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UMC Repository: Recent submissions

  • Correction: A scoping review of statistical methods in studies of biomarker-related treatment heterogeneity for breast cancer (BMC Medical Research Methodology, (2023), 23, 1, (154), 10.1186/s12874-023-01982-w) 
    Sollfrank, L.; Linn, Sc; Hauptmann, M.; Jóźwiak, K. (BioMed Central, 2023-12)
    Following the publication of the original article [1], the authors noticed that the publisher had not updated the supplements after revision. They therefore requested to update the supplementary material 2. The original ...
  • Depression recurrence is accompanied by longer periods in default mode and more frequent attentional and reward processing dynamic brain-states during resting-state activity 
    Alonso, Sonsoles; Tyborowska, Anna; Ikani, Nessa; Mocking, Roel J.T.; Figueroa, Caroline A.; Schene, Aart H.; Deco, Gustavo; Kringelbach, Morten L.; Cabral, Joana; Ruhé, Henricus G. (Wiley-Liss Inc., 2023-12-01)
    Recurrence in major depressive disorder (MDD) is common, but neurobiological models capturing vulnerability for recurrences are scarce. Disturbances in multiple resting-state networks have been linked to MDD, but most ...
  • Unraveling Dexamethasone-Induced Neurobehavioral and Sleep Problems in Children With ALL: Which Determinants Are Important? 
    van Hulst, Annelienke M.; Grootenhuis, Martha A.; Verwaaijen, Emma J.; van Litsenburg, Raphaële R.L.; Li, Letao; van Zelst, Bertrand D.; Broer, Linda; Pluijm, Saskia M.F.; Pieters, Rob; Fiocco, Marta; van den Akker, Erica L.T.; van den Heuvel-Eibrink, Marry M. (Lippincott Williams & Wilkins, 2023-06-01)
    PURPOSE Dexamethasone, the preferred corticosteroid in most treatment protocols for pediatric acute lymphoblastic leukemia (ALL), can induce undesirable side effects. Neurobehavioral and sleep problems are frequently ...
  • Cognitive and Motor Therapy After Stroke Is Not Superior to Motor and Cognitive Therapy Alone to Improve Cognitive and Motor Outcomes: New Insights From a Meta-analysis 
    Embrechts, Elissa; McGuckian, Thomas B.; Rogers, Jeffrey M.; Dijkerman, Chris H.; Steenbergen, Bert; Wilson, Peter H.; Nijboer, Tanja C.W. (W.B. Saunders, 2023-10)
    Objective: To evaluate whether cognitive and motor therapy (CMT) is more effective than no therapy, motor therapy, or cognitive therapy on motor and/or cognitive outcomes after stroke. Additionally, this study evaluates ...
  • Interaction of dietary patterns with rs28362491 on severity of coronary artery stenosis in patients undergoing coronary angiography 
    Darabi, Zahra; Seyed Hosseini, Seyed Mostafa; Sarebanhassanabadi, Mohammadtaghi; Jambarsang, Sara; Vahidi Mehrjardi, Mohammad Yahya; Hosseinzadeh, Mahdieh; Beigrezaei, Sara; Vasmehjani, Azam Ahmadi; Taftian, Marzieh; Arabi, Vahid; Motallaei, Maryam; Yazdi, Faezeh Golvardi; Salehi-Abargouei, Amin; Nadjarzadeh, Azadeh (Nature Publishing Group, 2023-12)
    Coronary artery disease (CAD) is one of the most important cardiovascular diseases. Lifestyle and genetic factors play important roles in the development of CAD. The aim of the study is to examine the interaction of dietary ...
