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UMC Repository: Recent submissions

  • Brachytherapy for rhabdomyosarcoma: Survey of international clinical practice and development of guidelines 
    Dávila Fajardo, Raquel; Scarzello, Giovanni; Gaze, Mark N; Boterberg, Tom; Cameron, Alison; Fuchs, Joerg; Guérin, Florent; Hoskin, Peter; Krasin, Matthew J; Kroon, Petra; Magelssen, Henriette; Mercke, Claes; Merks, Johannes H M; Paulsen, Frank; Pommier, Pascal; Ramos, Monica; Rees, Helen; Rogers, Tim; Schmid, Maximilian; Seitz, Guido; Slater, Olga; Smeulders, Naima; Stenman, Jakob; Terwisscha, Sheila; Chargari, Cyrus; Mandeville, Henry C (Elsevier Ireland Ltd, 2024-06)
    BACKGROUND AND PURPOSE: The purpose of this study was to address the lack of published data on the use of brachytherapy in pediatric rhabdomyosarcoma by describing current practice as starting point to develop consensus ...
  • High SNR full brain relaxometry at 7T by accelerated MR-STAT 
    Versteeg, Edwin; Liu, Hongyan; van der Heide, Oscar; Fuderer, Miha; van den Berg, Cornelis A T; Sbrizzi, Alessandro (John Wiley and Sons Inc., 2024-07)
    Purpose: To demonstrate the feasibility and robustness of the Magnetic Resonance Spin TomogrAphy in Time-domain (MR-STAT) framework for fast, high SNR relaxometry at 7T. Methods: To deploy MR-STAT on 7T-systems, we designed ...
  • A comparison of four self-controlled study designs in an analysis of COVID-19 vaccines and myocarditis using five European databases 
    Schultze, Anna; Martin, Ivonne; Messina, Davide; Bots, Sophie; Belitser, Svetlana; José Carreras-Martínez, Juan; Correcher-Martinez, Elisa; Urchueguía-Fornes, Arantxa; Martín-Pérez, Mar; García-Poza, Patricia; Villalobos, Felipe; Pallejà-Millán, Meritxell; Alberto Bissacco, Carlo; Segundo, Elena; Souverein, Patrick; Riefolo, Fabio; Durán, Carlos E.; Gini, Rosa; Sturkenboom, Miriam; Klungel, Olaf; Douglas, Ian (Elsevier BV, 2024-04-30)
    Introduction: The aim of this study was to assess the possible extent of bias due to violation of a core assumption (event-dependent exposures) when using self-controlled designs to analyse the association between COVID-19 ...
  • Simplified consent in cluster randomised trials: the new EU Clinical Trials Regulation does not provide sufficient guidance 
    Goldstein, Cory E; van der Graaf, Rieke (BMJ Publishing Group, 2023-09-13)
    Cory Goldstein and Rieke van der Graaf argue that the new EU Clinical Trials Regulation on informed consent in cluster randomised trials is ambiguous and could lead to an overuse of opt-out consent approaches that provide ...
  • Ethical aspects of hemophilia gene therapy: a qualitative interview study with stakeholders 
    SYMPHONY consortium@SYMPHONY_NL (Wiley-Blackwell Publishing Ltd, 2023-10)
    BACKGROUND: There are great expectations for the potential role of gene therapy in the treatment of hemophilia. At the same time, developments in the field of hemophilia gene therapy have always raised ethical issues. It ...
  • Antibacterial CATH-2 Peptide Coating to Prevent Bone Implant-Related Infection 
    Keikhosravani, Pardis; Jahanmard, Fatemeh; Bollen, Tim; Nazmi, Kamran; Veldhuizen, Edwin J.A.; Gonugunta, Prasad; Anusuyadevi, Prasaanth Ravi; van der Wal, Bart C.H.; Vogely, Charles; Bikker, Floris J.; Taheri, Peyman; Weinans, Harrie; Amin Yavari, Saber (Wiley-Blackwell, 2023-09-25)
    The development of antibacterial coatings is a promising approach to preventing biofilm formation and reducing the overuse of systemic antibiotics. However, widespread antibiotic use has resulted in antibiotic-resistant ...
