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  • A Hypothesized Therapeutic Role of (Z)-Endoxifen in Duchenne Muscular Dystrophy (DMD) 
    Remmel, H Lawrence; Hammer, Sandra S; Neff, Laurence A; Dorchies, Olivier M; Scapozza, Leonardo; Fischer, Dirk; Quay, Steven C (2025-03-15)
    Duchenne Muscular Dystrophy (DMD) is an inherited, X-linked disorder that is progressive, debilitating, and ultimately fatal. The current therapeutic landscape offers no cures, but does include palliative treatments that ...
  • Neutrophil phenotypes quantify tissue damage caused by major surgery 
    de Fraiture, Emma J; Reniers, Ted; Vreeman, Nathalie E W; Rettig, Thijs C D; van Santvoort, Hjalmar C; Bikker, Angela; Vrisekoop, Nienke; Koenderman, Leo; Hietbrink, Falco; Noordzij, Peter G (Frontiers Media S. A., 2025-03-07)
    INTRODUCTION: Major surgery triggers an innate immune response that can become excessive, leading to immune suppression and an increased risk of infection. Neutrophils are crucial in this response, and changes in their ...
  • Comparative Analysis of Methods for Assessing On-Target Gene Editing Efficiencies 
    Yao, Bing; Yang, Qiangbing; Gonçalves, Manuel A F V; Schiffelers, Raymond; Sluijter, Joost P G; Lei, Zhiyong (Multidisciplinary Digital Publishing Institute (MDPI), 2025-03-01)
    Genome editing based on CRISPR-derived technologies has become a cornerstone in both fundamental research and clinical applications. Accurately measuring editing efficiency is crucial for developing and applying genome ...
  • Air pollution exposure and incidence of cardiometabolic diseases: Exploring the modifying role of dietary antioxidant intake in adults 
    Mishra, Shradha; Vaartjes, Ilonca; van der Schouw, Yvonne T; Bijnens, Esmée M; Boer, Jolanda M A; Downward, George S; Vermeulen, Roel C H; Verschuren, W Monique M; Nawrot, Tim S; Timmermans, Erik J (Elsevier, 2025-05)
    While the antioxidative potential of certain vitamins and minerals in cardio-protection has garnered increasing interest, their ability to attenuate associations between air pollution exposure and cardiometabolic diseases ...
  • Identification of a SNAI1 enhancer RNA that drives cancer cell plasticity 
    Fan, Chuannan; Wang, Qian; Krijger, Peter H L; Cats, Davy; Selle, Miriam; Khorosjutina, Olga; Dhanjal, Soniya; Schmierer, Bernhard; Mei, Hailiang; de Laat, Wouter; Ten Dijke, Peter (Nature Publishing Group, 2025-03-25)
    Enhancer RNAs (eRNAs) are a pivotal class of enhancer-derived non-coding RNAs that drive gene expression. Here we identify the SNAI1 enhancer RNA (SNAI1e; SCREEM2) as a key activator of SNAI1 expression and a potent enforcer ...
  • Assessing differential application of thromboprophylaxis regimes related to risk of pulmonary embolism and mortality in COVID-19 patients through instrumental variable analysis 
    Nab, Linda; Visser, Chantal; van Bussel, Bas C T; Beishuizen, Albertus; Bemelmans, Remy H H; Ten Cate, Hugo; Croles, F Nanne; van Guldener, Coen; de Jager, C Peter C; Huisman, Menno V; Nijziel, Marten R; Kamphuisen, Pieter W; Klok, Frederikus A; Koster, Stephanie C E; Kuşadasi, Nuray; Meijer, Karina; den Uil, Corstiaan A; Schutgens, Roger E G; Stam, Frank; Vlaar, Alexander P J; Vlot, Eline A; Linschoten, Marijke P M; Asselbergs, Folkert W; Kruip, Marieke J H A; le Cessie, Saskia; Cannegieter, Suzanne C; Dutch Covid and Thrombosis Coalition & the CAPACITY-COVID collaborative consortium (Nature Publishing Group, 2025-03-25)
    Thrombotic complications are common in Coronavirus disease 2019 (COVID-19) patients, with pulmonary embolism (PE) being the most frequent. Randomised trials have provided inconclusive results on the optimal dosage of ...
