2024-03-28T08:50:17Zhttps://dspace.library.uu.nl/oai/requestoai:dspace.library.uu.nl:1874/3818362020-05-19T17:31:23Zcom_1874_298213col_1874_298214
info:eu-repo/semantics/OpenAccess
Recurrent Cholera Outbreaks, Democratic Republic of the Congo, 2008-2017
Ingelbeen, Brecht
Hendrickx, David
Miwanda, Berthe
van der Sande, Marianne A. B.
Mossoko, Mathias
Vochten, Hilde
Riems, Bram
Nyakio, Jean-Paul
Vanlerberghe, Veerle
Lunguya, Octavie
Jacobs, Jan
Boelaert, Marleen
Kebela, Benoit Ilunga
Bompangue, Didier
Muyembe, Jean-Jacques
In 2017, the exacerbation of an ongoing countrywide cholera outbreak in the Democratic Republic of the Congo resulted in >53,000 reported cases and 1,145 deaths. To guide control measures, we analyzed the characteristics of cholera epidemiology in DRC on the basis of surveillance and cholera treatment center data for 2008–2017. The 2017 nationwide outbreak resulted from 3 distinct mechanisms: considerable increases in the number of cases in cholera-endemic areas, so-called hot spots, around the Great Lakes in eastern DRC; recurrent outbreaks progressing downstream along the Congo River; and spread along Congo River branches to areas that had been cholera-free for more than a decade. Case-fatality rates were higher in nonendemic areas and in the early phases of the outbreaks, possibly reflecting low levels of immunity and less appropriate prevention and treatment. Targeted use of oral cholera vaccine, soon after initial cases are diagnosed, could contribute to lower case-fatality rates.
2019-05
Article
image/pdf
https://dspace.library.uu.nl/handle/1874/381836
Emerging Infectious Diseases 25(5), 856-864 (2019)
en
1080-6040