Changes in the Synaptic Proteome in Tauopathy and Rescue of Tau-Induced Synapse Loss by C1q Antibodies

Dejanovic, Borislav; Huntley, Melanie A.; De Mazière, Ann; Meilandt, William J.; Wu, Tiffany; Srinivasan, Karpagam; Jiang, Zhiyu; Gandham, Vineela; Friedman, Brad A.; Ngu, Hai; Foreman, Oded; Carano, Richard A.D.; Chih, Ben; Klumperman, Judith; Bakalarski, Corey; Hanson, Jesse E.; Sheng, Morgan

doi:https://doi.org/10.1016/j.neuron.2018.10.014

Changes in the Synaptic Proteome in Tauopathy and Rescue of Tau-Induced Synapse Loss by C1q Antibodies

DSpace/Manakin Repository

Changes in the Synaptic Proteome in Tauopathy and Rescue of Tau-Induced Synapse Loss by C1q Antibodies

Dejanovic, Borislav; Huntley, Melanie A.; De Mazière, Ann; Meilandt, William J.; Wu, Tiffany; Srinivasan, Karpagam; Jiang, Zhiyu; Gandham, Vineela; Friedman, Brad A.; Ngu, Hai; Foreman, Oded; Carano, Richard A.D.; Chih, Ben; Klumperman, Judith; Bakalarski, Corey; Hanson, Jesse E.; Sheng, Morgan

(2018) Neuron, volume 100, issue 6, pp. 1322 - 1336.e7

(Article)

Abstract

Unbiased proteomics reveals multiple molecular changes at hippocampal synapses that occur prior to neurodegeneration in a taupathy/Alzheimer's disease mouse model. Complement C1q labels phospho-Tau-containing synapses and drives microglia-mediated synapse loss that can be rescued by a C1q-blocking antibody.

Download/Full Text

An Open Access version of this item is not available due to the copyright policy of the publisher.

Version on publisher website for UU-students and staff

Version on publisher website

Keywords: Alzheimer's disease, C1q, complement, GTPase, mass spectrometry, neurodegeneration, postsynaptic density, proteomics, synapse, Tau, Neuroscience(all)

DOI: https://doi.org/10.1016/j.neuron.2018.10.014

ISSN: 0896-6273

Publisher: Cell Press

(Peer reviewed)