  • Advocacy at the Eighth World Congress of Pediatric Cardiology and Cardiac Surgery 
    Zheleva, Bistra; Verstappen, Amy; Overman, David M.; Ahmad, Farhan; Ali, Sulafa K.M.; Al Halees, Zohair Y.; Atallah, Joumana Ghandour; Badhwar, Isabella E.; Baker-Smith, Carissa; Balestrini, Maria; Basken, Amy; Bassuk, Jonah S.; Benson, Lee; Capelli, Horacio; Carollo, Santo; Chowdhury, Devyani; Çiçek, M. Sertaç; Cohen, Mitchell I.; Cooper, David S.; Deanfield, John E.; Dearani, Joseph; Del Valle, Blanca; Dodds, Kathryn M.; Du, Junbao; Edwin, Frank; Ekure, Ekanem; Fatema, Nurun Nahar; Gomanju, Anu; Hasan, Babar; Henry, Lewis; Hugo-Hamman, Christopher; Iyer, Krishna S.; Jatene, Marcelo B.; Jenkins, Kathy J.; Karamlou, Tara; Karl, Tom R.; Kirklin, James K.; Kreutzer, Christián; Kumar, Raman Krishna; Lopez, Keila N.; Macedo, Alexis Palacios; Marino, Bradley S.; Marwali, Eva M.; Meijboom, Folkert J.; Mattos, Sandra S.; Najm, Hani; Newlin, Dan; Novick, William M.; Qureshi, Sir Shakeel A.; Rahmat, Budi; Raylman, Robert; Saltik, Irfan Levent; Sable, Craig; Sandoval, Nestor; Saxena, Anita; Scanlan, Emma; Sholler, Gary F.; Smith, Jodi; St Louis, James D.; Tchervenkov, Christo I.; Tiong, Koh Ghee; Vida, Vladimiro; Vosloo, Susan; Weinstein, Douglas J.Dj; Wilkinson, James L.; Zuhlke, Liesl; Jacobs, Jeffrey P. (Cambridge University Press, 2023-08-24)
    The Eighth World Congress of Pediatric Cardiology and Cardiac Surgery (WCPCCS) will be held in Washington DC, USA, from Saturday, 26 August, 2023 to Friday, 1 September, 2023, inclusive. The Eighth World Congress of Pediatric ...
  • Case series on clinical applications of liquid biopsy in pediatric solid tumors: towards improved diagnostics and disease monitoring 
    Gelineau, Nina U.; van Barneveld, Astrid; Samim, Atia; Van Zogchel, Lieke; Lak, Nathalie; Tas, Michelle L.; Matser, Yvette; Mavinkurve-Groothuis, Annelies M.C.; van Grotel, Martine; Zsiros, Jószef; van Eijkelenburg, Natasha K.A.; Knops, Rutger R.G.; van Ewijk, Roelof; Langenberg, Karin P.S.; Krijger, Ronald De; Hiemcke-Jiwa, Laura S.; Van Paemel, Ruben; Cornelli, Lotte; De Preter, Katleen; De Wilde, Bram; Van Der Schoot, Ellen; Tytgat, Godelieve (Frontiers Media S. A., 2023)
    Background and aims: Solid tumors account for about 30% of all pediatric cancers. The diagnosis is typically based on histological and molecular analysis of a primary tumor biopsy. Liquid biopsies carry several advantages ...
  • Predictive Clinical Neuroscience Portal (PCNportal): instant online access to research-grade normative models for clinical neuroscientists. 
    Barkema, Pieter; Rutherford, Saige; Lee, Hurng Chun; Kia, Seyed Mostafa; Savage, Hannah; Beckmann, Christian; Marquand, Andre (F1000 Research Ltd., 2023)
    Background: The neurobiology of mental disorders remains poorly understood despite substantial scientific efforts, due to large clinical heterogeneity and to a lack of tools suitable to map individual variability. Normative ...
  • ErbB2 (HER2)-CAR-NK-92 cells for enhanced immunotherapy of metastatic fusion-driven alveolar rhabdomyosarcoma 
    Heim, Catrin; Moser, Laura M.; Kreyenberg, Herman; Bonig, Halvard B.; Tonn, Torsten; Wels, Winfried S.; Gradhand, Elise; Ullrich, Evelyn; Meister, Michael T.; Koerkamp, Marian Groot; Holstege, Frank C.P.; Drost, Jarno; Klusmann, Jan Henning; Bader, Peter; Merker, Michael; Rettinger, Eva (Frontiers Media S. A., 2023)
    Introduction: Metastatic rhabdomyosarcoma (RMS) is a challenging tumor entity that evades conventional treatments and endogenous antitumor immune responses, highlighting the need for novel therapeutic strategies. Applying ...
