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UMC Repository: Recent submissions

  • Deuterium MRS for In Vivo Measurement of Lipogenesis in the Liver 
    Gursan, Ayhan; de Graaf, Robin A; Thomas, Monique A; Prompers, Jeanine J; De Feyter, Henk M (John Wiley & Sons Inc., 2025-04)
    Hepatic de novo lipogenesis (DNL) plays a key role in the pathogenesis of several metabolic diseases that affect the liver. In humans, the detection of deuterium (2H) in triglycerides from very low density lipoprotein ...
  • Vertebral Body Tethering in an Adult With Lumbar Idiopathic Scoliosis: Rationale and 6-Year Outcomes 
    Markowitz, Jonathan; Castelein, Rene; Lonner, Baron (Lippincott Williams & Wilkins, 2025-01)
    CASE: We report a case of adolescent-onset idiopathic scoliosis of the lumbar spine in a 43-year-old woman treated with nonfusion vertebral body tethering (VBT), a controversial and unreported technique in this age group. ...
  • Reticuloendothelial system blockade does not enhance siRNA-LNP circulation or tumor accumulation in mice 
    Escudé Martinez de Castilla, Pol; Estapé Senti, Mariona; Erkens, Sigrun; van Weerden, Wytske M.; Kooijmans, Sander A.A.; Fens, Marcel H.; Vader, Pieter; Schiffelers, Raymond M. (Elsevier, 2025-06)
    One of the biggest challenges for siRNA-based therapeutics is intracellular delivery into the target cell, which can be facilitated by encapsulating siRNA in lipid nanoparticles (LNPs). In this study, we formulated ...
  • Dutch advances in cardiology: a comprehensive pci registry, telemonitoring, and graft failure analysis 
    van der Harst, Pim (Bohn Stafleu van Loghum, 2025-03)
  • The Association Between Metabolic Dysfunction-Associated Steatotic Liver Disease and Change in Liver Stiffness in Patients With Chronic Hepatitis B 
    Patmore, Lesley A.; van Eekhout, Kirsi; Koc, Özgür M.; de Knegt, Robert J.; Janssen, Harry L.A.; Brouwer, Willem P.; Kramer, Matthijs; Honkoop, Pieter; de Bruijne, Joep; Boland, Greet J.; Postma, Douwe F.; Blokzijl, Hans; de Man, Robert A.; Takkenberg, R. Bart; Sonneveld, Milan J. (Wiley-Blackwell, 2025-03)
    Background and Aims: Metabolic dysfunction-associated steatotic liver disease (MASLD) is associated with an increased risk of liver-related events in patients with chronic hepatitis B (CHB), possibly by accelerating fibrosis ...
  • Van het huidige medisch model naar mensgerichte zorg in de toekomst 
    Velders, F. P. (Uitgeverij Boom, 2025-02)
    Achtergrond De geestelijke gezondheidszorg staat onder grote druk; het huidige systeem kraakt in al zijn voegen met wachttijden en bezuinigingen tegen de achtergrond van grote maatschappelijke transformaties. Doel Vanuit ...
  • De toekomst die we willen versus de toekomst die we krijgen 
    Tak, Lineke M.; De Fruyt, Jürgen; Konings, Mette J.; Bracke, Piet; Goethals, Kris R.; Dols, Annemiek (Uitgeverij Boom, 2025-02)
  • Netwerkzorg: waar wachten we op? 
    Hagoort, Karin; van Os, Jim J.; Scheepers, Floortje E. (Uitgeverij Boom, 2025)
    Achtergrond Betere samenwerking in netwerken is al jaren een veelgenoemde oplossingsrichting voor de problemen in de ggz. Echter, de praktijk verandert langzaam. Doel Begrijpen waarom netwerkzorg zo moeizaam zijn weg vindt ...