  • Trachelectomy and Cerclage Placement as Fertility-Sparing Surgery for Cervical Cancer-An Expert Survey 
    Smits, Anke; Wolswinkel, Janneke T; Eikelder, Mieke L G Ten; Abu-Rustum, Nadeem R; Baiocchi, Glauco; Beltman, Jogchum J; Covens, Allan; Cornel, Karlijn M C; Falconer, Henrik; Fotopoulou, Christina; Gerestein, Cornelis G; Gil-Ibanez, Blanca; Hillemanns, Peter; Köhler, Christhardt; Kucukmetin, Ali; van Lonkhuijzen, Luc R C W; Morice, Philippe; Nam, Joo Hyun; Perrotta, Myriam B; Persson, Jan; Plante, Marie; Querleu, Denis; Ribeiro, Reitan; Ungár, Laszlo; van Ham, Maaike A P C; Zusterzeel, Petra L M (MDPI Multidisciplinary Digital Publishing Institute, 2025-02-20)
    Background/Objectives: Fertility-sparing surgery (FSS) is a standard practice for managing early stage cervical cancer, yet significant variation exists in clinical approaches worldwide. Our objective was to ascertain ...
  • Stem cell culture conditions affect in vitro differentiation potential and mouse gastruloid formation 
    Blotenburg, Marloes; Suurenbroek, Lianne; Bax, Danique; de Visser, Joëlle; Bhardwaj, Vivek; Braccioli, Luca; de Wit, Elzo; van Boxtel, Antonius; Marks, Hendrik; Zeller, Peter (Public Library of Science, 2025-03-26)
    Aggregating low numbers of mouse embryonic stem cells (mESCs) and inducing Wnt signalling generates 'gastruloids', self-organising complex structures that display an anteroposterior organisation of cell types derived from ...
  • Modifiable risk factors and plasma proteomics in relation to complications of type 2 diabetes 
    Li, Ruyi; Tian, Shufan; Liu, Jun; Li, Rui; Zhu, Kai; Lu, Qi; Qiu, Zixin; Yu, Hancheng; Li, Lin; H Franco, Oscar; Pan, An; Liao, Yunfei; Liu, Gang (Nature Publishing Group, 2025-03-26)
    A comprehensive assessment of combined modifiable risk factors with common complications of type 2 diabetes (T2D) is lacking, and the potential role of proteomics remains unclear. Here, we examine the associations of ...
  • The value of 18F-FDG PET/CT and 18F-DOPA PET/CT in determining the initial surgical strategy of patients with medullary thyroid cancer: Preoperative PET/CT imaging for medullary thyroid cancer 
    Jager, Eline C; Brouwers, Adrienne H; Metman, Madelon J H; Aykan, Dilay; de Vries, Lisa H; Lodewijk, Lutske; Vriens, Menno R; Kruijff, Schelto; Links, Thera P (e-med, 2025-03-26)
    BACKGROUND: While total thyroidectomy with central neck dissection (CND) is standard for medullary thyroid cancer (MTC), performing a lateral neck dissection (LND) depends on locoregional metastatic spread and is usually ...
  • Tolerability and Pharmacokinetic Evaluation of Inhaled Dry Powder Tobramycin in Children with Cystic Fibrosis 
    Akkerman-Nijland, Anne M; Hagedoorn, Paul; Rottier, Bart L; Grasmeijer, Floris; Frijlink, Henderik Erik W; van Luin, Mathijs; Ter Weijden, E; Merkus, Peter J; Touw, Daan J; Akkerman, Onno W; Koppelman, Gerard H (Multidisciplinary Digital Publishing Institute, 2025-03-07)
    Background:Pseudomonas aeruginosa (Pa) is the predominant pulmonary pathogen in persons with Cystic Fibrosis (CF). Nebulization with tobramycin or colistin is mostly applied but has a significant treatment burden. Dry ...
  • Ventricular fibrillation induced by atrial threshold search: a case report 
    Sprenkeler, David; Hersbach, Ferry; Oomen, Ad; van Ofwegen-Hanekamp, Clara; Meine, Mathias (Oxford University Press, 2025-03)
    BACKGROUND: Implantable cardioverter defibrillators (ICDs) have been proven to reduce the risk of sudden cardiac death from ventricular tachyarrhythmias. However, ICDs can sometimes induce malignant arrhythmias. We describe ...
  • Evaluation of Elexacafor/Tezacaftor/Ivacaftor therapy after lung transplantation in Cystic Fibrosis: The Dutch National KOALA study 
    van Gemert, Johanna P; Luijk, Bart; Hellemons, Merel E; Visser, Klara A; Hansen, Carina M E; van der Meer, Renske; Gan, C Tji; van der Vaart, Hester; Akkerman, Onno W; Steenhuis, Willie N; Verkleij, Marieke; Heijerman, Harry G M; Verschuuren, Erik A M; KOALA study group (2025-02)
    BACKGROUND: Elexacaftor/Tezacaftor/Ivacaftor (ETI) for people with CF (PwCF) after lung transplantation (LTx) has been restrained due to uncertainties regarding efficacy and drug interactions. Given the persistence of ...
