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UMC Repository: Recent submissions

  • Metabolic dysfunction-associated steatotic liver disease and cardiovascular risk factors in rheumatoid arthritis 
    Saidi, A. N.; Theel, W. B.; Burggraaf, B.; van der Lelij, A. J.; Grobbee, D. E.; van Zeben, J. D.; van der Zwan-van Beek, E.; Rauh, S. P.; Cabezas, M. Castro (Springer Science and Business Media Deutschland GmbH, 2025)
    Objectives: Rheumatoid arthritis (RA) is a chronic autoimmune disease linked with metabolic dysfunction-associated steatotic liver disease (MASLD), which may increase cardiovascular (CV) risk. This study explores the ...
  • Key tips to shift student perspectives through transformative learning in medical education 
    Hart, Efraim J.; de Heer-Koster, Merel H.; van der Harst, Maria; Browne, Joyce L.; Scheele, Fedde (BioMed Central, 2025-02-07)
    Healthcare systems are increasingly complex, facing challenges such as rising costs, aging populations, and persistent health inequities. These challenges demand that medical education adapts, to equip health professionals ...
  • Swarm learning with weak supervision enables automatic breast cancer detection in magnetic resonance imaging 
    Saldanha, Oliver Lester; Zhu, Jiefu; Müller-Franzes, Gustav; Carrero, Zunamys I.; Payne, Nicholas R.; Escudero Sánchez, Lorena; Varoutas, Paul Christophe; Kyathanahally, Sreenath; Laleh, Narmin Ghaffari; Pfeiffer, Kevin; Ligero, Marta; Behner, Jakob; Abdullah, Kamarul A.; Apostolakos, Georgios; Kolofousi, Chrysafoula; Kleanthous, Antri; Kalogeropoulos, Michail; Rossi, Cristina; Nowakowska, Sylwia; Athanasiou, Alexandra; Perez-Lopez, Raquel; Mann, Ritse; Veldhuis, Wouter; Camps, Julia; Schulz, Volkmar; Wenzel, Markus; Morozov, Sergey; Ciritsis, Alexander; Kuhl, Christiane; Gilbert, Fiona J.; Truhn, Daniel; Kather, Jakob Nikolas (Springer Nature, 2025-02-06)
    Background: Over the next 5 years, new breast cancer screening guidelines recommending magnetic resonance imaging (MRI) for certain patients will significantly increase the volume of imaging data to be analyzed. While this ...
  • Imaging flow cytometry-based cellular screening elucidates pathophysiology in individuals with Variants of Uncertain Significance 
    Muffels, Irena Josephina Johanna; Waterham, Hans R.; D’Alessandro, Giuseppina; Zagnoli-Vieira, Guido; Sacher, Michael; Lefeber, Dirk J.; Van der Vinne, Celine; Roifman, Chaim M.; Gassen, Koen L.I.; Rehmann, Holger; Van Haaften-Visser, Desiree Y.; Nieuwenhuis, Edward S.S.; Jackson, Stephen P.; Fuchs, Sabine A.; Wijk, Femke; van Hasselt, Peter (BioMed Central, 2025-02-07)
    Background: Deciphering variants of uncertain significance (VUS) represents a major diagnostic challenge, partially due to the lack of easy-to-use and versatile cellular readouts that aid the interpretation of pathogenicity ...
  • A novel approach to glioblastoma multiforme treatment using modulation of key pathways by naturally occurring small molecules 
    Afshari, Amir R.; Sanati, Mehdi; Aminyavari, Samaneh; Keshavarzi, Zakieh; Ahmadi, Seyed Sajad; Oroojalian, Fatemeh; Karav, Sercan; Sahebkar, Amirhossein (Springer Science and Business Media Deutschland GmbH, 2025)
    Glioblastoma multiforme (GBM), the fatal primary brain malignancy in adults, represents significant health challenges, and its eradication has been the ultimate goal of numerous medical investigations. GBM therapy encompasses ...