  • Automated Radiographic Measurements of Knee Osteoarthritis 
    Rayegan, H.; Nguyen, H. C.; Weinans, H.; Gielis, W. P.; Ahmadi Brooghani, S. Y.; Custers, R. J.H.; van Egmond, N.; Lindner, C.; Arbabi, V. (SAGE Publications Inc., 2023-12)
    Objective: Herewith, we report the development of Orthopedic Digital Image Analysis (ODIA) software that is developed to obtain quantitative measurements of knee osteoarthritis (OA) radiographs automatically. Manual ...
  • Current clinical practice of knee osteotomy in the Netherlands 
    Nguyen, H. Chien; Rietbroek, Justin D.; van Egmond, Nienke; Weinans, Harrie; Emans, Pieter J.; Custers, Roel J.H. (Elsevier, 2023-03)
    Background: Realignment osteotomies is gaining popularity amongst Dutch orthopaedic surgeons. Exact numbers and used standards in clinical practice concerning osteotomies are unknown due to the absence of a national registry. ...
  • Global prevalence of basic life support training: A systematic review and meta-analysis 
    for the GOALS Workgroup (Elsevier Ireland Ltd, 2023-05)
    Background and Aims: Out-of-hospital cardiac arrest exerts a large disease burden, which may be mitigated by bystander cardiopulmonary resuscitation and automated external defibrillation. We aimed to estimate the global ...
  • Osteoimmunomodulatory GelMA/liposome coatings to promote bone regeneration of orthopedic implants 
    Jahanmard, F.; Khodaei, A.; Flapper, J.; Dogan, O.; Roohi, K.; Taheri, P.; Weinans, H.; Storm, G.; Croes, M.; Mastrobattista, E.; Amin Yavari, S. (Elsevier, 2023-06)
    Despite being the most widely used biomaterials in orthopedic surgery, metallic implants do not induce new bone growth because they are bioinert. Surface biofunctionalization of implants with immunomodulatory mediators is ...
  • Plasma Lipoprotein Lipase Is Associated with Risk of Future Major Adverse Cardiovascular Events in Patients Following Carotid Endarterectomy 
    Mekke, Joost M.; Verwer, Maarten C.; Stroes, Erik S.G.; Kroon, Jeffrey; Timmers, Leo; Pasterkamp, Gerard; de Borst, Gert J.; van der Laan, Sander W.; de Kleijn, Dominique P.V. (W.B. Saunders Ltd, 2023-05)
    Introduction: Carotid plaque intraplaque haemorrhage (IPH) is associated with future cardiovascular events. It was hypothesised that plasma proteins associated with carotid plaque IPH are also likely to be associated with ...
  • Unravelling the hip-spine dilemma from the CHECK-cohort: is sagittal pelvic morphology linked to radiographic signs of femoroacetabular impingement? 
    van Erp, Joost H.J.; Gielis, Willem Paul; Arbabi, Vahid; de Gast, Arthur; Weinans, Harrie; Kaas, Laurens; Castelein, René M.; Schlösser, Tom P.C. (Wichtig Publishing, 2023-11)
    Introduction: To date the aetiology of femoroacetabular impingement (FAI) is still not completely understood. There are mechanical theories that suggest symptomatic FAI is linked to sagittal pelvic morphology and ...
