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UMC Repository: Recent submissions

  • In vivo magnetic resonance imaging of the interstitial pressure gradients (pgMRI) using a pulsatile poroelastic computational model 
    McGarry, Matthew; Sowinski, Damian; Tan, Likun; Weaver, John; Zwanenburg, Jacobus J M; Paulsen, Keith (The Royal Society, 2025-04-04)
    Fluid movement in the interstitial space of the brain affects the clearance of waste products, which is an important factor in the pathophysiology of dementia. Estimating interstitial fluid (ISF) flow is critical to ...
  • Editorial Introduction 
    Juarez-Orozco, Luis Eduardo; Nathoe, Hendrik (Wiley-Blackwell, 2025-04)
  • Deep learning for electrocardiogram interpretation: Bench to bedside 
    Schots, Bas B S; Pizarro, Camila S; Arends, Bauke K O; Oerlemans, Marish I F J; Ahmetagić, Dino; van der Harst, Pim; van Es, René (Wiley-Blackwell, 2025-04)
    BACKGROUND: Recent advancements in deep learning (DL), a subset of artificial intelligence, have shown the potential to automate and improve disease recognition, phenotyping and prediction of disease onset and outcomes by ...
  • Expanding interpretability through complexity reduction in machine learning-based modelling of cardiovascular disease: A myocardial perfusion imaging PET/CT prognostic study 
    Lehtonen, Eero; Teuho, Jarmo; Vatandoust, Monire; Knuuti, Juhani; Knol, Remco J J; van der Zant, Friso M; Juárez-Orozco, Luis Eduardo; Klén, Riku (Wiley-Blackwell, 2025-04)
    BACKGROUND: Machine learning-based analysis can be used in myocardial perfusion imaging data to improve risk stratification and the prediction of major adverse cardiovascular events for patients with suspected or established ...
  • Novel insights into the regulation of neuron migration by axon guidance proteins 
    van Battum, Eljo Y; van den Munkhof, Marleen H; Pasterkamp, R Jeroen (Elsevier Limited, 2025-06)
    Neural circuit development requires precisely coordinated guidance of migrating neurons to their targets within the nervous system. A diverse array of molecular cues has been implicated in neuron migration, including signals ...
  • Engineered heart tissue patches: A milestone in cardiac regenerative medicine 
    van Mil, Alain; Janssen, Jasmijn; van Rooij, Eva (Cell Press, 2025-04-03)
    Researchers have demonstrated that a stem cell-derived heart muscle patch can safely remuscularize failing hearts.1 Published in Nature, the study shows successful long-term cardiac integration of a patch in a primate model ...
  • A rare triplication of 16p11.2: Unravelling the genomic complexity and review of the literature 
    van der Laan, Liselot; Kleinendorst, Lotte; Haagmans, Martin A; Roquas, Laura; van der Smagt, Jasper J; Koop, Klaas; Henneman, Peter; van Haelst, Mieke M (Elsevier Masson SAS, 2025-06)
    16p11.2 triplication is a rare chromosomal disorder associated with developmental delay, behavioral abnormalities, and various dysmorphic features. Here, we present a case study of a four-year-old girl with 16p11.2 ...
  • Towards an sEEG-based BCI using code-modulated VEP: A case study showing the influence of electrode location on decoding efficiency 
    Thielen, Jordy; Tangermann, Michael; Aarnoutse, Erik J; Ramsey, Nick F; Vansteensel, Mariska J (Elsevier Ireland Ltd, 2025-05)
  • EORTC consensus recommendations on the optimal management of colorectal cancer liver metastases 
    Bregni, Giacomo; Adams, Richard; Bale, Reto; Bali, Maria A; Bargellini, Irene; Blomqvist, Lennart; Brown, Gina; Cremolini, Chiara; Demetter, Pieter; Denecke, Timm; Dohan, Anthony; Dopazo, Cristina; Elez, Elena; Evrard, Serge; Feakins, Roger; Guckenberger, Matthias; Guren, Marianne Gronlie; Hawkins, Maria; Hoorens, Anne; Huguet, Emmanuel; Intven, Martijn; Koessler, Thibaud; Kunz, Wolfgang G; Lordick, Florian; Lucidi, Valerio; Mahnken, Andreas H; Malik, Hassan; Martinive, Philippe; Mauer, Murielle; Romero, Alejandra Méndez; Nagtegaal, Iris; Orsi, Franco; Oyen, Wim Jg; Pellerin, Olivier; Rengo, Marco; Ricke, Jens; Ricoeur, Alexis; Riddell, Angela; Ronot, Maxime; Scorsetti, Marta; Seligmann, Jenny; Sempoux, Christine; Sheahan, Kieran; Stättner, Stefan; Svrcek, Magali; Taieb, Julien; West, Nick; Wyrwicz, Lucjan; Zech, Christoph J; Moehler, Markus; Sclafani, Francesco (W.B. Saunders Ltd, 2025-05)
    Patients with colorectal cancer liver metastases have long represented a unique and thoroughly investigated population. Nevertheless, the optimal management of these is still controversial with a number of open questions ...
