Abstract
Microtubules are essental components of the eukaryotc cytoskeleton. They are subjected to
a number of post-translatonal modifcatons, which increase their heterogeneity, leading to
functonal specializaton. The combinaton of the post-translatonal modifcatons, together
with the diferental overexpression of tubulin isotypes, creates the tubulin code. This thesis
focuses on detyrosinaton, one of
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