External validation of prognostic models for preeclampsia in a Dutch multicenter prospective cohort
Lamain-de Ruiter, Marije; Kwee, Anneke; Naaktgeboren, Christiana A; Louhanepessy, Rebecca D; De Groot, Inge; Evers, Inge M; Groenendaal, Floris; Hering, Yolanda R; Huisjes, Anjoke J M; Kirpestein, Cornel; Monincx, Wilma M; Schielen, Peter C J I; Van 't Zelfde, Annewil; Van Oirschot, Charlotte M; Vankan-Buitelaar, Simone A; Vonk, Mariska A A W; Wiegers, Therese A; Zwart, Joost J; Moons, Karel G M; Franx, Arie; Koster, Maria P H
(2019) Hypertension in Pregnancy, volume 38, issue 2, pp. 78 - 88
(Article)
Abstract
Objective: To perform an external validation of all published prognostic models for first-trimester prediction of the risk of developing preeclampsia (PE). Methods: Women <14 weeks of pregnancy were recruited in the Netherlands. All systematically identified prognostic models for PE that contained predictors commonly available were eligible for external validation. Results:
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3,736 women were included; 87 (2.3%) developed PE. Calibration was poor due to overestimation. Discrimination of 9 models for LO-PE ranged from 0.58 to 0.71 and of 9 models for all PE from 0.55 to 0.75. Conclusion: Only a few easily applicable prognostic models for all PE showed discrimination above 0.70, which is considered an acceptable performance.
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Keywords: First trimester, external validation, preeclampsia, prognostic model, Models, Theoretical, Prognosis, Prospective Studies, Risk Assessment, Humans, Pre-Eclampsia/diagnosis, Pregnancy, Adult, Female, Obstetrics and Gynaecology, Internal Medicine, Journal Article, Multicenter Study, Validation Studies
ISSN: 1064-1955
Publisher: Informa Healthcare
Note: Funding Information: This work was supported by The Netherlands Organization for Health Research and Development under Grant [project nr 209020004]. Funding Information: This work was supported by The Netherlands Organization for Health Research and Development under Grant [project nr 209020004]. We would like to thank all pregnant women who participated in the RESPECT study. A special thanks to the midwifery practices and hospitals in our regional consortium (GCMN) for their help in recruiting participants and technicians (I. Belmouden, G. Diependaal, M. Jonker, P. Turion, S. Verhoef) of the National Institute for Public Health and the Environment (RIVM) and U. Koster for their help in analyzing the biochemical serum markers. Publisher Copyright: © 2019, © 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
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