  • Tofacitinib treatment for psoriatic skin lesions associated with Aicardi-Goutières syndrome 7/Singleton-Merten syndrome 1 
    Beerepoot, Shanice; Grinwis, Lucas; Vanderver, Adeline L; van der Knaap, Marjo S; Kuijpers, Taco W (BioMed Central, 2025-04-02)
    The purpose of this letter to the editor is to illustrate the effect of tofacitinib on psoriatic skin lesions in a patient with Aicardi-Goutières syndrome (AGS) type 7/Singleton-Merten syndrome 1. AGS is characterized by ...
  • Students' Use of a Learning Analytics Dashboard and Influence of Reference Frames: Goal Setting, Motivation, and Performance 
    de Vreugd, Lars; van Leeuwen, Anouschka; van der Schaaf, Marieke (Wiley-Blackwell Publishing Ltd, 2025-04)
    Background: University students need to self-regulate but are sometimes incapable of doing so. Learning Analytics Dashboards (LADs) can support students' appraisal of study behaviour, from which goals can be set and ...
  • Bowel tracking for MR-guided radiotherapy: simultaneous optimization of small bowel imaging and tracking 
    Damen, S.L.C.; van Lier, A.L.H.M.W.; Zachiu, C.; Raaymakers, B.W. (IOP Publishing Ltd., 2025-04-06)
    Objective. The small bowel is one of the most radiosensitive organs-at-risk during radiotherapy in the pelvis. This is further complicated due to anatomical and physiological motion. Thus, its accurate tracking becomes of ...
  • Invasive coronary function testing in clinical practice: Implementing the 2024 ESC guidelines on chronic coronary syndromes 
    Namba, Hanae F; Boerhout, Coen K M; Damman, Peter; Kunadian, Vijay; Escaned, Javier; Ong, Peter; Perera, Divaka; Berry, Colin; van de Hoef, Tim P; Piek, Jan J (Elsevier Ireland Ltd, 2025-07-01)
    Angina with non-obstructive coronary arteries (ANOCA) is increasingly recognized as a significant aspect of chronic coronary syndromes. These patients frequently experience recurrent angina, resulting in high healthcare ...
  • Gross tumor volume increase and need for adaptive radiotherapy in pediatric-type diffuse high-grade glioma of the midline structures 
    van Ommen, Fasco; van Genechten, Toon; Willemsen-Bosman, Mirjam E; Peters, Max; Seravalli, Enrica; van der Lugt, Jasper; Nievelstein, Rutger A J; Mueller, Sabine; Hulleman, Esther; van Vuurden, Dannis G; Kranendonk, Mariette E G; Hoving, Eelco W; Hoeben, Bianca A W; Janssens, Geert O (Elsevier Ireland Ltd, 2025-06)
    INTRODUCTION: Current pediatric-type diffuse high-grade glioma radiotherapy protocols apply a 1.0 cm clinical target volume (CTV) margin around the gross tumor volume (GTV). However, in adults with glioblastoma, large ...
  • Improving treatments for mental disorders using computational models 
    Ryan, Oisín; Haslbeck, Jonas M B; Robinaugh, Donald J (Elsevier Limited, 2025-06)
    Progress in the treatment of psychopathology has slowed and much remains unknown about how treatments achieve their beneficial effects. We propose that computational models can be used to provide new insights into how ...
  • Family history of pulmonary fibrosis impacts prognosis in patients with sarcoidosis 
    Planté-Bordeneuve, Thomas; Terwiel, Michelle; van der Vis, Joanne J; van Es, Wouter; Veltkamp, Marcel; Grutters, Jan C; van Moorsel, Coline H M (European Respiratory Society, 2025-01)
    Having a family member with pulmonary fibrosis (PF) impacts the prognosis of sarcoidosis patients, as the majority of patients reporting at least one relative with PF present fibrotic characteristics and one-third develop ...
  • Considerations and recommendations from the ISMRM diffusion study group for preclinical diffusion MRI: Part 1: In vivo small-animal imaging 
    Jelescu, Ileana O; Grussu, Francesco; Ianus, Andrada; Hansen, Brian; Barrett, Rachel L C; Aggarwal, Manisha; Michielse, Stijn; Nasrallah, Fatima; Syeda, Warda; Wang, Nian; Veraart, Jelle; Roebroeck, Alard; Bagdasarian, Andrew F; Eichner, Cornelius; Sepehrband, Farshid; Zimmermann, Jan; Soustelle, Lucas; Bowman, Christien; Tendler, Benjamin C; Hertanu, Andreea; Jeurissen, Ben; Verhoye, Marleen; Frydman, Lucio; van de Looij, Yohan; Hike, David; Dunn, Jeff F; Miller, Karla; Landman, Bennett A; Shemesh, Noam; Anderson, Adam; McKinnon, Emilie; Farquharson, Shawna; Dell'Acqua, Flavio; Pierpaoli, Carlo; Drobnjak, Ivana; Leemans, Alexander; Harkins, Kevin D; Descoteaux, Maxime; Xu, Duan; Huang, Hao; Santin, Mathieu D; Grant, Samuel C; Obenaus, Andre; Kim, Gene S; Wu, Dan; Le Bihan, Denis; Blackband, Stephen J; Ciobanu, Luisa; Fieremans, Els; Bai, Ruiliang; Leergaard, Trygve B; Zhang, Jiangyang; Dyrby, Tim B; Johnson, G Allan; Cohen-Adad, Julien; Budde, Matthew D; Schilling, Kurt G (John Wiley & Sons Inc., 2025-06)
    Small-animal diffusion MRI (dMRI) has been used for methodological development and validation, characterizing the biological basis of diffusion phenomena, and comparative anatomy. The steps from animal setup and monitoring, ...
