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UMC Repository: Recent submissions

  • Fasciculation distribution in a healthy population assessed with diffusion tensor imaging 
    Heskamp, Linda; Schlaffke, Lara; Forsting, Johannes; Sleutjes, Boudewijn T H M; Goedee, H Stephan; Froeling, Martijn (John Wiley & Sons Inc., 2025-03)
    Fasciculations, a hallmark of motor neuron diseases, also occur in healthy individuals, highlighting the need to understand fasciculation intensity and distribution. Motor unit MRI (MUMRI) can assess fasciculations in large ...
  • Enhancing work environments and reducing turnover intention: a multicenter longitudinal cohort study on differentiated nursing practices in Dutch hospitals 
    RN2Blend consortium (BioMed Central, 2025-01-10)
    Background: Addressing the growing challenge of nurse retention requires coordinated actions at national and global levels to improve recruitment, retention policies, and investments in the nursing work environment. The ...
  • Reprint of: From medical editors: a call to the global infectious diseases and clinical microbiology community 
    Huttner, Angela; Bonten, Marc; Davis, Joshua; Leibovici, Leonard; Tängdén, Thomas; Schwartz, Ilan (Elsevier, 2025-04)
  • Advancing Therapeutic Drug Monitoring for Oral Targeted Anticancer Drugs: From Hospital-Based Towards Home-Sampling 
    Meertens, Marinda; Rosing, Hilde; Steeghs, Neeltje; Beijnen, Jos H; Huitema, Alwin D R (John Wiley & Sons Inc., 2025-05)
    Home-sampling for therapeutic drug monitoring (TDM) for oral targeted anticancer drugs offers a promising alternative to traditional hospital-based sampling methods, though it presents challenges. This review aims to ...
  • Long-read sequencing identifies copy-specific markers of SMN gene conversion in spinal muscular atrophy 
    Zwartkruis, M M; Elferink, M G; Gommers, D; Signoria, I; Blasco-Pérez, L; Costa-Roger, M; van der Sel, J; Renkens, I J; Green, J W; Kortooms, J V; Vermeulen, C; Straver, R; van Deutekom, H W M; Veldink, J H; Asselman, F; Tizzano, E F; Wadman, R I; van der Pol, W L; van Haaften, G W; Groen, E J N (BioMed Central, 2025-03-21)
    BACKGROUND: The complex 2 Mb survival motor neuron (SMN) locus on chromosome 5q13, including the spinal muscular atrophy (SMA)-causing gene SMN1 and modifier SMN2, remains incompletely resolved due to numerous segmental ...
  • Problem Solved?: An Individual Ratio between Point-of-Care and Venous International Normalized Ratio Values in Two Patients with Antiphospholipid Syndrome: Two Case Reports 
    Geertsema-Hoeve, Bettina C; Radin, Massimo; Sciascia, Savino; Urbanus, Rolf T; Huisman, Albert; Borgsteede-de Wilde, Josine; Limper, Maarten (Thieme, 2025)
    Antiphospholipid syndrome (APS) is a rare autoimmune disorder characterized by thromboembolic and obstetric complications in the presence of persistent antiphospholipid antibodies (aPL). Treatment aims to prevent recurrent ...
  • European Association of Urology Guidelines on Muscle-invasive and Metastatic Bladder Cancer: Summary of the 2025 Guidelines 
    van der Heijden, Antoine G; Bruins, Harman Max; Carrion, Albert; Cathomas, Richard; Compérat, Eva; Dimitropoulos, Konstantinos; Efstathiou, Jason A; Fietkau, Rainer; Kailavasan, Mithun; Lorch, Anja; Martini, Alberto; Mertens, Laura S; Meijer, Richard P; Mariappan, Param; Milowsky, Matthew I; Neuzillet, Yann; Panebianco, Valeria; Sæbjørnsen, Sæbjørn; Smith, Emma J; Thalmann, George N; Rink, Michael (Elsevier, 2025-05)
    BACKGROUND AND OBJECTIVE: This publication represents a summary of the updated 2025 European Association of Urology (EAU) guidelines for muscle-invasive and metastatic bladder cancer (MMIBC). The aim is to provide practical ...
