Abstract
Poly(L-lactic acid) microspheres loaded with holmium-166 acetylacetonate (Ho-166-PLLA-MS) are a novel microdevice for intra-arterial radioembolization in patients with unresectable liver malignancies. The neutron activation in a nuclear reactor, in particular the gamma heating, damages the Ho-166-PLLA-MS. The degree of damage is dependent on the irradiation characteristics and irradiation time in
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