Abstract
INTRODUCTION: Cushing’s syndrome or hypercortisolism is one of the most frequently diagnosed endocrinopathies in dogs. At present, medical management of canine hypercortisolism consists of either trilostane or mitotane. Both treatments have disadvantages associated with undesired hypoadrenocorticism. Therefore, a more specific inhibition of cortisol production is desirable. The steroidogenic enzyme cytochrome
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