Modeling the Human Scarred Heart In Vitro : Toward New Tissue Engineered Models
Deddens, Janine C.; Sadeghi, Amir Hossein; Hjortnaes, Jesper; van Laake, Linda W.; Buijsrogge, Marc; Doevendans, Pieter A.; Khademhosseini, Ali; Sluijter, Joost P G
(2017) Advanced Healthcare Materials, volume 6, issue 3
(Article)
Abstract
Cardiac remodeling is critical for effective tissue healing, however, excessive production and deposition of extracellular matrix components contribute to scarring and failing of the heart. Despite the fact that novel therapies have emerged, there are still no lifelong solutions for this problem. An urgent need exists to improve the understanding
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of adverse cardiac remodeling in order to develop new therapeutic interventions that will prevent, reverse, or regenerate the fibrotic changes in the failing heart. With recent advances in both disease biology and cardiac tissue engineering, the translation of fundamental laboratory research toward the treatment of chronic heart failure patients becomes a more realistic option. Here, the current understanding of cardiac fibrosis and the great potential of tissue engineering are presented. Approaches using hydrogel-based tissue engineered heart constructs are discussed to contemplate key challenges for modeling tissue engineered cardiac fibrosis and to provide a future outlook for preclinical and clinical applications.
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Keywords: cardiac fibrosis, cardiac remodeling, cardiac tissue engineering, drug development, extracellular matrix, hydrogels, Biomaterials, Biomedical Engineering, Pharmaceutical Science, Journal Article, Review
ISSN: 2192-2640
Publisher: John Wiley and Sons Ltd
Note: © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
(Publisher version, Peer reviewed)
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