  • Microvascular endothelial dysfunction in skin is associated with higher risk of heart failure with preserved ejection fraction in women with type 2 diabetes: the Hoorn Diabetes Care System Cohort 
    Canto, Elisa Dal; van Deursen, L.; Hoek, A. G.; Elders, P. J.M.; den Ruijter, H. M.; van der Velden, J.; van Empel, V.; Serné, E. H.; Eringa, E. C.; Beulens, J. W.J. (BioMed Central, 2023-12)
    Background: Microvascular dysfunction plays a crucial role in complications of type 2 diabetes and might contribute to heart failure with preserved ejection fraction (HFpEF), a disease that disproportionally affects women. ...
  • Phenotypic variability of filamin C–related cardiomyopathy: Insights from a novel Dutch founder variant 
    Schoonvelde, Stephan A.C.; Ruijmbeek, Claudine W.B.; Hirsch, Alexander; van Slegtenhorst, Marjon A.; Wessels, Marja W.; von der Thüsen, Jan H.; Baas, Annette F.; Stroeks, Sophie L.V.M.; Verdonschot, Job A.J.; van der Zwaag, Paul A.; Verhagen, Judith M.A.; Michels, Michelle (Elsevier, 2023-11)
    Background: Dilated cardiomyopathy (DCM) can be caused by truncating variants in the filamin C gene (FLNC). A new pathogenic FLNC variant, c.6864_6867dup, p.(Val2290Argfs∗23), was recently identified in Dutch patients with ...
  • Prevalence, years lived with disability, and trends in anaemia burden by severity and cause, 1990–2021: findings from the Global Burden of Disease Study 2021 
    Kayode, G. A.; GBD 2021 Anaemia Collaborators (Lancet Publishing Group, 2023-09)
    Background: Anaemia is a major health problem worldwide. Global estimates of anaemia burden are crucial for developing appropriate interventions to meet current international targets for disease mitigation. We describe the ...
  • GWAS meta-analysis of over 29,000 people with epilepsy identifies 26 risk loci and subtype-specific genetic architecture 
    Stevelink, Remi; Campbell, Ciarán; Chen, Siwei; Abou-Khalil, Bassel; Adesoji, Oluyomi M.; Afawi, Zaid; Amadori, Elisabetta; Anderson, Alison; Anderson, Joseph; Andrade, Danielle M.; Annesi, Grazia; Auce, Pauls; Avbersek, Andreja; Bahlo, Melanie; Baker, Mark D.; Balagura, Ganna; Balestrini, Simona; Barba, Carmen; Barboza, Karen; Bartolomei, Fabrice; Bast, Thomas; Baum, Larry; Baumgartner, Tobias; Baykan, Betül; Bebek, Nerses; Becker, Albert J.; Becker, Felicitas; Bennett, Caitlin A.; Berghuis, Bianca; Berkovic, Samuel F.; Beydoun, Ahmad; Bianchini, Claudia; Bisulli, Francesca; Blatt, Ilan; Bobbili, Dheeraj R.; Borggraefe, Ingo; Bosselmann, Christian; Braatz, Vera; Bradfield, Jonathan P.; Brockmann, Knut; Brody, Lawrence C.; Buono, Russell J.; Busch, Robyn M.; Caglayan, Hande; Campbell, Ellen; Canafoglia, Laura; Kasteleijn-Nolst Trenite, Dorothee; Koeleman, Bobby P.C.; Lindhout, Dick; Sonsma, Anja C.M.; International League Against Epilepsy Consortium on Complex Epilepsies (Nature Research, 2023-09)
    Epilepsy is a highly heritable disorder affecting over 50 million people worldwide, of which about one-third are resistant to current treatments. Here we report a multi-ancestry genome-wide association study including ...
  • Circulating biomarkers associated with aortic diameter in male and female patients with thoracic aortic disease: A cross-sectional study 
    Meccanici, Frederike; Thijssen, Carlijn G.E.; Dekker, Silvy; Bons, Lidia R.; Gökalp, Arjen L.; De Rijke, Yolanda B.; Takkenberg, Johanna J.M.; Mokhles, Mostafa M.; Bekkers, Jos A.; Boersma, Eric; Bouwens, Elke; Van Der Bosch, Annemien E.; Van Kimmenade, Roland R.L.; Roos-Hesselink, Jolien W. (BMJ Publishing Group, 2023-06-29)
    Objective As thoracic aortic disease (TAD) is generally asymptomatic, biomarkers are needed to provide insight into early progression. We aimed to examine the association between circulating blood biomarkers and the maximal ...
