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UMC Repository: Recent submissions

  • Heritability of menopausal age in mothers and daughters 
    van Asselt, Kristel M.; Kok, Helen S.; Pearson, Peter L.; Dubas, Judith S.; Peeters, Petra H. M.; te Velde, Egbert R.; van Noord, Paulus A. H. (Elsevier, 2004)
    Objective: To determine the heritability of age at natural menopause from mother-daughter pairs. Design: Two-generation families were selected to study heritability of menopausal age. Setting: Subjects were drawn from a ...
  • Audit and Feedback Interventions for Antibiotic Prescribing in Primary Care: A Systematic Review and Meta-analysis 
    Xu, Alice X.T.; Brown, Kevin; Schwartz, Kevin L.; Aghlmandi, Soheila; Alderson, Sarah; Brehaut, Jamie C.; Brown, Benjamin C.; Bucher, Heiner C.; Clarkson, Janet; De Sutter, An; Francis, Nick A.; Grimshaw, Jeremy; Gunnarsson, Ronny; Hallsworth, Michael; Hemkens, Lars; Høye, Sigurd; Khan, Tasneem; Lecky, Donna M.; Leung, Felicia; Leung, Jeremy; Lindbæk, Morten; Linder, Jeffrey A.; Llor, Carl; Little, Paul; O'connor, Denise; Pulcini, Cline; Ramlackhan, Kalisha; Ramsay, Craig R.; Sundvall, Pär Daniel; Taljaard, Monica; Touboul Lundgren, Pia; Vellinga, Akke; Verbakel, Jan Y.; Verheij, Theo J.; Wikberg, Carl; Ivers, Noah (Oxford University Press, 2025-02-15)
    Background: This systematic review evaluates the effect of audit and feedback (A&F) interventions targeting antibiotic prescribing in primary care and examines factors that may explain the variation in effectiveness. ...
  • Low coverage of hepatitis D virus testing in individuals with hepatitis B virus and HIV, the Netherlands, 2000 to 2022 
    Boyd, Anders; Smit, Colette; van der Eijk, Annemiek A.; Zaaijer, Hans; Rijnders, Bart J.A.; van Welzen, Berend; Claassen, Mark A.A.; Pogány, Katalin; de Vries-Sluijs, Theodora E.M.S.; de Coul, Eline Op; van der Valk, Marc; ATHENA observational cohort (Centre Europeen pour la Surveillance Epidemiologique du SIDA, 2025-02-20)
    Background: Since 2009, European guidelines recommend individuals with hepatitis B virus (HBV) and HIV be tested for hepatitis D virus (HDV). Aim: To analyse HDV testing in individuals with HBV/HIV during routine practice ...
  • Local delivery of lipid-based nanoparticles containing microbial nucleic acid for osteoimmunomodulation 
    Rahmani, N. R.; Jahanmard, F.; Hassani Najafabadi, A.; Flapper, J.; Dogan, O.; Khodaei, A.; Storm, G.; Croes, M.; Kruyt, M. C.; Gawlitta, D.; Weinans, H.; Mastrobattista, E.; Amin Yavari, S. (Elsevier, 2025-05-01)
    Osteoimmunomodulation is a strategy to promote bone regeneration in implants by modifying the immune environment. CpG-containing oligonucleotides type C (CpG ODN C) and Polyinosinic:polycytidylic acid (Poly[I:C]) are analogs ...
  • Developmental trajectories of gyrification and sulcal morphometrics in children and adolescents at high familial risk for bipolar disorder or schizophrenia 
    Poortman, Simon R.; Jamarík, Jakub; ten Harmsen van der Beek, Louise; Setiaman, Nikita; Hillegers, Manon H.J.; Barendse, Marjolein E.A.; van Haren, Neeltje E.M. (Elsevier, 2025-04)
    Offspring of parents with severe mental illness are at increased risk of developing psychopathology. Identifying endophenotypic markers in high-familial-risk individuals can aid in early detection and inform development ...
  • Fast Analgesic Effect in Response Test with Topical Phenytoin Cream Correlates with Prolonged Pain Relief After Extended Use in Painful Diabetic Neuropathy 
    Kopsky, David J.; Vrancken, Alexander F.J.E.; van Eijk, Ruben P.A.; Alvarez-Jimenez, Ricardo; Szadek, Karolina M.; Liebregts, Remko; Steegers, Monique A.H. (Multidisciplinary Digital Publishing Institute, 2025-02)
    Background: Treatment of painful diabetic neuropathy (PDN) poses several challenges due to the limited effectiveness, high incidence of side effects, and potential drug interactions of oral neuropathic pain medication. ...
  • Signal transduction pathway activity in adult-type granulosa cell tumor samples 
    Brink, G. J.; Groeneweg, J. W.; van der Ploeg, P.; Jonges, G. N.; Gort, E. H.; Witteveen, P. O.; Zweemer, R. P.; Piek, J. M.J. (Academic Press Inc., 2025-04)
    Objective: This study aims to evaluate signal transduction pathway (STP) activity in adult-type granulosa cell tumors (aGCT) in order to identify potential therapeutic targets. These results are compared with STP activity ...
