Quality-of-life after radiotherapy for advanced laryngeal cancer : Results of a phase III trial of the Dutch Head and Neck Society
Janssens, Geert O.; Langendijk, Johannes A.; Terhaard, Chris H.; Doornaert, Patricia A.; Van Den Ende, Piet; De Jong, Martin A.; Takes, Robert P.; Span, Paul N.; Kaanders, Johannes H.
(2016) Radiotherapy & Oncology, volume 119, issue 2, pp. 213 - 220
(Article)
Abstract
Background/purpose To report on health-related quality-of-life (HRQoL) of patients with laryngeal cancer, treated in a randomized trial comparing accelerated radiotherapy with carbogen and nicotinamide (ARCON) against accelerated radiotherapy alone (AR). Material/methods HRQoL was assessed using the HRQoL Questionnaire-C30 (QLQ-C30) and the Head & Neck cancer module (QLQ-H&N35) at baseline, at
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completion of radiotherapy and at 6, 12, and 24 months post-baseline. Results From 269/345 patients (AR: 136/174; ARCON: 133/171) data on HRQoL were available for analysis. Moderate to severe clinical impact of the treatment was observed for nearly all items of the QLQ-C30 and QLQ-H&N35 between baseline and end-of-treatment. At 6 months, scores returned to baseline level with exception of dry mouth, sticky saliva, and taste/smell. No difference between AR and ARCON was observed. At 2 years from baseline, the percentage of patients reporting moderate to severe complaints of dry mouth, sticky saliva, or changes in taste/smell was 30%, 22% and 18%, respectively, while the majority of patients had no or few complaints of swallowing (79%) or speech (64%). Conclusions With accelerated radiotherapy, high local tumor control was obtained while maintaining good speech and swallowing function. Long-term dry mouth, sticky saliva and changes in taste/smell are limited to one quarter of patients. (ClinicalTrials.gov number, NCT00147732).
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Keywords: Accelerated radiotherapy, ARCON, Laryngeal cancer, Quality-of-life, Randomized trial, Medicine(all), Hematology, Oncology, Radiology Nuclear Medicine and imaging, Journal Article, Clinical Trial, Phase III, Research Support, Non-U.S. Gov't
ISSN: 0167-8140
Publisher: Elsevier Ireland Ltd
(Publisher version, Peer reviewed)
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