A guidance was developed to identify participants with missing outcome data in randomized controlled trials

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A guidance was developed to identify participants with missing outcome data in randomized controlled trials
 
Kahale, Lara A; Guyatt, Gordon H; Agoritsas, Thomas; Briel, Matthias; Busse, Jason W; Carrasco-Labra, Alonso; Khamis, Assem M; Zhang, Yuqing; Hooft, Lotty; Scholten, Rob J P M; Akl, Elie A
(2019) Journal of Clinical Epidemiology, volume 115, pp. 55 - 63
(Article)
Abstract
BACKGROUND AND OBJECTIVES: In order for authors of systematic reviews to address missing data in randomized controlled trials (RCTs), they need to first identify the number of trial participants with missing data. The objective of this study was to provide guidance for authors of systematic reviews on how to identify ... read more
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Keywords: Guidance, Meta-analysis, Missing data, Randomized controlled trials, Risk of bias, Systematic reviews, Epidemiology, Journal Article
DOI: https://doi.org/10.1016/j.jclinepi.2019.07.003
ISSN: 0895-4356
Publisher: Elsevier USA
Note: Funding Information: Funding: This paper is part of a project on addressing missing trial participant data in systematic reviews funded by the Cochrane Methods Innovation Fund. The funder was not involved in study design and the collection, analysis, and interpretation of data and the writing of the article and the decision to submit it for publication. The researchers are independent from the funder and had full access to all the data. Funding: This paper is part of a project on addressing missing trial participant data in systematic reviews funded by the Cochrane Methods Innovation Fund. The funder was not involved in study design and the collection, analysis, and interpretation of data and the writing of the article and the decision to submit it for publication. The researchers are independent from the funder and had full access to all the data. Conflicts of interest: All authors have completed the ICMJE uniform disclosure form and declare no support from any organization for the submitted work; no financial relationships with any organizations that might have an interest in the submitted work in the previous 3 years. They declare being involved in previous publications making recommendations on the topic missing data. Authors' contributions: L.A.K. G.H.G. and E.A.A. contributed to the conception and design of the article, data analysis, interpretation of data, and drafting the article. T.A. M.B. J.W.B. A.C.-L. A.M.K. Y.Z. L.H. and R.J.P.M.S. contributed to the critical revision of the article for important intellectual content. All authors reviewed and approved the final version. Funding: This paper is part of a project on addressing missing trial participant data in systematic reviews funded by the Cochrane Methods Innovation Fund. The funder was not involved in study design and the collection, analysis, and interpretation of data and the writing of the article and the decision to submit it for publication. The researchers are independent from the funder and had full access to all the data. Conflicts of interest: All authors have completed the ICMJE uniform disclosure form and declare no support from any organization for the submitted work; no financial relationships with any organizations that might have an interest in the submitted work in the previous 3 years. They declare being involved in previous publications making recommendations on the topic missing data. Publisher Copyright: © 2019 Elsevier Inc.
(Peer reviewed)