  • Training refugee and asylum seeking healthcare professionals: an ethical approach to UK workforce challenges 
    Awan, Aisha; Browne, Joyce L.; Ibrahim, Abdelnasser; Butler, Ceri; Drovandi, Aaron (BMJ Publishing Group, 2025-02-18)
  • Raising a child bereaved by domestic homicide: caregivers' experiences 
    Alisic, Eva; Groot, Arend; Snetselaar, Hanneke; Stroeken, Tielke (Co-Action Publishing, 2025)
    Background: Optimising support for children and families affected by fatal family violence requires understanding all aspects of their experience. So far, little is known regarding the views of those who provide a home to ...
  • Exploring Experiences and Designing Guidance for Involving and Engaging Children and Young People in James Lind Alliance Priority Setting Partnerships 
    Postma, Laura; Gibson, Faith; Jagt, Jasmijn Z.; Aussems, Karijn; Barrett, Helen; Luchtenberg, Malou; Schoemaker, Casper G.; Temple, Rachel K.; Aldiss, Susie (Wiley-Blackwell, 2025-04)
    Introduction: Setting research priorities together with children and young people (CYP) in James Lind Alliance (JLA) Priority Setting Partnerships (PSPs) is an example of involving CYP from the beginning of the research ...
  • Characterising the SARS-CoV-2 nucleocapsid (N) protein antibody response 
    Noble, C. C.A.; McDonald, E.; Nicholson, S.; Biering-Sørensen, S.; Pittet, L. F.; Byrne, A. L.; Croda, J.; Dalcolmo, M.; Lacerda, M. V.G.; Lucas, M.; Lynn, D. J.; Prat Aymerich, C.; Richmond, P. C.; Warris, A.; Curtis, N.; Messina, N. L. (W.B. Saunders Ltd, 2025-03)
    Objectives: SARS-CoV-2 nucleocapsid (N) protein antibodies can be used to identify the serological response to natural infection in those who have previously received a COVID-19 spike-based vaccine. Anti-N antibody responses ...
  • Risk of lymph node metastasis in pT2 rectal cancer: A nationwide retrospective analysis 
    behalf of the Dutch Snapshot Research Group and MIRECA (Taskforce for Minimally Invasive Rectal Carcinoma surgery (John Wiley & Sons Inc., 2025-02-01)
  • Nationwide implementation of the international multidisciplinary best-practice for locally advanced pancreatic cancer (PREOPANC-4): study protocol 
    Stoop, T. F.; Seelen, L. W.F.; van 't Land, F. R.; van der Hout, A. C.; Scheepens, J. C.M.; Ali, M.; Stiggelbout, A. M.; van der Kolk, B. M.; Bonsing, B. A.; Lips, D. J.; de Groot, D. J.A.; van Veldhuisen, E.; Kerver, E. D.; Manusama, E. R.; Daams, F.; Kazemier, G.; Cirkel, G. A.; van Tienhoven, G.; Patijn, G. A.; Lelieveld-Rier, H. N.; de Hingh, I. H.; van Hellemond, I. E.G.; Wijsman, J. H.; Erdmann, J. I.; Dutch Pancreatic Cancer Group (BioMed Central, 2025-02-19)
    BACKGROUND: The introduction of (m)FOLFIRINOX and gemcitabine-nab-paclitaxel has changed the perspective for patients with locally advanced pancreatic cancer (LAPC). Consequently, in experienced centres 23% of patients ...
  • Impact of increased diagnosis of early HIV infection and immediate antiretroviral treatment initiation on HIV transmission among men who have sex with men in the Netherlands 
    Teslya, Alexandra; Heijne, Janneke Cornelia Maria; van der Loeff, Maarten Franciscus Schim; van Sighem, Ard; Roberts, Jacob Aiden; Dijkstra, Maartje; de Bree, Godelieve J.; Schmidt, Axel Jeremias; Jonas, Kai J.; Kretzschmar, Mirjam E.; Rozhnova, Ganna (Public Library of Science, 2025-02)
    The number of new HIV infections among men who have sex with men (MSM) in the Netherlands has been decreasing, but additional efforts are required to bring it further down. This study aims to assess the impact of increased ...
  • Streptococcus pyogenes emm Type 3.93 Emergence, the Netherlands and England 
    Davies, Matthew A.; de Gier, Brechje; Guy, Rebecca L.; Coelho, Juliana; van Dam, Alje P.; van Houdt, Robin; Matamoros, Sébastien; van den Berg, Marit; Habermehl, Patrick E.; Moganeradj, Kartyk; Ryan, Yan; Platt, Steve; Hearn, Henry; Blakey, Eleanor; Chooneea, Darren; Vlaminckx, Bart J.M.; Lamagni, Theresa; van Sorge, Nina M. (Centers for Disease Control and Prevention (CDC), 2025-02)
    A global increase in the incidence of invasive group A Streptococcus (iGAS) infections was observed after lifting of COVID-19 related restrictions in 2022, and type M1UK dominated in many countries. After seasonal declines ...
