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Policy Actions Required to Improve Nutrition for Brain Health

Higgs, Suzanne; Aarts, Kristien; Adan, Roger A.H.; Buitelaar, Jan K.; Cirulli, Francesca; Cryan, John F.; Dickson, Suzanne L.; Korosi, Aniko; van der Beek, Eline M.; Dye, Louise (Wiley-Blackwell, 2025-03-01)

Brain health is a pressing global concern. Poor diet quality is a recognized major environmental risk factor for brain disorders and one of the few that is modifiable. There is substantial evidence that nutrition impacts ...
Coupling of cell shape, matrix and tissue dynamics ensures embryonic patterning robustness

Moghe, Prachiti; Belousov, Roman; Ichikawa, Takafumi; Iwatani, Chizuru; Tsukiyama, Tomoyuki; Erzberger, Anna; Hiiragi, Takashi (Nature Research, 2025-03)

Tissue patterning coordinates morphogenesis, cell dynamics and fate specification. Understanding how precision in patterning is robustly achieved despite inherent developmental variability during mammalian embryogenesis ...
Efficacy and safety of SARS-CoV-2 vaccination in pregnancy to prevent COVID-19 in mothers and early infancy

de Bruin, Odette; Phijffer, Emily Wem; Ahmadizar, Fariba; Van der Maas, Nicoline At; Wildenbeest, Joanne G; Sturkenboom, Miriam Cjm; Bont, Louis J; Durán, Carlos E; Bloemenkamp, Kitty Wm (John Wiley & Sons Inc., 2025-02-26)

Objectives: This is a protocol for a Cochrane Review (intervention). The objectives are as follows:. To assess the effects of SARS-CoV-2 vaccination during pregnancy, versus placebo or no vaccination during pregnancy, for ...
Incidence of Newly Diagnosed Cancer After Cerebral Venous Thrombosis

van de Munckhof, Anita; Verhoeven, Jamie I.; Vaartjes, Ilonca C.H.; van Es, Nick; de Leeuw, Frank Erik; Coutinho, Jonathan M. (American Medical Association, 2025-02-10)

Importance: Active cancer is a risk factor for cerebral venous thrombosis (CVT), but whether CVT is associated with occult cancer is unknown. Objective: To evaluate the incidence of newly diagnosed cancer after CVT. Design, ...
Generalizability of findings from four clinical cohort studies and a general population study to patients with bipolar I disorder in outpatient treatment in the Netherlands

Renes, Joannes W.; Kupka, Ralph W.; Nolen, Willem A.; Have, Margreet ten; van der Markt, Afra; Boks, Marco P.M.; Regeer, Eline J. (Springer Open, 2025-02-15)

Background: Little attention has been paid to the generalizability of cohort studies in bipolar disorder (BD) to patient with BD in everyday clinical practice. Methods: A sample of patients with bipolar I disorder (BD-I) ...
Feasibility and safety of biologic OviTex mesh in ventral mesh rectopexy: a prospective pilot study

Boom, M. A.; van der Schans, E. M.; Wijffels, N. A.T.; Verheijen, P. M.; Consten, E. C.J. (Springer Verlag Italia, 2025-12)

Background: Minimal-invasive ventral mesh rectopexy (VMR) is a widely accepted treatment for patients suffering from rectal prolapse. The type of mesh used in VMR remains a subject of debate. Currently, the most applied ...
Methods in dynamic treatment regimens using observational healthcare data: A systematic review

Liang, David; Paul, Animesh Kumar; Weir, Daniala L.; Deneer, Vera H.M.; Greiner, Russell; Siebes, Arno; Gardarsdottir, Helga (Elsevier Ireland Ltd, 2025-05)

We present a systematic review of methods used to estimate Dynamic Treatment Regimens (DTR) using observational healthcare data and provide a brief summary of their strengths and weaknesses, evaluation metrics, and suitable ...
Emergency department crowding in the Netherlands; evaluation of a real-time ambulance diversion dashboard