  • Assessing the quality of prediction models in health care using the Prediction model Risk Of Bias ASsessment Tool (PROBAST): an evaluation of its use and practical application 
    Kaul, Tabea; Damen, Johanna A A; Wynants, Laure; Van Calster, Ben; van Smeden, Maarten; Hooft, Lotty; Moons, Karel G M (Elsevier, 2025-05)
    BACKGROUND AND OBJECTIVES: Since 2019, the Prediction model Risk Of Bias ASsessment Tool (PROBAST; www.probast.org) has supported methodological quality assessments of prediction model studies. Most prediction model studies ...
  • Considerations and recommendations from the ISMRM diffusion study group for preclinical diffusion MRI: Part 2-Ex vivo imaging: Added value and acquisition 
    Schilling, Kurt G; Grussu, Francesco; Ianus, Andrada; Hansen, Brian; Howard, Amy F D; Barrett, Rachel L C; Aggarwal, Manisha; Michielse, Stijn; Nasrallah, Fatima; Syeda, Warda; Wang, Nian; Veraart, Jelle; Roebroeck, Alard; Bagdasarian, Andrew F; Eichner, Cornelius; Sepehrband, Farshid; Zimmermann, Jan; Soustelle, Lucas; Bowman, Christien; Tendler, Benjamin C; Hertanu, Andreea; Jeurissen, Ben; Verhoye, Marleen; Frydman, Lucio; van de Looij, Yohan; Hike, David; Dunn, Jeff F; Miller, Karla; Landman, Bennett A; Shemesh, Noam; Anderson, Adam; McKinnon, Emilie; Farquharson, Shawna; Dell'Acqua, Flavio; Pierpaoli, Carlo; Drobnjak, Ivana; Leemans, Alexander; Harkins, Kevin D; Descoteaux, Maxime; Xu, Duan; Huang, Hao; Santin, Mathieu D; Grant, Samuel C; Obenaus, Andre; Kim, Gene S; Wu, Dan; Le Bihan, Denis; Blackband, Stephen J; Ciobanu, Luisa; Fieremans, Els; Bai, Ruiliang; Leergaard, Trygve B; Zhang, Jiangyang; Dyrby, Tim B; Johnson, G Allan; Cohen-Adad, Julien; Budde, Matthew D; Jelescu, Ileana O (John Wiley & Sons Inc., 2025-06)
    The value of preclinical diffusion MRI (dMRI) is substantial. While dMRI enables in vivo non-invasive characterization of tissue, ex vivo dMRI is increasingly being used to probe tissue microstructure and brain connectivity. ...
  • Meta-analysis of genome-wide associations and polygenic risk prediction for atrial fibrillation in more than 180,000 cases 
    Roselli, Carolina; Surakka, Ida; Olesen, Morten S; Sveinbjornsson, Gardar; Marston, Nicholas A; Choi, Seung Hoan; Holm, Hilma; Chaffin, Mark; Gudbjartsson, Daniel; Hill, Matthew C; Aegisdottir, Hildur; Albert, Christine M; Alonso, Alvaro; Anderson, Christopher D; Arking, Dan E; Arnar, David O; Barnard, John; Benjamin, Emelia J; Braunwald, Eugene; Brumpton, Ben; Campbell, Archie; Chami, Nathalie; Chasman, Daniel I; Cho, Kelly; Choi, Eue-Keun; Christophersen, Ingrid E; Chung, Mina K; Conen, David; Crijns, Harry J; Cutler, Michael J; Czuba, Tomasz; Damrauer, Scott M; Dichgans, Martin; Dörr, Marcus; Dudink, Elton; Duong, ThuyVy; Erikstrup, Christian; Esko, Tõnu; Fatkin, Diane; Faul, Jessica D; Ferreira, Manuel; Freitag, Daniel F; Ganesh, Santhi K; Gaziano, J Michael; Geelhoed, Bastiaan; Ghouse, Jonas; Gieger, Christian; Giulianini, Franco; Graham, Sarah E; van der Harst, Pim; BioBank Japan Project (Nature Research, 2025-03)
    Atrial fibrillation (AF) is the most common heart rhythm abnormality and is a leading cause of heart failure and stroke. This large-scale meta-analysis of genome-wide association studies increased the power to detect ...