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UMC Repository: Recent submissions

  • Is it time to abandon staging surgery and prolonged follow-up in patients with primary adult-type granulosa cell tumor? 
    Brink, Geertruid J; Groeneweg, Jolijn W; Sickinghe, Ariane A; Nijman, Hans W; van Lonkhuijzen, Luc R C W; Lok, Christianne A R; Piek, Jurgen M J; Roes, Eva Maria; de Kroon, Cornelis D; Hofhuis, Ward; Jonges, Geertruida N; Gort, Eelke H; Witteveen, Petronella O; Zweemer, Ronald P (BioMed Central Ltd., 2025-02-22)
    BACKGROUND: As current literature does not provide sufficient data to support clear guidelines in patients with a rare adult-type granulosa cell tumor, we aim to investigate: (1) whether additional staging surgery following ...
  • Author Correction: FANCD2-FANCI surveys DNA and recognizes double- to single-stranded junctions 
    Alcón, Pablo; Kaczmarczyk, Artur P.; Ray, Korak Kumar; Liolios, Themistoklis; Guilbaud, Guillaume; Sijacki, Tamara; Shen, Yichao; McLaughlin, Stephen H.; Sale, Julian E.; Knipscheer, Puck; Rueda, David S.; Passmore, Lori A. (Nature Research, 2025-03)
    Correction to: Naturehttps://doi.org/10.1038/s41586-024-07770-w Published online 31 July 2024 In the version of the article initially published, we omitted to include in the Methods section entitled “Electron microscopy ...
  • Quality of Life Among Patients With Locally Advanced Pancreatic Cancer: A Prospective Nationwide Multicenter Study 
    Seelen, Leonard W F; Augustinus, Simone; Stoop, Thomas F; Bouwense, Stefan A W; Busch, Olivier R; Cirkel, Geert A; van Eijck, Casper H J; de Vos-Geelen, Judith; Groot Koerkamp, Bas; Haj Mohammad, Nadia; de Hingh, Ignace H J T; van Alphen, Evelien; Homs, Marjolein Y V; Liem, Mike S L; Los, Maartje; de Meijer, Vincent E; Mekenkamp, Leonie J M; Sprangers, Mirjam A G; Stommel, Martijn W J; Wilmink, Johanna W; Besselink, Marc G; van Santvoort, Hjalmar C; van Laarhoven, Hanneke W M; Molenaar, I Quintus; Dutch Pancreatic Cancer Group (Harborside Press, 2025-03)
    Background: Health care providers of patients with cancer should discuss the impact of treatment, such as multiagent chemotherapy and surgery, on quality of life (QoL). However, in the era of shared decision-making, data ...
  • GEVSod2 Powder: A Modified Product Based on Biovesicles Functioned in Air Pollution PM2.5-Induced Cardiopulmonary Injury 
    Zhang, Xiao; Ye, Xuan; Xie, Yuling; Yang, Zijiang; Spanos, Michail; Guo, Zilin; Jin, Yu Xin; Li, Guoping; Lei, Zhiyong; Schiffelers, Raymond M.; Sluijter, Joost P.G.; Wang, Hongyun; Chen, Huihua; Xiao, Junjie (American Association for the Advancement of Science, 2025-01)
    The prevention of air pollution-related cardiopulmonary disorders has been largely overlooked despite its important burden. Extracellular vesicles (EVs) have shown great potential as carriers for drug delivery. However, ...
  • The diagnosis of mucormycosis by PCR in patients at risk: a systematic review and meta-analysis 
    Brown, Lottie; Tschiderer, Lena; Alanio, Alexandre; Barnes, Rosemary A.; Chen, Sharon C.A.; Cogliati, Massimo; Cruciani, Mario; Donnelly, J. Peter; Hagen, Ferry; Halliday, Catriona; Klingspor, Lena; Lagrou, Katrien; Melchers, Willem; Millon, Laurence; Morio, Florent; Salvador, Elena; Stroffolini, Giacomo; Ruhnke, Markus; Toepfer, Stephanie; van Dijk, Karin; Borman, Andrew M.; Buitrago, María José; Gorton, Rebecca; Löffller, Jürgen; Rautemaa-Richardson, Riina; Sendid, Boualem; Willeit, Peter; White, P. Lewis; Lackner, Michaela (Elsevier, 2025-03)
    Background: This systematic review and meta-analysis aimed to examine the performance of polymerase chain reaction (PCR) assays for diagnosing mucormycosis. Methods: A standardised search was conducted from conception to ...
  • Effect of geriatric care on health outcomes in older patients with cardiac disease: A systematic review 
    Raijmann, Renee C.M.A.; van Dalen, Terésa N.; Koek, Huiberdina L.; van der Meer, Manon G.; Emmelot-Vonk, Marielle H.; Keijsers, Carolina J.P.W. (Elsevier Ireland Ltd, 2025-05)
    Background: As patients with cardiac disease age and become frail, their care needs become more complex. Therefore geriatric care might benefit these patients. This review summarizes current research investigating the ...
