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UMC Repository: Recent submissions

  • Cost-effectiveness of a nurse-led sexual rehabilitation intervention for women treated with radiotherapy for gynaecological cancer in a randomized trial 
    Suvaal, Isabelle; van den Hout, Wilbert B.; Hummel, Susanna B.; Mens, Jan Willem M.; Tuijnman-Raasveld, Charlotte C.; Velema, Laura A.; Westerveld, Henrike; Cnossen, Jeltsje S.; Snyers, An; Jürgenliemk-Schulz, Ina M.; Lutgens, Ludy C.H.W.; Beukema, Jannet C.; Haverkort, Marie A.D.; Nowee, Marlies E.; Nout, Remi A.; de Kroon, Cor D.; van Doorn, Helena C.; Creutzberg, Carien L.; ter Kuile, Moniek M. (Elsevier Ireland Ltd, 2025-02)
    Purpose: To compare the cost-effectiveness of a nurse-led sexual rehabilitation intervention with standard care in women treated with external beam radiotherapy, with or without brachytherapy, for gynaecological cancers. ...
  • Long Dosing Intervals of Parenteral Antiosteoporosis Medications and the Decrease in Societal Fracture Risk: An 11-Year Nationwide Population-Based Cohort Study 
    Fu, Shau Huai; Yen, Hung Kuan; Yang, Rong Sen; Hung, Chih Chien; Lin, Jou Wei; Lee, Ming Tsung; Chen, Ho Min; Wu, Chih Hsing; Hsu, Chih Cheng; Li, Chung Yi; Groot, Olivier Q.; Wang, Chen Yu (Elsevier Science, 2025-01)
    Objective: To evaluate the relationship between different dosing intervals of antiosteoporosis medications (AOMs) and the subsequent fracture risk among patients with newly initiated AOM therapies. Patients and Methods: ...
  • A 10-Year Longitudinal Study of Brain Cortical Thickness in People with First-Episode Psychosis Using Normative Models 
    Berthet, Pierre; Haatveit, Beathe C.; Kjelkenes, Rikka; Worker, Amanda; Kia, Seyed Mostafa; Wolfers, Thomas; Rutherford, Saige; Alnaes, Dag; Dinga, Richard; Pedersen, Mads L.; Dahl, Andreas; Fernandez-Cabello, Sara; Dazzan, Paola; Agartz, Ingrid; Nesvåg, Ragnar; Ueland, Torill; Andreassen, Ole A.; Simonsen, Carmen; Westlye, Lars T.; Melle, Ingrid; Marquand, Andre (Oxford University Press, 2024-12-20)
    BACKGROUND: Clinical forecasting models have potential to optimize treatment and improve outcomes in psychosis, but predicting long-term outcomes is challenging and long-term follow-up data are scarce. In this 10-year ...
  • Towards a common approach for managing food allergy and serious allergic reactions (anaphylaxis) at school. GA2LEN and EFA consensus statement 
    Deschildre, Antoine; Alvaro-Lozano, Montserrat; Muraro, Antonella; Podesta, Marcia; de Silva, Debra; Giovannini, Mattia; Barni, Simona; Dribin, Timothy E.; Sandoval-Ruballos, Mónica; Anagnostou, Aikaterini; Fiocchi, Alessandro; Toniolo, Alice; Bird, Andrew; Sanz, Angel Sánchez; Asarnoj, Anna; Nowak-Wegrzyn, Anna; Vlieg-Boerstra, Berber; Vickery, Brian P.; Venter, Carina; Nilsson, Caroline; Parente, Cecilia; Demoulin, Céline; Fleischer, David M.; Bijlhout, Diola; Knol, Edward F.; Garrow, Eleanor; Cook, Emma E.; Schultz, Fallon; Lazzarotto, Francesca; Mori, Francesca; Wong, Gary; Lack, Gideon; Roberts, Graham; Marino, Gustavo Andres; Elberink, H. N.G.Oude; Brough, Helen A.; Sampson, Hugh A.; Lieberman, Jay; Gerdts, Jennifer; Zhao, Jing; Gradman, Josefine; Upton, Julia E.M.; Wang, Julie; Palosuo, Kati; Järvinen, Kirsi M.; Beyer, Kirsten; Shen, Kunling; Polloni, Laura; Mandelbaum, Lianne; Tanno, Luciana Kase; Bilaver, Lucy A.; Shaker, Marcus S.; Worm, Margitta; Said, Maria; Kelly, Mary; Marchisotto, Mary Jane; Makris, Michael; Odemyr, Mikaela; Fernandez-Rivas, Montserrat; Ebisawa, Motohiro; Patel, Nandinee; Rodríguez del Río, Pablo; Vichyanond, Pakit; Turner, Paul; Smith, Pete; Gaspar, Pilar Morón; Chinthrajah, R. Sharon; Rachid, Rima; Bonaguro, Roberta; Gupta, Ruchi; Schnadt, Sabine; Sato, Sakura; Arasi, Stefania; Leonard, Stephanie; Poblete, Sung; Halken, Susanne; Le, Thuy My; Pouessel, Guillaume; Dunn, Tracey; Cardona, Victoria; Zuberbier, Torsten (BioMed Central, 2025-01)
    GA2LEN and EFA propose minimum specifications for all industrialised countries/regions to work towards to support students with food allergies in educational settings. We reviewed research and legislation and gained feedback ...