  • The 2023 generation 
    Achinger-Kawecka, Joanna; Correa, Santiago; Hu, Jing; Li, Gaopeng; Lindeboom, Rik G H; Misale, Sandra; Monkkonen, Teresa; Nirmal, Ajit J; Prekovic, Stefan; Sinha, Sanju; Trigos, Anna S; Watson, Caroline J (Nature Research, 2023-12)
  • Predicting response to enzalutamide and abiraterone in metastatic prostate cancer using whole-omics machine learning 
    de Jong, Anouk C.; Danyi, Alexandra; van Riet, Job; de Wit, Ronald; Sjöström, Martin; Feng, Felix; de Ridder, Jeroen; Lolkema, Martijn P. (Nature Publishing Group, 2023-04-08)
    Response to androgen receptor signaling inhibitors (ARSI) varies widely in metastatic castration resistant prostate cancer (mCRPC). To improve treatment guidance, biomarkers are needed. We use whole-genomics (WGS; n = 155) ...
  • Comprehensive benchmark and architectural analysis of deep learning models for nanopore sequencing basecalling 
    Pagès-Gallego, Marc; de Ridder, Jeroen (BioMed Central, 2023-04-11)
    Background: Nanopore-based DNA sequencing relies on basecalling the electriccurrent signal. Basecalling requires neural networks to achieve competitive accuracies.To improve sequencing accuracy further, new models are ...
  • Echtvar: compressed variant representation for rapid annotation and filtering of SNPs and indels 
    Pedersen, Brent S.; de Ridder, Jeroen (Oxford University Press, 2023-01-11)
    Germline and somatic variants within an individual or cohort are interpreted with information from large cohorts. Annotation with this information becomes a computational bottleneck as population sets grow to terabytes of ...
  • Case Report: Immune dysregulation associated with long-lasting regression of a (pre)leukemic clone 
    Koedijk, Joost B; van Beek, Thomas B; Vermeulen, Marijn A; Kester, Lennart A; Schweighart, Elizabeth K; Nierkens, Stefan; Belderbos, Mirjam E; Zwaan, C Michel; Heitink-Pollé, Katja M J; Heidenreich, Olaf (Frontiers Media S. A., 2023-10-16)
    Regression of leukemia in the absence of disease-modifying therapy remains poorly understood, although immunological mechanisms are thought to play a role. Here, we present a unique case of a 17-year-old boy with immune ...
  • Immune Response following BNT162b2 mRNA COVID-19 Vaccination in Pediatric Cancer Patients 
    Schmidt, K L Juliëtte; Dautzenberg, Noël M M; Hoogerbrugge, Peter M; Lindemans, Caroline A; Nierkens, Stefan; Smits, Gaby; Van Binnendijk, Rob S; Bont, Louis J; Tissing, Wim J E (Multidisciplinary Digital Publishing Institute (MDPI), 2023-05)
    COVID-19 vaccinations are recommended for children with cancer but data on their vaccination response is scarce. This study assesses the antibody and T-cell response following a 2- or 3-dose vaccination with BNT162b2 mRNA ...
  • Early immune reconstitution as predictor for outcomes after allogeneic hematopoietic cell transplant; a tri-institutional analysis 
    Troullioud Lucas, Alexandre G; Lindemans, Caroline A; Bhoopalan, Senthil Velan; Dandis, Rana; Prockop, Susan E; Naik, Swati; Keerthi, Dinesh; de Koning, Coco; Sharma, Akshay; Nierkens, Stefan; Boelens, Jaap Jan (Informa Healthcare, 2023-09)
    Background aims: CD4 immune reconstitution (IR) after allogeneic hematopoietic cell transplant (allo-HCT) correlates with lower non-relapse mortality (NRM), but its impact on leukemia relapse remains less clear, especially ...
  • Definitions, incidence and outcome of poor graft function after hematopoietic cell transplantation: A systematic review and meta-analysis 
    Müskens, Konradin F; Lindemans, Caroline A; Dandis, Rana; Nierkens, Stefan; Belderbos, Mirjam E (Churchill Livingstone, 2023-07)
    Poor graft function (PGF) after allogeneic hematopoietic stem cell transplantation (HCT) is a serious complication with high morbidity and mortality. The reported incidence of PGF, its risk factors and outcome vary ...