  • Development of GROVE: A Guideline for RepOrting Vignette Experiments conducted in a healthcare context 
    Hillen, Marij A; Visser, Leonie N C; Labrie, Nanon H M; van Vliet, Liesbeth M; Saha, Som; Blanch-Hartigan, Danielle; Smets, Ellen M A; GROVE Working group (Elsevier Ireland Ltd, 2025-07)
    OBJECTIVE: Experimental studies using vignettes investigate the impact of healthcare professional or patient/client characteristics, communication, and/or other behaviors on outcomes. To ensure methodological rigor and ...
  • Management of patients with small pancreatic neuroendocrine tumors from a biomarker and surgical perspective 
    Verschuur, Anna Vera D; Chen, Lin; Nieveen van Dijkum, Els J; Luchini, Claudio; Halfdanarson, Thorvardur R; Hong, Seung-Mo; Singhi, Aatur D; Brosens, Lodewijk A A; Heaphy, Christopher M (BioScientifica Ltd., 2025-05)
    Pancreatic neuroendocrine tumors (PanNETs) have an age-adjusted incidence of 1.5 per 100,000 people, with a notable rise in the incidence of small (≤2 cm) non-functional PanNETs (NF-PanNETs) in recent decades. While surgery ...
  • Probast+ai: an updated quality, risk of bias, and applicability assessment tool for prediction models using regression or artificial intelligence methods 
    Moons, Karel G M; Damen, Johanna A A; Kaul, Tabea; Hooft, Lotty; Andaur Navarro, Constanza; Dhiman, Paula; Beam, Andrew L; Van Calster, Ben; Celi, Leo Anthony; Denaxas, Spiros; Denniston, Alastair K; Ghassemi, Marzyeh; Heinze, Georg; Kengne, André Pascal; Maier-Hein, Lena; Liu, Xiaoxuan; Logullo, Patricia; McCradden, Melissa D; Liu, Nan; Oakden-Rayner, Lauren; Singh, Karandeep; Ting, Daniel S; Wynants, Laure; Yang, Bada; Reitsma, Johannes B; Riley, Richard D; Collins, Gary S; van Smeden, Maarten (BMJ Publishing Group, 2025-03-24)
  • The Moderating Role of Genetic and Environmental Risk Factors for Schizophrenia on the Relationship between Autistic Traits and Psychosis Expression in the General Population 
    Karacam Dogan, Melike; Prachason, Thanavadee; Lin, Bochao; Pries, Lotta-Katrin; Arias-Magnasco, Angelo; Bortoletto, Riccardo; Menne-Lothmann, Claudia; Decoster, Jeroen; van Winkel, Ruud; Collip, Dina; Delespaul, Philippe; De Hert, Marc; Derom, Catherine; Thiery, Evert; Jacobs, Nele; van Os, Jim; Rutten, Bart; Brondino, Natascia; Colizzi, Marco; Luykx, Jurjen; Fusar-Poli, Laura; Guloksuz, Sinan (Oxford University Press, 2025-01)
    Background: Psychosis-related environmental risks in autism, along with genetic overlaps between autism and psychosis, have been well-established. However, their moderating roles in the relationship between autistic traits ...
  • Robotic- assisted minimally invasive Ivor-Lewis handsewn anastomosis technique and outcomes from a large-volume European centre 
    Ng, Annalisa Y L; Goense, Lucas; Van De Horst, Sylvia; Van Den Berg, Jan Willem; Ruurda, Jelle P; Van Hillegersberg, Richard (Wiley-Blackwell, 2025-04)
    In minimally invasive transthoracic esophagectomy, intrathoracic anastomoses are usually performed with stapling devices to avoid a technically challenging handsewn technique in the upper mediastinum. Few have published ...