  • Ex vivo T-lymphopoiesis assays assisting corrective treatment choice for genetically undefined T-lymphocytopaenia 
    Golwala, Zainab M; Goncalves, Helena Spiridou; Moirangthem, Ranjita Devi; Evans, Grace; Lizot, Sabrina; de Koning, Coco; Garrigue, Alexandrine; Corredera, Marta Martin; Ocampo-Godinez, Juan Moises; Howley, Evey; Kricke, Susanne; Awuah, Arnold; Obiri-Yeboa, Irene; Rai, Rajeev; Sebire, Neil; Bernard, Fanette; De Braem, Victoria Bordon Cueto; Boztug, Kaan; Cole, Theresa; Gennery, Andrew R; Hackett, Scott; Hambleton, Sophie; Holm, Mette; Kusters, Maaike A; Klocperk, Adam; Marzollo, Antonio; Marcus, Nufar; Nademi, Zohreh; Schmid, Jana Pachlopnik; Pichler, Herbert; Sellmer, Anna; Soler-Palacin, Pere; Soomann, Maarja; Torpiano, Paul; van Montfrans, Joris; Nierkens, Stefan; Adams, Stuart; Buckland, Matthew; Gilmour, Kimberly; Worth, Austen; Thrasher, Adrian J; Davies, E Graham; André, Isabelle; Kreins, Alexandra Y (Academic Press Inc., 2025-05)
    Persistent selective T-lymphocytopenia is found both in SCID and congenital athymia. Without molecular diagnosis, it is challenging to determine whether HCT or thymus transplantation ought to be performed. Ex vivo ...
  • The sac evolution imaging follow-up after endovascular aortic repair: An international expert opinion-based Delphi consensus study 
    Tinelli, Giovanni; D'Oria, Mario; Sica, Simona; Mani, Kevin; Rancic, Zoran; Resch, Timothy Andrew; Beccia, Flavia; Azizzadeh, Ali; Da Volta Ferreira, Marcelo Martins; Gargiulo, Mauro; Lepidi, Sandro; Tshomba, Yamume; Oderich, Gustavo S.; Haulon, Stéphan; SLIM F-U EVAR, Collaborative Study Group (Mosby Inc., 2024-09)
    Objective: Management of follow-up protocols after endovascular aortic repair (EVAR) varies significantly between centers and is not standardized according to sac regression. By designing an international expert-based ...
  • Editor's Choice – European Society for Vascular Surgery (ESVS) 2024 Clinical Practice Guidelines on the Management of Abdominal Aorto-Iliac Artery Aneurysms 
    Wanhainen, Anders; Van Herzeele, Isabelle; Bastos Goncalves, Frederico; Bellmunt Montoya, Sergi; Berard, Xavier; Boyle, Jonathan R.; D'Oria, Mario; Prendes, Carlota F.; Karkos, Christos D.; Kazimierczak, Arkadiusz; Koelemay, Mark J.W.; Kölbel, Tilo; Mani, Kevin; Melissano, Germano; Powell, Janet T.; Trimarchi, Santi; Tsilimparis, Nikolaos; Antoniou, George A.; Björck, Martin; Coscas, Raphael; Dias, Nuno V.; Kolh, Philippe; Lepidi, Sandro; Mees, Barend M.E.; Resch, Timothy A.; Ricco, Jean Baptiste; Tulamo, Riikka; Twine, Christopher P.; Branzan, Daniela; Cheng, Stephen W.K.; Dalman, Ronald L.; Dick, Florian; Golledge, Jonathan; Haulon, Stephan; van Herwaarden, Joost A.; Ilic, Nikola S.; Jawien, Arkadiusz; Mastracci, Tara M.; Oderich, Gustavo S.; Verzini, Fabio; Yeung, Kak Khee; ESVS Guidelines Committee; Document reviewers: (W.B. Saunders Ltd, 2024-02)
    Objective: The European Society for Vascular Surgery (ESVS) has developed clinical practice guidelines for the care of patients with aneurysms of the abdominal aorta and iliac arteries in succession to the 2011 and 2019 ...
