BACKGROUND: Clinical machine learning research and artificial intelligence driven clinical decision support models rely on clinically accurate labels. Manually extracting these labels with the help of clinical specialists ...

Objective: To evaluate the impact of postoperative radiotherapy (PORT) on oncological outcomes in node-negative early-stage oral squamous cell carcinoma (OSCC) with perineural invasion (PNI). Methods: A systematic review ...

Objectives: The menopause transition increases the risk of chronic conditions in women. Given the crucial role of diet in health, we identified dietary patterns that explain variations in factors related to major health ...

Background: The equivalent dipole layer (EDL) relates local endocardial and epicardial transmembrane potentials to body surface potentials and can therefore be used to gain insight into cardiac activation and recovery. To ...

The cytokine interferon-gamma plays a multifaceted role in intestinal immune responses ranging from anti- to proinflammatory depending on the setting. Here, using a 3D co-culture system based on human intestinal epithelial ...

PURPOSE Treatment stratification in ALL includes diverse (cyto)genetic aberrations, requiring diverse tests to yield conclusive data. We optimized the diagnostic workflow to detect all relevant aberrations with a limited ...

Due to the minimal survival benefits of existing therapies for pediatric diffuse midline glioma (DMG) patients, new therapeutic modalities are being investigated. Immunotherapies such as CAR-T cells and oncolytic viruses ...