Baan-Kooman, E. C.M.; Mol, S.; van der Linden, M. C.; Gaakeer, M. I.; de Ridder, V. A. (Springer London, 2025-01-21)

Background: Emergency department (ED) crowding is a growing concern worldwide and associated with negative effects. In 2013, 68% of Dutch ED-managers experienced crowding on several days of the week. This resulted into the ...
Nurse staffing issues are just the tip of the iceberg: a qualitative study about nurses' perceptions of nurse staffing

van Oostveen, Catharina J; Mathijssen, Elke; Vermeulen, Hester (Elsevier Limited, 2015-08)

OBJECTIVE: To obtain in-depth insight into the perceptions of nurses in the Netherlands regarding current nurse staffing levels and use of nurse-to-patient-ratios (NPR) and patient classification systems (PCS). BACKGROUND: ...
[18F]FDG PET/CT identifies infectious and inflammatory foci in persistent critical illness.

van Leer, Bram; Haitsma Mulier, Jelle L G; van Stee, Cornelis P; Demenaga, Kiki M; Slart, Riemer H J A; van Meurs, Matijs; Glaudemans, Andor W J M; Nijsten, Maarten W N; Derde, Lennie P G; Pillay, Janesh (Springer-Verlag GmbH and Co. KG, 2025-02-20)

PURPOSE: Some ICU patients remain critically ill despite reversal of the original admission diagnosis, driven by a cascade of events resulting in new and persistent organ failure. Secondary infections and systemic inflammation ...
Fetal brain development in fetal growth restriction using MRI: a systematic review

Meijerink, L; van Ooijen, I M; Alderliesten, T; Terstappen, F; Benders, M J N L; Bekker, M N (BioMed Central, 2025-02-26)

Background: This systematic review investigates potential differences in brain development between growth restricted (FGR)-fetuses compared to appropriate for gestational age (AGA) fetuses using MRI. Methods: PubMed, Embase, ...
Community-Engaged Learning Within the Medical Curriculum: Evaluating Learning Outcomes and Implementation Challenges

Pandit, Rahul; Essers, Rens L.; Pennings, Helena J. M. (2025)

Community engaged learning (CEL) is a teaching methodology which aims to bridge the gap between academia and society by collaborating on community-based projects. Inspired by theories of experiential learning and social ...
Using patient videos in Pharmacology education within Medicine and Pharmacy curricula

Jonge, Roos de; Wessel, Emma; van Houwelingen, Anneke H; Pandit, Rahul (Elsevier, 2025-06-05)

Safe and effective pharmacotherapy not only requires biomedical and pharmacological knowledge, but also insight into the patient's perspective. Although factors such as personal beliefs, acceptance of side effects or ...
SMN1 Duplications Are Associated With Progressive Muscular Atrophy, but Not With Multifocal Motor Neuropathy and Primary Lateral Sclerosis

Bos, Jeroen W.; Groen, Ewout J.N.; Wadman, Renske I.; Curial, Chantall A.D.; Molleman, Naomi N.; Zegers, Marinka; Van Vught, Paul W.J.; Snetselaar, Reinier; Vijzelaar, Raymon; Van Der Pol, W. Ludo; Van Den Berg, Leonard H. (Lippincott Williams & Wilkins, 2021-08-22)

ObjectiveTo assess the association between copy number (CN) variation in the survival motor neuron (SMN) locus and multifocal motor neuropathy (MMN), progressive muscular atrophy (PMA), and primary lateral sclerosis (PLS) ...
Statistical documentation for multi-disease, multi-domain platform trials: our experience with the Staphylococcus aureus Network Adaptive Platform trial

Mahar, Robert K; McGlothlin, Anna; Dymock, Michael; Barina, Lauren; Bonten, Marc; Bowen, Asha; Cheng, Matthew P; Daneman, Nick; Goodman, Anna L; Lee, Todd C; Lewis, Roger J; Lumley, Thomas; McLean, Alistair R D; McQuilten, Zoe; Mora, Jocelyn; Paterson, David L; Price, David J; Roberts, Jason; Snelling, Tom; Tverring, Jonas; Webb, Steve A; Yahav, Dafna; Davis, Joshua S; Tong, Steven Y C; Marsh, Julie A; SNAP Global Trial Steering Committee (BioMed Central, 2025-02-11)