  • Altered circadian rhythmicity of the QT interval predicts mortality in a large real-world academic hospital population 
    van de Leur, Rutger R.; du Pré, Bastiaan C.; Printezi, Markella I.; Hassink, Rutger J.; Doevendans, Pieter A.; van Es, René; van Laake, Linda W. (Elsevier, 2025-01-15)
    Objective and rationale: Small studies have shown that the QT interval follows a circadian rhythm. This finding has never been confirmed in a large real-world hospital population and the clinical meaning of disrupted ...
  • Metastatic breast cancer patients’ preferences for exercise programs: a latent class analysis using data from a survey in five European countries 
    Sweegers, Maike G.; Depenbusch, Johanna; Aaronson, Neil K.; Hiensch, Anouk E.; Wengström, Yvonne; Backman, Malin; Gunasekara, Nadira; Clauss, Dorothea; Belloso, Jon; Lachowicz, Milena; May, Anne M.; Steindorf, Karen; Stuiver, Martijn M. (Springer-Verlag, 2025-01)
    Purpose: We aimed to identify metastatic breast cancer (MBC) patients’ preferences for exercise programs and identify patients’ characteristics associated with these preferences, to facilitate implementation of exercise ...
  • Impact of Open Surgical Descending Repair on Aortic Stiffness in an Ex Vivo Porcine Model 
    de Kort, Jasper F.; Mandigers, Tim J.; Pascaner, Ariel F.; Conti, Michele; Schembri, Martina; Jelic, Sonja; Caimi, Alessandro; Bissacco, Daniele; Domanin, Maurizio; Heijmen, Robin H.; van Herwaarden, Joost A.; Auricchio, Ferdinando; Trimarchi, Santi (Elsevier, 2025-03)
    Background: Previous studies have strongly suggested that stent-graft deployment and acute arch angulation increase aortic stiffness, the impact of surgical interposition grafting remains unclear. We investigated the impact ...
  • Identifying predictors of nosocomial pneumonia in trauma patients admitted to a level-1 trauma center 
    Kobes, T.; Sweet, A. A.R.; IJpma, F. F.A.; Leenen, L. P.H.; Houwert, R. M.; van Wessem, K. J.P.; Groenwold, R. H.H.; van Baal, M. C.P.M. (Springer-Verlag, 2025-12)
    Background: Nosocomial pneumonia is common in trauma patients and associated with an adverse prognosis. We recently externally validated and recalibrated an existing formula to predict nosocomial pneumonia risk. Identifying ...
  • Protocol for genome-wide analysis of somatic variants at single-cell resolution using primary template-directed DNA amplification 
    Derks, Lucca L.M.; van Leeuwen, Anaïs J.C.N.; Steemers, Alexander S.; Trabut, Laurianne; van Roosmalen, Markus J.; Poort, Vera M.; Hagelaar, Rico; Verheul, Mark; Middelkamp, Sjors; van Boxtel, Ruben (Cell Press, 2025-03-21)
    The study of somatic mutations in single cells provides insights into aging and carcinogenesis, which is complicated by the dependency on whole-genome amplification (WGA). Here, we describe a detailed workflow starting ...