  • Patients’ and plastic surgeons’ experiences with an online patient decision aid for breast reconstruction: considerations for nationwide implementation 
    Stege, Jacqueline A.ter; Engelhardt, Ellen G.; Woerdeman, Leonie A.E.; Oldenburg, Hester S.A.; Kieffer, Jacobien M.; Hahn, Daniela E.E.; van Duijnhoven, Frederieke H.; van Huizum, Martine A.; The, Regina; Karssen, Klemens; Kuenen, Marianne; Gerritsma, Miranda A.; Ruhe, Quinten; Krabbe-Timmerman, Irene S.; Riet, Martijne van’t; Kimmings, Nikola; Corten, Eveline M.L.; Sherman, Kerry A.; Witkamp, Arjen J.; Bleiker, Eveline M.A. (BioMed Central, 2025-02-06)
    Background: Women diagnosed with breast cancer undergoing a mastectomy often have the option to undergo breast reconstruction (BR). BR decisions are complex and have considerable impact. We developed a patient decision aid ...
  • German translation, transcultural adaptation and test-retest reliability of the headache screening questionnaire 
    Gubser, Ramon; Speksnijder, Caroline M.; van der Meer, Hedwig A.; Ernst, Markus J. (Elsevier, 2025-06)
    Introduction: Tension-type headache (TTH) and migraines are frequent headache types. For appropriate treatment, physiotherapists need to be able to recognize these two headache types. The Dutch Headache Screening Questionnaire ...
  • Evaluation of MRI technologies for surgical spine planning and navigation 
    Rommelspacher, Yorck; Schulte, André Pascal; Tanner, Stephan; Schellhammer, Frank; Kling, Sabine; Seevinck, Peter; Gironés Sangüesa, Marta; Strauss, Andreas Christian (Springer-Verlag, 2025)
    Purpose: CT is considered the gold standard to assess bone morphology, whereas MRI is the imaging modality of choice to assess soft tissue. To reduce the ionising radiation exposure of the patient from CT, new MRI technologies ...
  • Analysis of a mouse germ cell tumor model establishes pluripotency-associated miRNAs as conserved serum biomarkers for germ cell cancer detection 
    Loehr, Amanda R.; Timmerman, Dennis M.; Liu, Michelle; Gillis, Ad J.M.; Matthews, Melia; Bloom, Jordana C.; Nicholls, Peter K.; Page, David C.; Miller, Andrew D.; Looijenga, Leendert H.J.; Weiss, Robert S. (Nature Publishing Group, 2025-02-06)
    Malignant testicular germ cells tumors (TGCTs) are the most common solid cancers in young men. Current TGCT diagnostics include conventional serum protein markers, but these lack the sensitivity and specificity to serve ...
  • Two-Eyed Seeing and other Indigenous perspectives for neuroscience 
    Illes, J.; Perreault, M. L.; Bassil, K.; Bjaalie, J. G.; Taylor-Bragge, R. L.; Chneiweiss, H.; Gregory, T. R.; Kumar, B. N.; Matshabane, O. P.; Svalastog, A. L.; Velarde, M. R. (Nature Research, 2025-02-05)
    The integration of Indigenous perspectives and knowledge with biomedical approaches in neurosciences can significantly broaden the understanding of the human brain and mind. Drawing upon the writings of Elders in Canada, ...
  • Antibiotic stewardship in acute pancreatitis 
    van Santvoort, Hjalmar; Voermans, Rogier P.; Zyromski, Nicholas J.; Siriwardena, Ajith K. (John Wiley & Sons Inc., 2025-02-01)
  • Urinary Catecholamines Predict Relapse During Complete Remission in High-Risk Neuroblastoma 
    Matser, Yvette A H; Samim, Atia; Fiocco, Marta; van de Mheen, Marieke; van der Ham, Maria; de Sain-van der Velden, Monique G M; Verhoeven-Duif, Nanda M; van Grotel, Martine; Kraal, Kathelijne C J M; Dierselhuis, Miranda P; van Eijkelenburg, Natasha K A; Langenberg, Karin P S; van Noesel, Max M; van Kuilenburg, André B P; Tytgat, Godelieve A M (Lippincott Williams & Wilkins, 2025-01)
    PURPOSEUrinary catecholamine metabolites are well-known biomarkers for the diagnosis (Dx) of neuroblastoma, but their clinical significance in determining therapy response during treatment is not well established. Therefore, ...
