a distinct methylation profile and a higher risk of leptomeningeal spread 
    Hinz, Felix; Friedel, Dennis; Korshunov, Andrey; Ippen, Franziska M.; Bogumil, Henri; Banan, Rouzbeh; Brandner, Sebastian; Hasselblatt, Martin; Boldt, Henning B.; Dirse, Vaidas; Dohmen, Hildegard; Aronica, Eleonora; Brodhun, Michael; Broekman, Marike L.D.; Capper, David; Cherkezov, Asan; Deng, Maximilian Y.; van Dis, Vera; Felsberg, Jörg; Frank, Stephan; French, Pim J.; Gerlach, Rüdiger; Göbel, Kirsten; Goold, Eric; Hench, Jürgen; Kantelhardt, Sven; Kohlhof-Meinecke, Patricia; Krieg, Sandro; Mawrin, Christian; Morrison, Gillian; Mühlebner, Angelika; Ozduman, Koray; Pfister, Stefan M.; Poliani, Pietro Luigi; Prinz, Marco; Reifenberger, Guido; Riemenschneider, Markus J.; Sankowski, Roman; Schrimpf, Daniel; Sill, Martin; Snuderl, Matija; Verdijk, Robert M.; Voisin, Mathew R.; Wesseling, Pieter; Wick, Wolfgang; Reuss, David E.; von Deimling, Andreas; Sahm, Felix; Maas, Sybren L.N.; Suwala, Abigail K. (Springer, 2025-06)
    IDH-mutant astrocytomas are diffuse gliomas that are defined by characteristic mutations in IDH1 or IDH2 and do not have complete 1p/19q co-deletion. The established grading criteria include histological features of brisk ...
  • A phase 2 trial investigating the efficacy and safety of the mPGES-1 inhibitor vipoglanstat in systemic sclerosis-related Raynaud's 
    Tornling, Göran; Edenius, Charlotte; Pauling, John D.; Denton, Christopher P.; Olsson, Anna; Kowalski, Jan; Murray, Andrea; Anderson, Marina; Bhat, Smita; Del Galdo, Francesco; Hall, Frances; Korkosz, Mariusz; Krasowska, Dorota; Olas, Jacek; Smith, Vanessa; Van Laar, Jacob M.; Vonk, Madelon C.; Wojteczek, Anna; Herrick, Ariane L. (Oxford University Press, 2025-02-01)
    Objective: Our objective was to test the hypothesis, in a double-blind, placebo-controlled study that vipoglanstat, an inhibitor of microsomal prostaglandin E synthase-1 (mPGES-1), which decreases prostaglandin E2 (PGE2) ...
  • The Youth Fitness International Test (YFIT) battery for monitoring and surveillance among children and adolescents: A modified Delphi consensus project with 169 experts from 50 countries and territories 
    Ortega, Francisco B.; Zhang, Kai; Cadenas-Sanchez, Cristina; Tremblay, Mark S.; Jurak, Gregor; Tomkinson, Grant R.; Ruiz, Jonatan R.; Keller, Katja; Nyström, Christine Delisle; Sacheck, Jennifer M.; Pate, Russell; Weston, Kathryn L.; Kidokoro, Tetsuhiro; Poon, Eric T.; Wachira, Lucy Joy M.; Ssenyonga, Ronald; Gomes, Thayse Natacha Q.F.; Cristi-Montero, Carlos; Fraser, Brooklyn J.; Niessner, Claudia; Onywera, Vincent O.; Liu, Yang; Liang, Li Lin; Prince, Stephanie A.; Lubans, David R.; Lang, Justin J.; Oyeyemi, Adewale L.; Marques, Adilson; Gribbon, Aidan; Gaya, Anelise Reis; García-Hermoso, Antonio; Sääkslahti, Arja; Emeljanovas, Arunas; Faigenbaum, Avery; Nakabazzi, Bernadette; Leskošek, Bojan; Popovic, Boris; O'Keeffe, Brendan; Timmons, Brian W.; Mieziene, Brigita; Fraser, Brooklyn; Brand, Caroline; Anza-Ramirez, Cecilia; Alvarez-Bueno, Celia; Agostinis-Sobrinho, Cesar A.; Hillman, Charles H.; Niessner, Claudia; Drenowatz, Clemens; Magnussen, Costan G.; Takken, Tim; study group (Elsevier, 2025-12)
    Background: Physical fitness in childhood and adolescence is associated with a variety of health outcomes and is a powerful marker of current and future health. However, inconsistencies in tests and protocols limit ...