  • Updating methods for artificial intelligence–based clinical prediction models: a scoping review 
    Meijerink, Lotta M.; Dunias, Zoë S.; Leeuwenberg, Artuur M.; de Hond, Anne A.H.; Jenkins, David A.; Martin, Glen P.; Sperrin, Matthew; Peek, Niels; Spijker, René; Hooft, Lotty; Moons, Karel G.M.; van Smeden, Maarten; Schuit, Ewoud (Elsevier, 2025-02)
    Objectives: To give an overview of methods for updating artificial intelligence (AI)-based clinical prediction models based on new data. Study Design and Setting: We comprehensively searched Scopus and Embase up to August ...
  • The role of the psychedelic experience in psilocybin treatment for treatment-resistant depression 
    Goodwin, Guy M.; Aaronson, Scott T.; Alvarez, Oscar; Carhart-Harris, Robin; Chai-Rees, Jamie; Croal, Megan; DeBattista, Charles; Dunlop, Boadie W.; Feifel, David; Hellerstein, David J.; Husain, Muhammad I.; Kelly, John R.; Kirlic, Namik; Licht, Rasmus W.; Marwood, Lindsey; Meyer, Thomas D.; Mistry, Sunil; Nowakowska, Ania; Páleníček, Tomáš; Repantis, Dimitris; Schoevers, Robert A.; Simmons, Hollie; Somers, Metten; Teoh, Emma; Tsai, Joyce; Wahba, Mourad; Williams, Sam; Young, Allan H.; Young, Matthew B.; Zisook, Sidney; Malievskaia, Ekaterina (Elsevier, 2025-03-01)
    Objective: To determine the relationships between psilocybin dose, psychedelic experiences, and therapeutic outcome in treatment-resistant depression. Methods: For treatment-resistant depression, 233 participants received ...
  • Deep-learning-based extraction of circle of Willis topology with anatomical priors 
    Alblas, Dieuwertje; Vos, Iris N.; Lipplaa, Micha M.; Brune, Christoph; van der Schaaf, Irene C.; Velthuis, Mireille R.E.; Velthuis, Birgitta K.; Kuijf, Hugo J.; Ruigrok, Ynte M.; Wolterink, Jelmer M. (Nature Publishing Group, 2024-12)
    The circle of Willis (CoW) is a circular arrangement of arteries in the human brain, exhibiting significant anatomical variability. The CoW is extensively studied in relation to neurovascular pathologies, with certain ...
  • Incorporating patient-specific prior clinical knowledge to improve clinical target volume auto-segmentation generalisability for online adaptive radiotherapy of rectal cancer: A multicenter validation 
    Ferreira Silvério, Nicole; van den Wollenberg, Wouter; Betgen, Anja; Wiersema, Lisa; Marijnen, Corrie A.M.; Peters, Femke; van der Heide, Uulke A.; Simões, Rita; Intven, Martijn P.W.; van der Bijl, Erik; Janssen, Tomas (Elsevier Ireland Ltd, 2025-02)
    Background & purpose: Deep learning (DL) based auto-segmentation has shown to be beneficial for online adaptive radiotherapy (OART). However, auto-segmentation of clinical target volumes (CTV) is complex, as clinical ...
  • Learning from post-COVID-19 condition for epidemic preparedness: a variable catalogue for future post-acute infection syndromes 
    Górska, Anna; Canziani, Lorenzo Maria; Rinaldi, Eugenia; Pana, Zoi D.; Beale, Sarah; Bai, Francesca; Boxma-de Klerk, Bianca M.; de Bruijn, Simeon; Donà, Daniele; Ekkelenkamp, Miquel B.; Incardona, Francesca; Mallon, Patrick; Marchetti, Giulia C.; Puhan, Milo; Riva, Agostino; Simensen, Victoria C.; Vaillant, Michel; van der Zalm, Marieke M.; van Kuijk, Sander M.J.; Wingerden, Sophie van; Judd, Ali; Tacconelli, Evelina; Peñalvo, José L. (Elsevier, 2025-03)
    Scope: The emergence of post-COVID-19 condition (PCC) after SARS-CoV-2 infection underscores the critical need for preparedness in addressing future post-acute infection syndromes (PAIS), particularly those linked to ...
