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UMC Repository: Recent submissions

  • The microtubule signature in cardiac disease: etiology, disease stage, and age dependency 
    Algül, Sıla; Dorsch, Larissa M.; Sorop, Oana; Vink, Aryan; Michels, Michelle; dos Remedios, Cristobal G.; Dalinghaus, Michiel; Merkus, Daphne; Duncker, Dirk J.; Kuster, Diederik W.D.; van der Velden, Jolanda (Springer Science and Business Media Deutschland GmbH, 2023-10)
    Employing animal models to study heart failure (HF) has become indispensable to discover and test novel therapies, but their translatability remains challenging. Although cytoskeletal alterations are linked to HF, the ...
  • STAT1 regulates immune-mediated intestinal stem cell proliferation and epithelial regeneration 
    Takashima, Shuichiro; Sharma, Roshan; Chang, Winston; Calafiore, Marco; Fu, Ya Yuan; Jansen, Suze A.; Ito, Takahiro; Egorova, Anastasiya; Kuttiyara, Jason; Arnhold, Viktor; Sharrock, Jessica; Santosa, Endi; Chaudhary, Ojasvi; Geiger, Heather; Iwasaki, Hiromi; Liu, Chen; Sun, Joseph; Robine, Nicolas; Mazutis, Linas; Lindemans, Caroline A.; Hanash, Alan M. (Nature Publishing Group, 2025-01-02)
    The role of the immune system in regulating tissue stem cells remains poorly understood, as does the relationship between immune-mediated tissue damage and regeneration. Graft vs. host disease (GVHD) occurring after ...
  • NRG Oncology International Consensus Contouring Atlas on Target Volumes and Dosing Strategies for Dose-Escalated Pancreatic Cancer Radiation Therapy 
    Sanford, Nina N; Narang, Amol K; Aguilera, Todd A; Bassetti, Michael F; Chuong, Michael D; Erickson, Beth A; Goodman, Karyn A; Herman, Joseph M; Intven, Martijn; Kilcoyne, Aoife; Kim, Hyun; Paulson, Eric; Reyngold, Marsha; Tsai, Susan; Tchelebi, Leila T; Tuli, Richard; Versteijne, Eva; Wei, Alice C; Wo, Jennifer Y; Zhang, Ying; Hong, Theodore S; Hall, William A (Elsevier, 2025-03-15)
    PURPOSE: Dose-escalated radiation therapy is increasingly used in the treatment of pancreatic cancer; however, approaches to target delineation vary widely. We present the first North American cooperative group consensus ...
  • Routine Imaging or Symptomatic Follow-Up After Resection of Pancreatic Adenocarcinoma 
    Andel, Paul C M; van Goor, Iris W J M; Augustinus, Simone; Berrevoet, Frederik; Besselink, Marc G; Bhojwani, Rajesh; Boggi, Ugo; Bouwense, Stefan A W; Cirkel, Geert A; van Dam, Jacob L; Djanani, Angela; Dorcaratto, Dimitri; Dreyer, Stephan; den Dulk, Marcel; Frigerio, Isabella; Ghorbani, Poya; Goetz, Mara R; Groot Koerkamp, Bas; Gryspeerdt, Filip; Hidalgo Salinas, Camila; Intven, Martijn; Izbicki, Jakob R; Jorba Martin, Rosa; Kauffmann, Emanuele F; Klug, Reinhold; Liem, Mike S L; Luyer, Misha D P; Maglione, Manuel; Martin-Perez, Elena; Meerdink, Mark; de Meijer, Vincent E; Nieuwenhuijs, Vincent B; Nikov, Andrej; Nunes, Vitor; Pando Rau, Elizabeth; Radenkovic, Dejan; Roeyen, Geert; Sanchez-Bueno, Francisco; Serrablo, Alejandro; Sparrelid, Ernesto; Tepetes, Konstantinos; Thakkar, Rohan G; Tzimas, George N; Verdonk, Robert C; Ten Winkel, Meike; Zerbi, Alessandro; Groot, Vincent P; Molenaar, I Quintus; Daamen, Lois A; van Santvoort, Hjalmar C; European-African Hepato-Pancreato-Biliary Association (American Medical Association, 2025-01)
    IMPORTANCE: International guidelines lack consistency in their recommendations regarding routine imaging in the follow-up after pancreatic resection for pancreatic ductal adenocarcinoma (PDAC). Consequently, follow-up ...
  • Mechanistic Study on the Degradation of Hydrolysable Core-Crosslinked Polymeric Micelles 
    Hebels, Erik R.; van Steenbergen, Mies J.; Haegebaert, Ragna; Seinen, Cornelis W.; Mesquita, Barbara S.; van den Dikkenberg, Antoinette; Remaut, Katrien; Rijcken, Cristianne J.F.; van Ravensteijn, Bas G.P.; Hennink, Wim E.; Vermonden, Tina (American Chemical Society, 2023-08-29)
    Core-crosslinked polymeric micelles (CCPMs) are an attractive class of nanocarriers for drug delivery. Two crosslinking approaches to form CCPMs exist: either via a low-molecular-weight crosslinking agent to connect ...
