Recently added

DSpace/Manakin Repository

UMC Repository: Recent submissions

  • Pyruvate Kinase Function Correlates With Red Blood Cell Properties and Clinical Manifestations in Sickle Cell Disease 
    Traets, M J M; Bos, J F; van der Veen, S; van Pelt, L; van Dijk, M J; van Oirschot, B A; de Wilde, J R A; Jans, J J; van Solinge, W W; Schols, S E M; Lauw, M N; Cnossen, M H; Nur, E; Biemond, Bart J.; Rijneveld, A W; van Beers, E J; van Wijk, R; Rab, M A E (John Wiley & Sons Inc., 2025-05)
    Pyruvate kinase (PK) is a key enzyme involved in the final step of glycolysis, essential to produce adenosine triphosphate (ATP). Relatively decreased red blood cell (RBC) PK activity (reflected by a lower PK/hexokinase ...
  • Neurodevelopmental Outcomes After Nitric Oxide During Cardiopulmonary Bypass for Open Heart Surgery: A Randomized Clinical Trial 
    Long, Debbie A.; Gibbons, Kristen S.; Horton, Stephen B.; Johnson, Kerry; Buckley, David H.F.; Erickson, Simon; Festa, Marino; d'Udekem, Yves; Alphonso, Nelson; Le Marsney, Renate; Winlaw, David S.; Masterson, Kate; van Loon, Kim; Young, Paul J.; Schibler, Andreas; Schlapbach, Luregn J.; Butt, Warwick; NITRIC Study Group and the Australian and New Zealand Intensive Care Society Paediatric Study Group (ANZICS PSG) (American Medical Association, 2025-02-05)
    Importance: Children with congenital heart defects who undergo cardiopulmonary bypass (CPB) surgery are at risk for delayed or impaired neurodevelopmental outcomes. Nitric oxide (NO) added to the CPB oxygenator may reduce ...
  • VPS41 recruits biosynthetic LAMP-positive vesicles through interaction with Arl8b 
    Sanzà, Paolo; van der Beek, Jan; Draper, Derk; de Heus, Cecilia; Veenendaal, Tineke; Brink, Corlinda Ten; Farías, Ginny G.; Liv, Nalan; Klumperman, Judith (Rockefeller University Press, 2025-04-03)
    Vacuolar protein sorting 41 (VPS41), a component of the homotypic fusion and protein sorting (HOPS) complex for lysosomal fusion, is essential for the trafficking of lysosomal membrane proteins via lysosome-associated ...
  • Population Pharmacokinetics of Cobicistat and its Effect on the Pharmacokinetics of the Anticancer Drug Olaparib 
    Overbeek, Joanneke K.; van Erp, Nielka P.; Burger, David M.; den Broeder, Alfons A.; Koolen, Stijn L.W.; Huitema, Alwin D.R.; ter Heine, Rob (Adis, 2025)
    Objectives: Pharmacokinetic (PK) boosting is the intentional use of strong inhibitors of metabolic enzymes or transporters to boost the systemic exposure of a therapeutic drug. PK boosting is expanding to therapeutic areas ...
  • Patient-reported outcomes after immediate and delayed DIEP-flap breast reconstruction in the setting of post-mastectomy radiation therapy: results of the multicenter UMBRELLA breast cancer cohort 
    Jansen, Britt A.M.; Bargon, Claudia A.; Bouman, Maria A.; van der Molen, Dieuwke R.Mink; Postma, Emily L.; van der Leij, Femke; Zonnevylle, Erik; Ruhe, Quinten; Bruekers, Sven E.; Maarse, Wiesje; Siesling, Sabine; Young-Afat, Danny A.; Doeksen, Annemiek; Verkooijen, Helena M.; UMBRELLA Study Group (Springer New York, 2025-04)
    Purpose: Timing of Deep Inferior Epigastric artery Perforator (DIEP)-flap breast reconstruction in the context of post-mastectomy radiotherapy for breast cancer patients is topic of debate. We compared the impact of immediate ...
  • Survival After Endocarditis Surgery Needing Venoarterial Extracorporeal Membrane Oxygenation Support: Results from the Netherlands Heart Registration 
    Heinen, Floris J; Akin, Sakir; van den Brink, Floris S; Ayan, Khalil; Hermanns, Henning; van der Stoel, Michelle D; Post, Marco C; Klautz, Robert J M; Tanis, Wilco; Cardiothoracic Surgery Registration Committee of the Netherlands Heart Registration (Elsevier, 2025-05-15)
    The incidence of venoarterial extracorporeal membrane oxygenation (VA-ECMO) support after cardiac surgery ranges from 0.4% to 3.7%, with in-hospital mortality rates reported at 60%. While the incidence of VA-ECMO after ...