  • Associations between momentary mental states and concurrent social functioning after remission from first episode psychosis: A HAMLETT ecological momentary assessment study 
    HAMLETT-OPHELIA Consortium (Elsevier Limited, 2025-01)
    Background: Symptom severity and social functioning are important outcomes after first episode psychosis (FEP), yet current evidence about associations between them is inconsistent and lacks (subclinical) momentary insights. ...
  • Retinoblastoma Protein Loss in p53 Abnormal Endometrial Carcinoma: Histologic and Clinicopathological Correlates 
    Serbes, Ezgi Dicle; Horeweg, Nanda; Parra-Herran, Carlos; van Rijnsoever, Renske; Jobsen, Jan J.; Jurgenliemk-Schulz, Ina; Kuijsters, Nienke; Nout, Remi A.; Haverkort, Marie A.D.; Powell, Melanie E.; Khaw, Pearly; Plante, Marie; Genestie, Catherine; Nijman, Hans W.; Creutzberg, Carien L.; Bosse, Tjalling; Kramer, Claire J.H. (Elsevier, 2025-03)
    Of the 4 molecular subtypes of endometrial cancer (EC), p53-abnormal (p53abn) EC is associated with abundant copy number alterations and the worst clinical outcome. Patients with p53abn EC have the highest risk of disease ...
  • Age- and sex-related differences in social competence and emotion labeling in pre-adolescence 
    Buimer, Elizabeth E.L.; Pas, Pascal; van den Boomen, Carlijn; Raemaekers, Mathijs; Brouwer, Rachel M.; Hulshoff Pol, Hilleke E. (Elsevier, 2025-01)
    Identification of facial expressions is important to navigate social interactions and associates with developmental outcomes. It is presumed that social competence, behavioral emotion labeling and neural emotional face ...
  • Ischemia during exercise stress testing, an indication of coronary vasomotor dysfunction? 
    Schipaanboord, Diantha J.M.; Jansen, Tijn P.J.; Scherpenhuijzen, Luuk; Crooijmans, Caïa; Dimitriu-Leen, Aukelien C.; van der Harst, Pim; van de Hoef, Tim P.; van Es, René; den Ruijter, Hester M.; Damman, Peter; Onland-Moret, N. Charlotte; Elias-Smale, Suzette E. (Elsevier, 2025-02)
    Background: Recently it has been suggested that coronary microvascular dysfunction (CMD) may explain the high false-positive rate of exercise electrocardiographic stress testing (EST). However, patients with angina but ...
  • Association between gut microbiome profiles and host metabolic health across the life course: a population-based study 
    Li, Ruolin; Kurilshikov, Alexander; Yang, Shuyue; van Oortmerssen, Julie A.E.; van Hilten, Arno; Ahmadizar, Fariba; Roshchupkin, Gennady; Kraaij, Robert; Duijts, Liesbeth; Fu, Jingyuan; Ikram, M. Kamran; Jaddoe, Vincent W.V.; Uitterlinden, André G.; Rivadeneira, Fernando; Kavousi, Maryam; Zhernakova, Alexandra; Medina-Gomez, Carolina (Elsevier, 2025-03)
    Background: The human gut microbiome changes considerably over time. Previous studies have shown that gut microbiome profiles correlate with multiple metabolic traits. As disease development is likely a lifelong process, ...
  • Effect of selective dorsal rhizotomy on bladder dysfunction in children with spastic cerebral palsy 
    Jiang, Wenbin; Wang, Junlu; Robe, Pierre A.; Wei, Min; Li, Sen; Wang, Rui; Zhan, Qijia; Xiao, Bo (Nature Publishing Group, 2024-12)
    This study investigated the prevalence and severity of lower urinary tract symptoms (LUTS) in children with spastic cerebral palsy (SCP) and evaluated the effect of selective dorsal rhizotomy (SDR) in alleviating these ...