  • Duration of Effectiveness Evaluation of Additional Risk Minimisation Measures for Centrally Authorised Medicinal Products in the EU Between 2012 and 2021 
    Essink, Sharon C.M.; Zomerdijk, Inge M.; Straus, Sabine M.J.M.; Gardarsdottir, Helga; De Bruin, Marie L. (Adis, 2023-10)
    Introduction: In studies evaluating the effectiveness of additional risk minimisation measures (aRMMs), the need for speed must be properly balanced with the quality of the study. We assessed the duration of aRMM effectiveness ...
  • Emergency transfemoral valve-in-valve transcatheter aortic valve implantation in patient with chronic type A aortic dissection 
    Aarts, Hugo M.; van Nieuwkerk, Astrid C.; Baan, Jan; Delewi, Ronak; Beijk, Marcel A.M. (Bohn Stafleu van Loghum, 2023-12)
  • Hybridizing machine learning in survival analysis of cardiac PET/CT imaging 
    Juarez-Orozco, Luis Eduardo; Niemi, Mikael; Yeung, Ming Wai; Benjamins, Jan Walter; Maaniitty, Teemu; Teuho, Jarmo; Saraste, Antti; Knuuti, Juhani; van der Harst, Pim; Klén, Riku (Springer New York, 2023-12)
    Background: Machine Learning (ML) allows integration of the numerous variables delivered by cardiac PET/CT, while traditional survival analysis can provide explainable prognostic estimates from a restricted number of input ...
  • Acetabular dysplasia and the risk of developing hip osteoarthritis within 4-8 years: An individual participant data meta-analysis of 18,807 hips from the World COACH consortium 
    Riedstra, Noortje S.; Boel, Fleur; van Buuren, Michiel M.A.; Ahedi, Harbeer; Arbabi, Vahid; Arden, Nigel; Baart, Sara J.; Bierma-Zeinstra, Sita M.A.; Cicuttini, Flavia M.; Cootes, Timothy F.; Crossley, Kay M.; Felson, David T.; Giellis, Willem Paul; Heerey, Joshua; Jones, Graeme; Kluzek, Stefan; Lane, Nancy E.; Lindner, Claudia; Lynch, John A.; van Meurs, Joyce B.J.; Mosler, Andrea; Nelson, Amanda E.; Nevitt, Michael C.; Oei, Edwin H.; Runhaar, Jos; Tang, Jinchi; Weinans, Harrie; Agricola, Rintje (W.B. Saunders Ltd, 2025-03)
    Objective: To study the association between various radiographic definitions of acetabular dysplasia (AD) and incident radiographic hip osteoarthritis (RHOA), and to analyze in subgroups. Methods: Hips free of RHOA at ...
  • Immunotherapeutic targeting of aging-associated isoDGR motif in chronic lung inflammation 
    Kalailingam, Pazhanichamy; Ngan, So Fong Cam; Iyappan, Ranjith; Nehchiri, Afra; Mohd-Kahliab, Khalilatul Hanisah; Lee, Benjamin Sian Teck; Sharma, Bhargy; Machan, Radek; Bo, Sint Thida; Chambers, Emma S.; Fajardo, Val A.; Macpherson, Rebecca E.K.; Liu, Jian; Klentrou, Panagiota; Tsiani, Evangelia Litsa; Lim, Kah Leong; Su, I. Hsin; Gao, Yong Gui; Richar, A. Mark; Kalaria, Raj N.; Chen, Christopher P.; Balion, Cynthia; de Kleijn, Dominique; McCarthy, Neil E.; Sze, Siu Kwan (Wiley-Blackwell, 2025-04)
    Accumulation of damaged biomolecules in body tissues is the primary cause of aging and age-related chronic diseases. Since this damage often occurs spontaneously, it has traditionally been regarded as untreatable, with ...
  • Inconsistency identification in network meta-analysis via stochastic search variable selection 
    Seitidis, Georgios; Nikolakopoulos, Stavros; Ntzoufras, Ioannis; Mavridis, Dimitris (John Wiley & Sons Inc., 2023-11-20)
    The reliability of the results of network meta-analysis (NMA) lies in the plausibility of the key assumption of transitivity. This assumption implies that the effect modifiers' distribution is similar across treatment ...