  • Cognitive Behavioral Therapy for Childhood Prolonged Grief Disorder for Bereaved Children and Adolescents With Comorbid Problems: Case Vignettes 
    Djelantik, A. A.A.Manik J.; Spuij, Mariken (Elsevier, 2025-02)
    The cognitive behavioral therapy (CBT) protocol for prolonged grief disorder in children and adolescents has demonstrated effectiveness in multiple studies, including a large randomized controlled trial. However, in clinical ...
  • Glycolytic reprogramming shapes the histone acetylation profile of activated CD4+ T cells in juvenile idiopathic arthritis 
    Mocholi, Enric; Corrigan, Edward; Chalkiadakis, Theo; Gulersonmez, Can; Stigter, Edwin; Vastert, Bas; van Loosdregt, Jorg; Prekovic, Stefan; Coffer, Paul J. (Cell Press, 2025-02-25)
    Juvenile idiopathic arthritis (JIA) is an autoimmune disease characterized by accumulation of activated CD4+ T cells in the synovial fluid (SF) of affected joints. JIA CD4+ T cells exhibit a unique inflammation-associated ...
  • Side-effects in women treated with adjuvant endocrine therapy for breast cancer 
    Rademaker, L. M.; Gal, R.; May, A. M.; Batenburg, M. C.T.; van der Leij, F.; Bijlsma, R. M.; Verkooijen, H. M.; Doeksen, A.; Ernst, M. F.; Evers, D. J.; van der Pol, C. C.; Monninkhof, E. M. (Churchill Livingstone, 2025-04)
    Many women with breast cancer prematurely discontinue adjuvant endocrine therapy, leading to increased mortality. We performed a cross-sectional survey (n = 456) within the Dutch UMBRELLA-cohort to gain insight into the ...
  • Cerebral blood flow and cognitive functioning in patients undergoing transcatheter aortic valve implantation 
    van Nieuwkerk, Astrid C.; Hemelrijk, Kimberley I.; Aarts, Hugo M.; Leeuwis, Anna E.; Majoie, Charles B.L.M.; Daemen, Mat J.A.P.; Bron, Esther E.; Moonen, Justine E.F.; de Sitter, Alexandra; Bouma, Berto J.; Harms, Alexander; van der Flier, Wiesje M.; Baan, Jan; Piek, Jan J.; Biessels, Geert Jan; Delewi, Ronak (Elsevier, 2025-03)
    Background: Approximately one-third of patients with symptomatic severe aortic valve stenosis scheduled for transcatheter aortic valve implantation (TAVI) have some degree of cognitive impairment. The effect of TAVI on ...
  • For brain health, one drink a day is not better than none 
    Singh, Sanjula D.; Senff, Jasper R.; Anderson, Christopher D.; Rosand, Jonathan (Elsevier Limited, 2025-03)
  • Palbociclib exposure in relation to efficacy and toxicity in patients with advanced breast cancer 
    Buijs, S. M.; Mohmaed Ali, M. I.; Oomen-de Hoop, E.; Braal, C. L.; Wortelboer, N.; van Ommen-Nijhof, A.; Sonke, G. S.; Konings, I. R.; Jager, A.; Steeghs, N.; Siebinga, H.; Mathijssen, R. H.J.; Huitema, A. D.R.; Koolen, S. L.W. (Elsevier, 2025-03)
    Background: Data on exposure–response or exposure–toxicity relationships of cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) are limited and inconclusive. We aimed to investigate whether there is an association between ...
  • Comparison of 18F-FET-PET- and MRI-based target definition for re-irradiation treatment of recurrent diffuse glioma 
    Everard, Albert; Versnel, Daniel; Ruijters, Veerle; Tolboom, Nelleke; Philippens, Marielle; Snijders, Tom; Verhoeff, Joost; David, Szabolcs; Beijst, Casper (Elsevier Ireland Ltd, 2025-05)
    Background and purpose: The target area definition for re-irradiation of recurrent glioma typically relies on T1-weighted gadolinium-enhanced MRI (T1Gd), but T1Gd fails to capture glioma infiltration. While T2 FLAIR and ...
  • Does stroke volume limit exercise capacity in TGA patients after the arterial switch operation? 
    Joosen, Renée S.; Voskuil, Michiel; de Pater, Wieke G.; Wijk, Sebastiaan W.H.van; Suchá, Dominika; Wijk, Abraham van; der Zwaan, Heleen B.van; Krings, Gregor J.; Takken, Tim; Breur, Johannes M.P.J. (Elsevier, 2025-03)
    Background: Patients with transposition of the great arteries (TGA) experience reduced exercise capacity after the arterial switch operation (ASO), possibly due to limited stroke volume. This study evaluates the role of ...
