European Ultrahigh-Field Imaging Network for Neurodegenerative Diseases (EUFIND)
Düzel, Emrah; Acosta-Cabronero, Julio; Berron, David; Biessels, Geert Jan; Björkman-Burtscher, Isabella; Bottlaender, Michel; Bowtell, Richard; Buchem, Mark V; Cardenas-Blanco, Arturo; Boumezbeur, Fawzi; Chan, Dennis; Clare, Stuart; Costagli, Mauro; de Rochefort, Ludovic; Fillmer, Ariane; Gowland, Penny; Hansson, Oskar; Hendrikse, Jeroen; Kraff, Oliver; Ladd, Mark E; Ronen, Itamar; Petersen, Esben; Rowe, James B; Siebner, Hartwig; Stoecker, Tony; Straub, Sina; Tosetti, Michela; Uludag, Kamil; Vignaud, Alexandre; Zwanenburg, Jaco; Speck, Oliver
(2019) Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, volume 11, pp. 538 - 549
(Article)
Abstract
Introduction: The goal of European Ultrahigh-Field Imaging Network in Neurodegenerative Diseases (EUFIND) is to identify opportunities and challenges of 7 Tesla (7T) MRI for clinical and research applications in neurodegeneration. EUFIND comprises 22 European and one US site, including over 50 MRI and dementia experts as well as neuroscientists. Methods:
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EUFIND combined consensus workshops and data sharing for multisite analysis, focusing on 7 core topics: clinical applications/clinical research, highest resolution anatomy, functional imaging, vascular systems/vascular pathology, iron mapping and neuropathology detection, spectroscopy, and quality assurance. Across these topics, EUFIND considered standard operating procedures, safety, and multivendor harmonization. Results: The clinical and research opportunities and challenges of 7T MRI in each subtopic are set out as a roadmap. Specific MRI sequences for each subtopic were implemented in a pilot study presented in this report. Results show that a large multisite 7T imaging network with highly advanced and harmonized imaging sequences is feasible and may enable future multicentre ultrahigh-field MRI studies and clinical trials. Discussion: The EUFIND network can be a major driver for advancing clinical neuroimaging research using 7T and for identifying use-cases for clinical applications in neurodegeneration.
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Keywords: Alzheimer's disease (AD), Magnetic resonance imaging (MRI), Mild cognitive impairment (MCI), Parkinson's disease (PD), Subjective cognitive decline (SCD), Ultrahigh-field MRI, Vascular dementia, Clinical Neurology, Psychiatry and Mental health
ISSN: 2352-8729
Publisher: Elsevier BV
(Publisher version, Peer reviewed)