  • Elevated Plasma Complement Factors in CRB1-Associated Inherited Retinal Dystrophies 
    Moekotte, Lude; de Boer, Joke H.; Hiddingh, Sanne; de Ligt, Aafke; Nguyen, Xuan Thanh An; Hoyng, Carel B.; Inglehearn, Chris F.; McKibbin, Martin; Lamey, Tina M.; Thompson, Jennifer A.; Chen, Fred K.; McLaren, Terri L.; AlTalbishi, Alaa; Panneman, Daan M.; Boonen, Erica G.M.; Banfi, Sandro; Bocquet, Béatrice; Meunier, Isabelle; De Baere, Elfride; Koenekoop, Robert; Ołdak, Monika; Rivolta, Carlo; Roberts, Lisa; Ramesar, Raj; Strupaitė-Šileikiene, Rasa; Kohl, Susanne; Farrar, G. Jane; van Vugt, Marion; van Setten, Jessica; Roosing, Susanne; van den Born, L. Ingeborgh; Boon, Camiel J.F.; van Genderen, Maria M.; Kuiper, Jonas J.W. (Association for Research in Vision and Ophthalmology Inc., 2025-02)
    PURPOSE. To determine the profile of inflammation-related proteins and complement system factors in the plasma of CRB1-associated inherited retinal dystrophies (CRB1-IRDs). METHODS. We used the Olink Explore 384 Inflammation ...
  • The extended speech reception threshold model: Predicting speech intelligibility in different types of non-stationary noise in hearing-impaired listeners 
    Rhebergen, Koenraad S.; Dreschler, Wouter A. (Acoustical Society of America, 2025-02-01)
    The speech reception threshold (SRT) model of Plomp [J. Acoust. Soc. Am. 63(2), 533-549 (1978)] can be used to describe SRT (dB signal-to-noise ratio) for 50% of sentences correct in stationary noise in normal-hearing (NH) ...
  • Risk prediction of cardiovascular disease in the Asia-Pacific region: The SCORE2 Asia-Pacific model 
    Abdullah, Noraidatulakma; Abdul Jalal, Muhammad Irfan; Barr, Elizabeth L.M.; Chamnan, Parinya; Chong, Chean Lin; Cuenza, Lucky; Gao, Pei; Graham, Ian; Hilal, Saima; Holtrop, Joris; Jamal, Rahman; Kalhan, Tosha Ashish; Kaneko, Hidehiro; Lee, Chi Ho; Lim, Charlie G.Y.; Liu, Xiaofei; Magliano, Dianna J.; Motamed, Nima; Moradi-Lakeh, Maziar; Ong, Sok King; Perera, Ruwanthi; Prasad, Kameshwar; Shaw, Jonathan E.; De Silva, Janaka; Sim, Xueling; Suzuki, Yuta; Tan, Kathryn C.B.; Tang, Xun; Venkataraman, Kavita; Wickremasinghe, Rajitha; Yasunaga, Hideo; Zamani, Farhad; Hageman, Steven H.J.; Huang, Zijuan; Lee, Hokyou; Kaptoge, Stephen; Dorresteijn, Jannick A.N.; Pennells, Lisa; Di Angelantonio, Emanuele; Visseren, Frank L.J.; Kim, Hyeon Chang; Johar, Sofian; Di Angelantonio, Emanuele; Papadakis, Michael; Timmis, Adam; Aboyans, Victor; Vardas, Panos; McEvoy, John William; Kavousi, Maryam; Ferrieres, Jean; SCORE2 Asia-Pacific writing group,European Society of Cardiology and European Association of Preventive Cardiology: Cardiovascular Risk Collaboration (ESC CRC), the ASEAN Federation of Cardiology (AFC), and the Asian-Pacific Society of Cardiology (APSC) (Oxford University Press, 2025-02-21)
    Background and Aims: To improve upon the estimation of 10-year cardiovascular disease (CVD) event risk for individuals without prior CVD or diabetes mellitus in the Asia-Pacific region by systematic recalibration of the ...
  • Autonomy and prevention: From conflicting to complementary aims of prenatal screening 
    Dondorp, Wybo; de Wert, Guido; Becking, Ellis C.; Scheffer, Peter G.; Bekker, Mireille; Henneman, Lidewij (2025-03-01)
    From an ethical point of view, there is an important distinction between two types of prenatal screening. The first of these targets maternal or foetal conditions (e.g., infectious diseases, blood group sensitization) where ...
  • Long-term hemodynamic responses and reverse remodeling after pharmacotherapy in HFpEF versus HFrEF: a systematic review and meta-analysis 
    van de Bovenkamp, Arno A.; Nassiri, Soufiane; Bakermans, Adrianus J.; Burchell, George L.; de Man, Frances S.; van Loon, Ramon B.; Handoko, M. Louis (American Physiological Society, 2025-03-01)
    The acute response to therapeutic afterload reduction differs between heart failure with preserved (HFpEF) versus reduced ejection fraction (HFrEF), with larger left ventricular (LV) stroke work augmentation in HFrEF ...