  • Tunable Bicontinuous Macroporous Cell Culture Scaffolds via Kinetically Controlled Phase Separation 
    Dudaryeva, Oksana Y.; Cousin, Lucien; Krajnovic, Leila; Gröbli, Gian; Sapkota, Virbin; Ritter, Lauritz; Deshmukh, Dhananjay; Cui, Yifan; Style, Robert W.; Levato, Riccardo; Labouesse, Céline; Tibbitt, Mark W. (Wiley-Blackwell, 2025-02-19)
    3D scaffolds enable biological investigations with a more natural cell conformation. However, the porosity of synthetic hydrogels is often limited to the nanometer scale, which confines the movement of 3D encapsulated cells ...
  • ESAIC focused guideline for the use of cardiac biomarkers in perioperative risk evaluation 
    Lurati Buse, Giovanna; Bollen Pinto, Bernardo; Abelha, Fernando; Abbott, Tom E.F.; Ackland, Gareth; Afshari, Arash; De Hert, Stefan; Fellahi, Jean Luc; Giossi, Laure; Kavsak, Peter; Longrois, Dan; M'Pembele, Rene; Nucaro, Anthony; Popova, Ekaterine; Puelacher, Christian; Richards, Toby; Roth, Sebastian; Sheka, Mootii; Szczeklik, Wojciech; Van Waes, Judith; Walder, Bernhard; Chew, Michelle S. (Lippincott Williams & Wilkins, 2023-12-01)
    BACKGROUNDIn recent years, there has been increasing focus on the use of cardiac biomarkers in patients undergoing noncardiac surgery.AIMSThe aim of this focused guideline was to provide updated guidance regarding the pre-, ...
  • Treatment time and learning curve analysis of 1.5 T MR-Linac workflows led by radiation oncologists or therapists 
    Westerhoff, J. M.; Raaijmakers, F. J.; Daamen, L. A.; de Groot-van Breugel, E. N.; Meijers, L. T.C.; van der Voort van Zyp, J. R.N.; Verhoeff, J. J.C.; Mook, S.; Verkooijen, H. M.; Intven, M. P.W. (Elsevier Ireland Ltd, 2025-03)
    Background and purpose: This study assessed the treatment time of online adaptive (i.e. Adapt-to-Shape, ATS) and virtual couch shift (i.e. Adapt-to-Position, ATP) magnetic resonance guided radiotherapy (MRgRT) on a 1.5 ...
  • Minimally invasive plate osteosynthesis (MIPO) for scapular fractures 
    van de Wall, B. J.M.; Hoepelman, R. J.; Michelitsch, C.; Diwersi, N.; Sommer, C.; Babst, R.; Beeres, F. J.P. (Urban und Vogel, 2023-12)
    Objective: Presentation of a minimally invasive surgical approach for the treatment of scapular fractures and the clinical outcome using this technique. Indications: Displaced extra-articular fractures of the scapula body ...
  • Changes in the Prevalence of Infection in Pregnant Women during the COVID-19 Lockdown 
    Werter, Dominique E.; Schuster, Heleen J.; Schneeberger, Caroline; Pajkrt, Eva; de Groot, Christianne J.M.; van Leeuwen, Elisabeth; Kazemier, Brenda M. (MDPI AG, 2023-08)
    Background: During the outbreak of SARS-CoV-2, strict mitigation measures and national lockdowns were implemented. Our objective was to investigate to what extent the prevalence of some infections in pregnancy was altered ...
  • Variability of the Human Serum Metabolome over 3 Months in the EXPOsOMICS Personal Exposure Monitoring Study 
    Oosterwegel, Max J.; Ibi, Dorina; Portengen, Lützen; Probst-Hensch, Nicole; Tarallo, Sonia; Naccarati, Alessio; Imboden, Medea; Jeong, Ayoung; Robinot, Nivonirina; Scalbert, Augustin; Amaral, Andre F.S.; van Nunen, Erik; Gulliver, John; Chadeau-Hyam, Marc; Vineis, Paolo; Vermeulen, Roel; Keski-Rahkonen, Pekka; Vlaanderen, Jelle (2023-08-29)
    Liquid chromatography coupled to high-resolution mass spectrometry (LC-HRMS) and untargeted metabolomics are increasingly used in exposome studies to study the interactions between nongenetic factors and the blood metabolome. ...