  • Recovery of cardiovascular diagnostic testing in Italy 1 year after coronavirus disease-2019 outbreak compared with other countries in Europe and worldwide: results from the International Atomic Energy Agency INCAPS COVID 2 survey 
    Pontone, Gianluca; Bremner, Luca; Del Torto, Alberico; Albano, Domenico; Baritussio, Anna; Bauckneht, Matteo; Cuocolo, Alberto; Frantellizzi, Viviana; Gatti, Marco; Gimelli, Alessia; Guglielmo, Marco; Leccisotti, Lucia; Marcassa, Claudio; Russo, Vincenzo; Sciagrà, Roberto; Williams, Michelle C; Better, Nathan; Cerci, Rodrigo; Choi, Andrew D; Dorbala, Sharmila; Hirschfeld, Cole B; Karthikeyan, Ganesan; Pascual, Thomas N B; Shaw, Leslee J; Villines, Todd C; Vitola, Joao; Cohen, Yosef; Malkovskiy, Eli; Randazzo, Michael; Pynda, Yaroslav; Dondi, Maurizio; Einstein, Andrew J; Paez, Diana (2024-01)
    AIMS: Recovery of cardiovascular diagnostic testing in Italy after the coronavirus disease-2019 (COVID-19) pandemic has not been quantified. The study aims to describe cardiac diagnostic procedure volumes, centres practice ...
  • Staphylococcus aureus-specific TIGIT+ Treg are present in the blood of healthy subjects - a hurdle for vaccination? 
    Clegg, Jonah; Mnich, Malgorzata E; Carignano, Alberto; Cova, Giovanni; Tavarini, Simona; Sammicheli, Chiara; Clemente, Bruna; Smith, Megan; Siena, Emilio; Bardelli, Monia; Brazzoli, Michela; Bagnoli, Fabio; McLoughlin, Rachel M; Soldaini, Elisabetta (Frontiers Media S. A., 2024)
    Staphylococcus aureus poses an enormous burden of morbidity and mortality worldwide. Making an efficacious vaccine has however proven extremely challenging. Due to colonizing interactions, pre-existing S. aureus-specific ...
  • Shear wave elastography to unmask differences in myocardial stiffness between athletes and sedentary non-athletes 
    Taha, Karim; Bekhuis, Youri; de Bosscher, Ruben; Dausin, Christophe; Orlowska, Marta; Youssef, Ahmed S; Bézy, Stéphanie; Cornelissen, Véronique; Herbots, Lieven; Willems, Rik; Voigt, Jens-Uwe; D'hooge, Jan; Claessen, Guido (2024-10)
    AIMS: Myocardial stiffening naturally occurs with aging and contributes to diastolic dysfunction. Assessing myocardial stiffness non-invasively could improve the sensitivity of diastolic function evaluation in clinical ...
  • Erratum to “Unhealthy lifestyle behaviors, overweight, and obesity among childhood cancer survivors in the Netherlands: A DCCSS LATER study” 
    Bouwman, Eline; Penson, Adriaan; de Valk, Maud; van den Oever, Selina R; van der Pal, Helena J H; van Dulmen-den Broeder, Eline; Blijlevens, Nicole M A; Bresters, Dorine; Feijen, Elizabeth A M; van den Heuvel-Eibrink, Marry M; van der Heiden-van der Loo, Margriet; Michel, Gisela; Ronckers, Cécile M; Teepen, Jop C; Tissing, Wim J E; Versluys, Birgitta A B; Kremer, Leontien C M; Pluijm, Saskia M F; Loonen, Jacqueline J; Dutch LATER Study Group and the PanCareFollowUp Consortium (John Wiley & Sons Inc., 2025-01-01)
    This erratum corrects the following: Bouwman E, Penson A, de Valk M, et al. Unhealthy lifestyle behaviors, overweight, and obesity among childhood cancer survivors in the Netherlands: A DCCSS LATER study. Cancer. ...
  • Unhealthy lifestyle behaviors, overweight, and obesity among childhood cancer survivors in the Netherlands: A DCCSS LATER study 
    Bouwman, Eline; Penson, Adriaan; de Valk, Maud; van den Oever, Selina R; van der Pal, Helena J H; van Dulmen-den Broeder, Eline; Blijlevens, Nicole M A; Bresters, Dorine; Feijen, Elizabeth A M; van den Heuvel-Eibrink, Marry M; van der Heiden-van der Loo, Margriet; Michel, Gisela; Ronckers, Cécile M; Teepen, Jop C; Tissing, Wim J E; Versluys, Birgitta A B; Kremer, Leontien C M; Pluijm, Saskia M F; Loonen, Jacqueline J; Dutch LATER Study Group and the PanCareFollowUp Consortium (John Wiley & Sons Inc., 2024-08-15)
    Background: The objective of this study was to examine the prevalence of unhealthy lifestyle behaviors, overweight, and obesity in Dutch childhood cancer survivors (CCSs) compared with sibling controls and the Dutch general ...
