Association between alcohol exposure and the risk of amyotrophic lateral sclerosis in the Euro-MOTOR study
D'Ovidio, Fabrizio; Rooney, James P K; Visser, Anne E; Manera, Umberto; Beghi, Ettore; Logroscino, Giancarlo; Vermeulen, Roel C H; Veldink, Jan Herman; van den Berg, Leonard H; Hardiman, Orla; Chiò, Adriano; Euro-MOTOR Consortium
(2019) Journal of neurology, neurosurgery, and psychiatry, volume 90, issue 1, pp. 11 - 19
(Article)
Abstract
OBJECTIVES: Several studies focused on the association between alcohol consumption and amyotrophic lateral sclerosis (ALS), although with inconsistent findings. Antioxidants may play a role since lyophilised red wine was found to prolong SOD1 mice lifespan. The aim of this international population-based case-control study performed in Ireland, The Netherlands and Italy
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was to assess the role of alcohol, and red wine in particular, in developing ALS. METHODS: Euro-MOTOR is a case-control study where patients with incident ALS and controls matched for gender, age and area of residency were recruited in a population-based design. Logistic regression models adjusted for sex, age, cohort, education, leisure time physical activity, smoking, heart problems, hypertension, stroke, cholesterol and diabetes were performed. RESULTS: 1557 patients with ALS and 2922 controls were enrolled in the study. Exposure to alcohol drinking was not significantly associated with ALS risk. A stratified analysis of exposure to alcohol by cohort revealed significant ORs in The Netherlands and in Apulia, with opposite directions (respectively 0.68 and 2.38). With regard to red wine consumption, only in Apulia the double-fold increased risk (OR 2.53) remained significant. A decreased risk was found for current alcohol drinkers (OR 0.83), while a significantly increased risk was detected among former drinkers (OR 1.63). Analysis of cumulative exposure to alcohol revealed no significant associations with ALS risk. CONCLUSION: With few exceptions, no significant association was found between alcohol consumption and ALS. The study of the association between alcohol and ALS requires a thorough exploration, especially considering the role of different type of alcoholic beverages.
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Keywords: Alcohol Drinking/epidemiology, Ireland/epidemiology, Humans, Middle Aged, Risk Factors, Logistic Models, Male, Case-Control Studies, Amyotrophic Lateral Sclerosis/epidemiology, Italy/epidemiology, Wine/statistics & numerical data, Female, Aged, Netherlands/epidemiology, Odds Ratio, Clinical Neurology, Psychiatry and Mental health, Surgery, Research Support, Non-U.S. Gov't, Journal Article
ISSN: 0022-3050
Publisher: BMJ Publishing Group
Note: Funding Information: Competing interests JpKR was funded by the health Research Board clinical Fellowship programme (hpF-2014-527). eB reports grants from UcB-pharma, grants from shire, grants from eIsaI, personal fees from Viropharma, grants from Italian Ministry of health, grants from Fondazione Borgonovo, grants from associazione IDIc 15, grants from european Union, outside the submitted work. Oh is funded by the health Research Board clinician scientist programme and science Foundation Ireland; has received speaking honoraria from Novartis, Biogen Idec, sanofi aventis and Merck-serono; has been a member of advisory panels for Biogen Idec, allergen, Ono pharmaceuticals, Novartis, cytokinetics and sanofi aventis; and serves as editor-in-chief of Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. LhvdB reports grants from european Union health seventh Framework programme (eUROMOTOR project), Netherlands aLs Foundation and The Netherlands Organization for health Research and Development (Vici scheme), serves on scientific advisory boards for the prinses Beatrix spierfonds, Thierry Latran Foundation, Biogen, cytokinetics, Orion and sarepta; serves on the editorial board of Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration and The Journal of Neurology, Neurosurgery, and Psychiatry. ac serves on the editorial advisory board of Amyotrophic Lateral Sclerosis; receives research support from the Italian Ministry of health (Ricerca Finalizzata), Regione piemonte (Ricerca Finalizzata), University of Turin, Fondazione Vialli e Mauro onlus and the european commission (health seventh Framework programme); and serves on scientific advisory boards for Biogen Idec, cytokinetics, Italfarmaco, Neuraltus and Mitsubishi Tanabe. FD, aeV, UM, RchV, GL and JhV report no disclosures relevant to the manuscript. Funding Information: Funding The research leading to these results has received funding from the european community’s health seventh Framework programme (Fp7/2007–2013; grant agreements no. 259867). Publisher Copyright: © Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ.
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