  • A review of materials used in tomographic volumetric additive manufacturing 
    Madrid-Wolff, Jorge; Toombs, Joseph; Rizzo, Riccardo; Bernal, Paulina Nuñez; Porcincula, Dominique; Walton, Rebecca; Wang, Bin; Kotz-Helmer, Frederik; Yang, Yi; Kaplan, David; Zhang, Yu Shrike; Zenobi-Wong, Marcy; McLeod, Robert R.; Rapp, Bastian; Schwartz, Johanna; Shusteff, Maxim; Talyor, Hayden; Levato, Riccardo; Moser, Christophe (Springer International Publishing AG, 2023-10)
    Volumetric additive manufacturing is a novel fabrication method allowing rapid, freeform, layer-less 3D printing. Analogous to computer tomography (CT), the method projects dynamic light patterns into a rotating vat of ...
  • Breaking Bad News to Learners: How Well Does the SPIKES Clinical Model Translate? 
    Mills, Lynnea M.; Cate, Olle Ten; Boscardin, Christy; O'Sullivan, Patricia S. (Ubiquity Press, 2024-12-27)
    When health professions learners do not meet standards on assessments, educators need to share this information with the learners and determine next steps to improve their performance. Those conversations can be difficult, ...
  • Exploring the Psychosocial Needs of Adolescents Whose Parent Is Diagnosed With Breast Cancer 
    Hertogh, Linda; van Rosmalen, Mandy; Jager, Agnes; de Man – van Ginkel, Janneke M.; Oldenmenger, Wendy H. (Elsevier, 2023-10)
    Purpose: Cancer has a major impact on the individual patient and their family, especially children. However, little is known about the needs of adolescents (10–19 years) whose parent is diagnosed with cancer, especially ...
  • Associations of systemic oxidative stress with functional outcomes after ST-segment elevation myocardial infarction 
    de Koning, Marie Sophie L.Y.; Al Ali, Lawien; Bourgonje, Arno R.; Assa, Solmaz; Pasch, Andreas; van Goor, Harry; Lipsic, Erik; van der Harst, Pim (Elsevier Ireland Ltd, 2023-11-15)
    Background: Ischemia-reperfusion is accompanied by oxidative stress. Serum free thiols (FTs; sulfhydryl groups) reliably reflect systemic oxidative stress. This study evaluates longitudinal changes in FTs and their ...
  • Sound-based assembly of three-dimensional cellularized and acellularized constructs 
    Tognato, Riccardo; Parolini, Romedi; Jahangir, Shahrbanoo; Ma, Junxuan; Florczak, Sammy; Richards, R. Geoff; Levato, Riccardo; Alini, Mauro; Serra, Tiziano (Elsevier, 2023-10)
    Herein we show an accessible technique based on Faraday waves that assist the rapid assembly of osteoinductive β-Tricalcium phosphate (β-TCP) particles as well as human osteoblast pre-assembled in spheroids. The hydrodynamic ...
  • Towards Automatically Filling Questionnaires from Clinical Records with Large Language Models 
    Nardoni, Valeria; Lippi, Marco; Hyeraci, Giulia; Maccari, Martina; Tarazjani, Amirreza Dehghan; Virgili, Gianni; Gini, Rosa; Marinai, Simone (CEUR-WS, 2024-12-20)
    The use of large language models in healthcare is rapidly growing. In this work, we are interested in analyzing the capabilities of large language models in filling questionnaires related to clinical practices, where the ...
  • Biologically Relevant Murine Models of Chronic Pseudomonas aeruginosa Respiratory Infection 
    Rodgers, Aoife M.; Lindsay, Jaime; Monahan, Avril; Dubois, Alice V.; Faniyi, Aduragbemi A.; Plant, Barry J.; Mall, Marcus A.; Ekkelenkamp, Miquel B.; Elborn, Stuart; Ingram, Rebecca J. (MDPI AG, 2023-08)
    Pseudomonas aeruginosa (P. aeruginosa) is an opportunistic pathogen and the leading cause of infection in patients with cystic fibrosis (CF). The ability of P. aeruginosa to evade host responses and develop into chronic ...
  • From profit to impact: lives saved and the future of RSV vaccine development 
    Mazur, Natalie; Löwensteyn, Yvette (Elsevier Limited, 2023-09)
  • Early and Intensive Motor Training for people with spinal cord injuries (the SCI-MT Trial): Protocol of the process evaluation 
    Chu, Jackie; Glinsky, Joanne V.; Liu, Hueiming; Ben, Marsha; Spooren, Annemie I.; Roberts, Sharon; Chen, Lydia W.; Di Natal, Fernanda; Tamburella, Federica; Jørgensen, Vivien; Gollan, Emilie J.; Agostinello, Jacqui; Van Laake-Geelen, Charlotte; Lincoln, Claire; Van Der Lede, Jessica; Stolwijk, Janneke M.; Bell, Chris; Paddison, Sue; Rainey, Donna; Scivoletto, Giorgio; Oostra, Kristine M.; Jan, Stephen; Sherrington, Catherine; Harvey, Lisa A. (BMJ Publishing Group, 2023-08-29)
    Introduction People with spinal cord injury receive physical rehabilitation to promote neurological recovery. Physical rehabilitation commences as soon as possible when a person is medically stable. One key component of ...