  • Barriers, facilitators, and other factors associated with health behaviors in childhood, adolescent, and young adult cancer survivors: A systematic review 
    de Beijer, Ismay A E; Bouwman, Eline; Mulder, Renée L; Steensma, Philippa; Brown, Morven C; Araújo-Soares, Vera; Balcerek, Magdalena; Bardi, Edit; Falck Winther, Jeanette; Frederiksen, Line Elmerdahl; van Gorp, Marloes; Oberti, Sara; van Kalsbeek, Rebecca J; Kepak, Tomas; Kepakova, Katerina; Gsell, Hannah; Kienesberger, Anita; van Litsenburg, Raphaële; Mader, Luzius; Michel, Gisela; Muraca, Monica; van den Oever, Selina R; van der Pal, Helena J H; Roser, Katharina; Skinner, Roderick; Stolman, Iridi; Uyttebroeck, Anne; Kremer, Leontien C M; Loonen, Jacqueline; van Dalen, Elvira C; Pluijm, Saskia M F; PanCareFollowUp Consortium (John Wiley & Sons Inc., 2024-06)
    BACKGROUND: Healthy behaviors are paramount in preventing long-term adverse health outcomes in childhood, adolescent, and young adult (CAYA) cancer survivors. We systematically reviewed and synthesized existing literature ...
  • Donor cytomegalovirus serology impacts overall survival in children receiving first unrelated hematopoietic stem cell transplant for acute leukemia: European Society of Bone Marrow Transplantation Pediatric Diseases Working Party Study 
    Ince, Elif; Galimard, Jaques-Emmanuel; Ifversen, Marianne; Dalissier, Arnaud; Szmit, Zofia; Mirci-Danicar, Oana; Locatelli, Franco; Sedlacek, Petr; Styczynski, Jan; Dalle, Jean-Hugues; Renard, Cecile; Balduzzi, Adriana; Lankester, Arjan; Bierings, Marc; Fagioli, Franca; Kielsen, Katrine; Rialland, Fanny; Büchner, Jochen; Taskinen, Mervi; Wynn, Robert; Jubert, Charlotte; Michel, Gérard; Pichler, Herbert; Krivan, Gergely; Cesaro, Simone; Corbacioglu, Selim; Meisel, Roland; Kalwak, Krzysztof (Ferrata Storti Foundation, 2025-04)
  • Sex Differences in Frequency, Severity, and Distribution of Cerebral Microbleeds 
    Fandler-Höfler, Simon; Eppinger, Sebastian; Ambler, Gareth; Nash, Philip; Kneihsl, Markus; Lee, Keon-Joo; Lim, Jae-Sung; Shiozawa, Masayuki; Koga, Masatoshi; Li, Linxin; Lovelock, Caroline; Chabriat, Hugues; Hennerici, Michael; Wong, Yuen Kwun; Mak, Henry Ka Fung; Prats-Sanchez, Luis; Martínez-Domeño, Alejandro; Inamura, Shigeru; Yoshifuji, Kazuhisa; Arsava, Ethem Murat; Horstmann, Solveig; Purrucker, Jan; Lam, Bonnie Yin Ka; Wong, Adrian; Kim, Young Dae; Song, Tae-Jin; Lemmens, Robin; Uysal, Ender; Tanriverdi, Zeynep; Bornstein, Natan M; Ben Assayag, Einor; Hallevi, Hen; Molad, Jeremy; Nishihara, Masashi; Tanaka, Jun; Coutts, Shelagh B; Polymeris, Alexandros; Wagner, Benjamin; Seiffge, David J; Lyrer, Philippe; Kappelle, L Jaap; Al-Shahi Salman, Rustam; Hernandez, Maria Valdes; Jäger, Hans R; Lip, Gregory Y H; Fischer, Urs; El-Koussy, Marwan; Mas, Jean-Louis; Legrand, Laurence; Bos, Daniel; Microbleeds International Collaborative Network (American Medical Association, 2024-10-01)
    Importance: Cerebral small vessel disease (SVD) is associated with various cerebrovascular outcomes, but data on sex differences in SVD are scarce. Objective: To investigate whether the frequency, severity, and distribution ...