  • Demonstration of motion-compensated volumetric modulated arc radiotherapy on an MR-linac 
    Borman, Pim T.S.; Uijtewaal, Prescilla; Snyder, Jeffrey; Allen, Bryan; Atienza, Caiden K.; Woodhead, Peter; Hyer, Daniel E.; Raaymakers, Bas W.; Fast, Martin F. (Elsevier, 2025-01)
    Intensity-modulated radiotherapy (IMRT) in combination with magnetic resonance imaging (MRI)-guided gated delivery represents the latest development in the treatment of abdominothoracic tumours on MR-linac. In contrast, ...
  • EPAS1 induction drives myocardial degeneration in desmoplakin-cardiomyopathy 
    Kyriakopoulou, Eirini; van Kampen, Sebastiaan J.; Wehrens, Martijn; Han, Su Ji; de Ruiter, Hesther; Monshouwer-Kloots, Jantine; Marshall, Emma; Brodehl, Andreas; van der Kraak, Petra; te Riele, Anneline S.J.M.; van Aarnhem, Egidius E.H.L.; van Laake, Linda W.; Tsui, Hoyee; Boogerd, Cornelis J.; van Rooij, Eva (Elsevier, 2025-03-21)
    Arrhythmogenic cardiomyopathy (ACM) is frequently attributed to desmosomal mutations, such as those in the desmoplakin (DSP) gene. Patients with DSP-cardiomyopathy are predisposed to myocardial degeneration and arrhythmias. ...
  • Pediatric cardiac arrest registries and survival outcomes: A European study 
    Markel, Franziska; Djakow, Jana; Biarent, Dominique; de Lucas, Nieves; Castillo, Jimena del; Skellett, Sophie; Turner, Nigel M.; Buysse, Corinne M.P.; Lauridsen, Kasper G. (2025-03)
    Objective: The epidemiology of pediatric cardiac arrest in Europe is largely unknown. We aimed to characterize pediatric cardiac arrest registries and obtain the first survival outcome data on pediatric cardiac arrest in ...
  • Exploring high-throughput drug sensitivity testing in neuroblastoma cell lines and patient-derived tumor organoids in the era of precision medicine 
    Langenberg, Karin P.S.; van Hooff, Sander R.; Koopmans, Bianca; Strijker, Josephine G.M.; Kholosy, Waleed M.; Ober, Kimberley; Zwijnenburg, Danny A.; van der Hoek, Jessica J.F.; Keller, Kaylee M.; Vernooij, Lindy; Schild, Linda G.; Looze, Eleonora J.; Ebus, Marli E.; Essing, Anke H.W.; Vree, Paula de; Tas, Michelle L.; Matser, Yvette A.H.; Wienke, Judith; Volckmann, Richard; Tops, Bastiaan B.J.; Kester, Lennart A.; Badloe, Shashi; Hehir-Kwa, Jayne Y.; Kemmeren, Patrick; Goemans, Bianca F.; Zwaan, C. Michel; Oehme, Ina; Jäger, Nathalie; Witt, Olaf; van Eijkelenburg, Natasha K.A.; Dierselhuis, Miranda P.; Tytgat, Godelieve A.M.; Wijnen, Marc H.W.; van Noesel, Max M.; de Krijger, Ronald R.; Eising, Selma; Koster, Jan; Dolman, Emmy M.; Molenaar, Jan J. (Elsevier Limited, 2025-03-11)
    Introduction: Despite druggable events to be present in 80 % of neuroblastomapatients within the Princess Máxima Center precision medicine program 'iTHER', clinical uptake of treatment recommendations has been low, and the ...
  • Multidrug micelles and sonopermeation for chemotherapy co-delivery to brain tumors 
    Dasgupta, Anshuman; May, Jan Niklas; Klinkenberg, Geir; Besse, Helena C.; Buhl, Eva Miriam; Moeckel, Diana; Mihyar, Rahaf; Peña, Quim; Shalmani, Armin Azadkhah; Hark, Christopher; Rix, Anne; Koletnik, Susanne; Metselaar, Josbert; Shi, Yang; Hennink, Wim E.; Storm, Gert; van Vuurden, Dannis; Moonen, Chrit; Ries, Mario; Schmid, Ruth; Kiessling, Fabian; Lammers, Twan (Elsevier, 2025-04-10)
    Brain tumors are difficult to target and treat. The blood-brain barrier (BBB) limits drug delivery to pathological sites, and standard mono-chemotherapy typically results in suboptimal efficacy and development of drug ...
  • The Prevalence and Associated Factors of Cancer-Related Worries in Adult Survivors of Childhood Cancer: A Systematic Review 
    Maas, Anne; Westerweel, Anne; Maurice-Stam, Heleen; Kremer, Leontien C.M.; van der Aa-van Delden, Alied M.; Zwerus, Daniël; van Dalen, Elvira C.; Grootenhuis, Martha A. (John Wiley & Sons Inc., 2025-02)
    Background: Many childhood cancer survivors (CCS) experience cancer-related worries (CRW), for example about late effects and cancer recurrence. CRW are associated with lower quality of life (QoL) and maladaptive health ...