Apolipoprotein-E polymorphism and response to pravastatin in men with coronary artery disease (REGRESS)
Maitland-Van Der Zee, Anke-Hilse; Jukema, J. Wouter; Zwinderman, Aeilko H.; Hallman, D. Michael; De Boer, Anthonius; Kastelein, John J. R.; De Knijff, Peter
(2006) Acta Cardiologica, volume 61, issue 3, pp. 327 - 331
(Article)
Abstract
Objectve - The influence of ApoE polymorphism on the efficacy of statins in lowering plasma lipids and lipoproteins and improving angiographic parameters was assessed. Methods: ApoE genotypes were studied in a group (n = 815) of well-characterised male coronary artery disease (CAD) patients who participated in the lipid-lowering regression study
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'Regression Growth Evaluation Statin Study (REGRESS). Results - There was a significant interaction between treatment (placebo/pravastatin) and APOE genotype when lipid levels were considered, APOE2 + carriers exhibited the largest improvement of HDL levels ( + 0.15 mmol/l) and LDL/HDL ratios (-0.60) compared with APOE3 + ( + 0.06 mmol/l, -0.043, respectively) and APOE4 + carriers ( + 0.07 mmol/l, -0.040). In contrast, APOE2 + allele carriers had the least effect in terms of angiographic parameters, although the difference was not statistically significant. Conclusions - The effects of statins in subjects with different ApoE genotypes were different with regard to the lipoprotein profile, but not with regard to angiographic parameters.
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Keywords: Apolipoprotein-E polymorphism, Coronary artery disease, Pharmacogenetics, Statin, apolipoprotein E, high density lipoprotein, low density lipoprotein, placebo, pravastatin, allele, angiocardiography, article, clinical trial, controlled clinical trial, controlled study, coronary artery disease, drug efficacy, drug mechanism, genotype, human, human cell, lipid blood level, major clinical study, male, protein polymorphism, randomized controlled trial, regression analysis
ISSN: 0001-5385
Publisher: Acta Cardiologica
(Peer reviewed)