Interaction between the nasal microbiota and S. pneumoniae in the context of live-attenuated influenza vaccine
de Steenhuijsen Piters, Wouter A.A.; Jochems, Simon P.; Mitsi, Elena; Rylance, Jamie; Pojar, Sherin; Nikolaou, Elissavet; German, Esther L.; Holloway, Mark; Carniel, Beatriz F.; Chu, Mei Ling J.N.; Arp, Kayleigh; Sanders, Elisabeth A.M.; Ferreira, Daniela M.; Bogaert, Debby
(2019) Nature Communications, volume 10, issue 1
(Article)
Abstract
Streptococcus pneumoniae is the main bacterial pathogen involved in pneumonia. Pneumococcal acquisition and colonization density is probably affected by viral co-infections, the local microbiome composition and mucosal immunity. Here, we report the interactions between live-attenuated influenza vaccine (LAIV), successive pneumococcal challenge, and the healthy adult nasal microbiota and mucosal immunity
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using an experimental human challenge model. Nasal microbiota profiles at baseline are associated with consecutive pneumococcal carriage outcome (non-carrier, low-dense and high-dense pneumococcal carriage), independent of LAIV co-administration. Corynebacterium/Dolosigranulum-dominated profiles are associated with low-density colonization. Lowest rates of natural viral co-infection at baseline and post-LAIV influenza replication are detected in the low-density carriers. Also, we detected the fewest microbiota perturbations and mucosal cytokine responses in the low-density carriers compared to non-carriers or high-density carriers. These results indicate that the complete respiratory ecosystem affects pneumococcal behaviour following challenge, with low-density carriage representing the most stable ecological state.
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Keywords: Adolescent, Adult, Carrier State/immunology, Coinfection/immunology, Female, Healthy Volunteers, Humans, Influenza Vaccines/administration & dosage, Influenza, Human/immunology, Male, Microbiota/immunology, Middle Aged, Nasal Mucosa/immunology, Pneumococcal Infections/immunology, Streptococcus pneumoniae/immunology, Vaccines, Attenuated/administration & dosage, Young Adult, Journal Article, Research Support, Non-U.S. Gov't
ISSN: 2041-1723
Publisher: Nature Publishing Group
(Peer reviewed)