  • Adjuvant Pembrolizumab in Stage II Melanoma: Outcomes by Primary Tumor Location in the Randomized, Double-Blind, Phase III KEYNOTE-716 Trial 
    Yoon, Charles H.; Ross, Merrick I.; Gastman, Brian R.; Luke, Jason J.; Ascierto, Paolo A.; Long, Georgina V.; Rutkowski, Piotr; Khattak, Muhammad; Del Vecchio, Michele; de la Cruz Merino, Luis; Mackiewicz, Jacek; Chiarion-Sileni, Vanna; Schadendorf, Dirk; Carlino, Matteo S.; Zhao, Yujie; Fukunaga-Kalabis, Mizuho; Krepler, Clemens; Eggermont, Alexander M M.; Gershenwald, Jeffrey E.; Sondak, Vernon K. (Springer New York, 2025-04)
    Background: Previous results from the KEYNOTE-716 trial demonstrated significantly improved recurrence-free survival (RFS) and distant metastasis-free survival (DMFS) with adjuvant pembrolizumab versus placebo in patients ...
  • Multicentre, 26-week, open-label phase 2 trial of the JAK inhibitor filgotinib in Behçet’s disease, idiopathic inflammatory myopathies and IgG4-related disease: DRIMID study protocol 
    Geertsema-Hoeve, Bettina C.; van Laar, Jan A.M.; Raaphorst, Joost; Tas, Sander W.; Welsing, Paco M.J.; Goekoop, Robbert J.; Checa, Cesar Magro; Thurlings, Rogier M.; Rekers, Nicolle H.; Present, Erik; van Laar, Jacob M. (BMJ Publishing Group, 2025-02-06)
    Introduction Research into novel therapies for rare, immune-mediated inflammatory diseases (IMIDs) faces significant challenges, including small patient populations, complex clinical trial design and difficulties in patient ...
  • Response to the editorial commentary on ‘When you cannot trust what you see: The confounding effect’ 
    Braga, Luis H.; Dönmez, M. İrfan; Nieuwhof-Leppink, Anka; Cascio, Salvatore; Ching, Christina; Garriboli, Massimo; Haid, Bernhard; Rosoklija, Ilina; Nelson, Caleb P.; Harper, Luke (Elsevier, 2025-04)
  • Statistical Practice of Ordinal Outcome Analysis in Neurologic Trials: A Literature Review 
    Long, Yongxi; de Ruiter, Sophie C.; Luijten, Linda W.G.; Wiegers, Eveline J.A.; Dippel, Diederik W.J.; Van Doorn, Pieter A.; Jacobs, Bart C.; Steyerberg, Ewout W. (Lippincott Williams & Wilkins, 2025-02-25)
    Background and Objectives Ordinal scales are widely adopted as outcome measures in neurologic randomized controlled trials (RCTs). We aimed to evaluate which statistical methods have been used to test and estimate treatment ...
  • Neuroimaging correlates of domain-specific cognitive deficits in amyotrophic lateral sclerosis 
    Tan, Harold H.G.; Nitert, Abram D.; van Veenhuijzen, Kevin; Dukic, Stefan; van Zandvoort, Martine J.E.; Hendrikse, Jeroen; van Es, Michael A.; Veldink, Jan H.; Westeneng, Henk Jan; van den Berg, Leonard H. (Elsevier, 2025-01)
    Background: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with frequent extra-motor involvement. In the present study, we investigated whether specific cognitive and behavioral deficits in ALS ...