Platform trials have become widely adopted across multiple disease areas over recent years, however, guidelines for operationalising these trials have not kept pace. We outline a series of documents that summarise the ...
Independent and joint effects of genomic and exposomic loads for schizophrenia on psychotic experiences in adolescents of European ancestry

Di Vincenzo, Matteo; Prachason, Thanavadee; Sampogna, Gaia; Arias-Magnasco, Angelo; Lin, Bochao Danae; Pries, Lotta-Katrin; van Os, Jim; Rutten, Bart P F; Barzilay, Ran; Fiorillo, Andrea; Guloksuz, Sinan (2025-02-22)

This study aimed to assess the independent and joint associations of genomic and exposomic liabilities for schizophrenia with distressing psychotic experiences (PEs) and their persistence in early adolescence. The Adolescent ...
Determinants of patient satisfaction in clozapine users: results from the Clozapine International Consortium (CLOZIN)

CLOZIN collaborators (2025-02-23)

Clozapine is highly effective for treatment-resistant schizophrenia but is underutilized due to patient and clinician-related concerns. Little is known about the general level of patient satisfaction with clozapine and ...
Acinetobacter baumannii Clinical Isolates Resist Complement-Mediated Lysis by Inhibiting the Complement Cascade and Improperly Depositing MAC

Magda, Michal; Boschloo, Wendy; Bettoni, Serena; Fairley, Derek; Russo, Thomas A; Giske, Christian G; Tellapragada, Chaitanya; Rooijakkers, Suzan H M; Riesbeck, Kristian; Blom, Anna M (S. Karger AG, 2025)

Introduction: Acinetobacter baumannii is a gram-negative opportunistic bacterium that causes life-threatening infections in immunocompromised hosts. The complement system is a critical mechanism of innate immunity that ...
Evaluation of Systemic Sclerosis Primary Heart Involvement and Chronic Heart Failure in the European Scleroderma Trials and Research Cohort

Györfi, Andrea-Hermina; Filla, Tim; Polzin, Amin; Tascilar, Koray; Buch, Maya; Tröbs, Monique; Matei, Alexandru-Emil; Airo, Paolo; Balbir-Gurman, Alexandra; Kuwert, Frederic; Mihai, Carina; Kabala, Anna; Graßhoff, Hanna; Callaghan, Julia; Isomura, Yohei; Mansour, Jennifer; Spierings, Julia; Tennoe, Anders Heiervang; Selvi, Enrico; Riccieri, Valeria; Hoffmann-Vold, Anna-Maria; Bergmann, Christina; Schett, Georg; Hunzelmann, Nicolas; van Laar, Jacob M; Saketkoo, Lesley Ann; Kuwana, Masataka; Siegert, Elise; Riemekasten, Gabriela; Distler, Oliver; du Four, Tessa; Smith, Vanessa; Truchetet, Marie-Elise; Distler, Jörg H W; EUSTAR collaborators (Wiley-Blackwell, 2025-03-04)

BACKGROUND: Systemic sclerosis (SSc) primary heart involvement (SSc-pHI) is one of the leading causes of mortality in SSc. We aimed to evaluate risk factors for SSc-pHI and its progression and the outcomes in the EUSTAR ...
The EU global health strategy: from policy to implementation

Skordis, Jolene; Froeschl, Guenter; Baldi, Sante Leandro; Berner-Rodoreda, Astrid; Casamitjana, Nuria; Cobelens, Frank; Klipstein-Grobusch, Kerstin; Raviglione, Mario; Rocamora, Alberto; Vandamme, Anne-Mieke; Plasència, Antoni (BioMed Central Ltd., 2025-02-25)

In November 2022, a draft of the next EU Global Health Strategy was published. The European Global Health Research Institutes Network (EGHRIN) of 22 leading European Universities has analysed the Strategy. In this commentary, ...

Now showing items 401-420 of 40729