  • Reduction of Occupational Radiation Exposure During Endovascular Treatment of Peripheral Artery Disease Using Radiation Absorbing Drapes 
    Jansen, Marloes M.; Koster, Arjan; van Herwaarden, Joost A.; Hazenberg, Constantijn E.V.B. (Elsevier, 2022-08)
    Background: A chronic exposure to low dose radiation, as encountered in endovascular procedures, may impact the health of surgeons and radiologists over a timespan of several months to a lifetime. This study evaluates the ...
  • The association between device instructions for use adherence and outcomes after elective endovascular aortic abdominal aneurysm repair 
    De Guerre, Livia E.V.M.; O'Donnell, Thomas F.X.; Varkevisser, Rens R.B.; Swerdlow, Nicholas J.; Li, Chun; Dansey, Kirsten; van Herwaarden, Joost A.; Schermerhorn, Marc L.; Patel, Virendra I. (Mosby Inc., 2022-09)
    Objective: Aortic neck anatomy has a significant impact on the complexity of endovascular aortic aneurysm repair (EVAR), with concern that neck characteristics outside of the instructions for use (IFU) may result in worse ...
  • New tools to reduce radiation exposure during aortic endovascular procedures 
    Klaassen, Jurre; Vijn, Linde J.; Hazenberg, Constantijn E.V.B.; van Herwaarden, Joost A. (Taylor and Francis Ltd., 2022)
    Introduction: The evolution of endovascular surgery over the past 30 years has made it possible to treat increasingly complex vascular pathologies with an endovascular method. Although this generally speeds up the patient’s ...
  • Multicenter experience of upper extremity access in complex endovascular aortic aneurysm repair 
    Meertens, Max M.; van Herwaarden, Joost A.; de Vries, Jean Paul P.M.; Verhagen, Hence J.M.; van der Laan, Maarten J.; Reijnen, Michel M.P.J.; Schurink, Geert W.H.; Mees, Barend M.E. (Mosby Inc., 2022-11)
    Purpose: Upper extremity access (UEA) for antegrade cannulation of aortic side branches is a relevant part of endovascular treatment of complex aortic aneurysms and can be achieved using several techniques, sites, and ...
  • Cardiac and Aortic Modifications After Endovascular Repair for Blunt Thoracic Aortic Injury: A Systematic Review 
    Mandigers, Tim J.; Bissacco, Daniele; Domanin, Maurizio; D'Alessio, Ilenia; Tolva, Valerio S.; Piffaretti, Gabriele; van Herwaarden, Joost A.; Trimarchi, Santi (W.B. Saunders Ltd, 2022-08-01)
    Objective: Blunt thoracic aortic injury (BTAI) is a devastating condition that commonly occurs in healthy and young patients. Endovascular treatment is the first choice; however, it has also been demonstrated to alter ...
  • Trends in Medicare Payments for Beneficiaries With Aortic Stenosis 
    van Bakel, Pieter A.J.; Ahmed, Yunus; Hou, Hechuan; Sukul, Devraj; Likosky, Donald S.; van Herwaarden, Joost A.; Patel, Himanshu J.; Thompson, Michael P. (Wiley-Blackwell, 2022-07-19)
    BACKGROUND: Aortic stenosis (AS) is the most common form of valvular heart disease with an increasing prevalence. Management of AS has changed dramatically with the introduction of transcatheter aortic valve replacement ...
  • Left ventricular remodeling following aortic root and ascending aneurysm repair 
    Houben, Ignas B.; Chu, Angel K.Y.; Yang, Bo; Kim, Karen M.; Fukuhara, Shinichi; van Herwaarden, Joost A.; Moll, Frans L.; Nordsletten, David A.; Figueroa, C. Alberto; Burris, Nicholas S.; Patel, Himanshu J. (Frontiers Media S. A., 2022-10-25)
    Objective: Adverse left ventricular remodeling due to a mismatch between stiffness of native aortic tissue and current polyester grafts may be under-recognized. This study was conducted to evaluate the impact of proximal ...