  • Tailoring evidence to clinical practice 
    van der Harst, Pim (Bohn Stafleu van Loghum, 2025-02)
  • Treatment-Free Remission Outcomes in a BCR::ABL1 Digital PCR Selected Clinical Cohort of CML Patients 
    Kockerols, C.; Valk, P. J.M.; Hogenbirk, P.; Geelen, I.; Blijlevens, N. M.A.; Janssen, J. J.W.M.; Hoogendoorn, M.; Kersting, S.; Klein, S. K.; Daenen, L. G.M.; Donker, M.; te Boekhorst, P. A.W.; Jie, K. S.G.; Corsten, M.; Cruijsen, M. J.; Levenga, H.; Smit, W. M.; Levin, M. D.; de Jongh, E.; de Jonge, S.; Vlot, A. J.; Durian, M. F.; Zwaginga, J. J.; Mohlmann, M.; Wustman, T. J.; Blommers, R.; Cornelissen, J. J.; Westerweel, P. E.; Collaborating Authors (Wiley-Blackwell, 2025-05)
    Approximately 40%–60% of patients reaching a stable deep molecular response during TKI treatment will maintain a state of remission after TKI discontinuation, denoted as treatment-free remission (TFR). Depth of molecular ...
  • Correction to: Neutralizing GDF-15 can overcome anti-PD-1 and anti-PD-L1 resistance in solid tumours (Nature, (2025), 637, 8048, (1218-1227), 10.1038/s41586-024-08305-z) 
    Melero, Ignacio; de Miguel Luken, Maria; de Velasco, Guillermo; Garralda, Elena; Martín-Liberal, Juan; Joerger, Markus; Alonso, Guzman; Goebeler, Maria Elisabeth; Schuler, Martin; König, David; Dummer, Reinhard; Reig, Maria; Rodriguez Ruiz, Maria Esperanza; Calvo, Emiliano; Esteban-Villarrubia, Jorge; Oberoi, Arjun; Sabat, Paula; Soto-Castillo, Juan José; Koster, Kira Lee; Saavedra, Omar; Sayehli, Cyrus; Gromke, Tanja; Läubli, Heinz; Ramelyte, Egle; Fortuny, Marta; Landa-Magdalena, Ana; Moreno, Irene; Torres-Jiménez, Javier; Hernando-Calvo, Alberto; Hess, Dagmar; Racca, Fabricio; Richly, Heike; Schmitt, Andreas M.; Eggenschwiler, Corinne; Sanduzzi-Zamparelli, Marco; Vilalta-Lacarra, Anna; Trojan, Jörg; Koch, Christine; Galle, Peter R.; Foerster, Friedrich; Trajanoski, Zlatko; Hackl, Hubert; Gogolla, Falk; Koll, Florestan J.; Wild, Peter; Chun, Felix Kyoung Hwan; Reis, Henning; Lloyd, Peter; Machacek, Matthias; Gajewski, Thomas F.; Fridman, Wolf H.; Eggermont, Alexander M.M.; Bargou, Ralf; Schöniger, Sandra; Rüschoff, Josef; Tereshchenko, Anastasiia; Zink, Carina; da Silva, Antonio; Lichtenegger, Felix S.; Akdemir, Julia; Rüdiger, Manfred; L’Huillier, Phil; Dutta, Aradhana; Haake, Markus; Auckenthaler, Alexandra; Gjorgjioska, Ana; Rössler, Bernhard; Hermann, Frank; Liebig, Mara; Reichhardt, Daniela; Schuberth-Wagner, Christine; Wischhusen, Jörg; Fettes, Petra; Auer, Marlene; Klar, Kathrin; Leo, Eugen (Nature Research, 2025)
    Correction to: Naturehttps://doi.org/10.1038/s41586-024-08305-z Published online 11 December 2024 In the version of the article initially published, the affiliation of Ralf Bargou was incorrect and has now been amended to ...
  • Medication adherence of patients with peripheral arterial disease to antithrombotic therapy: a systematic review 
    Wegerif, Emilien C.J.; Mol, Barend M.; Ünlü, Çağdaş; de Borst, Gert J. (BMJ Publishing Group, 2025-02-22)
    Objectives Antithrombotic therapy (ATT) prevents atherothrombotic events (AE) in patients with peripheral arterial disease (PAD). However, the benefit may be compromised by poor medication adherence (MA). Therefore, our ...
  • 2021 European Society of Cardiology guidelines on cardiac pacing and cardiac resynchronisation therapy: Statement of endorsement by the NVVC 
    Maass, Alexander H.; Tuinenburg, Anton; Mairuhu, Gideon; Faes, Miriam C.; Klinkenberg, Theo J.; Ruigrok, Sanne; Koster, Marjolein; Stegeman, Bernardine H.; Luermans, Justin G.L.M. (Bohn Stafleu van Loghum, 2025-02)
    The European Society of Cardiology (ESC) has updated its guidelines on cardiac pacing and cardiac resynchronisation. As the majority are class II recommendations (61%) and based on expert opinion (59%), a critical appraisal ...