  • Managing hydrocephalus in 54 infants under 3 months of age: A single center cohort study 
    Van Rijen, S. R.M.; Groenendaal, F.; Han, K. S.; Tataranno, M. L.; Woerdeman, P. A. (Springer-Verlag, 2025-02-18)
    PURPOSE: Managing hydrocephalus in infants can be very challenging. The most used permanent hydrocephalus treatment in young patients is a ventriculoperitoneal shunt (VPS) placement. Obstructive hydrocephalus in selected ...
  • Profiling and semi-quantitation of urine sulfatides by UHPLC-Orbitrap-HRMS 
    van der Ham, Maria; Hoytema van Konijnenburg, Eva; van Rossum, Wouter; Gerrits, Johan; van Hasselt, Peter; Prinsen, Hubertus; Jans, Judith; Schlotawa, Lars; Laugwitz, Lucia; de Sain-van der Velden, Monique (Elsevier, 2025-05-08)
    Background: Sulfatides are a class of sphingolipids which are abundant in the myelin sheet and oligodendrocytes, therefore they play a crucial role in the nervous system. Abnormal sulfatide excretion has been linked to ...
  • B cell stimulation changes the structure and higher-order organization of the inactive X chromosome 
    Sierra, Isabel; Toothacre, Natalie E.; van der Weide, Robin H.; Lovell, Claudia D.; Nguyen, Son C.; Barnett, R. Jordan; Cook, Ashley L.; Ryu, Han Seul; Pyfrom, Sarah; Wang, Harrison; Beiting, Daniel; Philips-Cremins, Jennifer E.; Joyce, Eric F.; Anguera, Montserrat C. (Cell Press, 2025-03-25)
    X chromosome inactivation (XCI) equalizes X-linked gene expression between sexes. B cells exhibit dynamic XCI, with Xist RNA/heterochromatic marks absent on the inactive X (Xi) in naive B cells but returning following ...
  • Resectability assessment of colorectal liver metastases by an expert panel: Potential impact on hospitals referring patients for local treatment 
    Bond, Marinde J.G.; Verhoef, Cornelis; Kazemier, Geert; Kok, Niels F.M.; Gerhards, Michael F.; Kuhlmann, Koert F.D.; Leclercq, Wouter K.G.; Rijken, Arjen M.; Liem, Mike S.L.; de Wilt, Johannes H.W.; Klaase, Joost M.; Chapelle, Thiery; Grünhagen, Dirk J.; Molenaar, I. Quintus; van Dam, Ronald R.M.; May, Anne M.; Punt, Cornelis J.A.; Swijnenburg, Rutger Jan (W.B. Saunders Ltd, 2025-06)
    Background: Patients with colorectal liver-only metastases (CRLM) eligible for local treatment (resection/ablation) do not always receive this potentially curative treatment due to the lack of clear resectability criteria ...
  • Case-mix adjustment for between-hospital comparisons in oesophageal and gastric cancer surgery 
    van der Linde, Margrietha; Visser, Maurits R.; Eijkenaar, Frank; Oude Voshaar, Martijn A.H.; van Hillegersberg, Richard; van Sandick, Johanna W.; van Berge Henegouwen, Mark I.; Wijnhoven, Bas P.L.; Lingsma, Hester F.; Dutch Upper Gastrointestinal Cancer Audit (DUCA) Group (W.B. Saunders Ltd, 2025-06)
    Background: Clinical and pathological outcomes of oesophagogastric cancer surgery are used for benchmarking hospital performance. The extent to which case-mix adjustment is required for valid hospital comparisons is unknown. ...
  • Adherence to Mediterranean-Like Dietary Pattern in Association with Gastroesophageal Reflux Disease in Adolescents 
    AhmadiVasmehjani, Azam; Beigrezaei, Sara; Nafei, Zahra; Behniafard, Nasrin; Darabi, Zahra; Salehi-Abargouei, Amin; Aflatoonian, Majid (Shahid Sadoughi University of Medical Sciences, 2025-02)
    Background: Gastroesophageal reflux disease (GERD) is a common esophageal disorder affecting adolescents. Recent studies have indicated that the risk of GERD may be influenced by different dietary patterns. This study aimed ...
  • Digital technologies in genetic counseling: Recommendations for a morally sound integration 
    van Lingen, Marlies N.; Giesbertz, Noor A.A.; Jongsma, Karin R. (Lippincott Williams & Wilkins, 2025-04)
    To address the increasing demand for clinical genetic counseling, digital technologies are currently being developed to increase efficiency and overcome logistical and societal barriers in genetic health care. However, it ...