  • Patient-Specific Computational Modeling of Different Cannulation Strategies for Extracorporeal Membrane Oxygenation 
    Ahmed, Yunus; Lynch, Sabrina R.; Haft, Jonathan W.; Moll, Frans L.; Van Herwaarden, Joost A.; Burris, Nicholas S.; Patel, Himanshu J.; Figueroa, C. Alberto (Lippincott Williams & Wilkins, 2022-11-01)
    Institution of extracorporeal membrane oxygenation (ECMO) results in unique blood flow characteristics to the end-organ vascular beds. We studied the interplay between cardiac-driven and extracorporeal membrane oxygenation ...
  • Editor's Choice – European Society for Vascular Surgery (ESVS) 2023 Clinical Practice Guidelines on Radiation Safety 
    Modarai, Bijan; Haulon, Stéphan; Ainsbury, Elizabeth; Böckler, Dittmar; Vano-Carruana, Eliseo; Dawson, Joseph; Farber, Mark; Van Herzeele, Isabelle; Hertault, Adrien; van Herwaarden, Joost; Patel, Ashish; Wanhainen, Anders; Weiss, Salome; ESVS Guidelines Committee, Guidelines Committee; Bastos Gonçalves, Frederico; Björck, Martin; Chakfé, Nabil; de Borst, Gert J.; Coscas, Raphaël; Dias, Nuno V.; Dick, Florian; Hinchliffe, Robert J.; Kakkos, Stavros K.; Koncar, Igor B.; Kolh, Philippe; Lindholt, Jes S.; Trimarchi, Santi; Tulamo, Riikka; Twine, Christopher P.; Vermassen, Frank; Document Reviewers, Reviewers; Bacher, Klaus; Brountzos, Elias; Fanelli, Fabrizio; Fidalgo Domingos, Liliana A.; Gargiulo, Mauro; Mani, Kevin; Mastracci, Tara M.; Maurel, Blandine; Morgan, Robert A.; Schneider, Peter (W.B. Saunders Ltd, 2023-02)
  • Uncertainty of risk estimates from clinical prediction models: Rationale, challenges, and approaches 
    Riley, Richard D.; Collins, Gary S.; Kirton, Laura; Snell, Kym I.E.; Ensor, Joie; Whittle, Rebecca; Dhiman, Paula; Van Smeden, Maarten; Liu, Xiaoxuan; Alderman, Joseph; Nirantharakumar, Krishnarajah; Manson-Whitton, Jay; Westwood, Andrew J.; Cazier, Jean Baptiste; Moons, Karel G.M.; Martin, Glen P.; Sperrin, Matthew; Denniston, Alastair K.; Harrell, Frank E.; Archer, Lucinda (BMJ Publishing Group, 2025-02-13)
  • Interleaved Whole Brain 23Na-MRI and 31P-MRSI Acquisitions at 7 Tesla 
    Shams, Zahra; Dai, Jiying; Gosselink, Mark W  J; Hoogduin, Hans J  M; van der Kemp, Wybe J  M; Visser, Fredy; Klomp, Dennis W  J; Wijnen, Jannie P; Wiegers, Evita C (John Wiley & Sons Inc., 2025-03)
    Non-1H nuclei magnetic resonance spectroscopy (MRS) offers insights into metabolism, which may aid for example early stages of disease diagnosis, tissue characterization or therapy response evaluation. Sodium MRI can provide ...
  • Long-term imaging of individual ribosomes reveals ribosome cooperativity in mRNA translation 
    Madern, Maximilian F.; Yang, Sora; Witteveen, Olivier; Segeren, Hendrika A.; Bauer, Marianne; Tanenbaum, Marvin E. (Elsevier, 2025-04-03)
    The genetic information stored in mRNAs is decoded by ribosomes during mRNA translation. mRNAs are typically translated by multiple ribosomes simultaneously, but it is unclear whether and how the activity of different ...