  • Thoracic Aortic Aneurysm Growth Rates and Predicting Factors: A Systematic Review and Meta-Analysis 
    Henry, Matthew; Campello Jorge, Carlos A; van Bakel, Pieter A J; Knauer, Heather A; MacEachern, Mark; van Herwaarden, Joost A; Teixidó-Tura, Gisela; Evangelista, Arturo; Jeremy, Richmond W; Figueroa, C A; Patel, Himanshu J; Hofmann Bowman, Marion; Eagle, Kim; Burris, Nicholas S (Wiley-Blackwell, 2025-04-01)
    BACKGROUND: Thoracic aortic aneurysm (TAA) is an indolent, potentially fatal disease, which progresses at variable rates that are influenced by pathogenesis and patient characteristics. We conducted a systematic review and ...
  • Venous and arterial thrombosis in patients receiving immune checkpoint inhibitors 
    van Lent, Anouk; Puscasu, Rebeca; Kaasjager, Karin A H; Haitjema, Saskia; Suelmann, Britt B M; Verhaar, Marianne C; Khairoun, Meriem; Ocak, Gurbey (Public Library of Science, 2025-04-01)
    BACKGROUND: Immune checkpoint inhibitors (ICPi) have been associated with a prothrombotic and pro-atherogenic tendency which could lead to an increased risk of thrombosis. The aim of this study was to investigate the ...
  • Perspectives on the role of "-Omics" in predicting response to immunotherapy 
    Di Giacomo, Anna Maria; Subudhi, Sumit; Vos, Wim; Andreatta, Massimo; Carmona, Santiago; McTavish, Will; Seliger, Barbara; Ibrahim, Ramy; Lahn, Michael; Smith, Michael; Eggermont, Alexander; Fox, Bernard A; Maio, Michele (Elsevier Limited, 2025-05-02)
    The annual Immuno-Oncology "Think Tank" held in October 2023 in Siena reviewed the rapidly evolving systems-biological approaches which are now providing a deeper understanding of tumor and tumor microenvironment heterogeneity. ...
  • Older patients' experiences and needs regarding pharmacotherapeutic care in-hospital and after discharge 
    Engelen, Eline M C; Knol, Wilma; Wuyts, Stephanie C M; Theunissen, Darshana A; Vondeling, Ariel M; Cooijmans, Sjacky; van Herwaarden, Noortje; Kramers, Cornelis; van den Bemt, Patricia M L A; van Agtmael, Michiel A; Bouvy, Marcel L (Elsevier Ireland Ltd, 2025-07)
    OBJECTIVE: This qualitative study explores the experiences and needs of older patients with polypharmacy regarding transitional pharmacotherapeutic care during hospital admission and following discharge, identifying areas ...
  • Two-year survival and disease recurrence after endosonography with or without confirmatory mediastinoscopy for resectable lung cancer (a short communication of the MEDIASTrial follow-up) 
    Bousema, Jelle E; Spaans, Louisa N; Dijkgraaf, Marcel G W; van der Heijden, Erik H F M; Verhagen, Ad F T M; Annema, Jouke T; van den Broek, Frank J C; MEDIASTrial study group; de Jong, Wouter (Elsevier Ireland Ltd, 2025-04)
    Resectable non-small cell lung cancer (NSCLC) with increased risk of mediastinal nodal involvement requires invasive staging prior to surgical resection. The MEDIASTrial was a multicenter non-inferiority trial randomly ...
  • A fusion protein that targets antigen-loaded extracellular vesicles to B cells enhances antigen-specific T cell expansion 
    Offens, Annemarijn; Teeuwen, Loes; Gucluler-Akpinar, Gozde; Steiner, Loïc; Kooijmans, Sander; Mamand, Doste; Weissinger, Hannah; Käll, Alexander; Eldh, Maria; Wiklander, Oscar P B; Andaloussi, Samir E L; Karlsson, Mikael C I; Vader, Pieter; Gabrielsson, Susanne (Elsevier, 2025-06-10)
    Extracellular vesicles (EVs) have the potential to modulate immune responses via their cargo molecules and are being explored as vehicles in cancer immunotherapy. Dendritic cell-derived EVs can induce antigen-specific ...
  • Brain Markers of Resilience to Psychosis in High-Risk Individuals: A Systematic Review and Label-Based Meta-Analysis of Multimodal MRI Studies 
    Collin, Guusje; Goldenberg, Joshua E; Chang, Xiao; Qi, Zhenghan; Whitfield-Gabrieli, Susan; Cahn, Wiepke; Wang, Jijun; Stone, William S; Keshavan, Matcheri S; Shenton, Martha E (Multidisciplinary Digital Publishing Institute (MDPI), 2025-03-17)
    Background/Objectives: Most individuals who have a familial or clinical risk of developing psychosis remain free from psychopathology. Identifying neural markers of resilience in these at-risk individuals may help clarify ...