Purpose of Review: Cartilage injury does not heal spontaneously. The current cell-based cartilage treatments have either demonstrated poor clinical outcomes, require two surgeries, or are costly and logistically challenging. ...

Interactions between T- and B cells in the germinal center reaction are instrumental for the initiation, maintenance, and downregulation of the human adaptive immune response, leading to the production of antigen-specific ...

Soluble thallium salts are highly toxic, with mortality rates exceeding 70% in animals compared to 6%-15% in humans. Early identification of thallium intoxicated patients and decreasing the toxic load by targeted treatment ...

BACKGROUND: Melanoma is an aggressive form of skin cancer in which tumor-infiltrating lymphocytes (TILs) are a biomarker for recurrence and treatment response. Manual TIL assessment is prone to interobserver variability, ...

OBJECTIVE: To compare the 12-year effectiveness of pelvic floor muscle training versus midurethral sling surgery for moderate to severe female stress urinary incontinence. DESIGN: Observational follow-up study of a randomised ...

BACKGROUND: Aggregation of cohort data increases precision for studying neurodegenerative disease pathways, but efforts to combine data and expertise are often hampered by infrastructural, ethical and legal considerations. ...

Neonatology care, the care for premature and severely ill babies, is increasingly confronted with capacity challenges. The entire perinatal care chain, including the Neonatal Intensive Care Unit (NICU), operates at high ...

Cell division drives somatic evolution but is challenging to quantify. We developed a framework to count cell divisions with DNA replication-related mutations in polyguanine homopolymers. Analyzing 505 samples from 37 ...

PURPOSE: The heterogeneity of very old patients (age ≥ 80 years) and the prevalence of complex geriatric syndromes in this cohort constitute major challenges for the classical methods of evidence-based medicine to inform ...