  • Aortic, musculoskeletal and organ characteristics on computed tomography in knee osteoarthritis - an explorative study in the IMI-APPROACH cohort 
    Harlianto, Netanja I; de Jong, Pim A; Foppen, Wouter; Bennink, Edwin; Bunk, Stijn; Mastbergen, Simon C; Vorselaars, Adriane D M; Voortman, Mareye; Kloppenburg, Margreet; Blanco, Francisco J; Haugen, Ida K; Berenbaum, Francis; Popuri, Karteek; Beg, Mirza Faisal; Jansen, Mylène P (Springer-Verlag, 2025-03)
    The systemic associations with knee osteoarthritis (KOA) are incompletely understood. This study explores aortic disease, musculoskeletal and organ findings in patients with KOA in relation to their symptoms or radiographic ...
  • Tailoring organ dysfunction criteria for critically ill children with cancer 
    Wösten-van Asperen, RM; Hines, Melissa; Schlapbach, Luregn J.; Agulnik, Asya (Elsevier, 2025-04)
  • The Phoenix Sepsis Score in Pediatric Oncology Patients With Sepsis at PICU Admission: Test of Performance in a European Multicenter Cohort, 2018-2020 
    Wösten-van Asperen, Roelie M; la Roi-Teeuw, Hannah M; Tissing, Wim J E; Jordan, Iolanda; Dohna-Schwake, Christian; Bottari, Gabriella; Pappachan, John; Crazzolara, Roman; Amigoni, Angela; Mizia-Malarz, Agnieszka; Moscatelli, Andrea; Sánchez-Martín, María; Willems, Jef; Schlapbach, Luregn J; PICU Oncology Kids in Europe Research (POKER) group research consortium of European Society for Paediatric and Neonatal Intensive Care (ESPNIC) (Lippincott Williams & Wilkins, 2025-02-01)
    OBJECTIVES: The Pediatric Sepsis Definition Task Force developed and validated a new organ dysfunction score, the Phoenix Sepsis Score (PSS), as a predictor of mortality in children with suspected or confirmed infection. ...
  • Salvageable locoregional recurrence and stoma rate after local excision of pT1-2 rectal cancer: A nationwide cross-sectional cohort study 
    Moolenaar, L. R.; van Geffen, E. G.M.; Hazen, S. J.A.; Sluckin, T. C.; Beets, Geerard L.; Leijtens, J. W.A.; Talsma, A. K.; de Wilt, J. H.W.; Tanis, P. J.; Kusters, M.; Hompes, R.; Tuynman, J. B.; DUTCH SNAPSHOT RESEARCH GROUP; Collaborators Snapshot Registry (W.B. Saunders Ltd, 2025-06)
    Background: Screening has increased the incidence of early-stage rectal cancer and interest in rectal-preserving treatment strategies. Although guidelines recommend completion total mesorectal excision (cTME) in the presence ...
  • ADAMTS5-specific gapmer release from an albumin biomolecular assembly and cartilage internalization triggered by ultrasound 
    Elkhashab, Marwa; Barreto, Goncalo; Le Bourlout, Yohann; Creemers, Laura B; Nieminen, Heikki J; Howard, Kenneth A (Informa Healthcare, 2025-12)
    OBJECTIVE: Antisense oligonucleotides (ASOs) have reached the clinic; however, they lack tissue specificity. Albumin is a plasma-abundant macromolecule that has been shown to accumulate in inflamed tissues. In this work, ...
  • Establishment of an ex vivo cartilage damage model by combined collagenase treatment and mechanical loading 
    Wen, Liru; Grad, Sibylle; Creemers, Laura B; Stoddart, Martin J (BioMed Central Ltd., 2025-02-11)
    BACKGROUND: There is a substantial need for ex vivo cartilage damage models to assess new emerging cartilage repair strategies. Ex vivo cartilage explant models have the advantages of achieving standardized and reproducible ...
  • Intrapatient 16a-[ 18F]Fluoro-17b-Estradiol PET Heterogeneity as a Prognostic Factor for Endocrine Therapy Response and Survival in Patients with Estrogen Receptor–Positive Metastatic Breast Cancer 
    van Geel, Jasper J.L.; Moustaquim, Jasmine; Boers, Jorianne; Elias, Sjoerd G.; Smeets, Esther M.M.; Knip, Jelijn J.; Glaudemans, Andor W.J.M.; de Vries, Erik F.J.; Hospers, Geke A.P.; van Kruchten, Michel; Stokkel, Marcel; Oprea-Lager, Daniela E.; Menke-van der Houven van Oordt, Willemien C.; de Vries, Elisabeth G.E.; Schröder, Carolina P.; IMPACT-Metastatic Breast Consortium (Society of Nuclear Medicine Inc., 2025-02-01)
    Intrapatient heterogeneity of estrogen receptor (ER) expression on 16a-[18F]fluoro-17b-estradiol ([18F]FES) PET is related to outcome in patients with ER-positive metastatic breast cancer (MBC), but a validated and practical ...